{"id":"https://openalex.org/W7213601228","doi":"https://doi.org/10.1016/j.omtn.2026.103105","title":"Systemic and local delivery of siRNA to the CNS and periphery via anti-IGF1R antibody conjugation","display_name":"Systemic and local delivery of siRNA to the CNS and periphery via anti-IGF1R antibody conjugation","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213601228","doi":"https://doi.org/10.1016/j.omtn.2026.103105","pmid":"https://pubmed.ncbi.nlm.nih.gov/42927339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13695317"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2026.103105","doi":"https://doi.org/10.1016/j.omtn.2026.103105","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103105","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtn.2026.103105","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055928714","display_name":"Mengnan Tian","orcid":"https://orcid.org/0000-0002-5011-2719","observed_orcids":["https://orcid.org/0000-0002-5011-2719"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengnan Tian","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087420885","display_name":"Mehran Nikan","orcid":"https://orcid.org/0009-0001-4696-9269","observed_orcids":["https://orcid.org/0009-0001-4696-9269"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehran Nikan","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042885479","display_name":"Miran Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Miran Yoo","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123021388","display_name":"Stephanie K. Klein","orcid":"https://orcid.org/0000-0003-1430-5553","observed_orcids":["https://orcid.org/0000-0003-1430-5553"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Klein","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060925274","display_name":"Seung\u2010Hwan Kwon","orcid":"https://orcid.org/0000-0002-5862-1630","observed_orcids":["https://orcid.org/0000-0002-5862-1630"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung-Hwan Kwon","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061311837","display_name":"John E. Matson","orcid":"https://orcid.org/0009-0002-4489-1338","observed_orcids":["https://orcid.org/0009-0002-4489-1338"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Matson","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061808243","display_name":"Dongin Kim","orcid":"https://orcid.org/0000-0003-2078-6138","observed_orcids":["https://orcid.org/0000-0003-2078-6138"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongin Kim","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124765511","display_name":"Jinwon Jung","orcid":"https://orcid.org/0000-0002-7981-3316","observed_orcids":["https://orcid.org/0000-0002-7981-3316"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinwon Jung","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114322661","display_name":"Sumin Hyeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sumin Hyeon","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124860038","display_name":"Byeong Min Yoo","orcid":"https://orcid.org/0009-0006-1557-8720","observed_orcids":["https://orcid.org/0009-0006-1557-8720"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byeong Min Yoo","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081687815","display_name":"Hyeon Ji Park","orcid":"https://orcid.org/0000-0002-2148-2171","observed_orcids":["https://orcid.org/0000-0002-2148-2171"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeon Ji Park","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017629694","display_name":"Michael Tanowitz","orcid":"https://orcid.org/0009-0005-0509-4186","observed_orcids":["https://orcid.org/0009-0005-0509-4186"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tanowitz","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005681369","display_name":"Asa Wahlander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asa Wahlander","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083663537","display_name":"Weon\u2010Kyoo You","orcid":"https://orcid.org/0000-0003-3833-798X","observed_orcids":["https://orcid.org/0000-0003-3833-798X"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Weon-Kyoo You","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090149353","display_name":"Hakju Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hakju Kwon","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077675886","display_name":"Janel Huffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janel Huffman","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090950544","display_name":"Thazha P. Prakash","orcid":"https://orcid.org/0000-0002-7466-3312","observed_orcids":["https://orcid.org/0000-0002-7466-3312"]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thazha P. Prakash","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152130359","display_name":"Sang Hoon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Hoon Lee","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124813115","display_name":"Hien Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800035258","display_name":"Ionis Pharmaceuticals (United States)","ror":"https://ror.org/00t8bew53","country_code":"US","type":"company","lineage":["https://openalex.org/I2800035258"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hien Zhao","raw_affiliation_strings":["Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ionis Pharmaceuticals Inc., 2855 Gazelle Ct, Carlsbad, CA 92010, USA","institution_ids":["https://openalex.org/I2800035258"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061154922","display_name":"Sungwon An","orcid":"https://orcid.org/0000-0001-8828-1908","observed_orcids":["https://orcid.org/0000-0001-8828-1908"]},"institutions":[{"id":"https://openalex.org/I4210105578","display_name":"ABL Bio (South Korea)","ror":"https://ror.org/01e0hcx30","country_code":"KR","type":"company","lineage":["https://openalex.org/I4210105578"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sungwon An","raw_affiliation_strings":["ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-8828-1908","affiliations":[{"raw_affiliation_string":"ABL Bio Inc., 456, Bongeunsa-ro, Gangnam-gu, Seoul 06153, Republic of Korea","institution_ids":["https://openalex.org/I4210105578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061154922","https://openalex.org/A5124813115"],"corresponding_institution_ids":["https://openalex.org/I2800035258","https://openalex.org/I4210105578"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56300114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4","first_page":"103105","last_page":"103105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.9729999899864197},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9589999914169312},{"id":"https://openalex.org/keywords/central-nervous-system-delivery","display_name":"central nervous system delivery","score":0.753000020980835},{"id":"https://openalex.org/keywords/oligonucleotide-therapeutics","display_name":"oligonucleotide therapeutics","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tissue-penetration","display_name":"tissue penetration","score":0.5139999985694885},{"id":"https://openalex.org/keywords/knockdown","display_name":"knockdown","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5800999999046326},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4948999881744385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41850000619888306},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4133000075817108},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3828999996185303},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34940001368522644},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.2687999904155731}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.omtn.2026.103105","doi":"https://doi.org/10.1016/j.omtn.2026.103105","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103105","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},{"id":"doi:10.64898/2026.01.30.702950","doi":"https://doi.org/10.64898/2026.01.30.702950","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.01.30.702950","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/02/02/2026.01.30.702950.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13695317","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695317/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695317/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:42927339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42927339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4d3f7befb59e41df972a0d7712b4a444","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4d3f7befb59e41df972a0d7712b4a444","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 37, Iss 4, Pp 103105- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2026.103105","doi":"https://doi.org/10.1016/j.omtn.2026.103105","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2026.103105","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314430","display_name":"Ionis Pharmaceuticals","ror":"https://ror.org/00t8bew53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213601228.pdf","grobid_xml":"https://content.openalex.org/works/W7213601228.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2093529351","https://openalex.org/W2127716652","https://openalex.org/W2143743183","https://openalex.org/W2146072976","https://openalex.org/W2314772071","https://openalex.org/W2474157905","https://openalex.org/W2509039973","https://openalex.org/W2762583518","https://openalex.org/W2771554318","https://openalex.org/W2793073482","https://openalex.org/W2965851198","https://openalex.org/W3030202434","https://openalex.org/W3099473825","https://openalex.org/W3114205754","https://openalex.org/W3165627834","https://openalex.org/W4200588978","https://openalex.org/W4205824800","https://openalex.org/W4210594377","https://openalex.org/W4255884628","https://openalex.org/W4281688566","https://openalex.org/W4292702578","https://openalex.org/W4308523103","https://openalex.org/W4309770648","https://openalex.org/W4313414644","https://openalex.org/W4365149913","https://openalex.org/W4378070663","https://openalex.org/W4383552050","https://openalex.org/W4383820686","https://openalex.org/W4386804199","https://openalex.org/W4401596729","https://openalex.org/W4412737073"],"related_works":["https://openalex.org/W4411506255","https://openalex.org/W4281688566","https://openalex.org/W2232271610","https://openalex.org/W7162147067","https://openalex.org/W2474157905","https://openalex.org/W4285090011","https://openalex.org/W2062493873","https://openalex.org/W2411060373","https://openalex.org/W2078434398","https://openalex.org/W2344281125"],"abstract_inverted_index":{"ABSTRACT":[0],"siRNA":[1,36,102],"delivery":[2,146,174],"platforms":[3],"capable":[4,171],"of":[5,20,172,190],"accessing":[6],"both":[7,176],"central":[8,94,177],"and":[9,59,106,122,178],"peripheral":[10,111,179],"tissues":[11,98],"are":[12,147],"critically":[13],"needed":[14],"to":[15,37,100,149,160],"expand":[16],"the":[17,45,150,154,187],"therapeutic":[18,188],"potential":[19],"oligonucleotides.":[21],"To":[22],"address":[23],"this,":[24],"we":[25],"developed":[26],"a":[27,53,182],"novel":[28],"siRNA-antibody":[29],"conjugate":[30,129],"by":[31],"attaching":[32],"an":[33,38,61,168],"Hprt":[34,77,89,115],"-targeting":[35],"engineered":[39],"antibody":[40,55,62],"shuttle.":[41],"This":[42],"shuttle":[43],"targets":[44],"insulin-like":[46],"growth":[47],"factor":[48],"1":[49],"receptor":[50,170],"(IGF1R)":[51],"using":[52],"fused":[54],"fragment":[56],"(Clone":[57],"F)":[58],"utilizes":[60],"backbone":[63],"with":[64,125,137],"no":[65],"tissue-relevant":[66],"binding":[67],"in":[68,81,119],"this":[69],"study.":[70],"The":[71,128],"resulting":[72],"conjugate,":[73],"designated":[74],"Clone":[75,87,113],"F-":[76,88,114],",":[78],"demonstrated":[79,90],"robust":[80],"vivo":[82],"knockdown":[83,118],"across":[84,133,175],"multiple":[85],"tissues.":[86],"enhanced":[91],"penetration":[92],"into":[93],"nervous":[95],"system":[96],"(CNS)":[97],"compared":[99],"unconjugated":[101],"following":[103],"intracerebroventricular":[104],"(ICV)":[105],"intravenous":[107],"(IV)":[108],"administration.":[109],"In":[110],"tissues,":[112,180],"achieved":[116],"widespread":[117],"muscle,":[120],"heart,":[121],"lung,":[123],"consistent":[124],"IGF1R":[126,166],"expression.":[127],"was":[130],"well":[131],"tolerated":[132],"all":[134],"routes,":[135],"including":[136],"repeated":[138],"dosing.":[139],"Although":[140],"several":[141],"receptor-mediated":[142],"approaches":[143],"for":[144,185],"CNS":[145],"progressing":[148],"clinic":[151],"(e.g.,":[152],"targeting":[153],"transferrin":[155],"receptor),":[156],"clinical":[157],"validation":[158],"remains":[159],"be":[161],"demonstrated.":[162],"Our":[163],"findings":[164],"highlight":[165],"as":[167],"alternative":[169],"supporting":[173],"offering":[181],"complementary":[183],"strategy":[184],"expanding":[186],"landscape":[189],"oligonucleotide":[191],"delivery.":[192]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-19T00:00:00"}