{"id":"https://openalex.org/W7213458177","doi":"https://doi.org/10.1177/17534259261473360","title":"Primary human dermal fibroblasts selectively sense LPS, poly I:C and ADP heptose and initiate immune response mostly through chemokine secretion","display_name":"Primary human dermal fibroblasts selectively sense LPS, poly I:C and ADP heptose and initiate immune response mostly through chemokine secretion","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7213458177","doi":"https://doi.org/10.1177/17534259261473360","pmid":"https://pubmed.ncbi.nlm.nih.gov/42751893","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13724911"},"language":"en","primary_location":{"id":"doi:10.1177/17534259261473360","doi":"https://doi.org/10.1177/17534259261473360","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17534259261473360","pdf_url":null,"source":{"id":"https://openalex.org/S141804158","display_name":"Innate Immunity","issn_l":"1753-4259","issn":["1753-4259","1753-4267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innate Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/17534259261473360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julie Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Klein","raw_affiliation_strings":["Institut Pasteur","Universit\u00e9 Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9","institution_ids":["https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020097136","display_name":"Christophe Gallard","orcid":"https://orcid.org/0000-0002-6338-3534","observed_orcids":["https://orcid.org/0000-0002-6338-3534"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Gallard","raw_affiliation_strings":["Institut Pasteur","Universit\u00e9 Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9","institution_ids":["https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039239476","display_name":"Brigitte David\u2010Watine","orcid":"https://orcid.org/0000-0002-3292-0042","observed_orcids":["https://orcid.org/0000-0002-3292-0042"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Brigitte David-Watine","raw_affiliation_strings":["Institut Pasteur","Universit\u00e9 Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9","institution_ids":["https://openalex.org/I204730241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065161854","display_name":"Catherine Werts","orcid":"https://orcid.org/0000-0003-3079-5476","observed_orcids":["https://orcid.org/0000-0003-3079-5476"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Catherine Werts","raw_affiliation_strings":["Institut Pasteur","Universit\u00e9 Paris Cit\u00e9"],"raw_orcid":"https://orcid.org/0000-0003-3079-5476","affiliations":[{"raw_affiliation_string":"Institut Pasteur","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9","institution_ids":["https://openalex.org/I204730241"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065161854"],"corresponding_institution_ids":["https://openalex.org/I157536573","https://openalex.org/I204730241"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60783504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":null,"first_page":"17534259261473360","last_page":"17534259261473360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8730000257492065},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.8100000023841858},{"id":"https://openalex.org/keywords/adp-heptose","display_name":"ADP-heptose","score":0.9039999842643738},{"id":"https://openalex.org/keywords/alpk1","display_name":"ALPK1","score":0.796999990940094},{"id":"https://openalex.org/keywords/chemokine-secretion","display_name":"chemokine secretion","score":0.7829999923706055},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.878000020980835},{"id":"https://openalex.org/keywords/nod1","display_name":"NOD1","score":0.6480000019073486},{"id":"https://openalex.org/keywords/skin-defense","display_name":"skin defense","score":0.5429999828338623},{"id":"https://openalex.org/keywords/sentinel-cells","display_name":"sentinel cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8402000069618225},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.7049999833106995},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.6815000176429749},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6031000018119812},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5698000192642212},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5529999732971191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5424000024795532},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5259000062942505},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5227000117301941},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4869000017642975},{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.46779999136924744},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4431999921798706},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.4361000061035156},{"id":"https://openalex.org/C2777291061","wikidata":"https://www.wikidata.org/wiki/Q18035347","display_name":"NOD1","level":5,"score":0.4334000051021576},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3862000107765198},{"id":"https://openalex.org/C157081693","wikidata":"https://www.wikidata.org/wiki/Q21113934","display_name":"CCL18","level":4,"score":0.38260000944137573},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.350600004196167},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.3310999870300293},{"id":"https://openalex.org/C103474210","wikidata":"https://www.wikidata.org/wiki/Q142851","display_name":"Immune receptor","level":3,"score":0.32600000500679016},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.29980000853538513},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27799999713897705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2750999927520752},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C188899842","wikidata":"https://www.wikidata.org/wiki/Q1483180","display_name":"Pathogen-associated molecular pattern","level":5,"score":0.2587999999523163},{"id":"https://openalex.org/C116024289","wikidata":"https://www.wikidata.org/wiki/Q18039820","display_name":"Interleukin 20","level":5,"score":0.2533000111579895}],"mesh":[{"descriptor_ui":"D000094406","descriptor_name":"Innate Immunity Recognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097912","descriptor_name":"Toll-Like Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000244","descriptor_name":"Adenosine Diphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051192","descriptor_name":"Receptors, Pattern Recognition","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1177/17534259261473360","doi":"https://doi.org/10.1177/17534259261473360","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17534259261473360","pdf_url":null,"source":{"id":"https://openalex.org/S141804158","display_name":"Innate Immunity","issn_l":"1753-4259","issn":["1753-4259","1753-4267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innate Immunity","raw_type":"journal-article"},{"id":"doi:10.64898/2026.04.28.721398","doi":"https://doi.org/10.64898/2026.04.28.721398","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.28.721398","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/04/30/2026.04.28.721398.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13724911","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724911/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724911/pdf/10.1177_17534259261473360.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innate Immun","raw_type":"Text"},{"id":"pmid:42751893","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42751893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innate immunity","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05806050v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05806050","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Innate Immunity, In press, 32, ⟨10.1177/17534259261473360⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:276ea1e16ce14bb8b7dabcaa1ba3c9b4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/276ea1e16ce14bb8b7dabcaa1ba3c9b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Innate Immunity, Vol 32 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/17534259261473360","doi":"https://doi.org/10.1177/17534259261473360","is_oa":true,"landing_page_url":"https://doi.org/10.1177/17534259261473360","pdf_url":null,"source":{"id":"https://openalex.org/S141804158","display_name":"Innate Immunity","issn_l":"1753-4259","issn":["1753-4259","1753-4267"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innate Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213458177.pdf","grobid_xml":"https://content.openalex.org/works/W7213458177.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1488709028","https://openalex.org/W1613884642","https://openalex.org/W1974545869","https://openalex.org/W2048000602","https://openalex.org/W2107277218","https://openalex.org/W2115583388","https://openalex.org/W2129540623","https://openalex.org/W2165626477","https://openalex.org/W2623604452","https://openalex.org/W2921469094","https://openalex.org/W2943603108","https://openalex.org/W2944088013","https://openalex.org/W4214659214","https://openalex.org/W4312223461","https://openalex.org/W4321601035","https://openalex.org/W4387429281","https://openalex.org/W4389060521","https://openalex.org/W4399671286","https://openalex.org/W7119839282"],"related_works":["https://openalex.org/W7160250083","https://openalex.org/W2049241020","https://openalex.org/W1977455495","https://openalex.org/W2013370842","https://openalex.org/W2523482311","https://openalex.org/W2079260693","https://openalex.org/W2747367442","https://openalex.org/W2082821194","https://openalex.org/W2024803597","https://openalex.org/W4405196718"],"abstract_inverted_index":{"ABSTRACT":[0],"Fibroblasts":[1,54],"are":[2],"traditionally":[3],"considered":[4],"structural":[5],"cells":[6,260],"that":[7,255],"maintain":[8],"tissue":[9],"homeostasis":[10],"and":[11,50,82,100,102,131,140,146,151,166,186,251,284],"facilitate":[12],"repair.":[13],"However,":[14],"accumulating":[15],"evidence":[16],"suggests":[17,254],"they":[18],"also":[19],"participate":[20],"in":[21,261],"innate":[22,37,235],"immunity,":[23],"although":[24,205],"their":[25],"pattern":[26,67],"recognition":[27,68],"capabilities":[28],"remain":[29],"incompletely":[30],"characterized.":[31],"Here,":[32],"we":[33],"systematically":[34],"assessed":[35],"the":[36,91,143,167],"immune":[38,85,236,277],"responses":[39,253],"of":[40,60,94,119,142,179,184,266],"commercially":[41],"available":[42],"primary":[43,225],"human":[44,226],"dermal":[45,227],"fibroblasts":[46,228,256],"from":[47,149],"a":[48,51,58,116,230],"male":[49],"female":[52],"donor.":[53],"were":[55,154,192],"stimulated":[56],"with":[57,174,211],"panel":[59],"microbe-associated":[61],"molecular":[62],"patterns":[63,270],"(MAMPs)":[64],"targeting":[65],"various":[66],"receptors":[69,73,76,191],"(PRRs),":[70],"including":[71],"Toll-like":[72],"(TLRs),":[74],"NOD-like":[75],"(NODs),":[77],"Alpha":[78],"kinase":[79],"1":[80],"(ALPK1)":[81,135],"STING.":[83],"Innate":[84],"activation":[86,139,208,286],"was":[87,110,202,209],"quantified":[88],"by":[89,105,112],"measuring":[90],"nuclear":[92],"translocation":[93],"NF-\u03baB":[95,138],"via":[96],"high":[97,219],"content":[98],"microscopy":[99],"cytokines":[101,162],"chemokines":[103,144],"secretion":[104,141],"ELISA;":[106],"baseline":[107],"PRRs":[108,180],"expression":[109,183],"determined":[111],"quantitative":[113],"PCR.":[114],"Only":[115],"restricted":[117,239],"subset":[118],"agonists,":[120],"specifically":[121],"E.":[122],"coli":[123],"LPS":[124],"(TLR4),":[125],"Poly":[126,158],"I:C":[127,159],"(TLR3":[128],"/":[129],"RIG-I)":[130],"unexpectedly":[132],"ADP":[133],"heptose":[134],"induced":[136],"robust":[137],"IL-8":[145],"MCP-1.":[147],"Apart":[148],"IL-6":[150],"RANTES,":[152],"which":[153],"produced":[155],"exclusively":[156],"following":[157],"stimulation,":[160],"pro-inflammatory":[161],"(IL-1\u03b2,":[163],"TNF,":[164],"IFN-\u03b2)":[165],"anti-inflammatory":[168],"cytokine":[169,252],"IL-10":[170],"remained":[171],"undetectable.":[172],"Consistent":[173],"this":[175],"limited":[176],"reactivity,":[177],"qPCR":[178],"revealed":[181,217],"basal":[182],"TLR4":[185],"ALPK1,":[187],"whereas":[188],"most":[189],"other":[190],"expressed":[193,204],"at":[194,271],"very":[195],"low":[196,272],"or":[197],"undetectable":[198],"levels.":[199],"Notably,":[200],"NOD1":[201,213],"highly":[203,231],"no":[206],"cell":[207],"observed":[210],"several":[212],"agonists.":[214],"Dose-response":[215],"analysis":[216],"surprisingly":[218],"sensitivity":[220],"to":[221,240,274],"LPS.":[222],"In":[223],"conclusion,":[224],"exhibit":[229],"selective":[232],"but":[233],"sensitive":[234],"response,":[237],"largely":[238],"chemokine":[241,250],"production":[242],"upon":[243],"PRR":[244],"activation.":[245],"This":[246],"unexpected":[247],"dissociation":[248],"between":[249],"function":[257],"as":[258],"sentinel":[259],"early":[262],"skin":[263],"defense,":[264],"capable":[265],"detecting":[267],"key":[268],"microbial":[269],"concentrations,":[273],"orchestrate":[275],"local":[276],"surveillance.":[278],"Further":[279],"investigation":[280],"into":[281],"interindividual":[282],"variability":[283],"context-dependent":[285],"is":[287],"needed.":[288]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-17T00:00:00"}