{"id":"https://openalex.org/W7213607388","doi":"https://doi.org/10.64898/2026.09.17.752471","title":"Decoupling Transcription from Cell Fate Preserves Germ Cell Totipotency","display_name":"Decoupling Transcription from Cell Fate Preserves Germ Cell Totipotency","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213607388","doi":"https://doi.org/10.64898/2026.09.17.752471","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779799","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596436"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.17.752471","doi":"https://doi.org/10.64898/2026.09.17.752471","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.17.752471","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42779799/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010371981","display_name":"Sherilyn Grill","orcid":"https://orcid.org/0000-0003-3201-0214","observed_orcids":["https://orcid.org/0000-0003-3201-0214"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherilyn Grill","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0003-3201-0214","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085159937","display_name":"Arjuna Rajakumar","orcid":"https://orcid.org/0000-0001-5937-0856","observed_orcids":["https://orcid.org/0000-0001-5937-0856"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjuna Rajakumar","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0001-5937-0856","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152146887","display_name":"Anais Tsai","orcid":"https://orcid.org/0000-0002-0998-9877","observed_orcids":["https://orcid.org/0000-0002-0998-9877"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana\u00efs Tsai","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Department of Biology, MIT, Cambridge, Mati"],"raw_orcid":"https://orcid.org/0000-0002-0998-9877","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Department of Biology, MIT, Cambridge, Mati","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064613968","display_name":"Claire Martel","orcid":"https://orcid.org/0009-0009-6211-3792","observed_orcids":["https://orcid.org/0009-0009-6211-3792"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Martel","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":"https://orcid.org/0009-0009-6211-3792","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152115139","display_name":"Lake V Palmeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lake V. Palmeri","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062905755","display_name":"Xinlei Gao","orcid":"https://orcid.org/0000-0002-8813-6329","observed_orcids":["https://orcid.org/0000-0002-8813-6329"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinlei Gao","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0002-8813-6329","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048335967","display_name":"Amelie A. Raz","orcid":"https://orcid.org/0000-0002-4651-0626","observed_orcids":["https://orcid.org/0000-0002-4651-0626"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelie A. Raz","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA"],"raw_orcid":"https://orcid.org/0000-0002-4651-0626","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052153816","display_name":"Ruth Lehmann","orcid":"https://orcid.org/0000-0002-8454-5651","observed_orcids":["https://orcid.org/0000-0002-8454-5651"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ruth Lehmann","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Department of Biology, MIT, Cambridge, Mati"],"raw_orcid":"https://orcid.org/0000-0002-8454-5651","affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Department of Biology, MIT, Cambridge, Mati","institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052153816"],"corresponding_institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.19040000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primordial-germ-cells","display_name":"primordial germ cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6449999809265137},{"id":"https://openalex.org/keywords/zelda","display_name":"Zelda","score":0.550000011920929},{"id":"https://openalex.org/keywords/nanos","display_name":"Nanos","score":0.8650000095367432},{"id":"https://openalex.org/keywords/translation-repression","display_name":"translation repression","score":0.640999972820282},{"id":"https://openalex.org/keywords/open-chromatin","display_name":"open chromatin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drosophila-embryogenesis","display_name":"Drosophila embryogenesis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/germline-specification","display_name":"germline specification","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2910790502","wikidata":"https://www.wikidata.org/wiki/Q862600","display_name":"Totipotent","level":4,"score":0.9333000183105469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7864000201225281},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7738000154495239},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.7297000288963318},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7123000025749207},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6355000138282776},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6276000142097473},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.5583999752998352},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5270000100135803},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.49549999833106995},{"id":"https://openalex.org/C190446060","wikidata":"https://www.wikidata.org/wiki/Q5550959","display_name":"Germ line development","level":4,"score":0.4927000105381012},{"id":"https://openalex.org/C48221581","wikidata":"https://www.wikidata.org/wiki/Q1737962","display_name":"Germ plasm","level":3,"score":0.48660001158714294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47380000352859497},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C147724379","wikidata":"https://www.wikidata.org/wiki/Q2367421","display_name":"Piwi-interacting RNA","level":5,"score":0.3921000063419342},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.38350000977516174},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.35179999470710754},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C2780258238","wikidata":"https://www.wikidata.org/wiki/Q2520842","display_name":"Germ","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.2782999873161316},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.27399998903274536}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.17.752471","doi":"https://doi.org/10.64898/2026.09.17.752471","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.17.752471","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779799","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779799","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596436","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779799/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13596436","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779799/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1512191091","https://openalex.org/W1967341601","https://openalex.org/W1974822125","https://openalex.org/W1975944495","https://openalex.org/W1983538883","https://openalex.org/W1986626974","https://openalex.org/W1988344228","https://openalex.org/W1991840483","https://openalex.org/W2004533772","https://openalex.org/W2007473333","https://openalex.org/W2007497552","https://openalex.org/W2027703497","https://openalex.org/W2028630156","https://openalex.org/W2041825762","https://openalex.org/W2042480114","https://openalex.org/W2042633640","https://openalex.org/W2043495620","https://openalex.org/W2047687392","https://openalex.org/W2047755766","https://openalex.org/W2050234082","https://openalex.org/W2054220127","https://openalex.org/W2056069458","https://openalex.org/W2059843465","https://openalex.org/W2063911875","https://openalex.org/W2063950568","https://openalex.org/W2073761355","https://openalex.org/W2075546889","https://openalex.org/W2082103906","https://openalex.org/W2087513467","https://openalex.org/W2088839833","https://openalex.org/W2090698995","https://openalex.org/W2095491090","https://openalex.org/W2102666135","https://openalex.org/W2102867231","https://openalex.org/W2109680952","https://openalex.org/W2111166800","https://openalex.org/W2120591530","https://openalex.org/W2138292740","https://openalex.org/W2138301522","https://openalex.org/W2144614846","https://openalex.org/W2144823539","https://openalex.org/W2148019518","https://openalex.org/W2159584345","https://openalex.org/W2161370538","https://openalex.org/W2161604785","https://openalex.org/W2181464620","https://openalex.org/W2259938310","https://openalex.org/W2296550214","https://openalex.org/W2568608184","https://openalex.org/W2800074119","https://openalex.org/W2949552670","https://openalex.org/W2950144017","https://openalex.org/W2951614277","https://openalex.org/W2953948304","https://openalex.org/W2984472267","https://openalex.org/W2999930226","https://openalex.org/W3111521801","https://openalex.org/W3120974422","https://openalex.org/W3134051383","https://openalex.org/W3155059563","https://openalex.org/W4289782042","https://openalex.org/W4308361273","https://openalex.org/W4386859240","https://openalex.org/W4390588488","https://openalex.org/W4403382001","https://openalex.org/W4409146570"],"related_works":["https://openalex.org/W2596913820","https://openalex.org/W2062961512","https://openalex.org/W1985126774","https://openalex.org/W2259261962","https://openalex.org/W2077383652","https://openalex.org/W2895347924","https://openalex.org/W2773319922","https://openalex.org/W2999929722","https://openalex.org/W4410820357","https://openalex.org/W4410551598"],"abstract_inverted_index":{"Abstract":[0],"Only":[1],"germ":[2,17,25,107],"cells":[3,26,108],"can":[4],"give":[5],"rise":[6],"to":[7,96],"a":[8,12],"totipotent":[9,99],"embryo,":[10,51],"yet":[11],"conserved":[13,83],"transcriptional":[14,73],"program":[15,47,74],"for":[16],"cell":[18,122],"identity":[19],"remains":[20],"elusive.":[21],"Profiling":[22],"Drosophila":[23],"primordial":[24],"(PGCs)":[27],"across":[28],"embryogenesis,":[29],"we":[30],"find":[31],"that":[32,94],"nascent":[33],"PGCs":[34,68,81],"are":[35],"not":[36,112],"silent,":[37],"as":[38,48],"previously":[39],"thought,":[40],"but":[41,79,116],"instead":[42],"transcribe":[43],"the":[44,49,62,82,98,104],"same":[45],"totipotency":[46],"early":[50],"reflecting":[52],"an":[53],"open":[54],"chromatin":[55,58,91],"state.":[56],"This":[57],"state,":[59],"established":[60],"by":[61,113,117],"pioneer":[63],"factor":[64],"Zelda,":[65],"persists":[66],"in":[67,80],"throughout":[69],"development.":[70],"The":[71],"associated":[72],"normally":[75],"drives":[76],"somatic":[77],"differentiation,":[78],"RNA-regulator":[84],"Nanos":[85],"represses":[86],"its":[87],"translation,":[88],"leaving":[89],"germline":[90],"uncommitted.":[92],"Cells":[93],"fail":[95],"establish":[97],"state":[100],"die":[101],"before":[102],"reaching":[103],"gonad.":[105],"Thus,":[106],"preserve":[109],"developmental":[110],"potential":[111],"restricting":[114],"transcription,":[115],"preventing":[118],"transcripts":[119],"from":[120],"determining":[121],"fate.":[123]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-19T00:00:00"}
