{"id":"https://openalex.org/W7213535481","doi":"https://doi.org/10.22146/ijp.18859","title":"LC-HRMS Profiling and Antibacterial Activity of Extract and Fraction of Phaleria macrocarpa (Scheff.) Boerl. Fruit","display_name":"LC-HRMS Profiling and Antibacterial Activity of Extract and Fraction of Phaleria macrocarpa (Scheff.) Boerl. Fruit","publication_year":2026,"publication_date":"2026-09-08","ids":{"openalex":"https://openalex.org/W7213535481","doi":"https://doi.org/10.22146/ijp.18859"},"language":"en","primary_location":{"id":"doi:10.22146/ijp.18859","doi":"https://doi.org/10.22146/ijp.18859","is_oa":true,"landing_page_url":"https://doi.org/10.22146/ijp.18859","pdf_url":"https://journal.ugm.ac.id/v3/IJP/article/download/18859/7436","source":{"id":"https://openalex.org/S2764873267","display_name":"INDONESIAN JOURNAL OF PHARMACY","issn_l":"2338-9427","issn":["2338-9427","2338-9486"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indonesian Journal of Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.ugm.ac.id/v3/IJP/article/download/18859/7436","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092376540","display_name":"Mutiara Imansari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257424","display_name":"Universitas Muhammadiyah Bandung","ror":"https://ror.org/05862k391","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257424"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mutiara Imansari","raw_affiliation_strings":["Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia","institution_ids":["https://openalex.org/I4405257424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045118842","display_name":"Wahyu Alfath Firdaus","orcid":"https://orcid.org/0009-0003-7617-3872","observed_orcids":["https://orcid.org/0009-0003-7617-3872"]},"institutions":[{"id":"https://openalex.org/I4405257424","display_name":"Universitas Muhammadiyah Bandung","ror":"https://ror.org/05862k391","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257424"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Wahyu Alfath Firdaus","raw_affiliation_strings":["Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia"],"raw_orcid":"https://orcid.org/0009-0003-7617-3872","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia","institution_ids":["https://openalex.org/I4405257424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121301550","display_name":"Sinta Dewi Sri Anggreini","orcid":"https://orcid.org/0009-0006-1308-5391","observed_orcids":["https://orcid.org/0009-0006-1308-5391"]},"institutions":[{"id":"https://openalex.org/I4405257424","display_name":"Universitas Muhammadiyah Bandung","ror":"https://ror.org/05862k391","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257424"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sinta Dewi Sri Anggreini","raw_affiliation_strings":["Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia"],"raw_orcid":"https://orcid.org/0009-0006-1308-5391","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia","institution_ids":["https://openalex.org/I4405257424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152064505","display_name":"Taufiqurahman Taufiqurahman","orcid":"https://orcid.org/0009-0009-8487-586X","observed_orcids":["https://orcid.org/0009-0009-8487-586X"]},"institutions":[{"id":"https://openalex.org/I4405257424","display_name":"Universitas Muhammadiyah Bandung","ror":"https://ror.org/05862k391","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257424"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Taufiqurahman Taufiqurahman","raw_affiliation_strings":["Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia"],"raw_orcid":"https://orcid.org/0009-0009-8487-586X","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia","institution_ids":["https://openalex.org/I4405257424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072557650","display_name":"Dwi Larasati Setyaningrum","orcid":"https://orcid.org/0000-0002-0824-0258","observed_orcids":["https://orcid.org/0000-0002-0824-0258"]},"institutions":[{"id":"https://openalex.org/I4405257424","display_name":"Universitas Muhammadiyah Bandung","ror":"https://ror.org/05862k391","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405257424"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Dwi Larasati Setyaningrum","raw_affiliation_strings":["Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-0824-0258","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Pharmacy, Universitas Muhammadiyah Bandung, Jl. Soekarno Hatta, Panyileukan, Bandung, West Java 40614, Indonesia","institution_ids":["https://openalex.org/I4405257424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405257424"],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phaleria-macrocarpa","display_name":"Phaleria macrocarpa","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mahkota-dewa","display_name":"mahkota dewa","score":0.972000002861023},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.953000009059906},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/minimum-bactericidal-concentration","display_name":"minimum bactericidal concentration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ethyl-acetate-fraction","display_name":"ethyl acetate fraction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8679999709129333},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/staphylococcus-epidermidis","display_name":"Staphylococcus epidermidis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7879999876022339},{"id":"https://openalex.org/keywords/taxifolin","display_name":"taxifolin","score":0.5950000286102295},{"id":"https://openalex.org/keywords/p-cymene","display_name":"p-cymene","score":0.6669999957084656},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5960000157356262},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.8026999831199646},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.794700026512146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6615999937057495},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.6538000106811523},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6198999881744385},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.6118000149726868},{"id":"https://openalex.org/C26381139","wikidata":"https://www.wikidata.org/wiki/Q1158816","display_name":"Minimum bactericidal concentration","level":4,"score":0.597599983215332},{"id":"https://openalex.org/C2779900937","wikidata":"https://www.wikidata.org/wiki/Q2442109","display_name":"Propionibacterium acnes","level":3,"score":0.4993000030517578},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4659000039100647},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.4636000096797943},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C2780847017","wikidata":"https://www.wikidata.org/wiki/Q826533","display_name":"Soxhlet extractor","level":3,"score":0.3684000074863434},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3382999897003174},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.2928999960422516},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C2778395939","wikidata":"https://www.wikidata.org/wiki/Q2160967","display_name":"Water extraction","level":3,"score":0.2727000117301941},{"id":"https://openalex.org/C74940592","wikidata":"https://www.wikidata.org/wiki/Q6723254","display_name":"Maceration (sewage)","level":2,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22146/ijp.18859","doi":"https://doi.org/10.22146/ijp.18859","is_oa":true,"landing_page_url":"https://doi.org/10.22146/ijp.18859","pdf_url":"https://journal.ugm.ac.id/v3/IJP/article/download/18859/7436","source":{"id":"https://openalex.org/S2764873267","display_name":"INDONESIAN JOURNAL OF PHARMACY","issn_l":"2338-9427","issn":["2338-9427","2338-9486"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indonesian Journal of Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.22146/ijp.18859","doi":"https://doi.org/10.22146/ijp.18859","is_oa":true,"landing_page_url":"https://doi.org/10.22146/ijp.18859","pdf_url":"https://journal.ugm.ac.id/v3/IJP/article/download/18859/7436","source":{"id":"https://openalex.org/S2764873267","display_name":"INDONESIAN JOURNAL OF PHARMACY","issn_l":"2338-9427","issn":["2338-9427","2338-9486"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310314959","host_organization_name":"Gadjah Mada University","host_organization_lineage":["https://openalex.org/P4310314959"],"host_organization_lineage_names":["Gadjah Mada University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indonesian Journal of Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213535481.pdf","grobid_xml":"https://content.openalex.org/works/W7213535481.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2003667761","https://openalex.org/W2104478003","https://openalex.org/W2146045401","https://openalex.org/W2301837119","https://openalex.org/W2312190923","https://openalex.org/W2746546304","https://openalex.org/W2911680585","https://openalex.org/W2999533877","https://openalex.org/W3201022908","https://openalex.org/W4213161941","https://openalex.org/W4281720266","https://openalex.org/W4312078775","https://openalex.org/W4390446666","https://openalex.org/W4395009167","https://openalex.org/W4405429941","https://openalex.org/W4407179483","https://openalex.org/W7134056394","https://openalex.org/W7216414228"],"related_works":["https://openalex.org/W2149170380","https://openalex.org/W2785888877","https://openalex.org/W7042274285","https://openalex.org/W3034054348","https://openalex.org/W4390446666","https://openalex.org/W3139682302","https://openalex.org/W7128545882","https://openalex.org/W2613449632","https://openalex.org/W4327858877","https://openalex.org/W2483759960"],"abstract_inverted_index":{"Antibiotics":[0],"have":[1],"been":[2],"found":[3],"to":[4,51],"treat":[5],"a":[6,13,128],"variety":[7],"of":[8,20,63,74,79,85,93,118,182,219,238,272],"infectious":[9],"diseases,":[10],"which":[11,244],"is":[12],"crucial":[14],"health":[15],"issue.":[16],"However,":[17],"the":[18,53,89,94,113,140,220,236],"emergence":[19],"drug":[21],"resistance":[22],"has":[23],"created":[24],"new":[25],"challenges":[26],"for":[27],"researchers.":[28],"Herbal":[29],"medicine,":[30],"especially":[31],"Phaleria":[32,80],"macrocarpa":[33,81],"(Scheff.)":[34,82],"Boerl":[35],"(as":[36],"known":[37],"as":[38,175],"Mahkota":[39,119],"Dewa":[40],"plants),":[41],"can":[42],"be":[43],"an":[44,176],"alternative":[45],"antibacterial":[46,177,229,246,279],"agent.":[47],"This":[48,144],"study":[49],"aims":[50],"determine":[52],"Minimum":[54,59],"Inhibitory":[55],"Concentration":[56,61],"(MIC)":[57],"and":[58,71,77,116,134,157,166,196,203,214,266,301],"Bactericidal":[60],"(MBC)":[62],"water":[64,69,106,123],"extracts,":[65],"ethyl":[66,132,179],"acetate":[67,133,180],"fraction,":[68],"fractions,":[70],"butanol":[72],"fractions":[73,223],"peels,":[75],"fruits,":[76],"seed":[78,117],"Boerl.":[83],"Identification":[84],"prediction":[86],"compounds":[87,230,241],"in":[88,242],"highest":[90],"antimicrobial":[91],"activity":[92,148],"samples":[95,174],"are":[96],"also":[97],"determined.":[98],"The":[99,171,233],"extraction":[100],"method":[101],"used":[102],"was":[103,109],"infusion":[104],"with":[105,186],"solvent.":[107],"Extraction":[108],"carried":[110],"out":[111],"on":[112],"peel,":[114],"fruit,":[115],"Dewa.":[120],"These":[121],"three":[122],"extracts":[124],"were":[125,178,199,210,224],"isolated":[126],"by":[127,226],"separatory":[129],"funnel":[130],"using":[131,139,231],"n-butanol":[135,270],"solvents.":[136],"Antimicrobial":[137],"testing":[138],"broth":[141],"microdilution":[142],"method.":[143],"assay":[145],"revealed":[146],"promising":[147],"against":[149,189],"both":[150],"gram-negative":[151],"bacteria":[152,159],"(Escherichia":[153],"coli":[154],"ATCC":[155,162,169],"8739)":[156],"gram-positive":[158],"(Staphylococcus":[160],"aureus":[161],"29213,":[163],"Staphylococcus":[164],"epidermidis,":[165,195],"Propionibacterium":[167],"acnes":[168,198],"6919).":[170],"most":[172,221],"active":[173,222],"fraction":[181,271],"flesh":[183,273],"fruits":[184],"(EAFFF)":[185],"MIC":[187],"value":[188],"E.":[190],"coli,":[191],"S.":[192,194],"aureus,":[193],"P.":[197],"12.500,":[200,211],"6.250,":[201,212,213],"3.125,":[202],"12.500":[204],"ppm,":[205],"whereas":[206],"each":[207],"MBC":[208],"values":[209],"25.000":[215],"ppm":[216],"respectively.":[217],"Two":[218],"identified":[225],"predicting":[227],"its":[228],"LC-HRMS.":[232],"results":[234],"showed":[235,276],"presence":[237],"10":[239],"predicted":[240,278],"EAFF":[243],"had":[245],"properties":[247],"including":[248],"2\u2019,":[249,281],"4\u2019,":[250,282,291],"3,":[251,283],"4,":[252,284],"alpha-pentahydroxy":[253,285],"dihydrochalcone":[254,286],"3\u2019-C-xyloside,":[255,287],"5,7,3\u20194\u2019,5\u2019-pentahydroxy-3,6,8-trimethoxyflavone,":[256],"p-cymene,":[257],"taxifolin":[258,294],"3-apioside,":[259,295],"eucalyptin,":[260],"2-(2\u2019-O-benzoyl)-C-\u03b2-D-glucopyranosil-1,3,6,7-tetrahydroxyxanthone,":[261],"(+)-ar-Turmerone,":[262],"2-hydroxy-N\u2019-[(E)-(2-hydroxy-3,5-dinitrophenyl)methylene]-2,2-diphenylacetohydrazide,":[263],"picroside":[264],"II,":[265],"vitexin":[267],"2\u201d-p-hydroxybenzoate":[268],"while":[269],"fruit":[274],"(BFFF)":[275],"8":[277],"compounds,":[280],"5,":[288],"7,":[289],"3\u2019,":[290],"5\u2019-pentahydroxy-3,6,8-trimethoxyflavone,":[292],"glycitein,":[293],"(-)-caryophyllene":[296],"oxide,":[297],"\u03b1-curcumene,":[298],"6,4\u2019-dihydroxyurone":[299],"4-O-rutinoside,":[300],"\u03b1-santonin.":[302]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-09-18T00:00:00"}