{"id":"https://openalex.org/W7213544879","doi":"https://doi.org/10.64898/2026.09.16.751696","title":"Shaping cryogenic 3D volume imaging by pFIB ion species and milling voltage","display_name":"Shaping cryogenic 3D volume imaging by pFIB ion species and milling voltage","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213544879","doi":"https://doi.org/10.64898/2026.09.16.751696"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.16.751696","doi":"https://doi.org/10.64898/2026.09.16.751696","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751696","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.751696.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.751696.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087782959","display_name":"Sanja Sviben","orcid":"https://orcid.org/0000-0001-5918-4834","observed_orcids":["https://orcid.org/0000-0001-5918-4834"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanja Sviben","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0001-5918-4834","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054747988","display_name":"Christopher Thompson","orcid":"https://orcid.org/0000-0003-2240-093X","observed_orcids":["https://orcid.org/0000-0003-2240-093X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Thompson","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0003-2240-093X","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152046174","display_name":"Corinna Braun","orcid":"https://orcid.org/0000-0002-5573-5616","observed_orcids":["https://orcid.org/0000-0002-5573-5616"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinna Braun","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-5573-5616","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005385007","display_name":"Krishnan Venkataraman","orcid":"https://orcid.org/0009-0007-1477-0574","observed_orcids":["https://orcid.org/0009-0007-1477-0574"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishnan Venkataraman","raw_affiliation_strings":["Center for Bioimage Informatics, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0009-0007-1477-0574","affiliations":[{"raw_affiliation_string":"Center for Bioimage Informatics, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095063970","display_name":"Jessica Heebner","orcid":"https://orcid.org/0000-0002-7025-7608","observed_orcids":["https://orcid.org/0000-0002-7025-7608"]},"institutions":[{"id":"https://openalex.org/I4210102558","display_name":"Thermo Fisher Scientific (Netherlands)","ror":"https://ror.org/01139ec29","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102558","https://openalex.org/I4210142480"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jessica Heebner","raw_affiliation_strings":["Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, 5651 GG, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7025-7608","affiliations":[{"raw_affiliation_string":"Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, 5651 GG, Netherlands","institution_ids":["https://openalex.org/I4210102558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111269332","display_name":"Ron Kelley","orcid":"https://orcid.org/0009-0001-8002-7128","observed_orcids":["https://orcid.org/0009-0001-8002-7128"]},"institutions":[{"id":"https://openalex.org/I4210102558","display_name":"Thermo Fisher Scientific (Netherlands)","ror":"https://ror.org/01139ec29","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102558","https://openalex.org/I4210142480"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ron Kelley","raw_affiliation_strings":["Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, 5651 GG, Netherlands"],"raw_orcid":"https://orcid.org/0009-0001-8002-7128","affiliations":[{"raw_affiliation_string":"Thermo Fisher Scientific, Materials and Structural Analysis Division, Achtseweg Noord, Eindhoven, 5651 GG, Netherlands","institution_ids":["https://openalex.org/I4210102558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036947358","display_name":"M. Zuhaib Qayyum","orcid":"https://orcid.org/0000-0003-2442-4812","observed_orcids":["https://orcid.org/0000-0003-2442-4812"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Zuhaib Qayyum","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0003-2442-4812","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037294534","display_name":"Abhay Kotecha","orcid":"https://orcid.org/0000-0002-4480-5439","observed_orcids":["https://orcid.org/0000-0002-4480-5439"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhay Kotecha","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-4480-5439","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027851248","display_name":"Ali Khalighifar","orcid":"https://orcid.org/0000-0002-2949-8143","observed_orcids":["https://orcid.org/0000-0002-2949-8143"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Khalighifar","raw_affiliation_strings":["Center for Bioimage Informatics, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0002-2949-8143","affiliations":[{"raw_affiliation_string":"Center for Bioimage Informatics, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029581589","display_name":"Georgios Skiniotis","orcid":"https://orcid.org/0000-0003-0238-7846","observed_orcids":["https://orcid.org/0000-0003-0238-7846"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Georgios Skiniotis","raw_affiliation_strings":["Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA"],"raw_orcid":"https://orcid.org/0000-0003-0238-7846","affiliations":[{"raw_affiliation_string":"Center of Excellence for Structural Cell Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Department of Structural Biology, St. Jude Children\u2019s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029581589"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13552","display_name":"Advanced Materials Characterization Techniques","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12166","display_name":"Ion-surface interactions and analysis","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-focused-ion-beam","display_name":"plasma focused ion beam","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ions","display_name":"ions","score":0.6620000004768372},{"id":"https://openalex.org/keywords/acceleration-voltage","display_name":"accelerating voltage","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ion-matter-interaction","display_name":"ion-matter interaction","score":0.4729999899864197},{"id":"https://openalex.org/keywords/ion-penetration","display_name":"ion penetration","score":0.46799999475479126},{"id":"https://openalex.org/keywords/atomic-displacements","display_name":"atomic displacements","score":0.8579999804496765},{"id":"https://openalex.org/keywords/specimen-charging","display_name":"specimen charging","score":0.7279999852180481},{"id":"https://openalex.org/keywords/monte-carlo-simulation","display_name":"Monte Carlo simulation","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.703499972820282},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6783999800682068},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.6384000182151794},{"id":"https://openalex.org/C547737533","wikidata":"https://www.wikidata.org/wiki/Q696","display_name":"Argon","level":2,"score":0.48420000076293945},{"id":"https://openalex.org/C161866238","wikidata":"https://www.wikidata.org/wiki/Q258563","display_name":"Focused ion beam","level":3,"score":0.4722999930381775},{"id":"https://openalex.org/C548442186","wikidata":"https://www.wikidata.org/wiki/Q1106","display_name":"Xenon","level":2,"score":0.4578000009059906},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.45089998841285706},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.44290000200271606},{"id":"https://openalex.org/C76737569","wikidata":"https://www.wikidata.org/wiki/Q1364934","display_name":"Propellant","level":2,"score":0.42320001125335693},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C88182573","wikidata":"https://www.wikidata.org/wiki/Q1139740","display_name":"High voltage","level":3,"score":0.39149999618530273},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.3874000012874603},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.37380000948905945},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C122802935","wikidata":"https://www.wikidata.org/wiki/Q829575","display_name":"Acceleration voltage","level":4,"score":0.365200012922287},{"id":"https://openalex.org/C193493375","wikidata":"https://www.wikidata.org/wiki/Q1306232","display_name":"Penetration depth","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C2781038479","wikidata":"https://www.wikidata.org/wiki/Q114675","display_name":"Mica","level":2,"score":0.3111000061035156},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3093000054359436},{"id":"https://openalex.org/C48736558","wikidata":"https://www.wikidata.org/wiki/Q16910983","display_name":"Ion milling machine","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C197977467","wikidata":"https://www.wikidata.org/wiki/Q550608","display_name":"Field ion microscope","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C50774322","wikidata":"https://www.wikidata.org/wiki/Q644248","display_name":"Ion beam","level":3,"score":0.28209999203681946},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2778702798","wikidata":"https://www.wikidata.org/wiki/Q2098457","display_name":"Plasma-immersion ion implantation","level":4,"score":0.2718000113964081},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.26759999990463257},{"id":"https://openalex.org/C107551265","wikidata":"https://www.wikidata.org/wiki/Q1458245","display_name":"Displacement (psychology)","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C108939769","wikidata":"https://www.wikidata.org/wiki/Q1139370","display_name":"Liquid nitrogen","level":2,"score":0.2540000081062317}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.16.751696","doi":"https://doi.org/10.64898/2026.09.16.751696","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751696","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.751696.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.16.751696","doi":"https://doi.org/10.64898/2026.09.16.751696","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751696","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.751696.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213544879.pdf","grobid_xml":"https://content.openalex.org/works/W7213544879.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W4414538083","https://openalex.org/W7165646813"],"related_works":["https://openalex.org/W4323782400","https://openalex.org/W4321453226","https://openalex.org/W4403496296","https://openalex.org/W4385072745","https://openalex.org/W4412908770","https://openalex.org/W4387376589","https://openalex.org/W2054917652","https://openalex.org/W6907907107","https://openalex.org/W4200215990","https://openalex.org/W7165646813"],"abstract_inverted_index":{"Abstract":[0],"Cryogenic":[1],"plasma":[2,42],"focused":[3],"ion":[4,53,96,165],"beam-scanning":[5],"electron":[6],"microscopy":[7],"(cryo-pFIB-SEM)":[8],"enables":[9],"nanoscale":[10],"volume":[11],"imaging":[12],"of":[13,21,143,206],"vitrified":[14],"cells":[15],"and":[16,40,55,61,75,83,85,98,112,124,130,137,179,203],"tissues,":[17],"but":[18],"the":[19,116,134,201,207],"fidelity":[20],"each":[22],"newly":[23],"exposed":[24],"block-face":[25,59],"depends":[26,182],"on":[27,70,183],"how":[28,52],"ions":[29],"interact":[30],"with":[31,73,115],"compositionally":[32],"heterogeneous":[33,121],"biological":[34,208],"material.":[35],"Using":[36],"xenon,":[37],"argon,":[38],"oxygen,":[39],"nitrogen":[41,86,125],"beams":[43],"across":[44],"a":[45,66,172,192],"30-2":[46],"kV":[47,82],"voltage":[48,57,109,163],"range,":[49],"we":[50],"examined":[51],"species":[54,166],"accelerating":[56,71,162],"influence":[58],"quality":[60,157],"ultrastructural":[62],"fidelity.":[63],"Curtaining":[64],"imposed":[65],"species-dependent":[67],"lower":[68],"limit":[69],"voltage,":[72],"xenon":[74],"argon":[76],"supporting":[77],"uniform":[78],"milling":[79,108,169,189],"to":[80,87,200],"10":[81],"oxygen":[84],"15":[88],"kV.":[89],"Monte":[90],"Carlo":[91],"simulations":[92],"predicted":[93],"substantially":[94],"reduced":[95],"penetration":[97],"atomic":[99],"displacement":[100],"under":[101],"these":[102,138,151],"species-specific":[103],"low-kV":[104,188],"conditions.":[105],"Experimentally,":[106],"lowering":[107],"suppressed":[110],"charging":[111],"topographic":[113],"artifacts,":[114],"largest":[117],"effects":[118],"observed":[119],"at":[120],"interfaces.":[122],"Oxygen":[123],"produced":[126],"greater":[127],"membrane":[128],"sharpness":[129],"organelle":[131,145],"contrast":[132],"than":[133],"noble":[135],"gases,":[136],"differences":[139],"influenced":[140],"machine-learning-based":[141],"recognition":[142],"fine":[144],"features":[146],"in":[147],"3D":[148],"datasets.":[149],"Together,":[150],"findings":[152],"show":[153],"that":[154,181],"cryo-pFIB-SEM":[155,197],"image":[156],"cannot":[158],"be":[159],"optimized":[160],"by":[161],"or":[164],"independently.":[167],"Instead,":[168],"performance":[170],"reflects":[171],"tradeoff":[173],"among":[174],"surface":[175],"fidelity,":[176],"charging,":[177],"contrast,":[178],"curtaining":[180],"local":[184],"specimen":[185],"composition.":[186],"Species-specific":[187],"therefore":[190],"provides":[191],"practical":[193],"framework":[194],"for":[195],"matching":[196],"acquisition":[198],"conditions":[199],"structural":[202],"biophysical":[204],"properties":[205],"target.":[209]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-18T00:00:00"}
