{"id":"https://openalex.org/W7213445741","doi":"https://doi.org/10.1016/j.chroma.2026.467449","title":"A DOE-optimized supercritical fluid chromatography-mass spectrometry workflow complementing liquid chromatography for comprehensive profiling of Trichoderma reesei specialized metabolism","display_name":"A DOE-optimized supercritical fluid chromatography-mass spectrometry workflow complementing liquid chromatography for comprehensive profiling of Trichoderma reesei specialized metabolism","publication_year":2026,"publication_date":"2026-09-17","ids":{"openalex":"https://openalex.org/W7213445741","doi":"https://doi.org/10.1016/j.chroma.2026.467449","pmid":"https://pubmed.ncbi.nlm.nih.gov/42804880"},"language":"en","primary_location":{"id":"doi:10.1016/j.chroma.2026.467449","doi":"https://doi.org/10.1016/j.chroma.2026.467449","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2026.467449","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.chroma.2026.467449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120795471","display_name":"Ilias El Ouar","orcid":"https://orcid.org/0009-0002-2117-3018","observed_orcids":["https://orcid.org/0009-0002-2117-3018"]},"institutions":[{"id":"https://openalex.org/I142476485","display_name":"\u00c9cole Polytechnique","ror":"https://ror.org/05hy3tk52","country_code":"FR","type":"education","lineage":["https://openalex.org/I142476485","https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I265217849","display_name":"IFP \u00c9nergies nouvelles","ror":"https://ror.org/03gcbhc33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I265217849"]},{"id":"https://openalex.org/I4210145102","display_name":"Institut Polytechnique de Paris","ror":"https://ror.org/042tfbd02","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I4405259868","display_name":"Laboratoire de Chimie Mol\u00e9culaire","ror":"https://ror.org/02w2x8s90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210128300","https://openalex.org/I4210145102","https://openalex.org/I4405259868"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ilias El Ouar","raw_affiliation_strings":["IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France; Laboratoire de Chimie Mol\u00e9culaire (LCM), CNRS UMR 9168, \u00c9cole Polytechnique, Institut Polytechnique de Paris, Route de Saclay, Palaiseau, 91128, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France; Laboratoire de Chimie Mol\u00e9culaire (LCM), CNRS UMR 9168, \u00c9cole Polytechnique, Institut Polytechnique de Paris, Route de Saclay, Palaiseau, 91128, France","institution_ids":["https://openalex.org/I142476485","https://openalex.org/I265217849","https://openalex.org/I4210145102","https://openalex.org/I4405259868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036958569","display_name":"Agn\u00e8s Le Masle","orcid":"https://orcid.org/0000-0002-1163-1233","observed_orcids":["https://orcid.org/0000-0002-1163-1233"]},"institutions":[{"id":"https://openalex.org/I265217849","display_name":"IFP \u00c9nergies nouvelles","ror":"https://ror.org/03gcbhc33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I265217849"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Agn\u00e8s Le Masle","raw_affiliation_strings":["IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France. Electronic address: agnes.le-masle@ifpen.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France. Electronic address: agnes.le-masle@ifpen.fr","institution_ids":["https://openalex.org/I265217849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052594379","display_name":"Fr\u00e9d\u00e9rique Bidard","orcid":"https://orcid.org/0000-0002-0322-5294","observed_orcids":["https://orcid.org/0000-0002-0322-5294"]},"institutions":[{"id":"https://openalex.org/I265217849","display_name":"IFP \u00c9nergies nouvelles","ror":"https://ror.org/03gcbhc33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I265217849"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique Bidard","raw_affiliation_strings":["IFP Energies nouvelles, 1-4 Avenue du Bois Pr\u00e9au, Rueil-Malmaison, 92852, France"],"raw_orcid":"https://orcid.org/0000-0002-0322-5294","affiliations":[{"raw_affiliation_string":"IFP Energies nouvelles, 1-4 Avenue du Bois Pr\u00e9au, Rueil-Malmaison, 92852, France","institution_ids":["https://openalex.org/I265217849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011300211","display_name":"Alexandra Berlioz\u2010Barbier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I265217849","display_name":"IFP \u00c9nergies nouvelles","ror":"https://ror.org/03gcbhc33","country_code":"FR","type":"facility","lineage":["https://openalex.org/I265217849"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexandra Berlioz-Barbier","raw_affiliation_strings":["IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IFP Energies nouvelles, Rond-point de l'\u00e9changeur de Solaize, BP 3, Solaize, 69360, France","institution_ids":["https://openalex.org/I265217849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001219856","display_name":"David Touboul","orcid":"https://orcid.org/0000-0003-2751-774X","observed_orcids":["https://orcid.org/0000-0003-2751-774X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I142476485","display_name":"\u00c9cole Polytechnique","ror":"https://ror.org/05hy3tk52","country_code":"FR","type":"education","lineage":["https://openalex.org/I142476485","https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I4210145102","display_name":"Institut Polytechnique de Paris","ror":"https://ror.org/042tfbd02","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I4405259868","display_name":"Laboratoire de Chimie Mol\u00e9culaire","ror":"https://ror.org/02w2x8s90","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210128300","https://openalex.org/I4210145102","https://openalex.org/I4405259868"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"David Touboul","raw_affiliation_strings":["Laboratoire de Chimie Mol\u00e9culaire (LCM), CNRS UMR 9168, \u00c9cole Polytechnique, Institut Polytechnique de Paris, Route de Saclay, Palaiseau, 91128, France"],"raw_orcid":"https://orcid.org/0000-0003-2751-774X","affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Mol\u00e9culaire (LCM), CNRS UMR 9168, \u00c9cole Polytechnique, Institut Polytechnique de Paris, Route de Saclay, Palaiseau, 91128, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I142476485","https://openalex.org/I4210145102","https://openalex.org/I4405259868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036958569"],"corresponding_institution_ids":["https://openalex.org/I265217849"],"apc_list":{"value":4040,"currency":"USD","value_usd":4040},"apc_paid":{"value":4040,"currency":"USD","value_usd":4040},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55650919,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1788","issue":null,"first_page":"467449","last_page":"467449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/supercritical-fluid-chromatography","display_name":"supercritical fluid chromatography","score":0.9039999842643738},{"id":"https://openalex.org/keywords/trichoderma-reesei","display_name":"Trichoderma reesei","score":0.9350000023841858},{"id":"https://openalex.org/keywords/fungal-secretome","display_name":"fungal secretome","score":0.9760000109672546},{"id":"https://openalex.org/keywords/specialized-metabolism","display_name":"specialized metabolism","score":0.746999979019165},{"id":"https://openalex.org/keywords/peptaibols","display_name":"peptaibols","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lipopeptides","display_name":"lipopeptides","score":0.8289999961853027},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/molecular-networking","display_name":"molecular networking","score":0.7860000133514404},{"id":"https://openalex.org/keywords/natural-product-discovery","display_name":"natural product discovery","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9591000080108643},{"id":"https://openalex.org/C2776125036","wikidata":"https://www.wikidata.org/wiki/Q2749932","display_name":"Trichoderma reesei","level":4,"score":0.8514999747276306},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7954000234603882},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5605999827384949},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.47679999470710754},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.44429999589920044},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4180999994277954},{"id":"https://openalex.org/C118419359","wikidata":"https://www.wikidata.org/wiki/Q682585","display_name":"Supercritical fluid","level":2,"score":0.4059000015258789},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4036000072956085},{"id":"https://openalex.org/C203147553","wikidata":"https://www.wikidata.org/wiki/Q332584","display_name":"Supercritical fluid chromatography","level":3,"score":0.392300009727478},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.30820000171661377},{"id":"https://openalex.org/C116817701","wikidata":"https://www.wikidata.org/wiki/Q5955221","display_name":"Hydrophilic interaction chromatography","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000089282","descriptor_name":"Secretome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006999","descriptor_name":"Hypocreales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006999","descriptor_name":"Hypocreales","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014242","descriptor_name":"Trichoderma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025924","descriptor_name":"Chromatography, Supercritical Fluid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056148","descriptor_name":"Chromatography, Reverse-Phase","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.chroma.2026.467449","doi":"https://doi.org/10.1016/j.chroma.2026.467449","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2026.467449","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},{"id":"pmid:42804880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42804880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of chromatography. A","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05777743v1","doi":null,"is_oa":true,"landing_page_url":"https://ifp.hal.science/hal-05777743","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Chromatography A, 2026, 1788, pp.467449. &#x27E8;10.1016/j.chroma.2026.467449&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.chroma.2026.467449","doi":"https://doi.org/10.1016/j.chroma.2026.467449","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chroma.2026.467449","pdf_url":null,"source":{"id":"https://openalex.org/S176136234","display_name":"Journal of Chromatography A","issn_l":"0021-9673","issn":["0021-9673","1873-3778"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Chromatography A","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322219","display_name":"IFP Energies Nouvelles","ror":"https://ror.org/03gcbhc33"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1857427934","https://openalex.org/W1987332056","https://openalex.org/W2063975178","https://openalex.org/W2419653649","https://openalex.org/W2751617862","https://openalex.org/W2806348584","https://openalex.org/W2808489521","https://openalex.org/W2897178933","https://openalex.org/W2905340019","https://openalex.org/W2967295860","https://openalex.org/W3036056676","https://openalex.org/W3087408956","https://openalex.org/W3104880653","https://openalex.org/W3168565641","https://openalex.org/W3185575514","https://openalex.org/W3208732044","https://openalex.org/W4200326115","https://openalex.org/W4283528325","https://openalex.org/W4386531953","https://openalex.org/W4389101526","https://openalex.org/W4412097888","https://openalex.org/W4417305182","https://openalex.org/W7129486005"],"related_works":["https://openalex.org/W2897069169","https://openalex.org/W2562096027","https://openalex.org/W3023927016","https://openalex.org/W2112245103","https://openalex.org/W2344851651","https://openalex.org/W1968868735","https://openalex.org/W2806348584","https://openalex.org/W2329874553","https://openalex.org/W3104770659","https://openalex.org/W2967295860"],"abstract_inverted_index":{"Fungal":[0],"secretomes":[1],"are":[2,34],"prolific":[3],"sources":[4],"of":[5,50,69,149,165,192,221],"structurally":[6,115],"diverse":[7],"bioactive":[8,222],"natural":[9,223],"products,":[10],"including":[11],"peptaibols,":[12],"lipopeptides,":[13],"and":[14,48,92,111,138,201,213],"polar":[15,31,142],"metabolites.":[16],"Their":[17],"chemical":[18,93,190,208],"complexity":[19],"makes":[20],"comprehensive":[21],"untargeted":[22,66],"profiling":[23,68],"a":[24,51,70,147,215],"persistent":[25],"analytical":[26,90],"challenge,":[27],"particularly":[28,118],"for":[29,64,218],"highly":[30,141],"compounds":[32,145],"that":[33,153,163,198],"poorly":[35],"retained":[36],"in":[37,109,210],"conventional":[38],"reversed-phase":[39],"liquid":[40],"chromatography":[41,54],"(RPLC).":[42],"This":[43],"study":[44],"presents":[45],"the":[46,65,120,177,188,193,206,219],"development":[47],"optimization":[49],"supercritical":[52],"fluid":[53],"(SFC)":[55],"method":[56,77],"coupled":[57],"to":[58,81,86,107,125,186],"high-resolution":[59],"tandem":[60],"mass":[61],"spectrometry":[62],"(HRMS/MS)":[63],"metabolite":[67,100],"Trichoderma":[71],"reesei":[72],"secretome":[73],"extract.":[74],"The":[75],"SFC":[76,200],"was":[78,184],"systematically":[79],"compared":[80,106],"an":[82],"established":[83],"RPLCHRMS/MS":[84],"workflow":[85],"evaluate":[87],"their":[88],"respective":[89],"performances":[91],"space":[94,209],"coverage.":[95],"RPLC":[96,157,171,202],"demonstrated":[97],"superior":[98],"overall":[99],"detectability,":[101],"with":[102],"3726":[103],"features":[104,167],"detected":[105],"2301":[108],"SFC,":[110,130],"excelled":[112],"at":[113],"resolving":[114],"related":[116],"isomers,":[117],"within":[119],"peptaibol":[121],"class":[122],"where":[123],"up":[124],"six":[126],"isomers":[127],"were":[128,168],"baseline-separated.":[129],"by":[131],"contrast,":[132],"provided":[133],"complementary":[134],"class-specific":[135],"retention":[136],"behavior":[137],"uniquely":[139],"revealed":[140],"amino":[143],"sugar-like":[144],"alongside":[146],"series":[148],"14-residue":[150],"harzianine-like":[151],"peptaibols":[152],"remained":[154],"undetected":[155],"under":[156],"conditions.":[158],"Molecular":[159],"networking":[160],"analysis":[161],"confirmed":[162],"43%":[164],"SFC-detected":[166],"absent":[169],"from":[170],"datasets,":[172],"demonstrating":[173],"substantial":[174],"orthogonality":[175],"between":[176],"two":[178],"separation":[179],"modes.":[180],"Neither":[181],"approach":[182],"alone":[183],"sufficient":[185],"capture":[187],"full":[189],"diversity":[191],"secretome.":[194],"These":[195],"findings":[196],"establish":[197],"integrating":[199],"workflows":[203],"substantially":[204],"expands":[205],"accessible":[207],"fungal":[211],"metabolomics":[212],"provides":[214],"robust":[216],"framework":[217],"discovery":[220],"products.":[224]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-17T00:00:00"}
