{"id":"https://openalex.org/W7213557131","doi":"https://doi.org/10.26434/chemrxiv.15009069/v1","title":"Comparative Characterization of Nitrogen\u2013Nitrogen Bond-Forming Piperazate Synthases to Improve Activity and Precision","display_name":"Comparative Characterization of Nitrogen\u2013Nitrogen Bond-Forming Piperazate Synthases to Improve Activity and Precision","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213557131","doi":"https://doi.org/10.26434/chemrxiv.15009069/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15009069/v1","doi":"https://doi.org/10.26434/chemrxiv.15009069/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009069/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009069/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009069/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102773313","display_name":"Simon Schr\u00f6der","orcid":"https://orcid.org/0009-0002-2778-6392","observed_orcids":["https://orcid.org/0009-0002-2778-6392"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Simon Schr\u00f6der","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071101600","display_name":"Lan Julij Zadravec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Lan Julij Zadravec","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124770101","display_name":"Nikita Pal","orcid":"https://orcid.org/0009-0001-9784-9814","observed_orcids":["https://orcid.org/0009-0001-9784-9814"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nikita Pal","raw_affiliation_strings":["Karl Gruber Institute of Molecular Biosciences","University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karl Gruber Institute of Molecular Biosciences","institution_ids":["https://openalex.org/I15766117"]},{"raw_affiliation_string":"University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026323739","display_name":"Angelina Osipyan","orcid":"https://orcid.org/0000-0001-5161-1504","observed_orcids":["https://orcid.org/0000-0001-5161-1504"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Angelina Osipyan","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093755913","display_name":"Hanna Mozer","orcid":"https://orcid.org/0009-0008-0435-8006","observed_orcids":["https://orcid.org/0009-0008-0435-8006"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Hanna Mozer","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007615034","display_name":"Simon P. Godehard","orcid":"https://orcid.org/0000-0002-1777-2168","observed_orcids":["https://orcid.org/0000-0002-1777-2168"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Simon P. Godehard","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012609717","display_name":"Alexander Pelzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Alexander Pelzer","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077309199","display_name":"Zvjezdana Findrik Bla\u017eevi\u0107","orcid":"https://orcid.org/0000-0002-5312-8951","observed_orcids":["https://orcid.org/0000-0002-5312-8951"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Zvjezdana Findrik Bla\u017eevi\u0107","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027940353","display_name":"Karl F. Gruber","orcid":"https://orcid.org/0000-0002-3485-9740","observed_orcids":["https://orcid.org/0000-0002-3485-9740","https://orcid.org/0000-0003-0214-449X"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Karl Gruber","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137655430","display_name":"Martin A. Hayes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin A. Hayes","raw_affiliation_strings":["]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030580114","display_name":"Sandy Schmidt","orcid":"https://orcid.org/0000-0002-8443-8805","observed_orcids":["https://orcid.org/0000-0002-8443-8805","https://orcid.org/0000-0001-8766-0834"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sandy Schmidt","raw_affiliation_strings":["Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe"],"raw_orcid":"https://orcid.org/0000-0002-8443-8805","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biosciences , University of Graz Humboldtstra\u00dfe","institution_ids":["https://openalex.org/I15766117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrazine-synthesis","display_name":"hydrazine synthesis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/enzyme-activity-profiling","display_name":"enzyme activity profiling","score":0.675000011920929},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.6420000195503235},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.6869999766349792},{"id":"https://openalex.org/keywords/substrate-scope","display_name":"substrate scope","score":0.6320000290870667},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7319999933242798},{"id":"https://openalex.org/keywords/streptomyces-griseochromogenes","display_name":"Streptomyces griseochromogenes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/enzyme-cascade","display_name":"enzyme cascade","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pharmaceutical-building-blocks","display_name":"pharmaceutical building blocks","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5821999907493591},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5627999901771545},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4975000023841858},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4927999973297119},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4821999967098236},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4611000120639801},{"id":"https://openalex.org/C2778012447","wikidata":"https://www.wikidata.org/wiki/Q1034415","display_name":"Scope (computer science)","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.4422000050544739},{"id":"https://openalex.org/C2780841128","wikidata":"https://www.wikidata.org/wiki/Q5073781","display_name":"Characterization (materials science)","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4011000096797943},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.3156999945640564},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.2865999937057495},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.26339998841285706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26434/chemrxiv.15009069/v1","doi":"https://doi.org/10.26434/chemrxiv.15009069/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009069/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009069/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/672bbdf0-444e-413c-99fb-16aba8810143","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/672bbdf0-444e-413c-99fb-16aba8810143","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schr\u00f6der, S, Zadravec, L J, Pal, N, Osipyan, A, Mozer, H, Godehard, S P, Pelzer, A, Bla\u017eevi\u0107, Z F, Gruber, K, Hayes, M A & Schmidt, S 2026 'Comparative Characterization of Nitrogen\u2013Nitrogen Bond-Forming Piperazate Synthases to Improve Activity and Precision' ChemRxiv. https://doi.org/10.26434/chemrxiv.15009069/v1","raw_type":"info:eu-repo/semantics/preprint"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15009069/v1","doi":"https://doi.org/10.26434/chemrxiv.15009069/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009069/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009069/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3951938444","display_name":null,"funder_award_id":"101073065","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5956220919","display_name":null,"funder_award_id":"101073065","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213557131.pdf","grobid_xml":"https://content.openalex.org/works/W7213557131.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410281178","https://openalex.org/W7165004440","https://openalex.org/W4389321330","https://openalex.org/W4415258324","https://openalex.org/W2695325110","https://openalex.org/W7155207796","https://openalex.org/W4392137861","https://openalex.org/W3207422998","https://openalex.org/W2359417303","https://openalex.org/W2320790738"],"abstract_inverted_index":{"Piperazate":[0],"synthases":[1],"(PZSs)":[2],"have":[3],"recently":[4],"gained":[5],"attention":[6],"as":[7],"enzymes":[8,140],"that":[9],"catalyze":[10],"the":[11,64,102,113,120,172],"formation":[12,153],"of":[13,23,66,101,145,176],"nitrogen-nitrogen":[14],"bonds,":[15],"offering":[16],"a":[17,89,142],"sustainable":[18],"alternative":[19],"to":[20,56,110,159],"traditional":[21],"synthesis":[22],"substituted":[24],"hydrazines.":[25],"Although":[26],"progress":[27],"has":[28,54],"been":[29],"made":[30],"in":[31,150,173,183],"elucidating":[32],"their":[33,44,151,181],"structure":[34],"and":[35,81,88,98,107,116,134,162,178],"mechanism,":[36],"an":[37],"exhaustive":[38],"study":[39],"characterizing":[40],"multiple":[41],"PZSs":[42,69,106,177],"regarding":[43,171],"activity":[45,65],"or":[46],"tendency":[47,158],"toward":[48],"side":[49,117],"reactions":[50],"under":[51,70],"varying":[52],"conditions":[53,73],"yet":[55],"be":[57,160],"conducted.":[58],"In":[59],"this":[60,157],"study,":[61],"we":[62,123],"profiled":[63],"eight":[67],"purified":[68],"80":[71],"different":[72],"each,":[74],"covering":[75],"pH,":[76],"buffers,":[77],"salinity,":[78],"temperature":[79],"dependence,":[80],"thermal":[82],"stability,":[83],"using":[84],"automated":[85],"liquid":[86],"handling":[87],"colorimetric":[90],"substrate":[91,114],"consumption":[92],"assay.":[93],"We":[94,155],"also":[95],"performed":[96],"kinetic":[97],"structural":[99],"analysis":[100],"two":[103,125],"most":[104],"promising":[105],"used":[108],"LC-MS":[109],"quantitatively":[111],"investigate":[112],"scope":[115],"reactions.":[118],"Among":[119],"investigated":[121],"enzymes,":[122],"identified":[124],"highly":[126],"active":[127],"synthases,":[128],"SbPZS":[129],"from":[130,136],"Streptomyces":[131,137],"sp.":[132],"B93":[133],"SgPZS":[135],"griseochromogenes.":[138],"Both":[139],"tolerated":[141],"broad":[143],"range":[144],"reaction":[146],"conditions,":[147],"but":[148],"differed":[149],"side-product":[152],"rates.":[154],"found":[156],"sequence-dependent":[161],"controlled":[163],"by":[164],"pH.":[165],"These":[166],"findings":[167],"provide":[168],"detailed":[169],"information":[170],"vitro":[174],"applicability":[175],"will":[179],"improve":[180],"use":[182],"(chemo-)enzymatic":[184],"cascades":[185],"for":[186],"synthesizing":[187],"pharmaceutical":[188],"building":[189],"blocks.":[190]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-18T00:00:00"}
