{"id":"https://openalex.org/W7213464933","doi":"https://doi.org/10.64898/2026.09.11.751086","title":"Na + /K + -ATPase Blockade Reversibly Attenuates Proliferation and Metabolic Function in K562 Human Myelogenous Leukemia Cells","display_name":"Na + /K + -ATPase Blockade Reversibly Attenuates Proliferation and Metabolic Function in K562 Human Myelogenous Leukemia Cells","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213464933","doi":"https://doi.org/10.64898/2026.09.11.751086","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596298"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.751086","doi":"https://doi.org/10.64898/2026.09.11.751086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.11.751086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.11.751086.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151959293","display_name":"Simon R Bowden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon R Bowden","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151961060","display_name":"Eli T Colton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eli T Colton","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151980502","display_name":"Amber D Norgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber D Norgaard","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151932134","display_name":"McKenzie M Haas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"McKenzie M Haas","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151960405","display_name":"Erynn R Dunnigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erynn R Dunnigan","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151946019","display_name":"Carly J Goven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly J Goven","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151940762","display_name":"Grace O Goven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace O Goven","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151991885","display_name":"Thomas J Hinnenkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Hinnenkamp","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151989081","display_name":"Keagan D Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keagan D Walker","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151967786","display_name":"Theresa M Ballance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa M Ballance","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151955185","display_name":"Blaise I Kathol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaise I Kathol","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089190215","display_name":"Elizabeth R. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth R Murphy","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128096324","display_name":"Kristian Van Slyke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristian M Van Slyke","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108885573","display_name":"Rylie Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rylie J Webb","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093483736","display_name":"Ashlin Schaefbauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashlin B Schaefbauer","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067829132","display_name":"Joseph P. Biggane","orcid":"https://orcid.org/0000-0001-8819-1064","observed_orcids":["https://orcid.org/0000-0001-8819-1064","https://orcid.org/0000-0002-7857-2450"]},"institutions":[{"id":"https://openalex.org/I36154649","display_name":"United Tribes Technical College","ror":"https://ror.org/02kk3dq58","country_code":"US","type":"education","lineage":["https://openalex.org/I36154649"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily R Biggane","raw_affiliation_strings":["Intertribal Research and Resource Center, United Tribes Technical College, Bismarck, ND, USA"],"raw_orcid":"https://orcid.org/0000-0001-8819-1064","affiliations":[{"raw_affiliation_string":"Intertribal Research and Resource Center, United Tribes Technical College, Bismarck, ND, USA","institution_ids":["https://openalex.org/I36154649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067829132","display_name":"Joseph P. Biggane","orcid":"https://orcid.org/0000-0001-8819-1064","observed_orcids":["https://orcid.org/0000-0001-8819-1064","https://orcid.org/0000-0002-7857-2450"]},"institutions":[{"id":"https://openalex.org/I116545467","display_name":"University of Mary","ror":"https://ror.org/055f0jp24","country_code":"US","type":"education","lineage":["https://openalex.org/I116545467"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph P Biggane","raw_affiliation_strings":["University of Mary, Bismarck, ND, USA"],"raw_orcid":"https://orcid.org/0000-0002-7857-2450","affiliations":[{"raw_affiliation_string":"University of Mary, Bismarck, ND, USA","institution_ids":["https://openalex.org/I116545467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067829132"],"corresponding_institution_ids":["https://openalex.org/I116545467"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.16670000553131104,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7549999952316284},{"id":"https://openalex.org/keywords/ion-homeostasis","display_name":"ion homeostasis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cdkn2a-deletion","display_name":"CDKN2A deletion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/p16ink4a","display_name":"p16INK4a","score":0.8289999961853027},{"id":"https://openalex.org/keywords/atp-consumption","display_name":"ATP consumption","score":0.4300000071525574},{"id":"https://openalex.org/keywords/drug-reversibility","display_name":"drug reversibility","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.6836000084877014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6010000109672546},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5824000239372253},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5156999826431274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5072000026702881},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.47769999504089355},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45559999346733093},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4535999894142151},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.43050000071525574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3995000123977661},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.37599998712539673},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.32409998774528503},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C2776309818","wikidata":"https://www.wikidata.org/wiki/Q4654794","display_name":"ATP-sensitive potassium channel","level":4,"score":0.3061000108718872},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3034999966621399},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C2779362680","wikidata":"https://www.wikidata.org/wiki/Q905000","display_name":"hERG","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.25}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.11.751086","doi":"https://doi.org/10.64898/2026.09.11.751086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.11.751086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596298","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779893/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.751086","doi":"https://doi.org/10.64898/2026.09.11.751086","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.751086","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.11.751086.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1981886027","display_name":"ND INBRE Health & the Environment","funder_award_id":"P20GM103442","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213464933.pdf","grobid_xml":"https://content.openalex.org/works/W7213464933.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W130020229","https://openalex.org/W287390018","https://openalex.org/W1956327946","https://openalex.org/W2003046273","https://openalex.org/W2004602806","https://openalex.org/W2012150510","https://openalex.org/W2016656445","https://openalex.org/W2020900688","https://openalex.org/W2023560061","https://openalex.org/W2035189255","https://openalex.org/W2054405945","https://openalex.org/W2082602069","https://openalex.org/W2083448771","https://openalex.org/W2101313549","https://openalex.org/W2104751647","https://openalex.org/W2122252852","https://openalex.org/W2124366608","https://openalex.org/W2125588561","https://openalex.org/W2136985880","https://openalex.org/W2161336797","https://openalex.org/W2162369109","https://openalex.org/W2224021986","https://openalex.org/W2227735896","https://openalex.org/W2626722091","https://openalex.org/W2747478469","https://openalex.org/W2785885120","https://openalex.org/W2884777311","https://openalex.org/W3045917855","https://openalex.org/W3087987920","https://openalex.org/W3201205228","https://openalex.org/W4386438505","https://openalex.org/W7126111491"],"related_works":["https://openalex.org/W3147649493","https://openalex.org/W3015110134","https://openalex.org/W2307292703","https://openalex.org/W3012296743","https://openalex.org/W4398254388","https://openalex.org/W2889840545","https://openalex.org/W2905693243","https://openalex.org/W2036491775","https://openalex.org/W194708996","https://openalex.org/W3176408188"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"Na":[2],"+":[3,5],"/K":[4],"-ATPase":[6],"consumes":[7],"a":[8,41,67,79,98,159,193],"substantial":[9],"portion":[10],"of":[11,50,70,83,162,200,211],"cellular":[12],"ATP":[13],"to":[14,130,142],"maintain":[15],"essential":[16],"electrochemical":[17],"gradients,":[18],"yet":[19],"its":[20,33],"role":[21,199],"in":[22,56,102,203,214],"regulating":[23],"cancer":[24,204,215],"cell":[25,71,89,216],"proliferation":[26,72,205],"and":[27,40,78,125,158,181,206],"phenotypic":[28],"plasticity":[29],"remains":[30],"complicated":[31],"by":[32,111],"dual":[34],"function":[35],"as":[36,147],"an":[37],"ion":[38,179],"transporter":[39],"scaffolding":[42],"receptor.":[43],"Here,":[44],"we":[45,191],"investigate":[46],"the":[47,198,201,208],"physiological":[48],"consequences":[49],"pharmacological":[51],"NKA":[52,113,172,202],"blockade":[53],"using":[54],"digoxin":[55,64,103],"K562":[57,137,175],"human":[58],"chronic":[59],"myelogenous":[60],"leukemia":[61],"cells.":[62],"Submicromolar":[63],"exposure":[65],"induced":[66],"concentration-dependent":[68],"attenuation":[69,124],"(IC":[73],"50":[74],"=":[75],"151.0":[76],"nM)":[77],"statistically":[80],"significant":[81],"depression":[82,127],"metabolic":[84,126],"reducing":[85],"capacity":[86],"without":[87],"impairing":[88],"viability.":[90],"Competitive":[91],"supplementation":[92],"with":[93],"extracellular":[94],"potassium":[95],"salts":[96],"produced":[97],"surmountable":[99],"rightward":[100],"shift":[101],"sensitivity,":[104],"confirming":[105],"that":[106,171],"growth":[107,123,176],"inhibition":[108],"is":[109],"driven":[110],"on-target":[112],"pump":[114],"occupancy":[115],"rather":[116,186],"than":[117,187],"non-specific":[118],"interactions.":[119],"Furthermore,":[120],"this":[121],"cytostatic":[122],"were":[128],"found":[129],"be":[131],"fully":[132],"reversible":[133],"upon":[134],"drug":[135],"clearance.":[136],"cells":[138],"are":[139],"largely":[140],"refractory":[141],"canonical":[143],"kinase-overdrive":[144],"stress":[145],"checkpoints":[146],"they":[148],"harbor":[149],"constitutive":[150],"BCR-ABL":[151],"tyrosine":[152],"kinase":[153],"activity":[154],"alongside":[155],"non-functional":[156],"TP53":[157],"homozygous":[160],"deletion":[161],"CDKN2A":[163],"(p16":[164],"INK4a":[165],").":[166],"Consequently,":[167],"these":[168],"findings":[169],"suggest":[170],"perturbation":[173],"attenuates":[174],"primarily":[177],"through":[178],"dyshomeostasis":[180],"secondary":[182],"active":[183],"transport":[184],"constraints":[185],"scaffold-mediated":[188],"signaling.":[189],"Overall,":[190],"present":[192],"novel":[194],"model":[195],"for":[196],"elucidating":[197],"dissecting":[207],"mechanistic":[209],"underpinnings":[210],"ion-mediated":[212],"alterations":[213],"physiology.":[217]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-17T00:00:00"}