{"id":"https://openalex.org/W7213458570","doi":"https://doi.org/10.64898/2026.09.11.750845","title":"BigHeart: Mapping connectivity in the adult human heart at the micron scale","display_name":"BigHeart: Mapping connectivity in the adult human heart at the micron scale","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213458570","doi":"https://doi.org/10.64898/2026.09.11.750845"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.750845","doi":"https://doi.org/10.64898/2026.09.11.750845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.11.750845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.11.750845.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004533558","display_name":"Joseph Brunet","orcid":"https://orcid.org/0000-0002-8424-9510","observed_orcids":["https://orcid.org/0000-0002-8424-9510"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Brunet","raw_affiliation_strings":["University College London;"],"raw_orcid":"https://orcid.org/0000-0002-8424-9510","affiliations":[{"raw_affiliation_string":"University College London;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036191036","display_name":"Andrew C. Cook","orcid":"https://orcid.org/0000-0001-5079-7546","observed_orcids":["https://orcid.org/0000-0001-5079-7546"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrew C. Cook","raw_affiliation_strings":["Institute of Cardiovascular Science, University College London, London, UK;"],"raw_orcid":"https://orcid.org/0000-0001-5079-7546","affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051702158","display_name":"Adam Szmul","orcid":"https://orcid.org/0000-0002-3068-1068","observed_orcids":["https://orcid.org/0000-0002-3068-1068"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adam Szmul","raw_affiliation_strings":["Satsuma Lab, UCL Hawkes Institute, University College London, UK;"],"raw_orcid":"https://orcid.org/0000-0002-3068-1068","affiliations":[{"raw_affiliation_string":"Satsuma Lab, UCL Hawkes Institute, University College London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151940897","display_name":"Marion Use","orcid":"https://orcid.org/0009-0001-9173-6595","observed_orcids":["https://orcid.org/0009-0001-9173-6595"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210095118","display_name":"Centre de Recherche en Neurosciences de Lyon","ror":"https://ror.org/00pdd0432","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210095118","https://openalex.org/I4210096427","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marion Use","raw_affiliation_strings":["Universite Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, BIORAN, 95 boulevard Pinel, Bron, 69500, France;"],"raw_orcid":"https://orcid.org/0009-0001-9173-6595","affiliations":[{"raw_affiliation_string":"Universite Claude Bernard Lyon 1, CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, BIORAN, 95 boulevard Pinel, Bron, 69500, France;","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210095118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120499149","display_name":"Lisa Chestnutt","orcid":"https://orcid.org/0009-0008-0783-7299","observed_orcids":["https://orcid.org/0009-0008-0783-7299"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lisa Chestnutt","raw_affiliation_strings":["Institute of Cardiovascular Science, University College London, London, UK;"],"raw_orcid":"https://orcid.org/0009-0008-0783-7299","affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135226675","display_name":"Akash Sivananthan","orcid":"https://orcid.org/0009-0009-8130-7998","observed_orcids":["https://orcid.org/0009-0009-8130-7998"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Akash Sivananthan","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, London, UK;"],"raw_orcid":"https://orcid.org/0009-0009-8130-7998","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036882097","display_name":"Hector Dejea","orcid":"https://orcid.org/0000-0003-2584-9812","observed_orcids":["https://orcid.org/0000-0003-2584-9812"]},"institutions":[{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hector Dejea","raw_affiliation_strings":["ESRF - The European Synchrotron, Grenoble, France;"],"raw_orcid":"https://orcid.org/0000-0003-2584-9812","affiliations":[{"raw_affiliation_string":"ESRF - The European Synchrotron, Grenoble, France;","institution_ids":["https://openalex.org/I2801997478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001115451","display_name":"Theresa Urban","orcid":"https://orcid.org/0000-0002-0352-8180","observed_orcids":["https://orcid.org/0000-0002-0352-8180"]},"institutions":[{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["FR","GB"],"is_corresponding":false,"raw_author_name":"Theresa Urban","raw_affiliation_strings":["University College London and European Synchrotron Radiation Facility;"],"raw_orcid":"https://orcid.org/0000-0002-0352-8180","affiliations":[{"raw_affiliation_string":"University College London and European Synchrotron Radiation Facility;","institution_ids":["https://openalex.org/I2801997478","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060647208","display_name":"Alexandre Bellier","orcid":"https://orcid.org/0000-0003-0907-0315","observed_orcids":["https://orcid.org/0000-0003-0907-0315"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandre Bellier","raw_affiliation_strings":["Univ. Grenoble Alpes, Department of Anatomy (LADAF), Sangria - LIG, CIC INSERM 1406, Grenoble, France;"],"raw_orcid":"https://orcid.org/0000-0003-0907-0315","affiliations":[{"raw_affiliation_string":"Univ. Grenoble Alpes, Department of Anatomy (LADAF), Sangria - LIG, CIC INSERM 1406, Grenoble, France;","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029969312","display_name":"Vaishnavi Sabarigirivasan","orcid":"https://orcid.org/0000-0003-2550-6262","observed_orcids":["https://orcid.org/0000-0003-2550-6262"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vaishnavi Sabarigirivasan","raw_affiliation_strings":["Institute of Cardiovascular Science, University College London, London, UK;"],"raw_orcid":"https://orcid.org/0000-0003-2550-6262","affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151941084","display_name":"Engel Klaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153902","display_name":"Siemens Healthineers (Germany)","ror":"https://ror.org/0449c4c15","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210153902"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Engel Klaus","raw_affiliation_strings":["Siemens Healthineers, Erlangen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Siemens Healthineers, Erlangen, Germany;","institution_ids":["https://openalex.org/I4210153902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019970528","display_name":"Ryo Torii","orcid":"https://orcid.org/0000-0001-9479-8719","observed_orcids":["https://orcid.org/0000-0001-9479-8719"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ryo Torii","raw_affiliation_strings":["University College London, UK;"],"raw_orcid":"https://orcid.org/0000-0001-9479-8719","affiliations":[{"raw_affiliation_string":"University College London, UK;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009829456","display_name":"Joseph Jacob","orcid":"https://orcid.org/0000-0002-8054-2293","observed_orcids":["https://orcid.org/0000-0002-8054-2293"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Jacob","raw_affiliation_strings":["University College London;"],"raw_orcid":"https://orcid.org/0000-0002-8054-2293","affiliations":[{"raw_affiliation_string":"University College London;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037458493","display_name":"Paul Tafforeau","orcid":"https://orcid.org/0000-0002-5962-1683","observed_orcids":["https://orcid.org/0000-0002-5962-1683"]},"institutions":[{"id":"https://openalex.org/I2801997478","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801997478"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Tafforeau","raw_affiliation_strings":["European Synchrotron Radiation Facility"],"raw_orcid":"https://orcid.org/0000-0002-5962-1683","affiliations":[{"raw_affiliation_string":"European Synchrotron Radiation Facility","institution_ids":["https://openalex.org/I2801997478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056573031","display_name":"Claire Walsh","orcid":"https://orcid.org/0000-0003-3769-3392","observed_orcids":["https://orcid.org/0000-0003-3769-3392"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Walsh","raw_affiliation_strings":["University College London;"],"raw_orcid":"https://orcid.org/0000-0003-3769-3392","affiliations":[{"raw_affiliation_string":"University College London;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085252036","display_name":"Peter David Lee","orcid":"https://orcid.org/0000-0002-3898-8881","observed_orcids":["https://orcid.org/0000-0002-3898-8881"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter D. Lee","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, London, UK;"],"raw_orcid":"https://orcid.org/0000-0002-3898-8881","affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, London, UK;","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5036191036"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.12700000405311584,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11984","display_name":"Anatomy and Medical Technology","score":0.12549999356269836,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-human-heart","display_name":"adult human heart","score":0.9139999747276306},{"id":"https://openalex.org/keywords/whole-heart-imaging","display_name":"whole-heart imaging","score":0.593999981880188},{"id":"https://openalex.org/keywords/hierarchical-phase-contrast-tomography","display_name":"HiP-CT","score":0.8569999933242798},{"id":"https://openalex.org/keywords/myocardial-structure","display_name":"myocardial structure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/atrioventricular-conduction-axis","display_name":"atrioventricular conduction axis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/purkinje-network","display_name":"Purkinje network","score":0.9020000100135803},{"id":"https://openalex.org/keywords/coronary-vessels","display_name":"coronary vessels","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lymphatic-collectors","display_name":"lymphatic collectors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/autonomic-nerves","display_name":"autonomic nerves","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2983437453","wikidata":"https://www.wikidata.org/wiki/Q1072","display_name":"Human heart","level":2,"score":0.739799976348877},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.45969998836517334},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4553999900817871},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4372999966144562},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42719998955726624},{"id":"https://openalex.org/C2776303644","wikidata":"https://www.wikidata.org/wiki/Q1020499","display_name":"Interfacing","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.37209999561309814},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3671000003814697},{"id":"https://openalex.org/C2777632367","wikidata":"https://www.wikidata.org/wiki/Q18379371","display_name":"Bundle branches","level":4,"score":0.35030001401901245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33410000801086426},{"id":"https://openalex.org/C2776024998","wikidata":"https://www.wikidata.org/wiki/Q509053","display_name":"Atrioventricular node","level":3,"score":0.3264000117778778},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C28289500","wikidata":"https://www.wikidata.org/wiki/Q7098868","display_name":"Optical mapping","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C171635847","wikidata":"https://www.wikidata.org/wiki/Q406983","display_name":"Micrometer","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C2779097318","wikidata":"https://www.wikidata.org/wiki/Q2993446","display_name":"Connectomics","level":4,"score":0.27160000801086426},{"id":"https://openalex.org/C85378888","wikidata":"https://www.wikidata.org/wiki/Q721856","display_name":"Endocardium","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.11.750845","doi":"https://doi.org/10.64898/2026.09.11.750845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.11.750845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.750845","doi":"https://doi.org/10.64898/2026.09.11.750845","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.750845","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.11.750845.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2030465100","display_name":"Imaging dynamics in biophysical/biochemical processes across the hierarchical scales (BioPro Network)","funder_award_id":"MR/R025673/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2259944664","display_name":null,"funder_award_id":"CiET 1819/10","funder_id":"https://openalex.org/F4320320005","funder_display_name":"Royal Academy of Engineering"},{"id":"https://openalex.org/G2947732725","display_name":null,"funder_award_id":"CIET 18/19","funder_id":"https://openalex.org/F4320320005","funder_display_name":"Royal Academy of Engineering"},{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3724840400","display_name":"Computer-based analysis of early fibrosing lung disease","funder_award_id":"209553","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3905734289","display_name":"Enhancing the characterisation of early respiratory disease to improve population health","funder_award_id":"227835/Z/23/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7193505718","display_name":null,"funder_award_id":"10.13039/100014989","funder_id":"https://openalex.org/F4320306192","funder_display_name":"Silicon Valley Community Foundation"},{"id":"https://openalex.org/G7626410085","display_name":"Organ-Cell-Molecular Imaging (OCMI): Integrating Human Heart Bioimaging Across Scales Using Foundation Models","funder_award_id":"310796","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G824480439","display_name":"Enhancing the characterisation of early respiratory disease to improve population health","funder_award_id":"227835","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8323936878","display_name":"Organ-Cell-Molecular Imaging (OCMI): Integrating Human Heart Bioimaging Across Scales Using Foundation Models","funder_award_id":"310796/Z/24/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8383275429","display_name":"Computer-based analysis of early fibrosing lung disease","funder_award_id":"209553/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320306192","display_name":"Silicon Valley Community Foundation","ror":"https://ror.org/001ader08"},{"id":"https://openalex.org/F4320309949","display_name":"Canadian Institute for Advanced Research","ror":"https://ror.org/01sdtdd95"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"},{"id":"https://openalex.org/F4320320637","display_name":"Great Ormond Street Hospital Charity","ror":"https://ror.org/03vjq7x94"},{"id":"https://openalex.org/F4320325311","display_name":"University College London Hospitals NHS Foundation Trust","ror":"https://ror.org/042fqyp44"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213458570.pdf","grobid_xml":"https://content.openalex.org/works/W7213458570.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W3208354138","https://openalex.org/W6886172571","https://openalex.org/W6886188713","https://openalex.org/W6904962550","https://openalex.org/W6905105406","https://openalex.org/W6942343872","https://openalex.org/W6942397411","https://openalex.org/W6942741066","https://openalex.org/W6960972753","https://openalex.org/W7134269737"],"related_works":["https://openalex.org/W7135203334","https://openalex.org/W7126144948","https://openalex.org/W2598320803","https://openalex.org/W4406724170","https://openalex.org/W2886077703","https://openalex.org/W3013901460","https://openalex.org/W7169613419","https://openalex.org/W2055642196","https://openalex.org/W4298315202","https://openalex.org/W2899202342"],"abstract_inverted_index":{"The":[0,72],"human":[1,42],"heart":[2,43],"depends":[3],"on":[4],"coordinated":[5],"muscular,":[6],"electrical,":[7],"vascular,":[8],"lymphatic,":[9],"and":[10,60,96,119],"neural":[11],"systems,":[12],"but":[13],"their":[14],"three-dimensional":[15,35],"relationships":[16],"remain":[17],"unresolved":[18],"at":[19,44],"microscopic":[20],"resolution":[21],"across":[22],"an":[23],"intact":[24],"adult":[25,41],"organ.":[26],"Using":[27],"hierarchical":[28,57],"phase-contrast":[29],"tomography,":[30],"we":[31],"generated":[32],"a":[33,39,79,111],"continuous":[34],"structural":[36],"reference":[37],"of":[38],"whole":[40],"8.01":[45],"micrometer":[46],"isotropic":[47],"voxel":[48],"size,":[49],"without":[50],"sectioning":[51],"or":[52],"staining.":[53],"Organ-wide":[54],"imaging":[55],"revealed":[56],"myocardial":[58,68],"architecture,":[59],"quantitative":[61],"orientation":[62],"analysis":[63],"identified":[64],"regional":[65],"differences":[66],"in":[67],"cell":[69],"aggregate":[70],"organization.":[71],"atrioventricular":[73],"conduction":[74],"axis":[75],"was":[76],"traced":[77],"into":[78],"distinct":[80],"subendocardial":[81],"Purkinje":[82],"network":[83],"interfacing":[84],"with":[85],"working":[86],"myocardium.":[87],"Integrated":[88],"segmentation":[89],"showed":[90],"that":[91],"coronary":[92],"vessels,":[93],"lymphatic":[94],"collectors,":[95],"autonomic":[97],"nerves":[98],"occupy":[99],"shared":[100],"epicardial":[101],"corridors.":[102],"This":[103],"publicly":[104],"accessible":[105],"dataset":[106],"integrates":[107],"cardiac":[108],"systems":[109],"within":[110],"common":[112],"spatial":[113],"framework":[114],"for":[115],"anatomy,":[116],"computational":[117],"modeling,":[118],"future":[120],"molecular":[121],"atlases.":[122]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-17T00:00:00"}