{"id":"https://openalex.org/W7213544392","doi":"https://doi.org/10.64898/2026.09.11.750994","title":"Ara h 2 and Fc\u03b5RI\u03b1 binding elicit state-dependent allostery in IgE","display_name":"Ara h 2 and Fc\u03b5RI\u03b1 binding elicit state-dependent allostery in IgE","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213544392","doi":"https://doi.org/10.64898/2026.09.11.750994"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.750994","doi":"https://doi.org/10.64898/2026.09.11.750994","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750994","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.11.750994.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.11.750994.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152063305","display_name":"Mathialagan Mugundhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I195296446","display_name":"Temasek Polytechnic","ror":"https://ror.org/03k1z9s75","country_code":"SG","type":"education","lineage":["https://openalex.org/I195296446"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mathialagan Mugundhan","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","School of Applied Sciences, Temasek Polytechnic, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"School of Applied Sciences, Temasek Polytechnic, Singapore","institution_ids":["https://openalex.org/I195296446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108147531","display_name":"Qinyu Jia","orcid":"https://orcid.org/0000-0002-4134-4606","observed_orcids":["https://orcid.org/0000-0002-4134-4606"]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Qinyu Jia","raw_affiliation_strings":["Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065942234","display_name":"Palur Venkata Raghuvamsi","orcid":"https://orcid.org/0000-0002-0897-6935","observed_orcids":["https://orcid.org/0000-0002-0897-6935"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Palur V Raghuvamsi","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013004721","display_name":"Su Ning Loh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Su Ning Loh","raw_affiliation_strings":["Protein and Proteomics Centre, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein and Proteomics Centre, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025465364","display_name":"Alicia Ghia Min Ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Alicia Ghia Min Ong","raw_affiliation_strings":["Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116690561","display_name":"Krithika Subramani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Krithika Subramani","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010114375","display_name":"Kamolrat Somboon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Kamolrat Somboon","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041438560","display_name":"Firdaus Samsudin","orcid":"https://orcid.org/0000-0003-2766-4459","observed_orcids":["https://orcid.org/0000-0003-2766-4459"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Firdaus Samsudin","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078663555","display_name":"Zhong\u2010Ping Yao","orcid":"https://orcid.org/0000-0003-3555-9632","observed_orcids":["https://orcid.org/0000-0003-3555-9632"]},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhong-Ping Yao","raw_affiliation_strings":["Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biology and Chemical Technology, Food Safety and Technology Research Centre, and Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong SAR, China","institution_ids":["https://openalex.org/I14243506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041958736","display_name":"Radoslaw Mikolaj Sobota","orcid":"https://orcid.org/0000-0002-2455-2526","observed_orcids":["https://orcid.org/0000-0002-2455-2526"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Radoslaw Mikolaj Sobota","raw_affiliation_strings":["Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038527769","display_name":"Samuel Ken\u2010En Gan","orcid":"https://orcid.org/0000-0001-9936-5090","observed_orcids":["https://orcid.org/0000-0001-9936-5090"]},"institutions":[{"id":"https://openalex.org/I4210153668","display_name":"Wenzhou-Kean University","ror":"https://ror.org/05609xa16","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153668"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Samuel Ken-En Gan","raw_affiliation_strings":["APD Lab, College of Science, Maths, and Technology, Wenzhou Kean University, Wenzhou, Zhejiang, China 325000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"APD Lab, College of Science, Maths, and Technology, Wenzhou Kean University, Wenzhou, Zhejiang, China 325000","institution_ids":["https://openalex.org/I4210153668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001674990","display_name":"Peter John Bond","orcid":"https://orcid.org/0000-0003-2900-098X","observed_orcids":["https://orcid.org/0000-0003-2900-098X"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Peter J Bond","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","Department of Biological Sciences, National University of Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152066477","display_name":"Zheng Ser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zheng Ser","raw_affiliation_strings":["Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I75573869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047413000","display_name":"Chinh Tran-To Su","orcid":"https://orcid.org/0000-0001-6465-5987","observed_orcids":["https://orcid.org/0000-0001-6465-5987"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Chinh Tran-To Su","raw_affiliation_strings":["Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047413000"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210148498"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ara-h-2","display_name":"Ara h 2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/fcepsilonrialpha","display_name":"Fc\u03b5RI\u03b1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/immunoglobulin-e","display_name":"immunoglobulin E","score":0.8809999823570251},{"id":"https://openalex.org/keywords/allosteric-communication","display_name":"allosteric communication","score":0.7440000176429749},{"id":"https://openalex.org/keywords/peanut-allergy","display_name":"peanut allergy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/fcepsilonri-signaling","display_name":"Fc\u03b5RI signaling","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cross-linking-mass-spectrometry","display_name":"cross-linking mass spectrometry","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange-mass-spectrometry","display_name":"hydrogen-deuterium exchange mass spectrometry","score":0.9369999766349792},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.5239999890327454},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.890500009059906},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.789900004863739},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6596999764442444},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4449999928474426},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42739999294281006},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4172999858856201},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.3822999894618988},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3801000118255615},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34130001068115234},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31290000677108765},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.29980000853538513},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.2825999855995178},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.11.750994","doi":"https://doi.org/10.64898/2026.09.11.750994","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750994","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.11.750994.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.750994","doi":"https://doi.org/10.64898/2026.09.11.750994","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750994","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.11.750994.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320337144","display_name":"National Supercomputing Center, Korea Institute of Science and Technology Information","ror":"https://ror.org/00cs28a13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213544392.pdf","grobid_xml":"https://content.openalex.org/works/W7213544392.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1544611381","https://openalex.org/W1580883960","https://openalex.org/W1857685991","https://openalex.org/W2010919000","https://openalex.org/W2019309109","https://openalex.org/W2040640809","https://openalex.org/W2047468595","https://openalex.org/W2064719289","https://openalex.org/W2065504830","https://openalex.org/W2085071459","https://openalex.org/W2091689358","https://openalex.org/W2105089097","https://openalex.org/W2139661475","https://openalex.org/W2149500199","https://openalex.org/W2154019529","https://openalex.org/W2158412800","https://openalex.org/W2315481252","https://openalex.org/W2884094674","https://openalex.org/W2898649585","https://openalex.org/W2898990880","https://openalex.org/W2903856687","https://openalex.org/W2910193359","https://openalex.org/W2913977622","https://openalex.org/W2939407540","https://openalex.org/W2969631456","https://openalex.org/W3003444709","https://openalex.org/W3009709124","https://openalex.org/W3012758763","https://openalex.org/W3015596566","https://openalex.org/W3027742687","https://openalex.org/W3104831469","https://openalex.org/W3182375950","https://openalex.org/W4308834828","https://openalex.org/W4316661395","https://openalex.org/W4361204970","https://openalex.org/W4385474105","https://openalex.org/W4386284145","https://openalex.org/W4391932887","https://openalex.org/W4401344159","https://openalex.org/W4404246309","https://openalex.org/W4415982680"],"related_works":["https://openalex.org/W4319937641","https://openalex.org/W2025373312","https://openalex.org/W7129519572","https://openalex.org/W2079208358","https://openalex.org/W4415982680","https://openalex.org/W4406281464","https://openalex.org/W4414263905","https://openalex.org/W2140268846","https://openalex.org/W2266030345","https://openalex.org/W1946894882"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Peanuts":[2],"are":[3,51],"among":[4],"the":[5,42,151,159,170,178,196,200,206,218,274,297,366],"most":[6],"prevalent":[7],"food":[8],"allergens":[9],"responsible":[10],"for":[11,236,247,305,380,393],"anaphylaxis,":[12],"particularly":[13],"in":[14,80,172,226,240,273,315,328,343],"children.":[15],"Allergic":[16],"responses":[17],"may":[18,385],"be":[19],"mitigated":[20],"by":[21,88,135,169],"disrupting":[22],"molecular":[23,90,363],"interactions":[24,260,270],"between":[25,101,199,261],"immunoglobulin-E":[26],"(IgE)":[27],"and":[28,37,69,83,137,191,202,223,243,263,325,339,384],"its":[29,70,224],"binding":[30,65,131,145,186,283,302,313,341],"partners:":[31],"peanut":[32,241],"allergen":[33],"(Ara":[34],"h":[35,61,143,189,268,288,317,337],"2)":[36],"IgE":[38,46,67,79,102,123,133,194,222,238,252,304,370],"receptors":[39],"(Fc\u03b5RIa).":[40],"However,":[41],"structural":[43,75,234],"dynamics":[44,76,91,168],"of":[45,77,182,187,221,276,281,388],"upon":[47],"engaging":[48],"these":[49],"factors":[50],"not":[52],"yet":[53],"fully":[54],"elucidated.":[55],"Objective":[56],"To":[57],"characterize":[58],"how":[59],"Ara":[60,142,188,287,316,336],"2":[62,144,190,269,289,338],"and/or":[63],"Fc\u03b5RI\u03b1":[64,130,192,264,340],"influence":[66],"flexibility":[68],"interdomain":[71,351],"communications.":[72],"Methods":[73],"The":[74,374],"full-length":[78],"various":[81],"unbound":[82],"bound":[84],"states":[85],"were":[86,104,112,125,271],"examined":[87],"combining":[89],"(MD)":[92],"simulations":[93],"with":[94,258,347],"cross-linking":[95],"mass":[96,117],"spectrometry":[97,118],"(XLMS).":[98],"Causal":[99],"relationship":[100],"domains":[103,161],"characterized":[105],"to":[106,165,193,208,286],"infer":[107],"allosteric":[108,197],"communication":[109,198],"pathways,":[110],"which":[111],"assessed":[113],"through":[114,323],"hydrogen-deuterium":[115],"exchange":[116],"(HDX-MS).":[119],"Results":[120],"Non-canonical":[121],"bent":[122,255],"conformations":[124,257],"identified.":[126],"We":[127],"demonstrate":[128],"that":[129,158],"immobilizes":[132],"predominantly":[134],"stabilizing":[136],"restricting":[138],"Fc":[139,203,294],"flexibility,":[140],"whereas":[141,327],"induces":[146],"specific":[147],"conformational":[148],"changes":[149],"within":[150,369],"Fc\u03b5RI\u03b1-binding":[152],"region.":[153],"Our":[154,212],"results":[155,342],"further":[156],"suggest":[157,244],"C\u03b5":[160],"retain":[162],"sufficient":[163],"freedom":[164],"enable":[166],"causal":[167],"Fabs":[171,201,262],"a":[173,233,291,344],"binding-dependent":[174,375],"manner,":[175],"thereby":[176],"modulating":[177],"receptor":[179,306,382],"engagement":[180],"potential":[181,245,378],"IgE.":[183],"Notably,":[184],"concurrent":[185],"shifts":[195,310,332],"regions":[204],"from":[205,355],"C\u03b53":[207,324],"C\u03b54":[209],"domain.":[210],"Conclusion":[211],"findings":[213],"provide":[214],"new":[215],"insights":[216],"into":[217,365],"dynamic":[219],"regulation":[220],"role":[225],"allergic":[227,372],"responses.":[228,373],"This":[229,360],"could":[230],"serve":[231],"as":[232],"framework":[235],"understanding":[237],"signaling":[239,309,320,331],"allergy":[242],"targets":[246,379],"therapeutic":[248],"interventions.":[249],"Key":[250],"messages":[251],"adopts":[253],"non-canonical":[254],"Fc\u03b5RI\u03b1-bound":[256,298,329],"unexpected":[259],"More":[265],"diverse":[266],"IgE-Ara":[267],"observed":[272],"presence":[275],"Fc\u03b5RI\u03b1,":[277],"indicating":[278],"receptor-mediated":[279],"stabilization":[280],"alternative":[282],"modes":[284],"Binding":[285],"promotes":[290],"more":[292,389],"compact":[293],"structure":[295],"resembling":[296],"state,":[299],"suggesting":[300],"antigen":[301],"primes":[303],"interaction.":[307],"Allosteric":[308],"depending":[311],"on":[312],"state:":[314],"2-bound":[318],"IgE,":[319],"is":[321],"mediated":[322],"C\u03b54,":[326],"states,":[330],"toward":[333],"C\u03b54.":[334],"Concurrent":[335],"\u201chub-dominated\u201d":[345],"network":[346],"fewer":[348],"but":[349],"stronger":[350],"dependencies,":[352],"integrating":[353],"inputs":[354],"Fab":[356],"movements.":[357],"Capsule":[358],"summary":[359],"study":[361],"provides":[362],"insight":[364],"cooperative":[367],"mechanisms":[368],"underlying":[371],"allostery":[376],"highlights":[377],"reducing":[381],"activation":[383],"inform":[386],"development":[387],"precise":[390],"anti-IgE":[391],"therapies":[392],"managing":[394],"allergies.":[395]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-18T00:00:00"}
