{"id":"https://openalex.org/W7213553597","doi":"https://doi.org/10.1016/j.phrs.2026.108462","title":"Engineering nanomedicines to reshape tertiary lymphoid structures: A new perspective on antitumor immunotherapy","display_name":"Engineering nanomedicines to reshape tertiary lymphoid structures: A new perspective on antitumor immunotherapy","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213553597","doi":"https://doi.org/10.1016/j.phrs.2026.108462","pmid":"https://pubmed.ncbi.nlm.nih.gov/42759587"},"language":"en","primary_location":{"id":"doi:10.1016/j.phrs.2026.108462","doi":"https://doi.org/10.1016/j.phrs.2026.108462","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.108462","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661826003774/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1043661826003774/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052521463","display_name":"Xueyi Song","orcid":"https://orcid.org/0000-0002-3274-0543","observed_orcids":["https://orcid.org/0000-0002-3274-0543"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueyi Song","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: xy_song1212@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: xy_song1212@163.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139254150","display_name":"Yao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yao Li","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: pharmlee@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: pharmlee@126.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152098737","display_name":"Shuai Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Ma","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 1125320328@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 1125320328@qq.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042012291","display_name":"Jiabin Xu","orcid":"https://orcid.org/0000-0002-9693-2261","observed_orcids":["https://orcid.org/0000-0002-9693-2261"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiabin Xu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 18653411936@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 18653411936@163.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152071252","display_name":"Yuxing Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxing Gao","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: gaoyuxing72@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: gaoyuxing72@163.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100374747","display_name":"Qian Wei","orcid":"https://orcid.org/0009-0001-6720-3721","observed_orcids":["https://orcid.org/0009-0001-6720-3721"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian Wei","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 584950932@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 584950932@qq.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003501770","display_name":"Mingyi Ju","orcid":"https://orcid.org/0000-0002-4084-3358","observed_orcids":["https://orcid.org/0000-0002-4084-3358"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyi Ju","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: myju@cmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: myju@cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138846112","display_name":"Lili Jie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Jie","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 20202323@cmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 20202323@cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102337929","display_name":"Jia Bi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Bi","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 124661284@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: 124661284@qq.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121698903","display_name":"Jiali Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Han","raw_affiliation_strings":["Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China. Electronic address: Jiali_han@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical University, Shenyang, 110001, PR China. Electronic address: Jiali_han@163.com","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084275831","display_name":"Heran Li","orcid":"https://orcid.org/0000-0003-2876-1525","observed_orcids":["https://orcid.org/0000-0003-2876-1525"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Heran Li","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China. Electronic address: liheranmm@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China. Electronic address: liheranmm@163.com","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052556650","display_name":"Lin Zhao","orcid":"https://orcid.org/0000-0001-9264-6455","observed_orcids":["https://orcid.org/0000-0001-9264-6455","https://orcid.org/0009-0007-9835-4059"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Zhao","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: lzhao@cmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-9264-6455","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China. Electronic address: lzhao@cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084063375","display_name":"Minjie Wei","orcid":"https://orcid.org/0000-0002-0404-7098","observed_orcids":["https://orcid.org/0000-0002-0404-7098","https://orcid.org/0000-0002-0782-6556","https://orcid.org/0000-0003-2174-9101","https://orcid.org/0000-0002-9128-3784"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minjie Wei","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China; Shenyang Kangwei Medical Analysis Laboratory, China Medical University, Shenyang, 110122, PR China. Electronic address: mjwei@cmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, PR China; Liaoning Key Laboratory of molecular targeted anti-tumor drug development and evaluation, China Medical University, Shenyang, 110122, PR China; Shenyang Kangwei Medical Analysis Laboratory, China Medical University, Shenyang, 110122, PR China. Electronic address: mjwei@cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052556650","https://openalex.org/A5084063375","https://openalex.org/A5084275831","https://openalex.org/A5100374747","https://openalex.org/A5139254150"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.48449269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"233","issue":null,"first_page":"108462","last_page":"108462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.906000018119812},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9599999785423279},{"id":"https://openalex.org/keywords/immune-cell-homing","display_name":"immune cell homing","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cross-presentation","display_name":"cross-presentation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"physiotherapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.7576000094413757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7347999811172485},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7106999754905701},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4077000021934509},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32260000705718994},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.25189998745918274},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2442999929189682},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.23639999330043793},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.20069999992847443},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.19460000097751617}],"mesh":[{"descriptor_ui":"D000072717","descriptor_name":"Tertiary Lymphoid Structures","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.phrs.2026.108462","doi":"https://doi.org/10.1016/j.phrs.2026.108462","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.108462","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661826003774/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},{"id":"pmid:42759587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42759587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.phrs.2026.108462","doi":"https://doi.org/10.1016/j.phrs.2026.108462","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.phrs.2026.108462","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1043661826003774/pdf","source":{"id":"https://openalex.org/S54485712","display_name":"Pharmacological Research","issn_l":"1043-6618","issn":["1043-6618","1096-1186"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1594720810","display_name":null,"funder_award_id":"82472136","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4085727205","display_name":null,"funder_award_id":"82373229","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8092872129","display_name":null,"funder_award_id":"82503158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000364755","display_name":null,"funder_award_id":"82674007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000365643","display_name":null,"funder_award_id":"2025M782306","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213553597.pdf","grobid_xml":"https://content.openalex.org/works/W7213553597.grobid-xml"},"referenced_works_count":184,"referenced_works":["https://openalex.org/W1554400778","https://openalex.org/W1908442436","https://openalex.org/W1969963445","https://openalex.org/W2013765163","https://openalex.org/W2046560134","https://openalex.org/W2055434207","https://openalex.org/W2056444555","https://openalex.org/W2079936875","https://openalex.org/W2083249633","https://openalex.org/W2095121454","https://openalex.org/W2099900951","https://openalex.org/W2115420093","https://openalex.org/W2134342374","https://openalex.org/W2138113004","https://openalex.org/W2143118772","https://openalex.org/W2144733364","https://openalex.org/W2145663629","https://openalex.org/W2149668671","https://openalex.org/W2151467658","https://openalex.org/W2161982171","https://openalex.org/W2167028666","https://openalex.org/W2234923158","https://openalex.org/W2254944169","https://openalex.org/W2255455167","https://openalex.org/W2403102474","https://openalex.org/W2466343307","https://openalex.org/W2497875668","https://openalex.org/W2528849844","https://openalex.org/W2556081639","https://openalex.org/W2564809671","https://openalex.org/W2584333012","https://openalex.org/W2588888588","https://openalex.org/W2616263591","https://openalex.org/W2734753117","https://openalex.org/W2754960822","https://openalex.org/W2758041750","https://openalex.org/W2767554904","https://openalex.org/W2767942587","https://openalex.org/W2779312016","https://openalex.org/W2787777580","https://openalex.org/W2789487202","https://openalex.org/W2836754285","https://openalex.org/W2847356344","https://openalex.org/W2883398259","https://openalex.org/W2891316662","https://openalex.org/W2891749984","https://openalex.org/W2894546855","https://openalex.org/W2897100571","https://openalex.org/W2898595766","https://openalex.org/W2901937103","https://openalex.org/W2904297611","https://openalex.org/W2909301717","https://openalex.org/W2945057866","https://openalex.org/W2965330503","https://openalex.org/W2970536272","https://openalex.org/W2979575610","https://openalex.org/W2981954871","https://openalex.org/W2994938720","https://openalex.org/W3000311037","https://openalex.org/W3001895421","https://openalex.org/W3003773438","https://openalex.org/W3003920454","https://openalex.org/W3004769637","https://openalex.org/W3006101076","https://openalex.org/W3011940221","https://openalex.org/W3012821758","https://openalex.org/W3015169272","https://openalex.org/W3015731029","https://openalex.org/W3035999666","https://openalex.org/W3037466102","https://openalex.org/W3040453954","https://openalex.org/W3042043324","https://openalex.org/W3044737312","https://openalex.org/W3049036915","https://openalex.org/W3096223612","https://openalex.org/W3106005610","https://openalex.org/W3108851962","https://openalex.org/W3109746568","https://openalex.org/W3126571838","https://openalex.org/W3128459342","https://openalex.org/W3132042942","https://openalex.org/W3138099194","https://openalex.org/W3152880902","https://openalex.org/W3162711975","https://openalex.org/W3171465065","https://openalex.org/W3186518830","https://openalex.org/W3193528666","https://openalex.org/W3211538174","https://openalex.org/W3214531234","https://openalex.org/W3217307638","https://openalex.org/W4200058053","https://openalex.org/W4205511851","https://openalex.org/W4206161296","https://openalex.org/W4206799282","https://openalex.org/W4210339030","https://openalex.org/W4213451834","https://openalex.org/W4214620261","https://openalex.org/W4221125550","https://openalex.org/W4226101171","https://openalex.org/W4281563307","https://openalex.org/W4288036375","https://openalex.org/W4295027234","https://openalex.org/W4296301871","https://openalex.org/W4304758344","https://openalex.org/W4309094126","https://openalex.org/W4310439038","https://openalex.org/W4310951074","https://openalex.org/W4310953233","https://openalex.org/W4312056482","https://openalex.org/W4312119708","https://openalex.org/W4316661780","https://openalex.org/W4319737564","https://openalex.org/W4361279890","https://openalex.org/W4362597065","https://openalex.org/W4365482895","https://openalex.org/W4366293315","https://openalex.org/W4376598482","https://openalex.org/W4378211218","https://openalex.org/W4380786205","https://openalex.org/W4382358300","https://openalex.org/W4382997825","https://openalex.org/W4385707981","https://openalex.org/W4385979608","https://openalex.org/W4386608057","https://openalex.org/W4387130918","https://openalex.org/W4387357201","https://openalex.org/W4387530591","https://openalex.org/W4389219683","https://openalex.org/W4389265544","https://openalex.org/W4390819995","https://openalex.org/W4391925760","https://openalex.org/W4392579327","https://openalex.org/W4392658556","https://openalex.org/W4392926962","https://openalex.org/W4393031839","https://openalex.org/W4393126719","https://openalex.org/W4394010927","https://openalex.org/W4394747404","https://openalex.org/W4394872649","https://openalex.org/W4396828232","https://openalex.org/W4400006175","https://openalex.org/W4400260814","https://openalex.org/W4401274889","https://openalex.org/W4401419197","https://openalex.org/W4401519600","https://openalex.org/W4402615067","https://openalex.org/W4403342618","https://openalex.org/W4403553989","https://openalex.org/W4404436467","https://openalex.org/W4404626067","https://openalex.org/W4405294422","https://openalex.org/W4406002750","https://openalex.org/W4406081093","https://openalex.org/W4406235475","https://openalex.org/W4406323323","https://openalex.org/W4406825270","https://openalex.org/W4406864506","https://openalex.org/W4407091561","https://openalex.org/W4407736897","https://openalex.org/W4408059687","https://openalex.org/W4408098038","https://openalex.org/W4408131618","https://openalex.org/W4408152119","https://openalex.org/W4408192459","https://openalex.org/W4408241219","https://openalex.org/W4409412608","https://openalex.org/W4409452172","https://openalex.org/W4410136796","https://openalex.org/W4410842671","https://openalex.org/W4411089059","https://openalex.org/W4411090838","https://openalex.org/W4411282897","https://openalex.org/W4412451957","https://openalex.org/W4413101055","https://openalex.org/W4413139928","https://openalex.org/W4414424162","https://openalex.org/W4414610874","https://openalex.org/W4415447342","https://openalex.org/W4416121561","https://openalex.org/W4416300002","https://openalex.org/W7118948978","https://openalex.org/W7119504797","https://openalex.org/W7138387078","https://openalex.org/W7165043649"],"related_works":["https://openalex.org/W7124450419","https://openalex.org/W7214226467","https://openalex.org/W7163653065","https://openalex.org/W2888580148","https://openalex.org/W4407736897","https://openalex.org/W2945057866","https://openalex.org/W4385707981","https://openalex.org/W4410608472","https://openalex.org/W4414399727","https://openalex.org/W7171549239"],"abstract_inverted_index":{"Tertiary":[0],"lymphoid":[1],"structures":[2],"(TLS),":[3],"which":[4],"form":[5],"as":[6,44,131],"tumor-localized":[7],"lymphoid-like":[8],"structures,":[9],"play":[10],"a":[11,162,168,177],"critical":[12],"role":[13],"in":[14,125,157],"enhancing":[15,112],"immune":[16,97,140],"responses":[17],"and":[18,35,47,62,73,111,145,160,176,183],"improving":[19],"prognosis.":[20],"However,":[21],"native":[22],"TLS":[23,75,86,129],"is":[24],"highly":[25],"prone":[26],"to":[27,95,103,115,154],"developmental":[28],"arrest":[29],"within":[30],"the":[31,71,122,151,181],"tumor":[32],"microenvironment":[33],"(TME),":[34],"conventional":[36],"free-circulating":[37],"drugs":[38],"suffer":[39],"from":[40],"significant":[41],"drawbacks":[42],"such":[43],"short":[45],"half-lives":[46],"high":[48],"systemic":[49],"toxicity.":[50],"Nanomedicines,":[51],"with":[52,138],"their":[53],"advantages":[54],"of":[55,186],"spatiotemporally":[56],"controlled":[57],"release,":[58],"deep":[59],"physical":[60,108,146],"penetration,":[61],"multi-target":[63],"co-delivery,":[64],"offer":[65],"an":[66,132],"engineered":[67,81],"solution":[68],"for":[69,84,107,164,180],"reshaping":[70],"TME":[72],"inducing":[74],"formation.":[76],"This":[77],"article":[78],"systematically":[79],"summarizes":[80],"intervention":[82],"strategies":[83],"nanomedicine-induced":[85],"formation":[87],"across":[88],"three":[89],"key":[90],"aspects:":[91],"activating":[92],"chemotactic":[93],"networks":[94],"accelerate":[96],"cell":[98],"homing;":[99],"targeting":[100],"matrix":[101],"reprogramming":[102],"induce":[104],"high-endothelial":[105],"microvessels":[106],"scaffold":[109],"construction;":[110],"antigen":[113],"cross-presentation":[114],"drive":[116],"germinal":[117],"center":[118],"(GC)":[119],"maturation.":[120],"Furthermore,":[121],"paper":[123,172],"explores":[124],"depth":[126],"how":[127],"nanomedicine-mediated":[128],"functions":[130],"immunological":[133],"hub,":[134],"generating":[135],"synergistic":[136],"effects":[137],"existing":[139],"checkpoint":[141],"inhibitors,":[142],"cellular":[143],"therapies,":[144],"therapies.":[147],"Finally,":[148],"it":[149],"analyzes":[150],"current":[152],"barriers":[153],"clinical":[155,184],"translation":[156],"this":[158,171],"field":[159],"outlines":[161],"blueprint":[163],"future":[165],"development.":[166],"Through":[167],"multidisciplinary":[169],"perspective,":[170],"provides":[173],"theoretical":[174],"guidance":[175],"technical":[178],"roadmap":[179],"design":[182],"application":[185],"next-generation":[187],"precision":[188],"immunotherapy":[189],"nanomedicines.":[190]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-18T00:00:00"}