{"id":"https://openalex.org/W7213452691","doi":"https://doi.org/10.2478/aiht-2026-77-4146","title":"Synergistic effects of combined exposure to hydroquinone and nitrofurantoin in T24 bladder cells: an in vitro toxicology study with implications for risk assessment","display_name":"Synergistic effects of combined exposure to hydroquinone and nitrofurantoin in T24 bladder cells: an in vitro toxicology study with implications for risk assessment","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7213452691","doi":"https://doi.org/10.2478/aiht-2026-77-4146","pmid":"https://pubmed.ncbi.nlm.nih.gov/42859409","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13613164"},"language":"en","primary_location":{"id":"doi:10.2478/aiht-2026-77-4146","doi":"https://doi.org/10.2478/aiht-2026-77-4146","is_oa":true,"landing_page_url":"https://doi.org/10.2478/aiht-2026-77-4146","pdf_url":"https://reference-global.com/download/article/10.2478/aiht-2026-77-4146.pdf","source":{"id":"https://openalex.org/S65005145","display_name":"Archives of Industrial Hygiene and Toxicology","issn_l":"0004-1254","issn":["0004-1254","0375-8591","1848-6312"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Industrial Hygiene and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://reference-global.com/download/article/10.2478/aiht-2026-77-4146.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090538486","display_name":"Ana Hu\u0111ek","orcid":"https://orcid.org/0000-0002-1466-169X","observed_orcids":["https://orcid.org/0000-0002-1466-169X"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ana Hu\u0111ek Turkovi\u0107","raw_affiliation_strings":["University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066672930","display_name":"\u017deljka Stane\u010di\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405258706","display_name":"BICRO BIOCENTAR d.o.o.","ror":"https://ror.org/0135tv209","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4405258706"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"\u017deljka Stane\u010di\u0107","raw_affiliation_strings":["BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia","institution_ids":["https://openalex.org/I4405258706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035008050","display_name":"Ana Butorac","orcid":"https://orcid.org/0000-0003-3890-1472","observed_orcids":["https://orcid.org/0000-0003-3890-1472"]},"institutions":[{"id":"https://openalex.org/I4405258706","display_name":"BICRO BIOCENTAR d.o.o.","ror":"https://ror.org/0135tv209","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4405258706"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ana Butorac","raw_affiliation_strings":["BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia","Selvita Ltd. , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia","institution_ids":["https://openalex.org/I4405258706"]},{"raw_affiliation_string":"Selvita Ltd. , Zagreb , Croatia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013855489","display_name":"Vilena Ka\u0161uba","orcid":"https://orcid.org/0000-0002-2151-0400","observed_orcids":["https://orcid.org/0000-0002-2151-0400"]},"institutions":[{"id":"https://openalex.org/I4210147716","display_name":"Institute for Medical Research and Occupational Health","ror":"https://ror.org/052zr0n46","country_code":"HR","type":"facility","lineage":["https://openalex.org/I1301669915","https://openalex.org/I4210147716","https://openalex.org/I4210154156"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Vilena Ka\u0161uba","raw_affiliation_strings":["Institute for Medical Research and Occupational Health , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Research and Occupational Health , Zagreb , Croatia","institution_ids":["https://openalex.org/I4210147716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003266662","display_name":"Marijana \u0106ur\u010di\u0107","orcid":"https://orcid.org/0000-0003-4028-3108","observed_orcids":["https://orcid.org/0000-0003-4028-3108","https://orcid.org/0000-0002-1767-4154"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Marijana \u0106ur\u010di\u0107","raw_affiliation_strings":["University of Belgrade Faculty of Pharmacy , Department of Toxicology \u201cAkademik Danilo Soldatovi\u0107\u201d , Belgrade , Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Belgrade Faculty of Pharmacy , Department of Toxicology \u201cAkademik Danilo Soldatovi\u0107\u201d , Belgrade , Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047068918","display_name":"Antonio Gagi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Antonio Gagi\u0107","raw_affiliation_strings":["University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067863191","display_name":"Ivana \u0160ola","orcid":"https://orcid.org/0000-0003-4668-6426","observed_orcids":["https://orcid.org/0000-0003-4668-6426"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ivana \u0160ola","raw_affiliation_strings":["University of Zagreb Faculty of Science , Department of Biology , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Science , Department of Biology , Zagreb , Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075104111","display_name":"Marija Lovri\u0107","orcid":"https://orcid.org/0000-0001-8826-2061","observed_orcids":["https://orcid.org/0000-0001-8826-2061"]},"institutions":[{"id":"https://openalex.org/I4405258706","display_name":"BICRO BIOCENTAR d.o.o.","ror":"https://ror.org/0135tv209","country_code":"HR","type":"facility","lineage":["https://openalex.org/I4405258706"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marija Lovri\u0107","raw_affiliation_strings":["BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BICRO BIOCentre Ltd., Central Laboratory , Zagreb , Croatia","institution_ids":["https://openalex.org/I4405258706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055297763","display_name":"Gordana Rusak","orcid":"https://orcid.org/0000-0002-8842-7871","observed_orcids":["https://orcid.org/0000-0002-8842-7871"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Gordana Rusak","raw_affiliation_strings":["University of Zagreb Faculty of Science , Department of Biology , Zagreb , Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Science , Department of Biology , Zagreb , Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017807926","display_name":"Ksenija Durgo","orcid":"https://orcid.org/0000-0002-9488-3873","observed_orcids":["https://orcid.org/0000-0002-9488-3873"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Ksenija Durgo","raw_affiliation_strings":["University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia"],"raw_orcid":"https://orcid.org/0000-0002-9488-3873","affiliations":[{"raw_affiliation_string":"University of Zagreb Faculty of Food Technology and Biotechnology , Zagreb , Croatia","institution_ids":["https://openalex.org/I181343428"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017807926"],"corresponding_institution_ids":["https://openalex.org/I181343428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61602865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"3","first_page":"169","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroquinone","display_name":"hydroquinone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitrofurantoin","display_name":"nitrofurantoin","score":1.0},{"id":"https://openalex.org/keywords/synergistic-toxicity","display_name":"synergistic toxicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/combined-chemical-exposure","display_name":"combined chemical exposure","score":0.7570000290870667},{"id":"https://openalex.org/keywords/t24-cells","display_name":"T24 cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8889999985694885},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.7829999923706055},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5820000171661377},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.5120000243186951},{"id":"https://openalex.org/keywords/risk-assessment","display_name":"risk assessment","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7038000226020813},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.6146000027656555},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6033999919891357},{"id":"https://openalex.org/C2777629877","wikidata":"https://www.wikidata.org/wiki/Q422669","display_name":"Nitrofurantoin","level":4,"score":0.5841000080108643},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5730000138282776},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5062000155448914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5030999779701233},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.45660001039505005},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45489999651908875},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39399999380111694},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.38109999895095825},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36640000343322754},{"id":"https://openalex.org/C2777550763","wikidata":"https://www.wikidata.org/wiki/Q419164","display_name":"Hydroquinone","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3465999960899353},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.32109999656677246},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25679999589920044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006873","descriptor_name":"Hydroquinones","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009582","descriptor_name":"Nitrofurantoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009582","descriptor_name":"Nitrofurantoin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2478/aiht-2026-77-4146","doi":"https://doi.org/10.2478/aiht-2026-77-4146","is_oa":true,"landing_page_url":"https://doi.org/10.2478/aiht-2026-77-4146","pdf_url":"https://reference-global.com/download/article/10.2478/aiht-2026-77-4146.pdf","source":{"id":"https://openalex.org/S65005145","display_name":"Archives of Industrial Hygiene and Toxicology","issn_l":"0004-1254","issn":["0004-1254","0375-8591","1848-6312"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Industrial Hygiene and Toxicology","raw_type":"journal-article"},{"id":"pmid:42859409","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42859409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arhiv za higijenu rada i toksikologiju","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13613164","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13613164/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arh Hig Rada Toksikol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bc20e00c404348cbb35523b019152ac4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bc20e00c404348cbb35523b019152ac4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za Higijenu Rada i Toksikologiju, Vol 77, Iss 3, Pp 169-181 (2026)","raw_type":"article"},{"id":"pmh:oai:farfar.pharmacy.bg.ac.rs:123456789/6614","doi":null,"is_oa":true,"landing_page_url":"https://farfar.pharmacy.bg.ac.rs/handle/123456789/6614","pdf_url":null,"source":{"id":"https://openalex.org/S7407055311","display_name":"FarFar - Pharmacy Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arhiv za higijenu rada i toksikologiju","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hrcak.srce.hr:351079","doi":null,"is_oa":true,"landing_page_url":"https://hrcak.srce.hr/351079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Issue 3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2478/aiht-2026-77-4146","doi":"https://doi.org/10.2478/aiht-2026-77-4146","is_oa":true,"landing_page_url":"https://doi.org/10.2478/aiht-2026-77-4146","pdf_url":"https://reference-global.com/download/article/10.2478/aiht-2026-77-4146.pdf","source":{"id":"https://openalex.org/S65005145","display_name":"Archives of Industrial Hygiene and Toxicology","issn_l":"0004-1254","issn":["0004-1254","0375-8591","1848-6312"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","ddh","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Industrial Hygiene and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213452691.pdf","grobid_xml":"https://content.openalex.org/works/W7213452691.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W125748176","https://openalex.org/W1929209294","https://openalex.org/W1983181105","https://openalex.org/W1996995371","https://openalex.org/W1998988938","https://openalex.org/W2027600073","https://openalex.org/W2062896439","https://openalex.org/W2067786443","https://openalex.org/W2075830408","https://openalex.org/W2089569641","https://openalex.org/W2098883242","https://openalex.org/W2103061344","https://openalex.org/W2163981954","https://openalex.org/W2565505411","https://openalex.org/W2780037255","https://openalex.org/W2924251506","https://openalex.org/W2939147992","https://openalex.org/W2947773779","https://openalex.org/W3072345956","https://openalex.org/W3151394550","https://openalex.org/W3169209665","https://openalex.org/W4210884542","https://openalex.org/W4233971050","https://openalex.org/W4243813731","https://openalex.org/W4307582512","https://openalex.org/W4309506674","https://openalex.org/W4318776473","https://openalex.org/W4366287784","https://openalex.org/W4386728322"],"related_works":["https://openalex.org/W2041825322","https://openalex.org/W2069786076","https://openalex.org/W7131666848","https://openalex.org/W2780037255","https://openalex.org/W265312356","https://openalex.org/W1968672915","https://openalex.org/W50483107","https://openalex.org/W2012482335","https://openalex.org/W2068693362","https://openalex.org/W3217314356"],"abstract_inverted_index":{"study":[0],"was":[1],"to":[2,8,23,42,52,106,120,133],"test":[3],"the":[4,76,86,144],"hypothesis":[5],"that":[6],"co-exposure":[7],"hydroquinone":[9,107,151],"and":[10,18,33,39,55,67,70,79,83,108,116,128,138,152],"nitrofurantoin":[11,109,153],"would":[12],"result":[13],"in":[14,45,62,114,154],"greater":[15],"cytotoxic,":[16],"oxidative,":[17],"genotoxic":[19,117],"effects":[20,36,118],"than":[21],"exposure":[22,41,105,159],"either":[24],"compound":[25],"alone.":[26],"To":[27],"do":[28],"that,":[29],"we":[30],"assessed":[31,74],"single":[32],"combined":[34,158],"toxic":[35],"of":[37,57,130,146,157],"two-":[38],"eight-hour":[40],"both":[43],"compounds":[44],"T24":[46],"human":[47],"bladder":[48],"carcinoma":[49],"cells":[50],"due":[51],"their":[53],"stability":[54],"retention":[56],"key":[58],"signalling":[59],"pathways":[60,131],"involved":[61],"oxidative":[63,71,134],"stress,":[64,135],"DNA":[65,136],"repair,":[66],"apoptosis.":[68],"Cytotoxicity":[69],"stress":[72],"were":[73,93],"with":[75,85],"neutral":[77],"red":[78],"2',7'-dichlorodihydrofluorescein":[80],"diacetate":[81],"assays":[82],"genotoxicity":[84],"cytokinesis-block":[87],"micronucleus":[88],"cytome":[89],"assay.":[90],"Proteomic":[91],"changes":[92],"examined":[94],"using":[95],"tandem":[96],"mass":[97,102],"tag":[98],"labelling":[99],"followed":[100],"by":[101],"spectrometry.":[103],"Combined":[104],"produced":[110],"a":[111],"synergistic":[112],"increase":[113],"cytotoxic":[115],"compared":[119],"single-compound":[121],"treatments,":[122],"including":[123],"reduced":[124],"nuclear":[125],"division":[126],"index":[127],"activation":[129],"related":[132],"damage,":[137],"proteotoxic":[139],"stress.":[140],"These":[141],"findings":[142],"highlight":[143],"importance":[145],"evaluating":[147],"interactions":[148],"between":[149],"plant-derived":[150],"risk":[155],"assessment":[156],"during":[160],"therapy.":[161]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-17T00:00:00"}