{"id":"https://openalex.org/W7213414690","doi":"https://doi.org/10.64898/2026.09.15.26363103","title":"A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (The DIGICHOL randomised controlled trial)","display_name":"A self-guided digital health application for LDL-cholesterol reduction in adults with hypercholesterolaemia (The DIGICHOL randomised controlled trial)","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213414690","doi":"https://doi.org/10.64898/2026.09.15.26363103"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.26363103","doi":"https://doi.org/10.64898/2026.09.15.26363103","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363103","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/16/2026.09.15.26363103.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/16/2026.09.15.26363103.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014151756","display_name":"Antje Riepenhausen","orcid":"https://orcid.org/0000-0001-8749-5349","observed_orcids":["https://orcid.org/0000-0001-8749-5349"]},"institutions":[{"id":"https://openalex.org/I4210140536","display_name":"GAIA (Germany)","ror":"https://ror.org/04rmmk750","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210140536"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Antje Riepenhausen","raw_affiliation_strings":["GAIA AG, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8749-5349","affiliations":[{"raw_affiliation_string":"GAIA AG, Hamburg, Germany","institution_ids":["https://openalex.org/I4210140536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151913237","display_name":"Clara Ekerdt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140536","display_name":"GAIA (Germany)","ror":"https://ror.org/04rmmk750","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210140536"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clara Ekerdt","raw_affiliation_strings":["GAIA AG, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GAIA AG, Hamburg, Germany","institution_ids":["https://openalex.org/I4210140536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013811958","display_name":"Bj\u00f6rn Meyer","orcid":"https://orcid.org/0000-0003-1100-0260","observed_orcids":["https://orcid.org/0000-0003-1100-0260"]},"institutions":[{"id":"https://openalex.org/I4210140536","display_name":"GAIA (Germany)","ror":"https://ror.org/04rmmk750","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210140536"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Meyer","raw_affiliation_strings":["GAIA AG, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GAIA AG, Hamburg, Germany","institution_ids":["https://openalex.org/I4210140536"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064118281","display_name":"Kamila Jauch\u2010Chara","orcid":"https://orcid.org/0000-0002-3597-6367","observed_orcids":["https://orcid.org/0000-0002-3597-6367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamila Jauch-Chara","raw_affiliation_strings":["Vincera Kliniken, Bad Waldsee, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vincera Kliniken, Bad Waldsee, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014151756"],"corresponding_institution_ids":["https://openalex.org/I4210140536"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.1688999980688095,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.9169999957084656},{"id":"https://openalex.org/keywords/digital-health-applications","display_name":"digital health applications","score":0.8830000162124634},{"id":"https://openalex.org/keywords/patient-activation","display_name":"patient activation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/non-hdl-cholesterol","display_name":"non-HDL cholesterol","score":0.9509999752044678},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-management","display_name":"lipid control","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mobile-health","display_name":"mobile health","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8662999868392944},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.6310999989509583},{"id":"https://openalex.org/C2780433410","wikidata":"https://www.wikidata.org/wiki/Q5276090","display_name":"Digital health","level":3,"score":0.5134000182151794},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5102999806404114},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4828000068664551},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.46050000190734863},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.4178999960422516},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.3952000141143799},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.31200000643730164},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.30869999527931213},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C2781318095","wikidata":"https://www.wikidata.org/wiki/Q33127638","display_name":"General practice","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C71405471","wikidata":"https://www.wikidata.org/wiki/Q757012","display_name":"Quality management","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.2549999952316284},{"id":"https://openalex.org/C3020759390","wikidata":"https://www.wikidata.org/wiki/Q4880694","display_name":"Behaviour change","level":3,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.15.26363103","doi":"https://doi.org/10.64898/2026.09.15.26363103","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363103","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/16/2026.09.15.26363103.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.26363103","doi":"https://doi.org/10.64898/2026.09.15.26363103","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26363103","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/16/2026.09.15.26363103.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213414690.pdf","grobid_xml":"https://content.openalex.org/works/W7213414690.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2037624022","https://openalex.org/W2115098571","https://openalex.org/W2161698110","https://openalex.org/W2164089346","https://openalex.org/W2753742974","https://openalex.org/W2793231057","https://openalex.org/W2953804067","https://openalex.org/W2987446524","https://openalex.org/W3002166001","https://openalex.org/W3006057482","https://openalex.org/W3142840603","https://openalex.org/W3172996796","https://openalex.org/W4254230094","https://openalex.org/W4413804012","https://openalex.org/W4413963213","https://openalex.org/W4417453601","https://openalex.org/W7153219523"],"related_works":["https://openalex.org/W7214221252","https://openalex.org/W4405104657","https://openalex.org/W7148313153","https://openalex.org/W7160244868","https://openalex.org/W4389952777","https://openalex.org/W7166323957","https://openalex.org/W2706140533","https://openalex.org/W4410369087","https://openalex.org/W2753805238","https://openalex.org/W4214733368"],"abstract_inverted_index":{"Abstract":[0],"Structured":[1],"lifestyle":[2,30,140],"modification":[3],"is":[4,12,143],"the":[5],"guideline-mandated":[6],"foundation":[7],"of":[8,94,114,137],"lipid":[9],"management":[10],"but":[11],"rarely":[13,144],"delivered":[14],"in":[15,32,76,146],"routine":[16,147],"care.":[17,148],"We":[18],"evaluated":[19],"lipodia":[20,57,65,104,130],",":[21],"a":[22,33,90,127,132],"fully":[23],"self-guided":[24,128],"digital":[25],"health":[26],"application":[27],"providing":[28],"structured":[29,139],"support,":[31],"pragmatic":[34],"randomised":[35,51],"controlled":[36],"trial":[37],"conducted":[38],"online.":[39],"Adults":[40],"with":[41,83,116],"LDL-cholesterol":[42,68],"above":[43],"their":[44],"risk-adapted":[45],"target":[46],"(n":[47],"=":[48,81,102],"278)":[49],"were":[50],"1:1":[52],"to":[53,70],"usual":[54,59,71],"care":[55,60,72],"plus":[56],"or":[58],"alone.":[61],"After":[62],"six":[63],"months,":[64],"significantly":[66,106],"reduced":[67],"relative":[69,77],"(adjusted":[73],"between-group":[74],"difference":[75],"change":[78],"\u22123.9%;":[79],"p":[80,101],"0.029),":[82],"nearly":[84],"twice":[85],"as":[86],"many":[87],"users":[88],"achieving":[89],"clinically":[91],"meaningful":[92],"reduction":[93],"at":[95],"least":[96],"10%":[97],"(41.7%":[98],"versus":[99],"23.8%;":[100],"0.002).":[103],"also":[105],"improved":[107],"patient":[108],"activation,":[109],"non-HDL-cholesterol,":[110],"and":[111,121,134],"health-related":[112],"quality":[113],"life,":[115],"high":[117],"uptake,":[118],"low":[119],"attrition,":[120],"no":[122],"adverse":[123],"device":[124],"effects.":[125],"As":[126],"tool,":[129],"provides":[131],"scalable":[133],"guideline-concordant":[135],"means":[136],"delivering":[138],"support":[141],"that":[142],"available":[145]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-17T00:00:00"}
