{"id":"https://openalex.org/W7213469707","doi":"https://doi.org/10.3389/fonc.2026.1773288","title":"Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer","display_name":"Association of tumor mutational burden and tumor-infiltrating lymphocytes with second primary cancer after complete resection of non-small cell lung cancer","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213469707","doi":"https://doi.org/10.3389/fonc.2026.1773288","pmid":"https://pubmed.ncbi.nlm.nih.gov/42824028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13626909"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1773288","doi":"https://doi.org/10.3389/fonc.2026.1773288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1773288","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1773288/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1773288/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079376279","display_name":"Marie-Pier Gauthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Marie-Pier Gauthier","raw_affiliation_strings":["Princess Margaret Cancer Centre, University Health Network"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102875053","display_name":"Maryam Karimi","orcid":"https://orcid.org/0000-0003-3301-8795","observed_orcids":["https://orcid.org/0000-0003-3301-8795"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maryam Karimi","raw_affiliation_strings":["Bureau de Biostatistique et d\u2019Epid\u00e9miologie, Gustave Roussy, Universit\u00e9 Paris-Saclay","Oncostat U1018, Inserm, Universit\u00e9 Paris-Saclay, Equipe Labellis\u00e9e Ligue Contre le Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau de Biostatistique et d\u2019Epid\u00e9miologie, Gustave Roussy, Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]},{"raw_affiliation_string":"Oncostat U1018, Inserm, Universit\u00e9 Paris-Saclay, Equipe Labellis\u00e9e Ligue Contre le Cancer","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062814767","display_name":"Stefan Michiels","orcid":"https://orcid.org/0000-0002-6963-2968","observed_orcids":["https://orcid.org/0000-0002-6963-2968"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stefan Michiels","raw_affiliation_strings":["Bureau de Biostatistique et d\u2019Epid\u00e9miologie, Gustave Roussy, Universit\u00e9 Paris-Saclay","Oncostat U1018, Inserm, Universit\u00e9 Paris-Saclay, Equipe Labellis\u00e9e Ligue Contre le Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bureau de Biostatistique et d\u2019Epid\u00e9miologie, Gustave Roussy, Universit\u00e9 Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]},{"raw_affiliation_string":"Oncostat U1018, Inserm, Universit\u00e9 Paris-Saclay, Equipe Labellis\u00e9e Ligue Contre le Cancer","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044291041","display_name":"Lesley Seymour","orcid":"https://orcid.org/0000-0001-8081-0799","observed_orcids":["https://orcid.org/0000-0001-8081-0799"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I4405267856","display_name":"Canadian Cancer Trials Group","ror":"https://ror.org/04rg46g58","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4405267856"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lesley Seymour","raw_affiliation_strings":["Canadian Cancer Trials Group and Queen\u2019s University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canadian Cancer Trials Group and Queen\u2019s University","institution_ids":["https://openalex.org/I204722609","https://openalex.org/I4405267856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023993622","display_name":"Elisabeth M. Brambilla","orcid":"https://orcid.org/0000-0001-7559-2141","observed_orcids":["https://orcid.org/0000-0001-7559-2141"]},"institutions":[{"id":"https://openalex.org/I4210160510","display_name":"Institut pour l'avanc\u00e9e des biosciences","ror":"https://ror.org/05kwbf598","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I2800555055","https://openalex.org/I4210128919","https://openalex.org/I4210139971","https://openalex.org/I4210150872","https://openalex.org/I4210160510","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I4210162920","display_name":"H\u00f4pital Albert Michallon","ror":"https://ror.org/05kfvx519","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2800555055","https://openalex.org/I4210162920"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elisabeth Brambilla","raw_affiliation_strings":["Department of Pathology, Institut Albert Bonniot, Hopital Albert Michallon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Institut Albert Bonniot, Hopital Albert Michallon","institution_ids":["https://openalex.org/I4210160510","https://openalex.org/I4210162920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111449926","display_name":"Thierry Le Chevalier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Le-Chevalier","raw_affiliation_strings":["Department of Medical Oncology, Gustave Roussy, University Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Gustave Roussy, University Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021624793","display_name":"Jean\u2010Charles Soria","orcid":"https://orcid.org/0000-0001-9597-0701","observed_orcids":["https://orcid.org/0000-0001-9597-0701"]},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Charles Soria","raw_affiliation_strings":["Department of Medical Oncology, Gustave Roussy, University Paris-Saclay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Gustave Roussy, University Paris-Saclay","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008573977","display_name":"Robert Arthur Kratzke","orcid":"https://orcid.org/0000-0002-1599-7494","observed_orcids":["https://orcid.org/0000-0002-1599-7494"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Kratzke","raw_affiliation_strings":["Division of Hematology-Oncology-Transplantation, University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology-Transplantation, University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006274190","display_name":"Stephen L. Graziano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen L. Graziano","raw_affiliation_strings":["Medical Oncology, SUNY Upstate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, SUNY Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068824818","display_name":"Ramaswamy Govindan","orcid":"https://orcid.org/0000-0002-6964-9612","observed_orcids":["https://orcid.org/0000-0002-6964-9612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramaswamy Govindan","raw_affiliation_strings":["Division of Medical Oncology, Department of Medicine, Washington University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Department of Medicine, Washington University School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073362806","display_name":"Ming\u2010Sound Tsao","orcid":"https://orcid.org/0000-0002-9160-5405","observed_orcids":["https://orcid.org/0000-0002-9160-5405"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ming-Sound Tsao","raw_affiliation_strings":["Department of Laboratory Medicine and Pathobiology, University of Toronto","Princess Margaret Cancer Centre, University Health Network"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075347427","display_name":"Frances A. Shepherd","orcid":"https://orcid.org/0000-0002-3610-3533","observed_orcids":["https://orcid.org/0000-0002-3610-3533"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Frances A. Shepherd","raw_affiliation_strings":["Department of Medicine, Division of Medical Oncology, University Health Network"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Medical Oncology, University Health Network","institution_ids":["https://openalex.org/I1325899441"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5075347427","https://openalex.org/A5079376279"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69930146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1773288","last_page":"1773288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.10019999742507935,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08839999884366989,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":1.0},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/r0-resection","display_name":"R0 resection","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tumor-genomic-instability","display_name":"tumor genomic instability","score":0.8930000066757202},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.9269999861717224},{"id":"https://openalex.org/keywords/competing-risks","display_name":"competing risks","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cancer-specific-mortality","display_name":"cancer-specific mortality","score":0.4429999887943268},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.6940000057220459},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8898000121116638},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7242000102996826},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6955999732017517},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6765999794006348},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6708999872207642},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.6650000214576721},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5954999923706055},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5859000086784363},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5070000290870667},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3716999888420105},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3582000136375427},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.3174999952316284},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.28110000491142273},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2680000066757202},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1773288","doi":"https://doi.org/10.3389/fonc.2026.1773288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1773288","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1773288/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13626909","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13626909/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13626909/pdf/fonc-16-1773288.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42824028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42824028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:50d38b918e5b4ba590c6d4c946970d03","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/50d38b918e5b4ba590c6d4c946970d03","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1773288","doi":"https://doi.org/10.3389/fonc.2026.1773288","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1773288","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1773288/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213469707.pdf","grobid_xml":"https://content.openalex.org/works/W7213469707.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1158033259","https://openalex.org/W1552804793","https://openalex.org/W1988262403","https://openalex.org/W1989169445","https://openalex.org/W2010624323","https://openalex.org/W2022495797","https://openalex.org/W2038981426","https://openalex.org/W2044198334","https://openalex.org/W2065028684","https://openalex.org/W2078406625","https://openalex.org/W2104543228","https://openalex.org/W2114446999","https://openalex.org/W2114855342","https://openalex.org/W2116730022","https://openalex.org/W2117994949","https://openalex.org/W2127342594","https://openalex.org/W2137737798","https://openalex.org/W2256341952","https://openalex.org/W2339638771","https://openalex.org/W2547187744","https://openalex.org/W2582960575","https://openalex.org/W2609015711","https://openalex.org/W2797499190","https://openalex.org/W2803375876","https://openalex.org/W2885229054","https://openalex.org/W2897305886","https://openalex.org/W2945996531","https://openalex.org/W4393410416","https://openalex.org/W4393935425","https://openalex.org/W4404181612","https://openalex.org/W4407132020"],"related_works":["https://openalex.org/W3030975652","https://openalex.org/W3120598699","https://openalex.org/W4415941039","https://openalex.org/W2796815428","https://openalex.org/W3157770914","https://openalex.org/W2898416788","https://openalex.org/W2970981278","https://openalex.org/W2948580424","https://openalex.org/W3137960754","https://openalex.org/W2988323039"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"risk":[2],"of":[3,13,52,189,202,234,278,310,319,330],"developing":[4,114,313],"second":[5],"primary":[6],"cancers":[7],"(SPC)":[8],"after":[9,246],"complete":[10,155],"surgical":[11],"resection":[12],"non-small":[14],"cell":[15],"lung":[16,334],"cancer":[17],"(NSCLC)":[18],"has":[19],"been":[20],"estimated":[21],"at":[22],"1-2%":[23],"per":[24],"patient-year.":[25],"We":[26],"investigated":[27],"whether":[28],"tumor":[29,34,134,268],"genomic":[30,269],"instability,":[31],"assessed":[32,42,75],"by":[33,43,126],"mutational":[35],"burden":[36],"(TMB),":[37],"and":[38,72,92,96,107,111,120,128,141,146,169,185,271,275,280],"host":[39,272],"immune":[40,273],"response,":[41,274],"tumor-infiltrating":[44],"lymphocytes":[45],"(TILs),":[46],"were":[47,69,74,98,116,149,174],"associated":[48,196,228,305],"with":[49,154,197,207,229,286,295,301,306,332],"the":[50,62,186,262,307,316],"development":[51],"SPC.":[53,190,314],"Methods:":[54],"Data":[55],"from":[56],"three":[57],"randomized":[58],"trials":[59],"included":[60],"in":[61,162,284,326],"Lung":[63],"Adjuvant":[64],"Cisplatin":[65],"Evaluation-Biomarker":[66],"(LACE-Bio)":[67],"meta-analysis":[68],"used.":[70],"TMB":[71,79,145,182,194,209,299],"TILs":[73,97,147,159,184,226],"on":[76],"FFPE":[77],"specimens.":[78],"was":[80,160,179,195,227,293,304],"categorized":[81],"into":[82],"tertiles":[83],"(high":[84],">7.8":[85],"mutations/MB,":[86,91],"moderate":[87,208,302],">4":[88],"to":[89,264],"\u22647.8":[90],"low":[93,193,298],"\u22644":[94],"mutations/MB),":[95],"classified":[99],"as":[100],"marked":[101],"vs.":[102],"other.":[103],"Associations":[104],"between":[105,181,267],"biomarkers":[106],"competing":[108,276,308],"endpoints":[109,277],"(SPC,":[110],"death":[112,203,235,281,311],"without":[113,172,204,236,282,312],"SPC)":[115],"evaluated":[117],"using":[118],"Fine":[119],"Gray":[121],"sub-distribution":[122],"hazard":[123,212],"models,":[124],"stratified":[125],"trial":[127],"adjusted":[129],"for":[130,151],"treatment,":[131],"age,":[132],"sex,":[133],"stage,":[135,137],"nodal":[136],"histology,":[138],"performance":[139],"status,":[140],"surgery":[142],"type.":[143],"Results:":[144],"assessments":[148],"available":[150],"879":[152],"patients":[153,285,331],"clinical":[156],"covariates.":[157],"Marked":[158,225],"observed":[161,294],"85":[163],"patients.":[164],"During":[165],"follow-up,":[166],"47":[167],"SPCs":[168],"392":[170],"deaths":[171],"SPC":[173,205,279,283,320],"observed.":[175],"No":[176,290],"clear":[177],"association":[178,240,292],"found":[180],"or":[183],"cumulative":[187,200,232],"incidence":[188,201,233],"In":[191],"contrast,":[192],"a":[198,230],"higher":[199],"compared":[206],"(multivariable":[210,248],"subdistribution":[211],"ratio":[213],"(sHR)":[214],"=":[215,223,250,256],"1.35":[216],"[95%":[217,252],"confidence":[218],"interval":[219],"(CI),":[220],"1.06-1.72],":[221],"p":[222,255],"0.02).":[224],"lower":[231],"SPC,":[237,296],"although":[238],"this":[239],"did":[241],"not":[242],"reach":[243],"statistical":[244],"significance":[245],"adjustment":[247],"sHR":[249],"0.71":[251],"CI,":[253],"0.46-1.10],":[254],"0.12).":[257],"Conclusion:":[258],"This":[259],"study":[260],"is":[261],"first":[263],"evaluate":[265],"associations":[266],"instability":[270],"completely":[287],"resected":[288],"NSCLC.":[289],"strong":[291],"whereas":[297],"(compared":[300],"TMB)":[303],"endpoint":[309],"Given":[315],"limited":[317],"number":[318],"events,":[321],"these":[322],"findings":[323],"require":[324],"confirmation":[325],"larger,":[327],"independent":[328],"cohorts":[329],"early-stage":[333],"cancer.":[335]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-17T00:00:00"}