{"id":"https://openalex.org/W7213456889","doi":"https://doi.org/10.1007/s10495-026-02467-z","title":"ZNF460\u2013SNRPB\u2013RDM1 splicing axis promotes clear cell renal cell carcinoma progression through regulation of DNA damage repair","display_name":"ZNF460\u2013SNRPB\u2013RDM1 splicing axis promotes clear cell renal cell carcinoma progression through regulation of DNA damage repair","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7213456889","doi":"https://doi.org/10.1007/s10495-026-02467-z"},"language":"en","primary_location":{"id":"doi:10.1007/s10495-026-02467-z","doi":"https://doi.org/10.1007/s10495-026-02467-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10495-026-02467-z","pdf_url":null,"source":{"id":"https://openalex.org/S120502300","display_name":"APOPTOSIS","issn_l":"1360-8185","issn":["1360-8185","1573-675X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Apoptosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10842124/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151941684","display_name":"Liu Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Liu","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151954739","display_name":"Yao Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Yao","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100529990","display_name":"Xiang Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Xiang","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151953771","display_name":"Wang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151989890","display_name":"Jiang Chunchao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunchao Jiang","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032545417","display_name":"Lixia Wang","orcid":"https://orcid.org/0000-0001-7991-4013","observed_orcids":["https://orcid.org/0000-0001-7991-4013"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lixia Wang","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016415183","display_name":"Jin Zhu","orcid":"https://orcid.org/0000-0002-3814-9885","observed_orcids":["https://orcid.org/0000-0002-3814-9885"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Zhu","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016415183","https://openalex.org/A5032545417"],"corresponding_institution_ids":["https://openalex.org/I4210124971"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.05299999937415123,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/snrpb","display_name":"SNRPB","score":0.9620000123977661},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.8510000109672546},{"id":"https://openalex.org/keywords/spliceosome","display_name":"spliceosome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8980000019073486},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.9359999895095825},{"id":"https://openalex.org/keywords/olaparib-sensitivity","display_name":"olaparib sensitivity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C40000846","wikidata":"https://www.wikidata.org/wiki/Q915868","display_name":"Spliceosome","level":5,"score":0.8104000091552734},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7146999835968018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.670799970626831},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.5745000243186951},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.5738999843597412},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5691999793052673},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5555999875068665},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5206999778747559},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49880000948905945},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46650001406669617},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45399999618530273},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4399999976158142},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4242999851703644},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.4203999936580658},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.41769999265670776},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.3926999866962433},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3856000006198883},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.37119999527931213},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3483000099658966},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2766000032424927},{"id":"https://openalex.org/C73758832","wikidata":"https://www.wikidata.org/wiki/Q7578564","display_name":"Splicing factor","level":5,"score":0.27549999952316284},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C97329493","wikidata":"https://www.wikidata.org/wiki/Q18053203","display_name":"Folliculin","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C2908584439","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"Small nuclear ribonucleoprotein","level":5,"score":0.2590000033378601},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s10495-026-02467-z","doi":"https://doi.org/10.1007/s10495-026-02467-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10495-026-02467-z","pdf_url":null,"source":{"id":"https://openalex.org/S120502300","display_name":"APOPTOSIS","issn_l":"1360-8185","issn":["1360-8185","1573-675X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Apoptosis","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10842124/v1","doi":"https://doi.org/10.21203/rs.3.rs-10842124/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10842124/v1","pdf_url":"https://www.researchsquare.com/article/rs-10842124/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10842124/v1","doi":"https://doi.org/10.21203/rs.3.rs-10842124/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10842124/v1","pdf_url":"https://www.researchsquare.com/article/rs-10842124/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213456889.pdf","grobid_xml":"https://content.openalex.org/works/W7213456889.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1978192207","https://openalex.org/W2022066102","https://openalex.org/W2025982232","https://openalex.org/W2041101161","https://openalex.org/W2086153601","https://openalex.org/W2092582534","https://openalex.org/W2099697409","https://openalex.org/W2119113195","https://openalex.org/W2413340136","https://openalex.org/W2536443857","https://openalex.org/W2552774482","https://openalex.org/W2573357293","https://openalex.org/W2884789147","https://openalex.org/W2903681230","https://openalex.org/W2906816588","https://openalex.org/W2943329972","https://openalex.org/W2952132334","https://openalex.org/W2982536002","https://openalex.org/W3007837073","https://openalex.org/W3016273280","https://openalex.org/W3026003425","https://openalex.org/W3027721570","https://openalex.org/W3036630705","https://openalex.org/W3107302670","https://openalex.org/W3119554079","https://openalex.org/W3137704083","https://openalex.org/W3155979978","https://openalex.org/W3175053183","https://openalex.org/W3182568394","https://openalex.org/W4213193900","https://openalex.org/W4366991253","https://openalex.org/W4382677556","https://openalex.org/W4387894234","https://openalex.org/W4400763614","https://openalex.org/W4401298440","https://openalex.org/W4401948805","https://openalex.org/W4405020326","https://openalex.org/W4405943176","https://openalex.org/W4407177408","https://openalex.org/W4410309443","https://openalex.org/W4412521516"],"related_works":["https://openalex.org/W3109756206","https://openalex.org/W4213108443","https://openalex.org/W2990853907","https://openalex.org/W4224313574","https://openalex.org/W4205095118","https://openalex.org/W7133239482","https://openalex.org/W2415496715","https://openalex.org/W3124250297","https://openalex.org/W2123469746","https://openalex.org/W1933586554"],"abstract_inverted_index":{"Abstract":[0],"Small":[1],"nuclear":[2],"ribonucleoprotein":[3],"polypeptide":[4],"B":[5],"(SNRPB)":[6],"is":[7,41,52,154],"one":[8],"of":[9,13,92,107,117,138,143,161],"the":[10,14,70,83,88,93,104,114,127,135,141,147],"core":[11,94],"proteins":[12],"spliceosome.":[15],"Although":[16],"its":[17,27,39],"role":[18],"in":[19,44,98,113,126,134],"spliceosome":[20,95],"assembly":[21],"has":[22,30],"been":[23],"well":[24],"-":[25,110],"established,":[26],"carcinogenic":[28,63],"potential":[29],"just":[31],"begun":[32],"to":[33,80,87,146],"be":[34,170],"revealed.":[35],"We":[36],"found":[37],"that":[38],"expression":[40,91,116,136],"significantly":[42],"increased":[43],"clear":[45],"cell":[46,48],"renal":[47],"carcinoma":[49],"(ccRCC)":[50],"and":[51,81,164],"associated":[53],"with":[54,103],"a":[55,62,122,157,171],"poor":[56],"prognosis.":[57],"Mechanistically,":[58],"this":[59,152],"study":[60],"reveals":[61],"axis":[64,153],"centered":[65],"around":[66],"abnormal":[67],"RNA":[68],"splicing:":[69],"ZNF460\u2013SNRPB\u2013RDM1":[71],"axis.":[72],"The":[73],"upstream":[74],"transcription":[75],"factor":[76],"ZNF460":[77],"directly":[78],"binds":[79],"activates":[82],"SNRPB":[84,97,101],"promoter,":[85],"leading":[86],"abnormally":[89],"high":[90],"protein":[96],"ccRCC.":[99],"Excessive":[100],"interferes":[102],"precise":[105],"splicing":[106],"RDM1":[108,119,139],"pre":[109],"mRNA,":[111],"resulting":[112],"dysregulated":[115],"functional":[118],"protein.":[120],"As":[121],"key":[123],"effector":[124],"molecule":[125],"homologous":[128],"recombination":[129],"repair":[130],"(HRR)":[131],"pathway,":[132],"changes":[133],"level":[137],"alter":[140],"sensitivity":[142],"ccRCC":[144,162],"cells":[145],"PARP":[148],"inhibitor":[149],"olaparib.":[150],"Therefore,":[151],"not":[155],"only":[156],"newly":[158],"discovered":[159],"driver":[160],"invasiveness":[163],"drug":[165],"resistance":[166],"but":[167],"may":[168],"also":[169],"new":[172],"therapeutic":[173],"target.":[174]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-17T00:00:00"}
