{"id":"https://openalex.org/W7213601332","doi":"https://doi.org/10.1016/j.cclet.2026.113442","title":"Cocrystallization of puerarin with berberine hydrochloride: The first drug-drug cocrystal of puerarin showcasing a potential combination therapy for metabolic diseases","display_name":"Cocrystallization of puerarin with berberine hydrochloride: The first drug-drug cocrystal of puerarin showcasing a potential combination therapy for metabolic diseases","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7213601332","doi":"https://doi.org/10.1016/j.cclet.2026.113442"},"language":"en","primary_location":{"id":"doi:10.1016/j.cclet.2026.113442","doi":"https://doi.org/10.1016/j.cclet.2026.113442","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2026.113442","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012493087","display_name":"Mingchao Yu","orcid":"https://orcid.org/0000-0001-5676-8551","observed_orcids":["https://orcid.org/0000-0001-5676-8551"]},"institutions":[{"id":"https://openalex.org/I4210145056","display_name":"Marine Biomedical Research Institute of Qingdao","ror":"https://ror.org/03pffnr86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210145056"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingchao Yu","raw_affiliation_strings":["Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China","School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":"https://orcid.org/0000-0001-5676-8551","affiliations":[{"raw_affiliation_string":"Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I4210145056","https://openalex.org/I59028903"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yifei Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Xie","raw_affiliation_strings":["Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152117902","display_name":"Xue Li","orcid":"https://orcid.org/0009-0007-9064-1133","observed_orcids":["https://orcid.org/0009-0007-9064-1133"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xue Li","raw_affiliation_strings":["Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":"https://orcid.org/0009-0007-9064-1133","affiliations":[{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","institution_ids":["https://openalex.org/I4210113896"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152149210","display_name":"Wen Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Ni","raw_affiliation_strings":["School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152147015","display_name":"Pengli Li","orcid":"https://orcid.org/0000-0002-5436-3830","observed_orcids":["https://orcid.org/0000-0002-5436-3830"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pengli Li","raw_affiliation_strings":["Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":"https://orcid.org/0000-0002-5436-3830","affiliations":[{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","institution_ids":["https://openalex.org/I4210113896"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083755299","display_name":"\u674e\u5ef6\u56e2","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yantuan Li","raw_affiliation_strings":["Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China","institution_ids":["https://openalex.org/I4210113896"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136166269","display_name":"Yang Lu","orcid":"https://orcid.org/0000-0002-2274-5703","observed_orcids":["https://orcid.org/0000-0002-2274-5703"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Lu","raw_affiliation_strings":["Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608005","display_name":"Jiaxiang Zhang","orcid":"https://orcid.org/0000-0002-5402-9277","observed_orcids":["https://orcid.org/0000-0002-5402-9277"]},"institutions":[{"id":"https://openalex.org/I4210145056","display_name":"Marine Biomedical Research Institute of Qingdao","ror":"https://ror.org/03pffnr86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210145056"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaxiang Zhang","raw_affiliation_strings":["Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China","School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China"],"raw_orcid":"https://orcid.org/0000-0002-5402-9277","affiliations":[{"raw_affiliation_string":"Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I4210145056","https://openalex.org/I59028903"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110906433","display_name":"Guanhua Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210145056","display_name":"Marine Biomedical Research Institute of Qingdao","ror":"https://ror.org/03pffnr86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210145056"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guanhua Du","raw_affiliation_strings":["Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China","Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao 266100, China","institution_ids":["https://openalex.org/I4210145056","https://openalex.org/I59028903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083755299","https://openalex.org/A5100608005","https://openalex.org/A5110906433","https://openalex.org/A5136166269","https://openalex.org/A5152117902","https://openalex.org/A5152147015"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210113896","https://openalex.org/I4210145056","https://openalex.org/I59028903"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"113442","last_page":"113442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10798","display_name":"Crystallography and molecular interactions","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.156700000166893,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/puerarin","display_name":"puerarin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/berberine-hydrochloride","display_name":"berberine hydrochloride","score":1.0},{"id":"https://openalex.org/keywords/co-crystallization","display_name":"co-crystallization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-drug-cocrystals","display_name":"drug-drug cocrystals","score":0.8119999766349792},{"id":"https://openalex.org/keywords/multi-target-drugs","display_name":"multi-target drugs","score":0.6499999761581421},{"id":"https://openalex.org/keywords/synergistic-combination-therapy","display_name":"synergistic combination therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9990000128746033},{"id":"https://openalex.org/keywords/molecular-interactions","display_name":"molecular interactions","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8320000171661377},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2778356392","wikidata":"https://www.wikidata.org/wiki/Q4392082","display_name":"Puerarin","level":3,"score":0.9927999973297119},{"id":"https://openalex.org/C100687433","wikidata":"https://www.wikidata.org/wiki/Q5139913","display_name":"Cocrystal","level":4,"score":0.9121000170707703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7486000061035156},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.704200029373169},{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.6201000213623047},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5884000062942505},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.28690001368522644},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.25130000710487366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23559999465942383}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.cclet.2026.113442","doi":"https://doi.org/10.1016/j.cclet.2026.113442","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cclet.2026.113442","pdf_url":null,"source":{"id":"https://openalex.org/S167919573","display_name":"Chinese Chemical Letters","issn_l":"1001-8417","issn":["1001-8417","1878-5964"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Chemical Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W2029667189","https://openalex.org/W2059828586","https://openalex.org/W2076287036","https://openalex.org/W2093240160","https://openalex.org/W2104919283","https://openalex.org/W2132525235","https://openalex.org/W2138501622","https://openalex.org/W2148284063","https://openalex.org/W2167810559","https://openalex.org/W2294788034","https://openalex.org/W2419040646","https://openalex.org/W2473083171","https://openalex.org/W2739303631","https://openalex.org/W2776666622","https://openalex.org/W2803023374","https://openalex.org/W2901226322","https://openalex.org/W2914510757","https://openalex.org/W2924395156","https://openalex.org/W2966405964","https://openalex.org/W2972739907","https://openalex.org/W2974443942","https://openalex.org/W2977572124","https://openalex.org/W3003265438","https://openalex.org/W3081700117","https://openalex.org/W3125543757","https://openalex.org/W3130053451","https://openalex.org/W3166260011","https://openalex.org/W3206786595","https://openalex.org/W4205758392","https://openalex.org/W4206368421","https://openalex.org/W4210370823","https://openalex.org/W4285187830","https://openalex.org/W4311281450","https://openalex.org/W4317211971","https://openalex.org/W4366765082"],"related_works":["https://openalex.org/W7125610400","https://openalex.org/W2993627824","https://openalex.org/W4410397726","https://openalex.org/W3125543757","https://openalex.org/W4377968199","https://openalex.org/W2973692726","https://openalex.org/W4362468008","https://openalex.org/W4386863841","https://openalex.org/W4401306072","https://openalex.org/W4352976739"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-19T00:00:00"}
