{"id":"https://openalex.org/W7213580729","doi":"https://doi.org/10.1016/j.jbc.2026.113580","title":"Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition","display_name":"Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213580729","doi":"https://doi.org/10.1016/j.jbc.2026.113580","pmid":"https://pubmed.ncbi.nlm.nih.gov/42124716","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13160135"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2026.113580","doi":"https://doi.org/10.1016/j.jbc.2026.113580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113580","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jbc.2026.113580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100255810","display_name":"Akanksha Swarup","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akanksha Swarup","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126964558","display_name":"Ryan A Kuhs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. Kuhs","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126971111","display_name":"Vanessa U Hardman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanessa U. Hardman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126969432","display_name":"Kennedy L Howard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kennedy L. Howard","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126957481","display_name":"Shradha Subbaraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shradha Subbaraman","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068742095","display_name":"Timothy A. Bolger","orcid":"https://orcid.org/0000-0001-9526-4110","observed_orcids":["https://orcid.org/0000-0001-9526-4110"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy A. Bolger","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA. Electronic address: tbolger@uga.edu"],"raw_orcid":"https://orcid.org/0000-0001-9526-4110","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, USA. Electronic address: tbolger@uga.edu","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068742095"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56253071,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"302","issue":"11","first_page":"113580","last_page":"113580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.8682000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.11209999769926071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ddx3x","display_name":"DDX3X","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ded1","display_name":"Ded1","score":0.8220000267028809},{"id":"https://openalex.org/keywords/rna-helicase","display_name":"RNA helicase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/torc1-inhibition","display_name":"TORC1 inhibition","score":0.8399999737739563},{"id":"https://openalex.org/keywords/rapamycin-resistance","display_name":"rapamycin resistance","score":0.9750000238418579},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/eif4g1","display_name":"eIF4G1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5709999799728394},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.546500027179718},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.5386999845504761},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.534600019454956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5152000188827515},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.4779999852180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4318999946117401},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32910001277923584},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.290800005197525},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26269999146461487},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.2574999928474426},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.25189998745918274}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jbc.2026.113580","doi":"https://doi.org/10.1016/j.jbc.2026.113580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113580","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"doi:10.64898/2026.02.25.708058","doi":"https://doi.org/10.64898/2026.02.25.708058","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.02.25.708058","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42124716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42124716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42759659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42759659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13160135","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13160135/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693076","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693076/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2026.113580","doi":"https://doi.org/10.1016/j.jbc.2026.113580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2026.113580","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5948373296","display_name":"Regulation of the Translational Response to Cellular Stress","funder_award_id":"R01GM136827","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W31179855","https://openalex.org/W1713545742","https://openalex.org/W1968727721","https://openalex.org/W1974625077","https://openalex.org/W1979855662","https://openalex.org/W2013564673","https://openalex.org/W2016747889","https://openalex.org/W2038598202","https://openalex.org/W2039379153","https://openalex.org/W2039885485","https://openalex.org/W2052439612","https://openalex.org/W2065118037","https://openalex.org/W2065740422","https://openalex.org/W2068413127","https://openalex.org/W2068868065","https://openalex.org/W2084667421","https://openalex.org/W2085795760","https://openalex.org/W2118211036","https://openalex.org/W2125655241","https://openalex.org/W2125786017","https://openalex.org/W2127643721","https://openalex.org/W2167179022","https://openalex.org/W2167532631","https://openalex.org/W2201115366","https://openalex.org/W2261626656","https://openalex.org/W2267877576","https://openalex.org/W2340787285","https://openalex.org/W2403997508","https://openalex.org/W2518959324","https://openalex.org/W2576890255","https://openalex.org/W2582303544","https://openalex.org/W2743276276","https://openalex.org/W2773247080","https://openalex.org/W2810523701","https://openalex.org/W2896835954","https://openalex.org/W2947128075","https://openalex.org/W2951659483","https://openalex.org/W2961707593","https://openalex.org/W3009520140","https://openalex.org/W3021032174","https://openalex.org/W3032152685","https://openalex.org/W3035972969","https://openalex.org/W3122206436","https://openalex.org/W3187751359","https://openalex.org/W3208165124","https://openalex.org/W4252935772","https://openalex.org/W4283701046","https://openalex.org/W4297408474","https://openalex.org/W4399913466"],"related_works":["https://openalex.org/W3122206436","https://openalex.org/W4400406372","https://openalex.org/W4385875283","https://openalex.org/W2053068023","https://openalex.org/W2566046346","https://openalex.org/W2340787285","https://openalex.org/W2894684675","https://openalex.org/W2886599869","https://openalex.org/W2323653024","https://openalex.org/W2950219014"],"abstract_inverted_index":{"Medulloblastoma":[0],"is":[1],"the":[2,22,29,55,80,83,93,105,115,145,154,174],"most":[3,30],"common":[4],"pediatric":[5],"brain":[6],"cancer,":[7],"but":[8],"current":[9],"treatments":[10],"are":[11],"largely":[12],"nonspecific,":[13],"often":[14],"causing":[15],"developmental":[16],"side":[17],"effects.":[18],"Genomic":[19],"sequencing":[20],"identified":[21],"RNA":[23],"helicase":[24],"DDX3X":[25,64,84,106,230],"as":[26],"one":[27],"of":[28,82,120,151,183,191,234],"frequently":[31],"mutated":[32],"genes":[33,214],"in":[34,45,60,92,108,167,198,206,224],"this":[35],"cancer":[36],"and":[37,65,153,203,251],"a":[38,204,207],"potential":[39],"treatment":[40],"target,":[41],"yet":[42],"its":[43,66],"role":[44],"tumor":[46,244],"progression":[47],"remains":[48],"elusive.":[49],"Prior":[50],"studies":[51],"have":[52,70],"indicated":[53],"that":[54,79,103,128,228],"mutations":[56,85,107],"cause":[57],"specific":[58,184],"defects":[59,91],"translation;":[61],"however,":[62],"both":[63],"yeast":[67,109],"ortholog":[68],"Ded1":[69,152,212],"also":[71],"been":[72],"associated":[73],"with":[74,193,215],"cellular":[75],"stress":[76],"responses,":[77],"suggesting":[78],"contribution":[81],"to":[86,96,135,141,178,246],"medulloblastoma":[87,253],"might":[88],"result":[89,166],"from":[90],"translational":[94],"response":[95],"stress.":[97],"Building":[98],"on":[99],"our":[100],"prior":[101],"study":[102],"replicated":[104],"DED1":[110],"(ded1-medulloblastoma-associated-mutants":[111],"[ded1-mam]),":[112],"we":[113,126],"examined":[114],"mutants'":[116],"effects":[117],"following":[118,171,200],"Target":[119],"Rapamycin":[121],"(TOR)":[122],"pathway":[123],"inactivation.":[124,160],"First,":[125],"demonstrated":[127,188],"ded1-mam":[129,146,199],"displayed":[130],"substantial":[131],"rapamycin-resistant":[132],"growth":[133,175,249],"compared":[134],"WT":[136],"cells.":[137],"In":[138],"addition,":[139],"similar":[140],"other":[142,240],"ded1":[143],"mutants,":[144],"had":[147],"increased":[148,168],"protein":[149,222],"abundance":[150],"translation":[155,170,182,190,233],"factor":[156],"eIF4G1":[157],"under":[158],"TOR":[159,201],"Notably,":[161],"these":[162],"differences":[163],"did":[164],"not":[165],"bulk":[169],"rapamycin;":[172],"rather,":[173],"phenotypes":[176],"appeared":[177],"be":[179],"driven":[180],"by":[181],"mRNAs.":[185],"Reporter":[186],"assays":[187],"enhanced":[189],"mRNA":[192],"an":[194],"unstructured":[195,217],"5'":[196,218],"UTR":[197],"inhibition":[202],"decrease":[205],"structured":[208,241],"reporter.":[209],"Furthermore,":[210],"known":[211],"target":[213],"relatively":[216],"UTRs":[219],"showed":[220],"upregulated":[221],"levels":[223],"rapamycin.":[225],"We":[226],"hypothesize":[227],"mutant":[229],"selectively":[231],"upregulates":[232],"unstructured,":[235],"progrowth":[236],"transcripts":[237],"while":[238],"downregulating":[239],"transcripts,":[242],"allowing":[243],"cells":[245],"bypass":[247],"stress-induced":[248],"controls":[250],"promoting":[252],"progression.":[254]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-19T00:00:00"}
