{"id":"https://openalex.org/W7213459479","doi":"https://doi.org/10.64898/2026.09.14.750963","title":"Extensive nuclear introgression accompanied ancient mitochondrial capture in the common ancestor of two sister hare species","display_name":"Extensive nuclear introgression accompanied ancient mitochondrial capture in the common ancestor of two sister hare species","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213459479","doi":"https://doi.org/10.64898/2026.09.14.750963"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.14.750963","doi":"https://doi.org/10.64898/2026.09.14.750963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.750963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.750963.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100724332","display_name":"Jos\u00e9 Costa","orcid":"https://orcid.org/0000-0001-8307-5988","observed_orcids":["https://orcid.org/0000-0001-8307-5988"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210105943","display_name":"Institut des Sciences de l'Evolution de Montpellier","ror":"https://ror.org/01cah1n37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I131077856","https://openalex.org/I159885104","https://openalex.org/I19894307","https://openalex.org/I2746051580","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210105943","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["FR","PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Costa","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;"],"raw_orcid":"https://orcid.org/0000-0001-8307-5988","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210105943","https://openalex.org/I4210166444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022221583","display_name":"Jo\u00e3o Pedro Marques","orcid":"https://orcid.org/0000-0001-9834-1361","observed_orcids":["https://orcid.org/0000-0001-9834-1361"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210105943","display_name":"Institut des Sciences de l'Evolution de Montpellier","ror":"https://ror.org/01cah1n37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I131077856","https://openalex.org/I159885104","https://openalex.org/I19894307","https://openalex.org/I2746051580","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210105943","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["FR","PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Pedro Marques","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;"],"raw_orcid":"https://orcid.org/0000-0001-9834-1361","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210105943","https://openalex.org/I4210166444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071359656","display_name":"Liliana Farelo","orcid":"https://orcid.org/0000-0003-4985-3592","observed_orcids":["https://orcid.org/0000-0003-4985-3592"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Liliana Farelo","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;"],"raw_orcid":"https://orcid.org/0000-0003-4985-3592","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101844681","display_name":"Edenise Andrade da Silva","orcid":"https://orcid.org/0000-0002-9680-3494","observed_orcids":["https://orcid.org/0000-0002-9680-3494","https://orcid.org/0009-0006-2867-9643"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Eug\u00e9nio Silva","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;"],"raw_orcid":"https://orcid.org/0000-0002-9680-3494","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008062441","display_name":"Sofia Granja Martins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sofia Granja Martins","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013357993","display_name":"Angela Trentacoste","orcid":"https://orcid.org/0000-0001-7096-5252","observed_orcids":["https://orcid.org/0000-0001-7096-5252"]},"institutions":[{"id":"https://openalex.org/I12203830","display_name":"British School at Rome","ror":"https://ror.org/04danph04","country_code":"IT","type":"education","lineage":["https://openalex.org/I12203830"]},{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"Angela Trentacoste","raw_affiliation_strings":["Archaeology and Palaeoecology, School of Natural and Built Environment, Queen\u2019s University Belfast, Belfast, United Kingdom;","The British School at Rome, Rome, Italy;"],"raw_orcid":"https://orcid.org/0000-0001-7096-5252","affiliations":[{"raw_affiliation_string":"Archaeology and Palaeoecology, School of Natural and Built Environment, Queen\u2019s University Belfast, Belfast, United Kingdom;","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"The British School at Rome, Rome, Italy;","institution_ids":["https://openalex.org/I12203830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018631862","display_name":"Greger Larson","orcid":"https://orcid.org/0000-0002-4092-0392","observed_orcids":["https://orcid.org/0000-0002-4092-0392"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Greger Larson","raw_affiliation_strings":["Palaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3QY, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0002-4092-0392","affiliations":[{"raw_affiliation_string":"Palaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3QY, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025323545","display_name":"Joel M. Alves","orcid":"https://orcid.org/0000-0001-6138-9134","observed_orcids":["https://orcid.org/0000-0001-6138-9134"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["GB","PT"],"is_corresponding":false,"raw_author_name":"Joel Alves","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Palaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3QY, United Kingdom;"],"raw_orcid":"https://orcid.org/0000-0001-6138-9134","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Palaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3QY, United Kingdom;","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069671174","display_name":"Jo\u00e3o Queir\u00f3s","orcid":"https://orcid.org/0000-0002-3633-7217","observed_orcids":["https://orcid.org/0000-0002-3633-7217"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Queir\u00f3s","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","EBM - Esta\u00e7\u00e3o Biol\u00f3gica de M\u00e9rtola, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-3633-7217","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"EBM - Esta\u00e7\u00e3o Biol\u00f3gica de M\u00e9rtola, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082851487","display_name":"Paulo C. Alves","orcid":"https://orcid.org/0000-0003-4797-0939","observed_orcids":["https://orcid.org/0000-0003-4797-0939"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulo C\u00e9lio Alves","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","EBM - Esta\u00e7\u00e3o Biol\u00f3gica de M\u00e9rtola, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4797-0939","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"EBM - Esta\u00e7\u00e3o Biol\u00f3gica de M\u00e9rtola, Pra\u00e7a Lu\u00eds de Cam\u00f5es, M\u00e9rtola, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028465471","display_name":"Pierre Boursot","orcid":"https://orcid.org/0000-0001-6366-2341","observed_orcids":["https://orcid.org/0000-0001-6366-2341"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210105943","display_name":"Institut des Sciences de l'Evolution de Montpellier","ror":"https://ror.org/01cah1n37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I131077856","https://openalex.org/I159885104","https://openalex.org/I19894307","https://openalex.org/I2746051580","https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210105943","https://openalex.org/I4210107625","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]},{"id":"https://openalex.org/I4210166444","display_name":"Institut de Recherche pour le D\u00e9veloppement","ror":"https://ror.org/05q3vnk25","country_code":"FR","type":"government","lineage":["https://openalex.org/I2802818602","https://openalex.org/I4210090127","https://openalex.org/I4210131494","https://openalex.org/I4210166444"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Boursot","raw_affiliation_strings":["Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;"],"raw_orcid":"https://orcid.org/0000-0001-6366-2341","affiliations":[{"raw_affiliation_string":"Institut des Sciences de l\u2019\u00c9volution Montpellier (ISEM), Universit\u00e9 de Montpellier, CNRS, IRD, Montpellier, France;","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210105943","https://openalex.org/I4210166444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002441472","display_name":"Jos\u00e9 Melo\u2010Ferreira","orcid":"https://orcid.org/0000-0003-4473-1908","observed_orcids":["https://orcid.org/0000-0003-4473-1908"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4390039289","display_name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos","ror":"https://ror.org/0476hs695","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4390039289"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Melo-Ferreira","raw_affiliation_strings":["BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;"],"raw_orcid":"https://orcid.org/0000-0003-4473-1908","affiliations":[{"raw_affiliation_string":"BIOPOLIS Program in Genomics, Biodiversity and Land Planning, CIBIO, Campus de Vair\u00e3o, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I4390039289"]},{"raw_affiliation_string":"CIBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado, Campus de Vair\u00e3o, Universidade do Porto, Vair\u00e3o, Portugal;","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"]},{"raw_affiliation_string":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Porto, Portugal;","institution_ids":["https://openalex.org/I182534213"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5002441472"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4390039289"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11354","display_name":"Evolution and Paleontology Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-introgression","display_name":"nuclear introgression","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitochondrial-replacement","display_name":"mitochondrial replacement","score":0.5860000252723694},{"id":"https://openalex.org/keywords/lepus-castroviejoi","display_name":"Lepus castroviejoi","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lepus-corsicanus","display_name":"Lepus corsicanus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lepus-timidus","display_name":"Lepus timidus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hybridization","display_name":"hybridization","score":0.5960000157356262},{"id":"https://openalex.org/keywords/pleistocene-climate-fluctuations","display_name":"Pleistocene climatic oscillations","score":0.8809999823570251},{"id":"https://openalex.org/keywords/ancestry-inference","display_name":"ancestry inference","score":0.3479999899864197},{"id":"https://openalex.org/keywords/recombination","display_name":"recombination","score":0.7369999885559082},{"id":"https://openalex.org/keywords/iberian-hare","display_name":"Iberian hare","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C8182607","wikidata":"https://www.wikidata.org/wiki/Q2094405","display_name":"Introgression","level":3,"score":0.9146999716758728},{"id":"https://openalex.org/C2554327","wikidata":"https://www.wikidata.org/wiki/Q2698599","display_name":"Coalescent theory","level":4,"score":0.7597000002861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.738099992275238},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.6941999793052673},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6930999755859375},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.6516000032424927},{"id":"https://openalex.org/C20750100","wikidata":"https://www.wikidata.org/wiki/Q7068120","display_name":"Nuclear gene","level":4,"score":0.5981000065803528},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5533000230789185},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.5303000211715698},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5194000005722046},{"id":"https://openalex.org/C66582369","wikidata":"https://www.wikidata.org/wiki/Q1567633","display_name":"Sister group","level":5,"score":0.4846999943256378},{"id":"https://openalex.org/C2780422015","wikidata":"https://www.wikidata.org/wiki/Q402152","display_name":"Ancestor","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36469998955726624},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.3495999872684479},{"id":"https://openalex.org/C94043034","wikidata":"https://www.wikidata.org/wiki/Q377756","display_name":"Phylogeography","level":4,"score":0.3443000018596649},{"id":"https://openalex.org/C17966761","wikidata":"https://www.wikidata.org/wiki/Q68947","display_name":"Subspecies","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C107023163","wikidata":"https://www.wikidata.org/wiki/Q143089","display_name":"Gene flow","level":4,"score":0.3133000135421753},{"id":"https://openalex.org/C53570757","wikidata":"https://www.wikidata.org/wiki/Q25546","display_name":"Pleistocene","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C181561989","wikidata":"https://www.wikidata.org/wiki/Q2581905","display_name":"Heteroplasmy","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C44671064","wikidata":"https://www.wikidata.org/wiki/Q189800","display_name":"Gene pool","level":4,"score":0.26570001244544983},{"id":"https://openalex.org/C115225378","wikidata":"https://www.wikidata.org/wiki/Q853848","display_name":"Allopatric speciation","level":3,"score":0.25999999046325684}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.14.750963","doi":"https://doi.org/10.64898/2026.09.14.750963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.750963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.14.750963","doi":"https://doi.org/10.64898/2026.09.14.750963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.750963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2376099204","display_name":null,"funder_award_id":"NORTE2030","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G276717047","display_name":"HybridChange \u2013 O potencial da hibridiza\u00e7\u00e3o para promover adapta\u00e7\u00e3o r\u00e1pida durante altera\u00e7\u00f5es clim\u00e1ticas","funder_award_id":"PTDC/BIA-EVL/1307/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2862029645","display_name":null,"funder_award_id":"10.54499/PTDC/BIA-EVL/1307/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4373822079","display_name":"Teaming to Upgrade to Excellence in Environmental Biology, Ecosystem Research and AgroBiodiversity","funder_award_id":"857251","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4623985339","display_name":null,"funder_award_id":"857251","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G4830123903","display_name":"The causes and consequences of ancient hybridization among hares (Lepus spp.)","funder_award_id":"UI/BD/154450/2022","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6997658380","display_name":null,"funder_award_id":"10.54499","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G8358766458","display_name":null,"funder_award_id":"NORTE2030-FEDER-02130700","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213459479.pdf","grobid_xml":"https://content.openalex.org/works/W7213459479.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410063189","https://openalex.org/W2100573978","https://openalex.org/W2142972966","https://openalex.org/W7098966099","https://openalex.org/W7097450692","https://openalex.org/W2107075375","https://openalex.org/W2580735442","https://openalex.org/W4400945171","https://openalex.org/W6910868300","https://openalex.org/W2090167441"],"abstract_inverted_index":{"Abstract":[0],"Pleistocene":[1],"climatic":[2],"oscillations":[3],"promoted":[4],"contact":[5],"and":[6,25,58,130,147,168,182,230,235],"hybridization":[7],"among":[8],"hare":[9,77,95,114,142],"species,":[10,17],"leaving":[11],"lasting":[12],"genomic":[13,109],"signatures.":[14],"Two":[15],"sister":[16,153],"L.":[18,26,37],"castroviejoi":[19],"(broom":[20],"hare,":[21,29,155,213],"endemic":[22,30],"to":[23,31,98,122,157,207],"Iberia)":[24],"corsicanus":[27],"(Italian":[28],"Italy),":[32],"carry":[33],"fixed":[34],"mitogenomes":[35,81],"from":[36],"timidus":[38],"(mountain":[39],"hare),":[40],"an":[41],"Arctic":[42],"species":[43],"widespread":[44],"in":[45,74,210,241],"southern":[46],"Europe":[47],"before":[48],"deglaciation.":[49],"Whether":[50],"such":[51],"turnover":[52],"was":[53],"accompanied":[54],"by":[55],"nuclear":[56,238],"introgression,":[57,115,239],"how":[59,226],"it":[60],"affects":[61],"their":[62,175],"genomes":[63,90],"today,":[64],"remains":[65],"unclear.":[66],"Here,":[67],"we":[68],"date":[69],"the":[70,75,119,140,193,211,242],"ancient":[71],"mitochondrial":[72,201],"replacement":[73],"broom-Italian":[76],"ancestor":[78,100],"using":[79],"whole":[80],"incorporating":[82],"Iron":[83],"Age":[84],"samples.":[85],"Coalescent":[86],"modelling":[87],"of":[88,118,139,172,184,244],"complete":[89],"infers":[91],"a":[92],"substantial":[93],"mountain":[94,141],"contribution":[96],"(24%)":[97],"this":[99,135],"\u223c900":[101],"Kya":[102],"(\u223c5N":[103],"generations).":[104],"Accordingly,":[105],"phylogenetic":[106],"segmentation":[107],"identified":[108],"segments":[110,164],"consistent":[111],"with":[112,137,145,200],"mountain-to-broom/Italian":[113],"covering":[116],"\u223c17.8%":[117],"autosomes,":[120],"close":[121],"\u223c18%":[123],"expected":[124],"under":[125],"drift,":[126],"given":[127],"admixture\u2019s":[128],"timing":[129],"magnitude.":[131],"Genome":[132],"polarisation":[133],"corroborates":[134],"estimate,":[136],"25\u201328%":[138],"genome":[143],"polarising":[144],"broom":[146],"Italian":[148],"hares":[149],"rather":[150],"than":[151],"its":[152],"Iberian":[154,212],"decreasing":[156],"15\u201318%":[158],"at":[159,174],"diagnostic":[160],"sites.":[161],"The":[162],"introgression":[163,186,194],"concentrate":[165],"fixed-introgression":[166],"sites":[167],"show":[169],"sharp":[170],"transitions":[171],"ancestry":[173],"borders.":[176],"Highly":[177],"introgressed":[178],"regions":[179,183],"are":[180,187],"gene-dense,":[181],"reduced":[185],"repeat-rich,":[188],"suggesting":[189],"that":[190,203,215],"recombination":[191],"shapes":[192],"landscape.":[195],"They":[196],"also":[197],"harbour":[198],"genes":[199],"function":[202],"mirror":[204],"candidates":[205],"linked":[206],"mito-nuclear":[208],"coadaptation":[209],"hinting":[214],"mitonuclear":[216],"interactions":[217],"may":[218],"influence":[219],"which":[220],"variants":[221],"persist.":[222],"Our":[223],"study":[224],"illustrates":[225],"combining":[227],"demographic,":[228],"phylogenomic":[229],"polarisation-based":[231],"methods":[232],"can":[233],"quantify":[234],"localize":[236],"extensive":[237],"even":[240],"absence":[243],"non-introgressed":[245],"reference":[246],"populations.":[247]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-17T00:00:00"}