{"id":"https://openalex.org/W7213439461","doi":"https://doi.org/10.52965/001c.169123","title":"Preliminary One-Year Observational Outcomes After GPS Leukocyte-Rich Platelet-Rich Plasma Injection for Kellgren-Lawrence Grade II and III Knee Osteoarthritis: A Japanese Real-World Case Series","display_name":"Preliminary One-Year Observational Outcomes After GPS Leukocyte-Rich Platelet-Rich Plasma Injection for Kellgren-Lawrence Grade II and III Knee Osteoarthritis: A Japanese Real-World Case Series","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213439461","doi":"https://doi.org/10.52965/001c.169123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42787870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13610512"},"language":"en","primary_location":{"id":"doi:10.52965/001c.169123","doi":"https://doi.org/10.52965/001c.169123","is_oa":true,"landing_page_url":"https://doi.org/10.52965/001c.169123","pdf_url":"https://orthopedicreviews.openmedicalpublishing.org/article/169123.pdf","source":{"id":"https://openalex.org/S165997499","display_name":"Orthopedic Reviews","issn_l":"2035-8164","issn":["2035-8164","2035-8237"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://orthopedicreviews.openmedicalpublishing.org/article/169123.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009134243","display_name":"Hiroyuki Maeda","orcid":"https://orcid.org/0000-0001-7708-1660","observed_orcids":["https://orcid.org/0000-0001-7708-1660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Maeda","raw_affiliation_strings":["Yamamoto-Maeda Memorial Maeda Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yamamoto-Maeda Memorial Maeda Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035237919","display_name":"Takahiro Maeda","orcid":"https://orcid.org/0000-0003-4530-6460","observed_orcids":["https://orcid.org/0000-0003-4530-6460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takahiro Maeda","raw_affiliation_strings":["Yamamoto-Maeda Memorial Maeda Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yamamoto-Maeda Memorial Maeda Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021029765","display_name":"Mutsuhiro Maeda","orcid":"https://orcid.org/0009-0007-1791-4588","observed_orcids":["https://orcid.org/0009-0007-1791-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mutsuhiro Maeda","raw_affiliation_strings":["Yamamoto-Maeda Memorial Maeda Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yamamoto-Maeda Memorial Maeda Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1200,"currency":"USD","value_usd":1200},"apc_paid":{"value":1200,"currency":"USD","value_usd":1200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6252905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"169123","last_page":"169123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.890999972820282},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.9160000085830688},{"id":"https://openalex.org/keywords/orthobiologic-therapy","display_name":"orthobiologic therapy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.5419999957084656},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/koos","display_name":"KOOS","score":0.8360000252723694},{"id":"https://openalex.org/keywords/kellgren-lawrence-grade","display_name":"Kellgren-Lawrence grade","score":0.8240000009536743},{"id":"https://openalex.org/keywords/japanese-patients","display_name":"Japanese patients","score":0.7360000014305115},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9648000001907349},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6723999977111816},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6653000116348267},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5913000106811523},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.44350001215934753},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4025999903678894},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3840000033378601},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.322299987077713},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2779279471","wikidata":"https://www.wikidata.org/wiki/Q6421876","display_name":"Knee pain","level":4,"score":0.28369998931884766},{"id":"https://openalex.org/C527108885","wikidata":"https://www.wikidata.org/wiki/Q835153","display_name":"Physical examination","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C101265243","wikidata":"https://www.wikidata.org/wiki/Q384445","display_name":"Case series","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2635999917984009},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C60465272","wikidata":"https://www.wikidata.org/wiki/Q494478","display_name":"Range of motion","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.52965/001c.169123","doi":"https://doi.org/10.52965/001c.169123","is_oa":true,"landing_page_url":"https://doi.org/10.52965/001c.169123","pdf_url":"https://orthopedicreviews.openmedicalpublishing.org/article/169123.pdf","source":{"id":"https://openalex.org/S165997499","display_name":"Orthopedic Reviews","issn_l":"2035-8164","issn":["2035-8164","2035-8237"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Reviews","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10121811/v1","doi":"https://doi.org/10.21203/rs.3.rs-10121811/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10121811/v1","pdf_url":"https://www.researchsquare.com/article/rs-10121811/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13610512","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13610512/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13610512/pdf/orthopedicreviews_2026_18_169123.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthop Rev (Pavia)","raw_type":"Text"},{"id":"pmid:42787870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42787870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.52965/001c.169123","doi":"https://doi.org/10.52965/001c.169123","is_oa":true,"landing_page_url":"https://doi.org/10.52965/001c.169123","pdf_url":"https://orthopedicreviews.openmedicalpublishing.org/article/169123.pdf","source":{"id":"https://openalex.org/S165997499","display_name":"Orthopedic Reviews","issn_l":"2035-8164","issn":["2035-8164","2035-8237"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Orthopedic Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213439461.pdf","grobid_xml":"https://content.openalex.org/works/W7213439461.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2006050540","https://openalex.org/W2011413868","https://openalex.org/W2161736885","https://openalex.org/W2170156250","https://openalex.org/W2276644929","https://openalex.org/W2535103699","https://openalex.org/W2563112167","https://openalex.org/W2614489220","https://openalex.org/W2894509586","https://openalex.org/W3016844721","https://openalex.org/W3176564191","https://openalex.org/W3196735421","https://openalex.org/W3216974417","https://openalex.org/W4220655132","https://openalex.org/W4221035936","https://openalex.org/W4401487715"],"related_works":["https://openalex.org/W7166738898","https://openalex.org/W4306837371","https://openalex.org/W4401316338","https://openalex.org/W4210804728","https://openalex.org/W4205377795","https://openalex.org/W3137786090","https://openalex.org/W4401819319","https://openalex.org/W1540655533","https://openalex.org/W4403344917","https://openalex.org/W4402585899"],"abstract_inverted_index":{"Background:":[0],"Platelet-rich":[1],"plasma":[2,94],"(PRP)":[3,95],"is":[4],"used":[5,148],"as":[6,159,346],"an":[7,104,194],"orthobiologic":[8],"injection":[9,23,58,326],"therapy":[10],"for":[11],"knee":[12,68,86],"osteoarthritis":[13,87],"(OA),":[14],"but":[15,288],"reported":[16],"outcomes":[17,50,173],"vary":[18],"according":[19],"to":[20,149,202,236,250,264,275],"PRP":[21,37,57,325,363],"formulation,":[22],"protocol,":[24],"comparator,":[25],"and":[26,117,134,143,153,177,185,216,283,306,333,350],"patient":[27],"selection.":[28],"Real-world":[29],"data":[30],"describing":[31],"the":[32,98,121,223],"Zimmer":[33],"Biomet":[34],"GPS":[35,55,91,106,196,323],"leukocyte-rich":[36,56,92,324],"system":[38],"in":[39,59,169,222,300,309],"Japanese":[40],"clinical":[41],"practice":[42],"remain":[43],"limited.":[44],"Purpose:":[45],"To":[46],"describe":[47],"1-year":[48,123,135,203,208],"patient-reported":[49],"after":[51],"a":[52,160],"single":[53],"intra-articular":[54],"patients":[60,77,219],"with":[61,78,131,193,329,361],"Kellgren-Lawrence":[62,80],"(KL)":[63,81],"grade":[64,82],"II":[65,83],"or":[66,84,205,355],"III":[67,85],"OA.":[69],"Methods:":[70],"This":[71],"retrospective":[72,320],"single-center":[73],"case":[74,321],"series":[75],"included":[76,128,174,221],"symptomatic":[79],"(OA)":[88],"who":[89],"underwent":[90],"platelet-rich":[93],"injection.":[96],"During":[97],"study":[99],"period,":[100],"20":[101,190],"patients/knees":[102,191],"received":[103],"initial":[105,195],"L-PRP":[107,197],"injection;":[108],"5":[109,199,214],"could":[110],"not":[111,157,290],"be":[112,344],"followed":[113],"at":[114,234,240,338],"1":[115,241,339],"year":[116,242],"were":[118,147,200,220],"excluded":[119],"from":[120,213,230,260],"paired":[122,132,225],"analysis.":[124,226],"The":[125,164],"final":[126,224],"analysis":[127],"15":[129,211,303,312],"knees":[130,212,304,313],"baseline":[133,151,235],"numeric":[136],"rating":[137],"scale":[138],"(NRS)":[139],"pain":[140,228,297,307,332],"data.":[141],"Radiography":[142],"magnetic":[144],"resonance":[145],"imaging":[146],"support":[150],"diagnosis":[152],"eligibility;":[154],"MRI":[155],"was":[156,167,327],"analyzed":[158],"longitudinal":[161],"structural":[162],"outcome.":[163],"primary":[165],"outcome":[166,209],"change":[168],"NRS":[170,227,296,331],"pain.":[171],"Secondary":[172],"Knee":[175],"injury":[176],"Osteoarthritis":[178],"Outcome":[179],"Score":[180],"(KOOS),":[181],"Locomo-25,":[182],"responder":[183],"status,":[184],"adverse":[186],"events.":[187],"Results:":[188],"Of":[189],"treated":[192],"injection,":[198],"lost":[201],"follow-up":[204],"had":[206],"unavailable":[207],"data;":[210],"male":[215],"10":[217],"female":[218],"improved":[229,259,330],"4.6":[231],"\u00b1":[232,238,262,266],"2.4":[233],"2.7":[237],"2.1":[239],"(mean":[243,268],"change,":[244,269],"-1.9":[245],"points;":[246,271],"95%":[247,272],"CI,":[248,273],"-3.4":[249],"-0.4;":[251],"P":[252,277],"=":[253,278],"0.015).":[254],"KOOS":[255,281,334],"quality":[256,335],"of":[257,302,311,336],"life":[258,337],"30.0":[261],"17.1":[263],"45.4":[265],"23.8":[267],"15.4":[270],"4.8":[274],"26.0;":[276],"0.010).":[279],"Other":[280],"domains":[282],"Locomo-25":[284],"showed":[285],"numerical":[286],"improvement":[287],"did":[289],"reach":[291],"statistical":[292],"significance.":[293],"A":[294],"\u226530%":[295],"reduction":[298],"occurred":[299],"7":[301],"(46.7%),":[305],"worsened":[308],"2":[310],"(13.3%).":[314],"Conclusions:":[315],"In":[316],"this":[317],"small":[318],"uncontrolled":[319],"series,":[322],"associated":[328],"year.":[340],"These":[341],"findings":[342],"should":[343],"interpreted":[345],"preliminary":[347],"observational":[348],"associations":[349],"cannot":[351],"establish":[352],"treatment":[353],"efficacy":[354],"safety.":[356],"Larger":[357],"prospective":[358],"controlled":[359],"studies":[360],"standardized":[362],"characterization":[364],"are":[365],"needed.":[366]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-17T00:00:00"}
