{"id":"https://openalex.org/W7213521906","doi":"https://doi.org/10.64898/2026.09.16.751805","title":"SRPK1 is a determinant of chemoresistance to Docetaxel in prostate cancer","display_name":"SRPK1 is a determinant of chemoresistance to Docetaxel in prostate cancer","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213521906","doi":"https://doi.org/10.64898/2026.09.16.751805"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.16.751805","doi":"https://doi.org/10.64898/2026.09.16.751805","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751805","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.16.751805.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.16.751805.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117230208","display_name":"Duygu Duzgun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duygu Duzgun","raw_affiliation_strings":["Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135838750","display_name":"William Read","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Read","raw_affiliation_strings":["Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045122768","display_name":"Sebastian Oltean","orcid":"https://orcid.org/0000-0001-7890-8439","observed_orcids":["https://orcid.org/0000-0001-7890-8439"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sebastian Oltean","raw_affiliation_strings":["Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045122768"],"corresponding_institution_ids":["https://openalex.org/I23923803"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/srpk1","display_name":"SRPK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/docetaxel-resistance","display_name":"docetaxel resistance","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8659999966621399},{"id":"https://openalex.org/keywords/srsf1","display_name":"SRSF1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/beta-iii-tubulin","display_name":"TUBB3","score":0.8119999766349792},{"id":"https://openalex.org/keywords/microtubule-bundling","display_name":"microtubule bundling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/bcl-x","display_name":"Bcl-x","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.8087999820709229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5443000197410583},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5090000033378601},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4936000108718872},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.48980000615119934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48240000009536743},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.46140000224113464},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3984000086784363},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.16.751805","doi":"https://doi.org/10.64898/2026.09.16.751805","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751805","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.16.751805.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.16.751805","doi":"https://doi.org/10.64898/2026.09.16.751805","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.16.751805","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.16.751805.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213521906.pdf","grobid_xml":"https://content.openalex.org/works/W7213521906.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2097694375","https://openalex.org/W2145903740","https://openalex.org/W3080179420"],"related_works":["https://openalex.org/W4409626541","https://openalex.org/W4252541155","https://openalex.org/W112845167","https://openalex.org/W2104394035","https://openalex.org/W2562390645","https://openalex.org/W2733456606","https://openalex.org/W2593417901","https://openalex.org/W2590632943","https://openalex.org/W3186035517","https://openalex.org/W3080179420"],"abstract_inverted_index":{"Abstract":[0],"Docetaxel":[1],"is":[2],"a":[3,52,217,238],"major":[4],"therapeutic":[5],"option":[6],"for":[7],"advanced":[8],"prostate":[9,63,230,243],"cancer,":[10],"but":[11],"the":[12,31,44,74,138,146,161,186,194,207],"development":[13],"of":[14,46,55,84,105,124,142,160,179,183,188,209,220,226],"acquired":[15,59],"resistance":[16,61,228],"substantially":[17,86],"limits":[18],"its":[19],"clinical":[20],"efficacy.":[21],"Although":[22],"multiple":[23,221],"mechanisms":[24],"have":[25],"been":[26],"implicated":[27],"in":[28,58,62,94,117,175,229],"docetaxel":[29,60,88,169,227],"resistance,":[30],"upstream":[32],"regulatory":[33],"pathways":[34],"coordinating":[35],"these":[36,212],"phenotypes":[37],"remain":[38],"incompletely":[39],"understood.":[40],"Here,":[41],"we":[42],"investigated":[43],"role":[45],"serine/arginine-rich":[47],"protein":[48,75],"kinase":[49],"1":[50],"(SRPK1),":[51],"key":[53],"regulator":[54,219],"pre-mRNA":[56],"splicing,":[57],"cancer.":[64,231],"Docetaxel-resistant":[65],"PC3":[66,96],"cells":[67,97,152,245],"showed":[68],"increased":[69,98,115,122,154,158],"SRPK1":[70,85,92,101,112,131,162,180,215],"expression":[71,93,104,135,156],"at":[72,206],"both":[73],"and":[76,107,127,136,148,157,190,197,200,223],"RNA":[77],"levels.":[78],"Genetic":[79],"depletion":[80,166,182],"or":[81,181],"pharmacological":[82],"inhibition":[83,102,113,132,178],"restored":[87,108,133,168],"sensitivity,":[89,170],"whereas":[90],"ectopic":[91],"parental":[95],"resistance.":[99,176],"Mechanistically,":[100],"reduced":[103,137],"\u03b2III-tubulin":[106],"docetaxel-induced":[109],"microtubule":[110],"bundling.":[111],"also":[114],"apoptosis":[116],"resistant":[118,143,242],"cells,":[119],"accompanied":[120],"by":[121],"cleavage":[123],"caspase-8,":[125],"caspase-9":[126],"PARP.":[128],"In":[129],"parallel,":[130],"E-cadherin":[134],"enhanced":[139],"migratory":[140],"phenotype":[141],"cells.":[144],"At":[145],"signalling":[147],"RNA-processing":[149],"levels,":[150],"docetaxel-resistant":[151],"exhibited":[153],"EGFR":[155],"phosphorylation":[159],"substrate":[163],"SRSF1.":[164],"SRSF1":[165,184],"partially":[167],"supporting":[171],"an":[172],"EGFR-SRPK1-SRSF1":[173],"pathway":[174],"Importantly,":[177],"altered":[185],"splicing":[187,203,234],"apoptosis\u2013":[189],"microtubule-associated":[191],"genes,":[192],"increasing":[193],"pro-apoptotic":[195],"Bcl-xS":[196],"MCL-1S":[198],"isoforms":[199],"shifting":[201],"tau":[202],"towards":[204],"3R":[205],"expense":[208],"4R.":[210],"Collectively,":[211],"findings":[213],"identify":[214],"as":[216],"central":[218],"phenotypic":[222],"molecular":[224],"features":[225],"Targeting":[232],"SRPK1-dependent":[233],"may":[235],"therefore":[236],"represent":[237],"strategy":[239],"to":[240,246],"re-sensitize":[241],"cancer":[244],"docetaxel.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-18T00:00:00"}
