{"id":"https://openalex.org/W7213469268","doi":"https://doi.org/10.64898/2026.09.15.751463","title":"A quantitative redox proteome of the human muscle response to exercise","display_name":"A quantitative redox proteome of the human muscle response to exercise","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213469268","doi":"https://doi.org/10.64898/2026.09.15.751463","pmid":"https://pubmed.ncbi.nlm.nih.gov/42780120","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596570"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.751463","doi":"https://doi.org/10.64898/2026.09.15.751463","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751463","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.15.751463.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.15.751463.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100662885","display_name":"Lei Yu","orcid":"https://orcid.org/0000-0002-8837-2022","observed_orcids":["https://orcid.org/0000-0002-8837-2022"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Lei","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070972811","display_name":"Jonathan J. Petrocelli","orcid":"https://orcid.org/0000-0003-1298-4257","observed_orcids":["https://orcid.org/0000-0003-1298-4257"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan J. Petrocelli","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151967142","display_name":"Anita Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Reddy","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060055700","display_name":"Carlos Henr\u00edquez\u2010Olgu\u00edn","orcid":"https://orcid.org/0000-0002-9315-9365","observed_orcids":["https://orcid.org/0000-0002-9315-9365"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4210113179","display_name":"Finis Terrae University","ror":"https://ror.org/0225snd59","country_code":"CL","type":"education","lineage":["https://openalex.org/I4210113179"]}],"countries":["CL","DK"],"is_corresponding":false,"raw_author_name":"Carlos Henr\u00edquez-Olguin","raw_affiliation_strings":["Center for Exercise Physiology and Metabolism, Department of Kinesiology, Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile","Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Exercise Physiology and Metabolism, Department of Kinesiology, Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile","institution_ids":["https://openalex.org/I4210113179"]},{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031855944","display_name":"Nils Burger","orcid":"https://orcid.org/0000-0003-3227-8894","observed_orcids":["https://orcid.org/0000-0003-3227-8894"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nils Burger","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126466236","display_name":"Sanghee Shin","orcid":"https://orcid.org/0000-0002-8786-6995","observed_orcids":["https://orcid.org/0000-0002-8786-6995"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanghee Shin","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024900540","display_name":"Bingsen Zhang","orcid":"https://orcid.org/0000-0001-8119-1715","observed_orcids":["https://orcid.org/0000-0001-8119-1715"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bingsen Zhang","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136638423","display_name":"Taylor Covington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor Covington","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA","Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046162311","display_name":"Markus Waldeck\u2010Weiermair","orcid":"https://orcid.org/0000-0002-5792-6766","observed_orcids":["https://orcid.org/0000-0002-5792-6766"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Markus Waldeck-Weiermair","raw_affiliation_strings":["Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria","Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151964390","display_name":"Jiuchun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiuchun Zhang","raw_affiliation_strings":["Department of Cell Biology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109672128","display_name":"Shelley M Wei","orcid":"https://orcid.org/0009-0002-8359-1880","observed_orcids":["https://orcid.org/0009-0002-8359-1880"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley M. Wei","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018757016","display_name":"Thomas E. Jensen","orcid":"https://orcid.org/0000-0001-6139-8268","observed_orcids":["https://orcid.org/0000-0001-6139-8268"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas E. Jensen","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091231606","display_name":"Christian T. Voldstedlund","orcid":"https://orcid.org/0000-0002-6368-8995","observed_orcids":["https://orcid.org/0000-0002-6368-8995"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian T. Voldstedlund","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065014773","display_name":"Christian Strini Carl","orcid":"https://orcid.org/0000-0002-9551-5837","observed_orcids":["https://orcid.org/0000-0002-9551-5837"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Christian S. Carl","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048291477","display_name":"Bente Kiens","orcid":"https://orcid.org/0000-0001-5705-5625","observed_orcids":["https://orcid.org/0000-0001-5705-5625"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bente Kiens","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012534532","display_name":"Erik Arne Richter","orcid":"https://orcid.org/0000-0002-6850-3056","observed_orcids":["https://orcid.org/0000-0002-6850-3056"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Erik A. Richter","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, The August Krogh Section for Human and Molecular Physiology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045774281","display_name":"Edward T. Chouchani","orcid":"https://orcid.org/0000-0002-9776-8790","observed_orcids":["https://orcid.org/0000-0002-9776-8790","https://orcid.org/0000-0002-9203-8094"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward T. Chouchani","raw_affiliation_strings":["Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","Department of Cell Biology, Harvard Medical School, Boston, MA, USA","Howard Hughes Medical Institute, Chevy Chase, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-9776-8790","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Dana\u2013Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Cell Biology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, MD, USA","institution_ids":["https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045774281"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.10220000147819519,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7929999828338623},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8460000157356262},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.7730000019073486},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/muscle-adaptation","display_name":"muscle adaptation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/muscle-hypertrophy","display_name":"muscle hypertrophy","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.8360999822616577},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7847999930381775},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5782999992370605},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5752999782562256},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5473999977111816},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.529699981212616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46239998936653137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46239998936653137},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C2781139505","wikidata":"https://www.wikidata.org/wiki/Q5201195","display_name":"Cysteine metabolism","level":4,"score":0.41530001163482666},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.4036000072956085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39100000262260437},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.3862999975681305},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.37279999256134033},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2909765735","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Muscle disorder","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C2993909470","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Human muscle","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.15.751463","doi":"https://doi.org/10.64898/2026.09.15.751463","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751463","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.15.751463.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42780120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42780120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596570","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596570/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.751463","doi":"https://doi.org/10.64898/2026.09.15.751463","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.751463","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.15.751463.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5339538127","display_name":"Delineating the p62 oligomerization-mediated muscle adaptation to exercise in heart failure-induced skeletal myopathy","funder_award_id":"25POST1376679","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5476537510","display_name":null,"funder_award_id":"NNF17SA0031406","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G8744584587","display_name":"Defining the landscape and mechanisms of protein redox regulation during aging","funder_award_id":"R56AG071966","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000235851","display_name":null,"funder_award_id":"AG071966","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000882899","display_name":"Defining the landscape and mechanisms of protein redox regulation during aging","funder_award_id":"R01AG071966","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000917780","display_name":"Defining mechanisms of extracellular succinate regulation over metabolic tissue function","funder_award_id":"R01DK123095","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306514","display_name":"Richard and Susan Smith Family Foundation","ror":"https://ror.org/05j95n956"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320324618","display_name":"Svenska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/016ks4x90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213469268.pdf","grobid_xml":"https://content.openalex.org/works/W7213469268.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W195660419","https://openalex.org/W1502967060","https://openalex.org/W1535567348","https://openalex.org/W1567934634","https://openalex.org/W1588818823","https://openalex.org/W1598106197","https://openalex.org/W1615913434","https://openalex.org/W1839260472","https://openalex.org/W1967236260","https://openalex.org/W1974714435","https://openalex.org/W1977767269","https://openalex.org/W1983015423","https://openalex.org/W1990119562","https://openalex.org/W1994133951","https://openalex.org/W1994408958","https://openalex.org/W1995381409","https://openalex.org/W2002357878","https://openalex.org/W2007636933","https://openalex.org/W2011124366","https://openalex.org/W2014205131","https://openalex.org/W2014918593","https://openalex.org/W2023598683","https://openalex.org/W2033228345","https://openalex.org/W2036787961","https://openalex.org/W2040125551","https://openalex.org/W2040593473","https://openalex.org/W2050959645","https://openalex.org/W2051698507","https://openalex.org/W2052403003","https://openalex.org/W2060989636","https://openalex.org/W2062221551","https://openalex.org/W2062899786","https://openalex.org/W2063198164","https://openalex.org/W2064853445","https://openalex.org/W2069168643","https://openalex.org/W2069532611","https://openalex.org/W2082476985","https://openalex.org/W2082879125","https://openalex.org/W2087350238","https://openalex.org/W2087986257","https://openalex.org/W2089178918","https://openalex.org/W2102354517","https://openalex.org/W2108577381","https://openalex.org/W2112645157","https://openalex.org/W2112956181","https://openalex.org/W2113529945","https://openalex.org/W2117396891","https://openalex.org/W2118683394","https://openalex.org/W2124409576","https://openalex.org/W2127974247","https://openalex.org/W2130025116","https://openalex.org/W2132357771","https://openalex.org/W2132943675","https://openalex.org/W2133284292","https://openalex.org/W2134567067","https://openalex.org/W2134611127","https://openalex.org/W2138786739","https://openalex.org/W2144970341","https://openalex.org/W2145149844","https://openalex.org/W2146124002","https://openalex.org/W2147459821","https://openalex.org/W2150718463","https://openalex.org/W2159675211","https://openalex.org/W2160411684","https://openalex.org/W2171103810","https://openalex.org/W2174265610","https://openalex.org/W2332777704","https://openalex.org/W2402820299","https://openalex.org/W2556822639","https://openalex.org/W2602775024","https://openalex.org/W2613629789","https://openalex.org/W2735235732","https://openalex.org/W2735370877","https://openalex.org/W2754409876","https://openalex.org/W2766339789","https://openalex.org/W2784022040","https://openalex.org/W2784311670","https://openalex.org/W2792996193","https://openalex.org/W2803552542","https://openalex.org/W2892478638","https://openalex.org/W2940118858","https://openalex.org/W2980184266","https://openalex.org/W3007811953","https://openalex.org/W3041413756","https://openalex.org/W3087102233","https://openalex.org/W3157357317","https://openalex.org/W3206012531","https://openalex.org/W4200123976","https://openalex.org/W4220835725","https://openalex.org/W4231435606","https://openalex.org/W4249001882","https://openalex.org/W4287881765","https://openalex.org/W4290648385","https://openalex.org/W4313545254","https://openalex.org/W4323348408","https://openalex.org/W4377989871","https://openalex.org/W4388153633","https://openalex.org/W4391687030","https://openalex.org/W4391979262","https://openalex.org/W4392818342","https://openalex.org/W4401125286","https://openalex.org/W4401549234","https://openalex.org/W4405374407","https://openalex.org/W4409053463","https://openalex.org/W4411090554","https://openalex.org/W7164197196"],"related_works":["https://openalex.org/W2079788591","https://openalex.org/W7134179716","https://openalex.org/W3206012531","https://openalex.org/W2233776427","https://openalex.org/W4366990911","https://openalex.org/W4396701826","https://openalex.org/W6941310217","https://openalex.org/W2793767436","https://openalex.org/W3007811953","https://openalex.org/W2021650235"],"abstract_inverted_index":{"ABSTRACT":[0],"Reactive":[1],"oxygen":[2],"species":[3],"(ROS)":[4],"regulate":[5],"protein":[6,31,61,149],"function":[7],"through":[8],"reversible":[9,72,154],"cysteine":[10,53,62,77,85,108,115,144,158],"oxidation.":[11],"In":[12],"human":[13,199],"skeletal":[14],"muscle,":[15,200],"exercise-induced":[16,182],"ROS":[17,34],"initiates":[18],"adaptations":[19],"such":[20],"as":[21],"mitochondrial":[22],"biogenesis,":[23],"increased":[24],"insulin":[25],"sensitivity,":[26],"and":[27,55,101,165],"hypertrophy.":[28],"However,":[29],"specific":[30],"targets":[32,117],"of":[33,94,104,124,127,156],"regulation":[35],"during":[36,66],"exercise":[37,170],"remain":[38],"unclear":[39],"owing":[40],"to":[41,58,169,184],"longstanding":[42],"challenges":[43],"in":[44,48,64,88,110,130,135,171,198],"analyzing":[45],"redox":[46,107],"proteomes":[47],"vivo":[49,172],".":[50,173,204],"We":[51,112,151],"applied":[52],"derivatization":[54],"multiplexed":[56],"proteomics":[57],"map":[59],"muscle":[60,136,167,185],"oxidation":[63,116,155],"humans":[65],"exercise.":[67],"The":[68],"OxiMuscle":[69],"dataset":[70],"quantifies":[71],"modifications":[73],"across":[74],"9,177":[75],"unique":[76],"sites":[78,140],"on":[79,145,195],"2,782":[80],"proteins,":[81],"comprising":[82],"17,492":[83],"individual":[84],"site":[86],"measurements":[87],"young":[89],"men":[90],"undergoing":[91],"three":[92],"types":[93],"exercise,":[95,125],"providing":[96],"the":[97,105,146],"first":[98],"comprehensive,":[99],"site-resolved":[100],"quantitative":[102],"analysis":[103],"exercise-regulated":[106],"proteome":[109],"humans.":[111],"systematically":[113],"define":[114,177],"regulated":[118],"by":[119],"at":[120,202],"least":[121],"one":[122],"form":[123],"many":[126],"which":[128],"reside":[129],"proteins":[131],"with":[132],"established":[133],"roles":[134],"physiology.":[137],"Among":[138],"these":[139,175],"is":[141],"a":[142,178,192],"redox-regulated":[143],"autophagy":[147,161,183],"receptor":[148],"p62.":[150],"demonstrate":[152],"that":[153],"this":[157],"regulates":[159],"p62-mediated":[160],"upon":[162],"myotube":[163],"contraction":[164],"mouse":[166],"adaptation":[168],"Together,":[174],"results":[176],"redox-driven":[179],"mechanism":[180],"linking":[181],"adaptation.":[186],"More":[187],"broadly,":[188],"our":[189],"findings":[190],"offer":[191],"comprehensive":[193],"resource":[194],"redox-signaling":[196],"networks":[197],"accessible":[201],"http://oximuscle-alb-1899330623.us-east-1.elb.amazonaws.com/":[203]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-09-17T00:00:00"}