{"id":"https://openalex.org/W7213453341","doi":"https://doi.org/10.64898/2026.09.14.751535","title":"Preserved CETP Activity and Early Serum Amyloid A are Associated with Improved Outcomes in Sepsis-Associated ARDS","display_name":"Preserved CETP Activity and Early Serum Amyloid A are Associated with Improved Outcomes in Sepsis-Associated ARDS","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213453341","doi":"https://doi.org/10.64898/2026.09.14.751535","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596304"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.14.751535","doi":"https://doi.org/10.64898/2026.09.14.751535","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751535","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.751535.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.751535.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046192519","display_name":"Ailing Ji","orcid":"https://orcid.org/0000-0003-0166-5226","observed_orcids":["https://orcid.org/0000-0003-0166-5226"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ailing Ji","raw_affiliation_strings":["Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143813306","display_name":"Osemwenoyenmwen Abu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Osemwenoyenmwen Abu","raw_affiliation_strings":["Departments of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038727976","display_name":"Luke W. Meredith","orcid":"https://orcid.org/0009-0001-0672-3133","observed_orcids":["https://orcid.org/0009-0001-0672-3133"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke W. Meredith","raw_affiliation_strings":["Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101544656","display_name":"Hui Yu","orcid":"https://orcid.org/0009-0002-5804-9627","observed_orcids":["https://orcid.org/0009-0002-5804-9627"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Yu","raw_affiliation_strings":["Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104600467","display_name":"Clairity Voy","orcid":"https://orcid.org/0009-0002-7807-7609","observed_orcids":["https://orcid.org/0009-0002-7807-7609"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clairity H. Voy","raw_affiliation_strings":["Physiology, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111532410","display_name":"Maria E. C. Bruno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria E.C. Bruno","raw_affiliation_strings":["Surgery, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057389125","display_name":"Scott M. Gordon","orcid":"https://orcid.org/0000-0001-9532-032X","observed_orcids":["https://orcid.org/0000-0001-9532-032X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott M. Gordon","raw_affiliation_strings":["Physiology, University of Kentucky, Lexington, Kentucky 40536, USA","Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050465459","display_name":"Gregory S. Hawk","orcid":"https://orcid.org/0000-0001-8935-9965","observed_orcids":["https://orcid.org/0000-0001-8935-9965"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S. Hawk","raw_affiliation_strings":["Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072669719","display_name":"Marlene E. Starr","orcid":"https://orcid.org/0000-0003-0304-348X","observed_orcids":["https://orcid.org/0000-0003-0304-348X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlene E. Starr","raw_affiliation_strings":["Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA","Surgery, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Surgery, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005176076","display_name":"Preetha Shridas","orcid":"https://orcid.org/0000-0002-2532-4007","observed_orcids":["https://orcid.org/0000-0002-2532-4007"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Preetha Shridas","raw_affiliation_strings":["Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA","Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005176076"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6244999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.36910000443458557,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.9639999866485596},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sepsis-associated-acute-respiratory-distress-syndrome","display_name":"sepsis-associated acute respiratory distress syndrome","score":0.9649999737739563},{"id":"https://openalex.org/keywords/rosuvastatin","display_name":"rosuvastatin","score":0.968999981880188},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.5609999895095825},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6060000061988831},{"id":"https://openalex.org/keywords/apache-score","display_name":"APACHE score","score":0.7979999780654907},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.3919999897480011},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.5649999976158142},{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.5080000162124634},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.4339999854564667},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.3330000042915344},{"id":"https://openalex.org/keywords/acute-respiratory-failure","display_name":"acute respiratory failure","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8849999904632568},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7300999760627747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6437000036239624},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5153999924659729},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4690999984741211},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.44940000772476196},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4259999990463257},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41130000352859497},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4027000069618225},{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.39890000224113464},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.3684999942779541},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35659998655319214},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C2780499067","wikidata":"https://www.wikidata.org/wiki/Q415159","display_name":"Rosuvastatin","level":2,"score":0.34389999508857727},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.325300008058548},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.14.751535","doi":"https://doi.org/10.64898/2026.09.14.751535","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751535","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.751535.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596304","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13596304/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.14.751535","doi":"https://doi.org/10.64898/2026.09.14.751535","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751535","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/17/2026.09.14.751535.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000891519","display_name":"Investigating the Role of HDL-Associated Serum Amyloid A in Sepsis-Induced Acute Lung Injury and Mortality","funder_award_id":"1r01hl173026-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213453341.pdf","grobid_xml":"https://content.openalex.org/works/W7213453341.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3107560778","https://openalex.org/W2322392387","https://openalex.org/W2724704915","https://openalex.org/W2156519908","https://openalex.org/W2897553891","https://openalex.org/W4392154934","https://openalex.org/W4361213586","https://openalex.org/W2290122435","https://openalex.org/W4401547760","https://openalex.org/W6939625883"],"abstract_inverted_index":{"Background:":[0],"Sepsis":[1,39],"is":[2,19],"a":[3,12,20,301],"life-threatening":[4],"condition":[5],"characterized":[6],"by":[7,496],"organ":[8,345,408],"dysfunction":[9],"resulting":[10],"from":[11,38,91,104],"dysregulated":[13],"host":[14],"response":[15],"to":[16,109,168,501],"infection.":[17],"It":[18],"leading":[21],"cause":[22],"of":[23,66,176,232,304,365,421],"in-hospital":[24],"mortality.":[25,305,508],"The":[26],"multicenter":[27],"Acute":[28],"Respiratory":[29],"Distress":[30],"Syndrome":[31],"Network":[32],"Statins":[33],"for":[34,247],"Acutely":[35],"Injured":[36],"Lungs":[37],"(ARDSNet-SAILS)":[40],"trial":[41],"found":[42],"that":[43],"rosuvastatin":[44],"(RS)":[45],"did":[46],"not":[47,453],"improve":[48],"clinical":[49,83,89,99],"outcomes":[50,84,147],"in":[51,164,178,192,203,285,351,379,424,431,440,455,484],"patients":[52,194],"with":[53,80,144,199,206,229,266,272,300,332,343,361,386,438,477],"sepsis-associated":[54],"ARDS":[55],"and":[56,60,74,82,88,101,117,127,131,142,146,152,174,187,223,236,238,244,251,259,269,326,402,406,416,447,468,480,491,507],"may":[57],"increase":[58,202],"hepatic":[59,396],"renal":[61,274,387],"dysfunction.":[62],"We":[63],"evaluated":[64],"associations":[65,143],"plasma":[67,86,102,295,311,356,465],"cholesterol":[68],"ester":[69],"transfer":[70],"protein":[71],"(CETP)":[72],"activity":[73,204,490],"Serum":[75],"Amyloid":[76],"A":[77],"(SAA)":[78],"levels":[79,119,280,297,313,322,339,358,378,423,430,471,493],"survival":[81,145,479],"using":[85,138,148],"samples":[87,103],"data":[90,100],"ARDSNet-SAILS":[92,106],"trial.":[93],"Methods:":[94],"This":[95],"secondary":[96],"analysis":[97],"included":[98],"471":[105],"participants,":[107],"randomized":[108],"placebo":[110],"(PL)":[111],"or":[112],"RS.":[113],"Plasma":[114,278],"CETP":[115,159,190,217,254,466,489],"activities":[116,160,191,467],"SAA":[118,279,296,312,321,338,357,377,422,429,470,492,506],"were":[120,136,161,261,298,328,340,359,383,494],"measured":[121],"at":[122,218,316,323,370],"enrollment":[123],"(Day":[124,390,411],"0,":[125,172,220,249,400,412],"n=466)":[126],"Days":[128,248,257,324,414,445],"3":[129,189,258,327,415],"(n=425)":[130],"6":[132,175,225,260,372],"(n=342).":[133],"Treatment":[134],"effects":[135],"assessed":[137],"linear":[139],"mixed":[140],"models,":[141],"Cox,":[149],"linear,":[150],"beta-binomial,":[151],"zero-inflated":[153],"negative":[154],"binomial":[155],"regression":[156],"models.":[157],"Results:":[158],"significantly":[162,227,263,282,309],"higher":[163,216,294,310,355,376,428],"the":[165,180,212,291,352,380,432,441,456,503],"survivors":[166,307,436],"compared":[167,437],"non-survivors":[169,315,439],"on":[170,256,444],"days":[171,276,347,389,398,410],"3,":[173,222,250,391,401],"analysis,":[177],"both":[179,286,418,488],"treatment":[181,214,287],"groups":[182,288],"(p<0.01).":[183,373],"Higher":[184,253,320],"Day":[185,188,219,221,224,317,336,371,393],"0":[186,318,325,337,446],"PL":[193,292,442],"independently":[195],"predicted":[196],"improved":[197,478],"survival,":[198],"every":[200],"3-unit":[201],"associated":[205,228,265,271,299,342,360,385,476],"18-19%":[207],"lower":[208,302],"mortality":[209,233],"risk.":[210],"In":[211,290,349],"RS":[213,353,381,457,497],"group,":[215,293,354],"was":[226,452],"reduced":[230,481],"hazard":[231,239,303,364],"(p=0.039,":[234],"0.005,":[235],"0.022,":[237],"ratios":[240],"=":[241],"0.87,":[242],"0.82,":[243],"0.80,":[245],"respectively,":[246],"6).":[252],"values":[255],"also":[262,329],"negatively":[264],"APACHE":[267,333],"score":[268],"positively":[270,341,384],"increased":[273,363],"dysfunction-free":[275,346,388,397,409],"(p=0.001).":[277],"decreased":[281],"over":[283],"time":[284],"(p<0.0001).":[289],"Accordingly,":[306],"had":[308],"than":[314],"(p=0.005).":[319],"inversely":[330],"correlated":[331],"scores,":[334],"while":[335,487],"overall":[344,407],"(p=0.002).":[348],"contrast,":[350],"an":[362],"mortality,":[366],"reaching":[367],"statistical":[368],"significance":[369],"Despite":[374],"this,":[375],"group":[382,443],"p=0.004;":[392],"6,":[394,417],"p=0.006),":[395],"(Days":[399],"6;":[403],"all":[404],"p\u22640.001),":[405],"p=0.017;":[413],"p<0.001).":[419],"Analysis":[420],"FPLC":[425],"fractions":[426],"demonstrated":[427],"HDL":[433],"fraction":[434],"among":[435],"3;":[448],"however,":[449],"this":[450],"difference":[451],"observed":[454],"group.":[458],"Conclusion:":[459],"Taken":[460],"together,":[461],"these":[462],"findings":[463],"identify":[464],"early":[469],"as":[472],"stable":[473],"prognostic":[474],"biomarkers":[475],"disease":[482],"severity":[483],"sepsis.":[485],"However,":[486],"unaffected":[495],"treatment,":[498],"it":[499],"appeared":[500],"modify":[502],"association":[504],"between":[505]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-17T00:00:00"}
