{"id":"https://openalex.org/W7213499829","doi":"https://doi.org/10.1093/cid/ciag485","title":"Health Economic Analysis of the AMBITION Protocol for Human Immunodeficiency Virus\u2013Associated Cryptococcal Meningitis in the United States","display_name":"Health Economic Analysis of the AMBITION Protocol for Human Immunodeficiency Virus\u2013Associated Cryptococcal Meningitis in the United States","publication_year":2026,"publication_date":"2026-08-07","ids":{"openalex":"https://openalex.org/W7213499829","doi":"https://doi.org/10.1093/cid/ciag485","pmid":"https://pubmed.ncbi.nlm.nih.gov/42752855"},"language":"en","primary_location":{"id":"doi:10.1093/cid/ciag485","doi":"https://doi.org/10.1093/cid/ciag485","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cid/ciag485","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114070791","display_name":"Devin C Clark","orcid":"https://orcid.org/0009-0001-4927-4657","observed_orcids":["https://orcid.org/0009-0001-4927-4657"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin C Clark","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0009-0001-4927-4657","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052151117","display_name":"Josh Banerjee","orcid":"https://orcid.org/0000-0002-3918-0120","observed_orcids":["https://orcid.org/0000-0002-3918-0120"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Banerjee","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0000-0002-3918-0120","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020881370","display_name":"Rachel P. Baden","orcid":"https://orcid.org/0009-0004-5620-7286","observed_orcids":["https://orcid.org/0009-0004-5620-7286"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Baden","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0009-0004-5620-7286","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles Coffey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Coffey","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","Hospital Administration, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Hospital Administration, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055174059","display_name":"Kusha Davar","orcid":"https://orcid.org/0000-0002-5153-2264","observed_orcids":["https://orcid.org/0000-0002-5153-2264"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kusha Davar","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0000-0002-5153-2264","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057724608","display_name":"Sarah Freling","orcid":"https://orcid.org/0009-0007-2414-2766","observed_orcids":["https://orcid.org/0009-0007-2414-2766"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Freling","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0009-0007-2414-2766","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032454786","display_name":"Reid Goodman","orcid":"https://orcid.org/0000-0002-7118-6100","observed_orcids":["https://orcid.org/0000-0002-7118-6100"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reid Goodman","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0000-0002-7118-6100","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082036341","display_name":"Amytis Towfighi","orcid":"https://orcid.org/0000-0002-9565-6787","observed_orcids":["https://orcid.org/0000-0002-9565-6787"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amytis Towfighi","raw_affiliation_strings":["Department of Neurology, University of Southern California , Los Angeles, California ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031638980","display_name":"Brad J. Spellberg","orcid":"https://orcid.org/0000-0002-3632-1709","observed_orcids":["https://orcid.org/0000-0002-3632-1709","https://orcid.org/0009-0009-4645-6971"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Spellberg","raw_affiliation_strings":["Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","Hospital Administration, Los Angeles General Medical Center , Los Angeles, California ,"],"raw_orcid":"https://orcid.org/0009-0009-4645-6971","affiliations":[{"raw_affiliation_string":"Department of Medicine, Keck School of Medicine, University of Southern California , Los Angeles, California ,","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Medicine, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":["https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Hospital Administration, Los Angeles General Medical Center , Los Angeles, California ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71120144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptococcal-meningitis","display_name":"cryptococcal meningitis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.6959999799728394},{"id":"https://openalex.org/keywords/liposomal-amphotericin-b","display_name":"liposomal amphotericin B","score":0.8960000276565552},{"id":"https://openalex.org/keywords/5-fluorocytosine","display_name":"5-fluorocytosine","score":0.878000020980835},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":0.9670000076293945},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.6240000128746033},{"id":"https://openalex.org/keywords/hospital-cost-reduction","display_name":"hospital cost savings","score":0.9440000057220459},{"id":"https://openalex.org/keywords/antifungal-therapy","display_name":"antifungal therapy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8819000124931335},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.7278000116348267},{"id":"https://openalex.org/C2985697011","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economic analysis","level":2,"score":0.5425999760627747},{"id":"https://openalex.org/C195487862","wikidata":"https://www.wikidata.org/wiki/Q850210","display_name":"Revenue","level":2,"score":0.5285000205039978},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.49959999322891235},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.45010000467300415},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.4336000084877014},{"id":"https://openalex.org/C2776125615","wikidata":"https://www.wikidata.org/wiki/Q18391886","display_name":"Economic evaluation","level":2,"score":0.42559999227523804},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.3880000114440918},{"id":"https://openalex.org/C2983335822","wikidata":"https://www.wikidata.org/wiki/Q942582","display_name":"Cost analysis","level":2,"score":0.38420000672340393},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C2775860198","wikidata":"https://www.wikidata.org/wiki/Q7257872","display_name":"Public hospital","level":2,"score":0.37779998779296875},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C2983635472","wikidata":"https://www.wikidata.org/wiki/Q334911","display_name":"Health insurance","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C524218345","wikidata":"https://www.wikidata.org/wiki/Q31218","display_name":"Health economics","level":3,"score":0.34610000252723694},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.33869999647140503},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.319599986076355},{"id":"https://openalex.org/C3019493264","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcal meningitis","level":4,"score":0.31610000133514404},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C515549039","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost-effectiveness analysis","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C3020336477","wikidata":"https://www.wikidata.org/wiki/Q6806585","display_name":"Treatment protocol","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2991717224","wikidata":"https://www.wikidata.org/wiki/Q334911","display_name":"Medical insurance","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C127454912","wikidata":"https://www.wikidata.org/wiki/Q942582","display_name":"Cost\u2013benefit analysis","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C145096142","wikidata":"https://www.wikidata.org/wiki/Q5333450","display_name":"Economic cost","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/cid/ciag485","doi":"https://doi.org/10.1093/cid/ciag485","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cid/ciag485","pdf_url":null,"source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:42752855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42752855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2144543496","https://openalex.org/W2331249764","https://openalex.org/W2611697423","https://openalex.org/W4220750098","https://openalex.org/W4309156015","https://openalex.org/W7125222511"],"related_works":["https://openalex.org/W4309156015","https://openalex.org/W7213524660","https://openalex.org/W4400139871","https://openalex.org/W4400139900","https://openalex.org/W7125222511","https://openalex.org/W4309107145","https://openalex.org/W6901629126","https://openalex.org/W4401843133","https://openalex.org/W4205670379","https://openalex.org/W4307180670"],"abstract_inverted_index":{"BACKGROUND:":[0],"Current":[1],"guideline-compliant":[2,75],"management":[3],"of":[4,9,21,58,100,176,221,227],"cryptococcal":[5],"meningitis":[6],"(CM),":[7],"comprised":[8],"lipid-based":[10],"amphotericin":[11,54],"(3-5":[12],"mg/kg/day)":[13,17],"and":[14,33,47,60,95,211],"flucytosine":[15],"(100":[16],"for":[18,77,164,219,225],"a":[19,86],"minimum":[20],"14":[22],"days,":[23],"is":[24],"associated":[25,69,207],"with":[26,44,55,70,79,103,144,166,208],"significant":[27],"costs":[28,68,125],"to":[29,108,149,180],"both":[30,209],"the":[31,45,71,104,114,160,203,222,230],"hospital":[32,91,115,173,210],"insurance":[34,136,183,187],"payor.":[35],"Recently":[36],"published":[37],"studies":[38],"have":[39],"found":[40],"comparable":[41],"patient":[42],"outcomes":[43],"cheaper":[46],"better":[48],"tolerated":[49],"AMBITION":[50,72,105,204,223],"protocol":[51,73,106,205,224],"(single-dose":[52],"liposomal":[53],"2":[56],"weeks":[57],"fluconazole":[59],"flucytosine).":[61],"METHODS:":[62],"This":[63],"retrospective,":[64],"economic":[65,200],"evaluation":[66,201],"analyzed":[67],"versus":[74],"care":[76],"patients":[78,102,111,143,152,165],"human":[80],"immunodeficiency":[81],"virus":[82],"(HIV)-associated":[83],"CM":[84,228],"at":[85],"large,":[87],"academic,":[88],"public":[89],"US":[90],"between":[92],"August":[93],"2020":[94],"July":[96],"2024.":[97],"RESULTS:":[98],"Treatment":[99],"34":[101],"compared":[107],"26":[109],"control":[110],"net":[112,172],"saved":[113,126],"$399":[116],"704":[117],"($11":[118],"756":[119],"per":[120],"patient),":[121],"calculated":[122],"as":[123],"variable":[124],"minus":[127],"revenue":[128],"lost.":[129],"Cost":[130],"savings":[131,193],"were":[132,141],"experienced":[133],"across":[134,194],"all":[135],"types":[137],"encountered;":[138],"however,":[139],"there":[140],"no":[142],"commercial":[145,182],"insurance.":[146],"In":[147,198],"order":[148],"accurately":[150],"model":[151],"who":[153],"develop":[154],"CM,":[155],"we":[156],"obtained":[157],"data":[158],"on":[159],"nationwide":[161],"payor":[162,188,195,212],"mix":[163],"advanced":[167],"HIV,":[168],"which":[169],"still":[170],"showed":[171],"savings,":[174],"though":[175],"smaller":[177],"magnitude":[178],"due":[179],"lost":[181],"payments.":[184],"From":[185],"an":[186],"perspective,":[189],"modeling":[190],"demonstrated":[191],"cost":[192],"mixes.":[196],"CONCLUSIONS:":[197],"this":[199],"study,":[202],"was":[206],"savings.":[213],"These":[214],"findings":[215],"provide":[216],"further":[217],"support":[218],"adoption":[220],"treatment":[226],"in":[229],"United":[231],"States.":[232]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-09-18T00:00:00"}