{"id":"https://openalex.org/W7213468607","doi":"https://doi.org/10.64898/2026.09.15.26363157","title":"GLP-1 Receptor Agonist Initiation Is Associated With Excess Skeletal Muscle Loss in Adults With Diabetes: A Prospective Population-Based MRI Study","display_name":"GLP-1 Receptor Agonist Initiation Is Associated With Excess Skeletal Muscle Loss in Adults With Diabetes: A Prospective Population-Based MRI Study","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213468607","doi":"https://doi.org/10.64898/2026.09.15.26363157"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.26363157","doi":"https://doi.org/10.64898/2026.09.15.26363157","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363157","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/17/2026.09.15.26363157.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/17/2026.09.15.26363157.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091742202","display_name":"Era Stambollxhiu","orcid":"https://orcid.org/0009-0000-5202-7887","observed_orcids":["https://orcid.org/0009-0000-5202-7887"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Era Stambollxhiu","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0000-5202-7887","affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085736208","display_name":"Jannik L\u00fcbberstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jannik Luebberstedt","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064515812","display_name":"Miriam Kumpf","orcid":"https://orcid.org/0000-0003-2290-648X","observed_orcids":["https://orcid.org/0000-0003-2290-648X"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miriam Kumpf","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2290-648X","affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105351693","display_name":"Stefan N. Willich","orcid":"https://orcid.org/0009-0006-1270-2597","observed_orcids":["https://orcid.org/0009-0006-1270-2597"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan N. Willich","raw_affiliation_strings":["Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0009-0006-1270-2597","affiliations":[{"raw_affiliation_string":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071563978","display_name":"Thomas Oskar Philipp Keil","orcid":"https://orcid.org/0000-0002-9108-3360","observed_orcids":["https://orcid.org/0000-0002-9108-3360"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210145479","display_name":"Bayerisches Landesamt f\u00fcr Gesundheit und Lebensmittelsicherheit","ror":"https://ror.org/04bqwzd17","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210145479"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Keil","raw_affiliation_strings":["Institute of Clinical Epidemiology and Biometry, University of W\u00fcrzburg, W\u00fcrzburg, Germany","Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","State Institute of Health I, Bavarian Health and Food Safety Authority, Erlangen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9108-3360","affiliations":[{"raw_affiliation_string":"Institute of Clinical Epidemiology and Biometry, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Institute of Social Medicine, Epidemiology and Health Economics, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"State Institute of Health I, Bavarian Health and Food Safety Authority, Erlangen, Germany","institution_ids":["https://openalex.org/I4210145479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060584500","display_name":"Tobias Pischon","orcid":"https://orcid.org/0000-0003-1568-767X","observed_orcids":["https://orcid.org/0000-0003-1568-767X"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Pischon","raw_affiliation_strings":["Biobank Technology Platform, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany","Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Molecular Epidemiology Research Group, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1568-767X","affiliations":[{"raw_affiliation_string":"Biobank Technology Platform, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Molecular Epidemiology Research Group, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080735824","display_name":"Thoralf Niendorf","orcid":"https://orcid.org/0000-0001-7584-6527","observed_orcids":["https://orcid.org/0000-0001-7584-6527"]},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thoralf Niendorf","raw_affiliation_strings":["Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7584-6527","affiliations":[{"raw_affiliation_string":"Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088727034","display_name":"Annette Peters","orcid":"https://orcid.org/0000-0001-6645-0985","observed_orcids":["https://orcid.org/0000-0001-6645-0985","https://orcid.org/0000-0003-0984-2258","https://orcid.org/0000-0002-4623-3614"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Peters","raw_affiliation_strings":["Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6645-0985","affiliations":[{"raw_affiliation_string":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027935660","display_name":"Sebastian Ziegelmayer","orcid":"https://orcid.org/0000-0001-8724-4718","observed_orcids":["https://orcid.org/0000-0001-8724-4718"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Ziegelmayer","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8724-4718","affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051070119","display_name":"Marcus R. Makowski","orcid":"https://orcid.org/0000-0001-8778-647X","observed_orcids":["https://orcid.org/0000-0001-8778-647X","https://orcid.org/0000-0002-1922-0826"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus R. Makowski","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8778-647X","affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006318966","display_name":"Keno K. Bressem","orcid":"https://orcid.org/0000-0001-9249-8624","observed_orcids":["https://orcid.org/0000-0001-9249-8624"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Keno K. Bressem","raw_affiliation_strings":["Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany","Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","Institute of Interventional and Diagnostic Radiology and Neuroradiology, University Hospital Essen, Essen, Germany","National Center for Tumor Diseases, NCT West, a partnership between DKFZ and University Hospital Essen, Essen, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9249-8624","affiliations":[{"raw_affiliation_string":"Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Interventional and Diagnostic Radiology and Neuroradiology, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"National Center for Tumor Diseases, NCT West, a partnership between DKFZ and University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005164520","display_name":"Lisa C. Adams","orcid":"https://orcid.org/0000-0001-5836-4542","observed_orcids":["https://orcid.org/0000-0001-5836-4542","https://orcid.org/0009-0003-2293-0380","https://orcid.org/0000-0002-2087-0172"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa C. Adams","raw_affiliation_strings":["Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5836-4542","affiliations":[{"raw_affiliation_string":"Institute for Diagnostic and Interventional Radiology, TUM School of Medicine and Health, Klinikum rechts der Isar, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5091742202"],"corresponding_institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.972000002861023},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/whole-body-mri","display_name":"whole-body MRI","score":0.7870000004768372},{"id":"https://openalex.org/keywords/muscle-mass","display_name":"muscle mass","score":0.44600000977516174},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8500000238418579},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8709999918937683},{"id":"https://openalex.org/keywords/deep-learning-segmentation","display_name":"deep learning segmentation","score":0.546999990940094},{"id":"https://openalex.org/keywords/muscle-mass-preservation","display_name":"muscle mass preservation","score":0.5120000243186951},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.7680000066757202},{"id":"https://openalex.org/keywords/protein-intake","display_name":"protein intake","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.807200014591217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7056000232696533},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6977999806404114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6883000135421753},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6581000089645386},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6158000230789185},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5910999774932861},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.45559999346733093},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.42320001125335693},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C2778514504","wikidata":"https://www.wikidata.org/wiki/Q797559","display_name":"Muscle tissue","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.2745000123977661}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.15.26363157","doi":"https://doi.org/10.64898/2026.09.15.26363157","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363157","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/17/2026.09.15.26363157.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.26363157","doi":"https://doi.org/10.64898/2026.09.15.26363157","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363157","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/17/2026.09.15.26363157.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3987985702","display_name":null,"funder_award_id":"01ER1301A/B/C","funder_id":"https://openalex.org/F4320334763","funder_display_name":"Leibniz-Gemeinschaft"},{"id":"https://openalex.org/G852547542","display_name":null,"funder_award_id":"01ER1511D","funder_id":"https://openalex.org/F4320334763","funder_display_name":"Leibniz-Gemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320334763","display_name":"Leibniz-Gemeinschaft","ror":"https://ror.org/01n6r0e97"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213468607.pdf","grobid_xml":"https://content.openalex.org/works/W7213468607.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415987720","https://openalex.org/W4403382203","https://openalex.org/W7203606521","https://openalex.org/W4416300119","https://openalex.org/W4415710219","https://openalex.org/W4400137596","https://openalex.org/W7221401892","https://openalex.org/W4402346997","https://openalex.org/W4409180155","https://openalex.org/W7153163453"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"To":[2],"determine":[3],"whether":[4,184],"glucagon-like":[5],"peptide":[6],"1":[7],"receptor":[8],"agonist":[9],"(GLP-1":[10],"RA)":[11],"initiation":[12,124,187],"is":[13,138,174,249],"associated":[14,189],"with":[15,35,61,90,125,190,199],"excess":[16,191],"skeletal":[17,213],"muscle":[18,73,136,168,192,214,237,247],"loss":[19,96,137,146,195,248,257],"on":[20,51,166],"repeat":[21],"whole-body":[22,43,117],"MRI.":[23],"Research":[24],"Design":[25],"and":[26,55,120,193,268,275],"Methods":[27],"In":[28,111],"the":[29,175,241],"German":[30],"National":[31],"Cohort,":[32],"58":[33],"adults":[34],"diabetes":[36],"who":[37],"initiated":[38],"a":[39,139,250],"GLP-1":[40,122,143,161,185,254],"RA":[41,123,144,186],"between":[42],"MRI":[44,118],"examinations":[45],"4.6":[46,206],"years":[47],"apart":[48],"were":[49,66,108],"matched":[50,69,126,197,216],"sex,":[52],"age,":[53],"BMI,":[54],"interval":[56],"to":[57,85,180],"130":[58],"never-exposed":[59],"controls":[60,198,217],"diabetes.":[62,200],"Deep-learning-segmented":[63],"tissue":[64,101],"volumes":[65],"compared":[67],"within":[68],"sets.":[70],"Results":[71],"Skeletal":[72,135,246],"volume":[74],"declined":[75],"2.75":[76],"percentage":[77,92,219],"points":[78,93],"more":[79,133,212],"in":[80,147,258],"initiators":[81,129,208],"(95%":[82],"CI":[83],"-4.51":[84],"-0.99;":[86],"P":[87],"=":[88,98],"0.003),":[89],"2.54":[91],"greater":[94,222],"weight":[95,145,223,256],"(P":[97],"0.021).":[99],"Adipose":[100],"differences":[102],"(\u22124.8%":[103],"internal":[104],"torso,":[105],"-3.2%":[106],"subcutaneous)":[107],"nonsignificant.":[109],"Conclusions":[110],"this":[112,156],"first":[113],"population-based":[114],"comparison":[115],"of":[116,142,160,235,243,253],"before":[119],"after":[121],"unexposed":[127],"controls,":[128],"lost":[130,209,228],"roughly":[131,210],"60%":[132,211],"muscle.":[134],"measurable":[140,251],"component":[141,252],"routine":[148,171,259],"care.":[149,260],"Article":[150],"Highlights":[151],"Why":[152],"did":[153,202],"we":[154,178,203],"undertake":[155],"study?":[157],"Rapid":[158],"uptake":[159],"RAs":[162],"has":[163],"outpaced":[164],"evidence":[165],"long-term":[167],"change":[169],"during":[170,266],"treatment.":[172],"What":[173,201,239],"specific":[176],"question":[177],"wanted":[179],"answer?":[181],"We":[182],"asked":[183],"was":[188,229],"fat":[194],"versus":[196],"find?":[204],"Over":[205],"years,":[207],"than":[215],"(\u22122.75":[218],"points)":[220],"alongside":[221],"loss.":[224,238],"Each":[225],"additional":[226,236],"kilogram":[227],"accompanied":[230],"by":[231],"about":[232],"100":[233],"mL":[234],"are":[240],"implications":[242],"our":[244],"findings?":[245],"RA-associated":[255],"Muscle":[261],"mass":[262],"should":[263],"be":[264],"monitored":[265],"treatment,":[267],"muscle-preservation":[269],"strategies":[270],"such":[271],"as":[272],"resistance":[273],"training":[274],"adequate":[276],"protein":[277],"intake":[278],"need":[279],"evaluation.":[280]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-17T00:00:00"}
