{"id":"https://openalex.org/W7213562105","doi":"https://doi.org/10.36721/pjps/2026.40.16394.1","title":"Dencichine ameliorates hepatic fibrosis by modulating the PI3K/AKT signaling pathway in cellular and murine models","display_name":"Dencichine ameliorates hepatic fibrosis by modulating the PI3K/AKT signaling pathway in cellular and murine models","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213562105","doi":"https://doi.org/10.36721/pjps/2026.40.16394.1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42924937"},"language":"en","primary_location":{"id":"doi:10.36721/pjps/2026.40.16394.1","doi":"https://doi.org/10.36721/pjps/2026.40.16394.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps/2026.40.16394.1","pdf_url":"https://pjps.pk/uploads/2026/09/1789714590.pdf","source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pjps.pk/uploads/2026/09/1789714590.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047753680","display_name":"Longkuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longkuan Li","raw_affiliation_strings":["The Third A liated Hospital of Guizhou Medical University Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third A liated Hospital of Guizhou Medical University Research","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huan Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Luo","raw_affiliation_strings":["The Third A liated Hospital of Guizhou Medical University Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third A liated Hospital of Guizhou Medical University Research","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zeyun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyun Liu","raw_affiliation_strings":["The Third A liated Hospital of Guizhou Medical University Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third A liated Hospital of Guizhou Medical University Research","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yingqiang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingqiang Chen","raw_affiliation_strings":["The Third A liated Hospital of Guizhou Medical University Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third A liated Hospital of Guizhou Medical University Research","institution_ids":["https://openalex.org/I149137203"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fuxue Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109381","display_name":"Affiliated Hospital of Guizhou Medical University","ror":"https://ror.org/02kstas42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuxue Meng","raw_affiliation_strings":["The Third Affiliated Hospital of Guizhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Guizhou Medical University","institution_ids":["https://openalex.org/I4210109381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64156089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"1","first_page":"208","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/panax-notoginseng","display_name":"Panax notoginseng","score":0.9829999804496765},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lx-2-cells","display_name":"LX-2 cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/pdgf-bb","display_name":"PDGF-BB","score":0.8949999809265137},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cyclin-e1","display_name":"cyclin E1","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antifibrotic-agents","display_name":"antifibrotic agents","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.7868000268936157},{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.5706999897956848},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5239999890327454},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.507099986076355},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.5029000043869019},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47209998965263367},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.46709999442100525},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.4650999903678894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.462799996137619},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45820000767707825},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4472000002861023},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4131999909877777},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4131999909877777},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C2781212864","wikidata":"https://www.wikidata.org/wiki/Q15551438","display_name":"Panax notoginseng","level":3,"score":0.38499999046325684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3765999972820282},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.37380000948905945},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C2779814568","wikidata":"https://www.wikidata.org/wiki/Q58345","display_name":"Laminin","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30489999055862427},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.2928999960422516},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2782999873161316},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2685999870300293},{"id":"https://openalex.org/C2780360765","wikidata":"https://www.wikidata.org/wiki/Q5198275","display_name":"Cyclin E1","level":5,"score":0.2648000121116638},{"id":"https://openalex.org/C2780692422","wikidata":"https://www.wikidata.org/wiki/Q18031995","display_name":"TIMP1","level":4,"score":0.2596000134944916}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058539","descriptor_name":"Phosphatidylinositol 3-Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.36721/pjps/2026.40.16394.1","doi":"https://doi.org/10.36721/pjps/2026.40.16394.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps/2026.40.16394.1","pdf_url":"https://pjps.pk/uploads/2026/09/1789714590.pdf","source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-7450683/v1","doi":"https://doi.org/10.21203/rs.3.rs-7450683/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7450683/v1","pdf_url":"https://www.researchsquare.com/article/rs-7450683/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:42924937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42924937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:183a5a44d4a6492d97d357143f93548c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/183a5a44d4a6492d97d357143f93548c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences, Vol 40, Iss 1 (2027)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.36721/pjps/2026.40.16394.1","doi":"https://doi.org/10.36721/pjps/2026.40.16394.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps/2026.40.16394.1","pdf_url":"https://pjps.pk/uploads/2026/09/1789714590.pdf","source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3050209880","display_name":null,"funder_award_id":"gzwkj2023-082","funder_id":"https://openalex.org/F4320326714","funder_display_name":"Department of Health of Guizhou Province"},{"id":"https://openalex.org/G4248972774","display_name":null,"funder_award_id":"Qiankehe Foundation-[2024] Youth 250","funder_id":"https://openalex.org/F4320326714","funder_display_name":"Department of Health of Guizhou Province"},{"id":"https://openalex.org/G6620362194","display_name":null,"funder_award_id":"gzwkj2023-022","funder_id":"https://openalex.org/F4320326714","funder_display_name":"Department of Health of Guizhou Province"}],"funders":[{"id":"https://openalex.org/F4320317797","display_name":"Health Commission of Guizhou Province","ror":"https://ror.org/027yzwq33"},{"id":"https://openalex.org/F4320326301","display_name":"Guizhou Medical University","ror":"https://ror.org/035y7a716"},{"id":"https://openalex.org/F4320326714","display_name":"Department of Health of Guizhou Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213562105.pdf","grobid_xml":"https://content.openalex.org/works/W7213562105.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1967661429","https://openalex.org/W2417283921","https://openalex.org/W2492473686","https://openalex.org/W2564360633","https://openalex.org/W2794330007","https://openalex.org/W2947549828","https://openalex.org/W4205608785","https://openalex.org/W4210687583","https://openalex.org/W4224985627","https://openalex.org/W4280581185","https://openalex.org/W4317941334","https://openalex.org/W4384564535","https://openalex.org/W4386271612","https://openalex.org/W4390570360","https://openalex.org/W4391078325","https://openalex.org/W4393155483","https://openalex.org/W4400839670","https://openalex.org/W4401732646","https://openalex.org/W4404312905","https://openalex.org/W4405166393","https://openalex.org/W4406127925","https://openalex.org/W4409873173","https://openalex.org/W7159795966"],"related_works":["https://openalex.org/W4413783545","https://openalex.org/W2996660275","https://openalex.org/W2466960890","https://openalex.org/W3172127205","https://openalex.org/W2610833176","https://openalex.org/W2378737383","https://openalex.org/W2417283921","https://openalex.org/W4311145818","https://openalex.org/W2102081625","https://openalex.org/W2067968257"],"abstract_inverted_index":{"BACKGROUND:":[0],"Fibrotic":[1],"liver":[2,67,234,262,275],"is":[3,29,40],"one":[4,128],"of":[5,10,43,109,122,139,220,223,245,255,274],"the":[6,14,107,243,253,272,280],"serious":[7,19],"pathophysiological":[8],"consequences":[9],"chronic":[11],"injury":[12,235],"to":[13,52,91,130,175,191,203],"liver,":[15],"may":[16,270],"progress":[17],"toward":[18],"complications":[20],"including":[21],"cirrhosis":[22],"and":[23,34,73,125,133,152,162,169,178,185,198,207,225,228,236,248,251,257],"hepatic":[24,57,93],"carcinoma.":[25],"OBJECTIVES:":[26],"Panax":[27],"notoginseng":[28],"used":[30,174,190],"for":[31,87],"both":[32],"therapeutic":[33],"prophylactic":[35],"purposes":[36],"in":[37,56,230,260],"TCM;":[38],"it":[39],"a":[41,74,110,120,217],"source":[42],"Dencichine,":[44],"an":[45,70],"active":[46],"substance":[47],"that":[48,268],"has":[49],"been":[50],"proven":[51],"exhibit":[53],"antifibrotic":[54],"properties":[55],"fibrosis.":[58,94],"The":[59,212],"present":[60],"study":[61],"investigated":[62],"how":[63],"Dencichine":[64,97,269],"treatment":[65],"ameliorates":[66],"fibrosis":[68,76,276],"using":[69],"animal":[71],"model":[72],"cellular":[75],"model.":[77],"METHODS:":[78],"Randomly":[79],"assigned,":[80],"male":[81],"C57BL/6J":[82],"mice":[83,232],"received":[84],"10%":[85],"CCl4":[86],"15":[88],"consecutive":[89],"weeks":[90],"induce":[92],"Treatment":[95],"with":[96,117,279],"was":[98,143,155],"initiated":[99],"from":[100,127],"7th":[101],"week":[102],"onward.":[103],"To":[104],"simulate":[105],"in-vitro":[106],"presence":[108],"fibrotic":[111,261],"microenvironment,":[112],"LX-2":[113],"cells":[114],"were":[115,173,189,201],"treated":[116,135],"PDGF-BB":[118],"at":[119],"concentration":[121],"20":[123],"ng/mL":[124],"incubated":[126],"up":[129],"four":[131],"days":[132],"then":[134],"by":[136,145,157,277],"various":[137],"doses":[138],"Dencichine.":[140],"Liver":[141],"function":[142],"evaluated":[144,156],"measuring":[146],"alanine":[147],"aminotransferase":[148],"(ALT),":[149],"AST,":[150],"HA":[151,227],"LN.":[153],"Histopathology":[154],"haematoxylin/eosin":[158],"(HE),":[159],"Masson's":[160],"trichrome":[161],"Sirius":[163],"red":[164],"stains.":[165],"Quantitative":[166],"real-time":[167],"PCR":[168],"western":[170],"blot":[171],"analyses":[172],"evaluate":[176],"mRNA":[177],"protein":[179],"expression":[180,244],"levels,":[181],"respectively.":[182,210],"Wound-healing":[183],"assays":[184],"transwell":[186],"chamber":[187],"experiments":[188],"assess":[192],"cell":[193,205,208],"migration;":[194],"EdU":[195],"proliferation":[196,206],"detection":[197],"flow":[199],"cytometry":[200],"performed":[202],"measure":[204],"cycle,":[209],"RESULTS:":[211],"most":[213],"important":[214],"results":[215,266],"are":[216],"considerable":[218],"reduction":[219],"serum":[221],"concentrations":[222],"AST":[224],"ALT,":[226],"laminin":[229],"CCl4-treated":[231],"decreased":[233],"ECM":[237],"deposition.":[238],"Furthermore,":[239],"this":[240],"compound":[241],"downregulated":[242],"cyclin":[246,249],"D1":[247],"E1":[250],"blocked":[252],"activation":[254],"PI3K":[256],"AKT":[258],"kinases":[259],"cells.":[263],"CONCLUSION:":[264],"These":[265],"indicate":[267],"slow":[271],"development":[273],"interfering":[278],"PI3K-AKT":[281],"signaling":[282],"cascade,":[283],"demonstrating":[284],"significant":[285],"anti-scarring":[286],"properties.":[287]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-18T00:00:00"}
