{"id":"https://openalex.org/W7213502976","doi":"https://doi.org/10.48550/arxiv.2609.18376","title":"Multi-contrast wide-field mid-infrared photothermal imaging","display_name":"Multi-contrast wide-field mid-infrared photothermal imaging","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213502976","doi":"https://doi.org/10.48550/arxiv.2609.18376"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2609.18376","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.18376","pdf_url":"https://arxiv.org/pdf/2609.18376","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2609.18376","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111163371","display_name":"Anooj Thayyil Raveendran","orcid":"https://orcid.org/0009-0009-9080-6430","observed_orcids":["https://orcid.org/0009-0009-9080-6430"]},"institutions":[{"id":"https://openalex.org/I2801349226","display_name":"Leibniz Institute of Photonic Technology","ror":"https://ror.org/02se0t636","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801349226","https://openalex.org/I315704651"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raveendran, Anooj Thayyil","raw_affiliation_strings":["Leibniz Institute of Photonic Technology , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Albert-Einstein-Str. 9 , 07745 Jena , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leibniz Institute of Photonic Technology , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Albert-Einstein-Str. 9 , 07745 Jena , Germany","institution_ids":["https://openalex.org/I2801349226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060183640","display_name":"Cornelia Reuter","orcid":"https://orcid.org/0000-0002-9060-3344","observed_orcids":["https://orcid.org/0000-0002-9060-3344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reuter, Cornelia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034127568","display_name":"Samir F. El\u2010Mashtoly","orcid":"https://orcid.org/0000-0001-6087-8817","observed_orcids":["https://orcid.org/0000-0001-6087-8817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"El-Mashtoly, Samir F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140247646","display_name":"J\u00fcrgen Popp","orcid":"https://orcid.org/0000-0003-4257-593X","observed_orcids":["https://orcid.org/0000-0003-4257-593X"]},"institutions":[{"id":"https://openalex.org/I2801349226","display_name":"Leibniz Institute of Photonic Technology","ror":"https://ror.org/02se0t636","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2801349226","https://openalex.org/I315704651"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Popp, J\u00fcrgen","raw_affiliation_strings":["Friedrich-Schiller-University Jena , Institute of Physical Chemistry , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Helmholtzweg 4 , 07743 Jena , Germany","Leibniz Institute of Photonic Technology , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Albert-Einstein-Str. 9 , 07745 Jena , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Schiller-University Jena , Institute of Physical Chemistry , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Helmholtzweg 4 , 07743 Jena , Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Leibniz Institute of Photonic Technology , Member of Leibniz Research Alliance Leibniz Health Technologies , Member of the Leibniz Center for Photonics in Infection Research , Albert-Einstein-Str. 9 , 07745 Jena , Germany","institution_ids":["https://openalex.org/I2801349226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5152029355","display_name":"Christoph Kraft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kraft, Christoph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11856","display_name":"Thermography and Photoacoustic Techniques","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wide-field-microscopy","display_name":"wide-field microscopy","score":0.7559999823570251},{"id":"https://openalex.org/keywords/multi-contrast-imaging","display_name":"multi-contrast imaging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/quantitative-phase-imaging","display_name":"quantitative phase imaging","score":0.8690000176429749},{"id":"https://openalex.org/keywords/point-spread-function","display_name":"point spread function","score":0.8840000033378601},{"id":"https://openalex.org/keywords/signal-to-noise-ratio","display_name":"signal-to-noise ratio","score":0.953000009059906},{"id":"https://openalex.org/keywords/submicron-resolution","display_name":"submicron resolution","score":0.7440000176429749},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mouse-lung","display_name":"mouse lung","score":0.8489999771118164},{"id":"https://openalex.org/keywords/polystyrene-microspheres","display_name":"polystyrene microspheres","score":0.9169999957084656}],"concepts":[{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6804999709129333},{"id":"https://openalex.org/C182606246","wikidata":"https://www.wikidata.org/wiki/Q7187926","display_name":"Photothermal therapy","level":2,"score":0.6581000089645386},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.5228000283241272},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.47909998893737793},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.475600004196167},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.4542999863624573},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.43059998750686646},{"id":"https://openalex.org/C2994073649","wikidata":"https://www.wikidata.org/wiki/Q7180908","display_name":"Phase imaging","level":3,"score":0.4198000133037567},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C69179731","wikidata":"https://www.wikidata.org/wiki/Q510427","display_name":"Point spread function","level":2,"score":0.38850000500679016},{"id":"https://openalex.org/C64389972","wikidata":"https://www.wikidata.org/wiki/Q2075980","display_name":"Biological specimen","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C2777922577","wikidata":"https://www.wikidata.org/wiki/Q146243","display_name":"Polystyrene","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.334199994802475},{"id":"https://openalex.org/C151193507","wikidata":"https://www.wikidata.org/wiki/Q898815","display_name":"Phase contrast microscopy","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3005000054836273},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C58640550","wikidata":"https://www.wikidata.org/wiki/Q7180908","display_name":"Phase-contrast imaging","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C159078339","wikidata":"https://www.wikidata.org/wiki/Q959005","display_name":"Hyperspectral imaging","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C77017923","wikidata":"https://www.wikidata.org/wiki/Q912313","display_name":"Optical microscope","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2609.18376","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.18376","pdf_url":"https://arxiv.org/pdf/2609.18376","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2609.18376","doi":"https://doi.org/10.48550/arxiv.2609.18376","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2609.18376","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2609.18376","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.18376","pdf_url":"https://arxiv.org/pdf/2609.18376","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213502976.pdf","grobid_xml":"https://content.openalex.org/works/W7213502976.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7167720631"],"related_works":["https://openalex.org/W3163447392","https://openalex.org/W4408603420","https://openalex.org/W7133969686","https://openalex.org/W7126293749","https://openalex.org/W7165691124","https://openalex.org/W4307282816","https://openalex.org/W7167720631","https://openalex.org/W4405633372","https://openalex.org/W7115709527","https://openalex.org/W3135837675"],"abstract_inverted_index":{"Wide-field":[0],"mid-infrared":[1],"photothermal":[2,66],"(MIP)":[3],"imaging":[4,9,76,85,151],"enables":[5],"high-speed,":[6],"chemically":[7],"specific":[8],"at":[10,129,170],"sub-micrometer":[11],"spatial":[12,108],"resolution":[13,109],"through":[14],"several":[15],"possible":[16],"contrast":[17,44,191],"mechanisms,":[18],"including":[19,157],"scattering":[20],"change,":[21],"fluorescence":[22],"modulation,":[23],"and":[24,84,92,105,116,167,172,199,224],"phase":[25,75],"change.":[26],"Each":[27],"mechanism":[28,45,68,98,192],"offers":[29,193],"distinct":[30,194],"advantages,":[31],"yet":[32],"existing":[33],"wide-field":[34,60,216],"MIP":[35,61,217],"instruments":[36],"have":[37],"typically":[38],"been":[39],"limited":[40],"to":[41,78,81,142],"a":[42,49,57,120,153,177,210],"single":[43],"so":[46],"far,":[47],"requiring":[48],"dedicated":[50],"instrument":[51],"for":[52,215],"each.":[53],"Here,":[54],"we":[55],"introduce":[56],"switchable":[58,212],"multi-contrast":[59,213],"microscope":[62],"that":[63,189],"allows":[64],"the":[65,82,89,106],"readout":[67],"(based":[69],"on":[70],"scattering-,":[71],"fluorescence-,":[72],"or":[73],"quantitative":[74],"(QPI))":[77],"be":[79],"matched":[80],"sample":[83,205],"conditions.":[86],"We":[87,148],"characterize":[88],"spectral":[90],"fidelity":[91],"signal-to-noise":[93],"(SNR)":[94],"ratio":[95],"of":[96,155,179],"each":[97,190],"using":[99,110],"5":[100,173],"\u03bcm":[101,174],"polystyrene":[102],"(PS)":[103],"beads,":[104],"effective":[107],"300":[111],"nm":[112,122,138],"PS":[113],"beads.":[114],"Scattering-":[115],"fluorescence-based":[117],"detection":[118,134],"achieved":[119],"sub-500":[121],"measured":[123],"point":[124],"spread":[125],"function":[126],"full":[127],"width":[128],"half":[130],"maximum,":[131],"while":[132],"QPI-based":[133],"reached":[135],"approximately":[136],"900":[137],"but":[139],"provided":[140],"up":[141],"26-fold":[143],"higher":[144],"SNR":[145],"than":[146],"scattering.":[147],"further":[149],"demonstrate":[150],"across":[152,185,222],"range":[154],"samples,":[156],"A549":[158],"cells":[159],"in":[160,196],"buffer,":[161],"mouse":[162],"lung":[163],"tissue":[164],"section,":[165],"bacteria,":[166],"SU8":[168],"polymer":[169,223],"1.4":[171],"thickness,":[175],"with":[176,219],"field":[178],"view":[180],"exceeding":[181],"200":[182],"\u03bcm.":[183],"Comparison":[184],"these":[186],"samples":[187],"shows":[188],"trade-offs":[195],"resolution,":[197],"sensitivity,":[198],"applicability,":[200],"guiding":[201],"readout-strategy":[202],"selection":[203],"by":[204],"type.":[206],"These":[207],"results":[208],"establish":[209],"flexible,":[211],"platform":[214],"imaging,":[218],"broad":[220],"applicability":[221],"biological":[225],"samples.":[226]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-18T00:00:00"}
