{"id":"https://openalex.org/W7213534934","doi":"https://doi.org/10.64898/2026.09.16.752125","title":"Fusion Oncoprotein EWSR1::FLI1 Invades Nucleosomes at Consensus ETS Motifs and GGAA Microsatellites","display_name":"Fusion Oncoprotein EWSR1::FLI1 Invades Nucleosomes at Consensus ETS Motifs and GGAA Microsatellites","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7213534934","doi":"https://doi.org/10.64898/2026.09.16.752125","pmid":"https://pubmed.ncbi.nlm.nih.gov/42780001","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596438"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.16.752125","doi":"https://doi.org/10.64898/2026.09.16.752125","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752125","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752125.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752125.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052830237","display_name":"Ruo-Wen Chen","orcid":"https://orcid.org/0000-0003-2101-6944","observed_orcids":["https://orcid.org/0000-0003-2101-6944","https://orcid.org/0000-0001-9719-0784"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruo-Wen Chen","raw_affiliation_strings":["Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-2101-6944","affiliations":[{"raw_affiliation_string":"Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126272687","display_name":"Runwei Zhou","orcid":"https://orcid.org/0009-0002-3852-0637","observed_orcids":["https://orcid.org/0009-0002-3852-0637"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runwei Zhou","raw_affiliation_strings":["Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0009-0002-3852-0637","affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"raw_affiliation_string":"Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065263517","display_name":"E. John Tokarsky","orcid":"https://orcid.org/0000-0003-4861-2412","observed_orcids":["https://orcid.org/0000-0003-4861-2412"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. John Tokarsky","raw_affiliation_strings":["Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-4861-2412","affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058299679","display_name":"Megann A. Boone","orcid":"https://orcid.org/0000-0002-7806-8027","observed_orcids":["https://orcid.org/0000-0002-7806-8027"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megann A. Boone","raw_affiliation_strings":["Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-7806-8027","affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066748871","display_name":"Andrea K. Byrum","orcid":"https://orcid.org/0000-0002-5597-8933","observed_orcids":["https://orcid.org/0000-0002-5597-8933"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea K. Byrum","raw_affiliation_strings":["Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-5597-8933","affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076813132","display_name":"Michael Guy Poirier","orcid":"https://orcid.org/0000-0002-1563-5792","observed_orcids":["https://orcid.org/0000-0002-1563-5792"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Poirier","raw_affiliation_strings":["Department of Physics, The Ohio State University, Columbus, OH 43212, USA","Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0002-1563-5792","affiliations":[{"raw_affiliation_string":"Department of Physics, The Ohio State University, Columbus, OH 43212, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Ohio State Biochemistry Program, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055782312","display_name":"Emily R. Theisen","orcid":"https://orcid.org/0000-0003-2923-1198","observed_orcids":["https://orcid.org/0000-0003-2923-1198"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily R. Theisen","raw_affiliation_strings":["Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-2923-1198","affiliations":[{"raw_affiliation_string":"Center for Childhood Cancer Research, Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055782312"],"corresponding_institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103","https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.6083999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.31200000643730164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewsr1-fli1","display_name":"EWSR1-FLI1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nucleosome-binding","display_name":"nucleosome binding","score":0.8180000185966492},{"id":"https://openalex.org/keywords/pioneer-transcription-factors","display_name":"pioneer transcription factors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/low-complexity-domain","display_name":"low-complexity domains","score":0.8059999942779541},{"id":"https://openalex.org/keywords/protein-dna-binding-affinity","display_name":"protein-DNA binding affinity","score":0.6639999747276306},{"id":"https://openalex.org/keywords/sequence-preference","display_name":"sequence preference","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.737500011920929},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6287999749183655},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.6050000190734863},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5831000208854675},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5339000225067139},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4880000054836273},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.46480000019073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4643000066280365},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4474000036716461},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4374000132083893},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41929998993873596},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.37779998779296875},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.3564999997615814},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.34150001406669617},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.3343000113964081},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.31189998984336853},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.30090001225471497},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C96739231","wikidata":"https://www.wikidata.org/wiki/Q4914025","display_name":"Binding selectivity","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2854999899864197},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.28189998865127563},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2718999981880188},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.16.752125","doi":"https://doi.org/10.64898/2026.09.16.752125","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752125","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752125.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596438","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596438/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596438/pdf/nihpp-2026.09.16.752125v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42780001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42780001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.16.752125","doi":"https://doi.org/10.64898/2026.09.16.752125","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.752125","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/18/2026.09.16.752125.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5844280962","display_name":"Typhoon FLA9500 Biomedical Imager","funder_award_id":"1s10od023582-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000873605","display_name":"Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation","funder_award_id":"R35GM139654","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306589","display_name":"Alex's Lemonade Stand Foundation for Childhood Cancer","ror":"https://ror.org/038ja4880"},{"id":"https://openalex.org/F4320315921","display_name":"CancerFree KIDS","ror":"https://ror.org/04jme7072"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213534934.pdf","grobid_xml":"https://content.openalex.org/works/W7213534934.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214048349","https://openalex.org/W7123735164","https://openalex.org/W4409626649","https://openalex.org/W7214031242","https://openalex.org/W4391444468","https://openalex.org/W2092360628","https://openalex.org/W2329165376","https://openalex.org/W2108696643","https://openalex.org/W7097874426","https://openalex.org/W4392994162"],"abstract_inverted_index":{"Ewing":[0],"sarcoma":[1],"is":[2],"an":[3],"aggressive":[4],"bone":[5],"malignancy":[6],"occurring":[7],"in":[8,49,98,112,119,131,151],"children,":[9],"adolescents,":[10],"and":[11,34,83,90,101,105,114,137,142,172],"young":[12],"adults.":[13],"Most":[14],"cases":[15],"are":[16,148],"caused":[17],"by":[18],"expression":[19],"of":[20,32,39,63],"the":[21,27,35,60,116,120],"fusion":[22],"oncoprotein":[23],"EWSR1::FLI1,":[24,66],"which":[25],"contains":[26],"low":[28],"complexity":[29],"domain":[30,37],"(LCD)":[31],"EWSR1":[33],"DNA-binding":[36],"(DBD)":[38],"FLI1.":[40],"Previous":[41],"genomic":[42],"studies":[43,68],"indicate":[44],"EWSR1::FLI1":[45,82,107,158,175,190],"accesses":[46],"GGAA":[47,181],"microsatellites":[48],"chromatin":[50],"to":[51,59,87,178],"function":[52],"as":[53],"a":[54,160,188],"potent":[55],"transcriptional":[56],"regulator.":[57],"Due":[58],"technical":[61],"challenges":[62],"purifying":[64],"full-length":[65,81,106,143,174],"mechanistic":[67],"biochemically":[69],"characterizing":[70],"its":[71,167],"pioneer":[72,162],"activities":[73],"have":[74],"been":[75],"lacking.":[76],"Here,":[77],"we":[78,127],"purified":[79],"both":[80,132],"truncated":[84,104,141],"DBD":[85,122],"constructs":[86],"conduct":[88],"biochemical":[89],"fluorescence-based":[91],"experiments":[92],"investigating":[93],"interactions":[94],"with":[95],"different":[96],"motifs":[97,185],"free":[99,133],"DNA":[100,134],"nucleosomes.":[102],"Both":[103],"show":[108],"efficient":[109],"target":[110,180],"binding":[111,135,168,176],"nucleosomes,":[113,171],"that":[115,157,173,186],"fourth":[117],"alpha-helix":[118],"FLI1":[121],"enhances":[123],"nucleosome-binding":[124,152],"efficiency.":[125],"Surprisingly,":[126],"also":[128],"observe":[129],"differences":[130],"affinity":[136],"sequence":[138],"preference":[139],"between":[140],"proteins,":[144],"though":[145],"these":[146],"changes":[147],"not":[149],"apparent":[150],"assays.":[153],"These":[154],"findings":[155],"reveal":[156],"possesses":[159],"key":[161],"factor":[163],"property,":[164],"efficiently":[165],"targeting":[166],"site":[169],"within":[170],"shifts":[177],"preferentially":[179],"repeats,":[182],"even":[183],"on":[184],"bind":[187],"single":[189],"protein.":[191]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-18T00:00:00"}