{"id":"https://openalex.org/W7213542194","doi":"https://doi.org/10.64898/2026.09.17.752365","title":"NAT10 supports CAG repeat-associated mRNA stabilization and is associated with hepatic metabolic reprogramming during spaceflight","display_name":"NAT10 supports CAG repeat-associated mRNA stabilization and is associated with hepatic metabolic reprogramming during spaceflight","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213542194","doi":"https://doi.org/10.64898/2026.09.17.752365"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.17.752365","doi":"https://doi.org/10.64898/2026.09.17.752365","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.17.752365","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.17.752365.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.17.752365.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041091227","display_name":"Ryota Kurimoto","orcid":"https://orcid.org/0000-0003-3029-5287","observed_orcids":["https://orcid.org/0000-0003-3029-5287"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ryota Kurimoto","raw_affiliation_strings":["Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan","Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035001251","display_name":"Tomoaki Tanaka","orcid":"https://orcid.org/0000-0002-9761-1750","observed_orcids":["https://orcid.org/0000-0002-9761-1750"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Tanaka","raw_affiliation_strings":["Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064282637","display_name":"Izumi Ohno","orcid":"https://orcid.org/0000-0001-6434-6797","observed_orcids":["https://orcid.org/0000-0001-6434-6797"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Izumi Ohno","raw_affiliation_strings":["Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072809750","display_name":"Tomoki Chiba","orcid":"https://orcid.org/0000-0001-5472-9030","observed_orcids":["https://orcid.org/0000-0001-5472-9030"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoki Chiba","raw_affiliation_strings":["Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080339510","display_name":"Takahide Matsushima","orcid":"https://orcid.org/0000-0002-7110-2261","observed_orcids":["https://orcid.org/0000-0002-7110-2261"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahide Matsushima","raw_affiliation_strings":["Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005964704","display_name":"Yutaro Uchida","orcid":"https://orcid.org/0000-0002-2790-6879","observed_orcids":["https://orcid.org/0000-0002-2790-6879"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaro Uchida","raw_affiliation_strings":["Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055110943","display_name":"Yuki Naito","orcid":"https://orcid.org/0000-0002-1182-6786","observed_orcids":["https://orcid.org/0000-0002-1182-6786"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Naito","raw_affiliation_strings":["NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NucleoTIDE and PepTIDE Drug Discovery Center, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065427229","display_name":"Hiroshi Asahara","orcid":"https://orcid.org/0000-0002-5215-8745","observed_orcids":["https://orcid.org/0000-0002-5215-8745"]},"institutions":[{"id":"https://openalex.org/I4400009020","display_name":"Institute of Science Tokyo","ror":"https://ror.org/05dqf9946","country_code":"JP","type":"education","lineage":["https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Asahara","raw_affiliation_strings":["Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems BioMedicine, Institute of Science Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4400009020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041091227"],"corresponding_institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4400009020"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nat10","display_name":"NAT10","score":1.0},{"id":"https://openalex.org/keywords/cag-repeat-expansion","display_name":"CAG repeat expansion","score":0.847000002861023},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ddx17","display_name":"DDX17","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dcp1a","display_name":"DCP1A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spaceflight","display_name":"spaceflight","score":0.7440000176429749},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.3230000138282776},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rna-modification","display_name":"RNA modification","score":0.6380000114440918},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/helicase-domain","display_name":"helicase domain","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7515000104904175},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6047999858856201},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5874000191688538},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5587999820709229},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5569999814033508},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5209000110626221},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.51910001039505},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41040000319480896},{"id":"https://openalex.org/C68592252","wikidata":"https://www.wikidata.org/wiki/Q17913854","display_name":"RNA Helicase A","level":5,"score":0.40849998593330383},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.3896999955177307},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.38179999589920044},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.376800000667572},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.36980000138282776},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3472999930381775},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.33709999918937683},{"id":"https://openalex.org/C70219777","wikidata":"https://www.wikidata.org/wiki/Q14911527","display_name":"Nonsense-mediated decay","level":5,"score":0.31619998812675476},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.29919999837875366},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.28540000319480896},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.17.752365","doi":"https://doi.org/10.64898/2026.09.17.752365","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.17.752365","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.17.752365.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.17.752365","doi":"https://doi.org/10.64898/2026.09.17.752365","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.17.752365","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.17.752365.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1562152159","display_name":"Elucidation of a novel regulatory mechanism of tumor suppressor microRNA let-7 in leukemia and its therapeutic application","funder_award_id":"22K07226","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G420130502","display_name":"\u65b0\u898fmRNA\u4fee\u98fe\u9175\u7d20\u306b\u3088\u308b\u304c\u3093\u6d78\u6f64\u8ee2\u79fb\u5236\u5fa1\u306e\u89e3\u660e\u3068\u6cbb\u7642\u5fdc\u7528","funder_award_id":"25K10441","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320318912","display_name":"SGH Foundation","ror":"https://ror.org/01tsvpv45"},{"id":"https://openalex.org/F4320322203","display_name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","ror":"https://ror.org/043s0fn12"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213542194.pdf","grobid_xml":"https://content.openalex.org/works/W7213542194.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222629207","https://openalex.org/W2904095049","https://openalex.org/W4306392327","https://openalex.org/W4362576491","https://openalex.org/W7160059983","https://openalex.org/W7134047299","https://openalex.org/W7221160917","https://openalex.org/W4389410663","https://openalex.org/W2901932654","https://openalex.org/W4399154762"],"abstract_inverted_index":{"Summary":[0],"The":[1],"regulatory":[2],"factors":[3],"underlying":[4],"posttranscriptional":[5,199],"adaptation":[6],"to":[7,35,88,98,187,200],"spaceflight":[8,150],"are":[9],"incompletely":[10],"understood.":[11],"We":[12],"identified":[13],"NAT10":[14,33,53,74,124,147,161,186],",":[15],"an":[16,36],"RNA":[17,20,119],"acetyltransferase,":[18],"among":[19],"modification":[21],"enzymes":[22],"significantly":[23],"upregulated":[24],"in":[25,44,137,149,163,192],"spaceflight-exposed":[26],"mouse":[27],"liver.":[28],"Transcriptome-wide":[29],"correlation":[30],"analysis":[31,145],"linked":[32],"expression":[34],"RNA-metabolism":[37],"module":[38],"enriched":[39],"for":[40,104],"CAG":[41,56,127,188],"repeat":[42],"density":[43],"coding":[45],"sequences.":[46],"Actinomycin":[47],"D":[48],"chase":[49],"assays":[50],"showed":[51,68],"that":[52],"knockdown":[54],"destabilized":[55],"repeat-containing":[57,128],"transcripts,":[58],"with":[59,101,126,130,152],"DDX17":[60,78,138],"serving":[61],"as":[62],"the":[63,81,93,169,173,193],"primary":[64],"validated":[65],"target;":[66],"DCP1A":[67,140],"a":[69,89,102,183],"directionally":[70],"consistent":[71,100],"pattern.":[72],"Wild-type":[73],"re-expression":[75],"fully":[76],"rescued":[77,85],"mRNA":[79,86,190],"stability,":[80],"acetyltransferase-dead":[82],"G641E":[83],"mutant":[84,96],"stability":[87],"comparable":[90],"extent,":[91],"and":[92,139,157,198],"K290A":[94],"helicase-domain":[95],"failed":[97],"rescue,":[99],"requirement":[103],"helicase":[105],"domain":[106],"integrity,":[107],"whereas":[108],"acetyltransferase":[109],"activity":[110],"was":[111],"not":[112,172],"strictly":[113],"required":[114],"under":[115],"these":[116],"experimental":[117],"conditions.":[118],"immunoprecipitation":[120],"further":[121],"supported":[122],"preferential":[123],"association":[125,132],"mRNAs,":[129],"reduced":[131],"after":[133],"single-site":[134],"CAGCAG":[135],"deletion":[136],"reporters.":[141],"Gene":[142],"set":[143],"enrichment":[144],"associated":[146],"upregulation":[148],"liver":[151],"suppressed":[153],"fatty":[154],"acid":[155],"beta-oxidation":[156],"induced":[158],"cholesterol":[159],"biosynthesis;":[160],"depletion":[162],"hepatocellular":[164],"carcinoma":[165],"cells":[166],"selectively":[167],"opposed":[168],"cholesterol-associated,":[170],"but":[171],"broader":[174],"metabolic,":[175],"component":[176],"of":[177,195],"this":[178],"signature.":[179],"These":[180],"findings":[181],"support":[182],"model":[184],"linking":[185],"repeat-associated":[189],"stabilization":[191],"context":[194],"hepatic":[196],"metabolic":[197],"spaceflight.":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-18T00:00:00"}