{"id":"https://openalex.org/W7213408035","doi":"https://doi.org/10.64898/2026.09.14.750986","title":"Extraocular Photoreception Controls Nocturnal Hatching via a Neuroendocrine Pathway in False Clownfish","display_name":"Extraocular Photoreception Controls Nocturnal Hatching via a Neuroendocrine Pathway in False Clownfish","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213408035","doi":"https://doi.org/10.64898/2026.09.14.750986"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.14.750986","doi":"https://doi.org/10.64898/2026.09.14.750986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750986","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.14.750986","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022418578","display_name":"Sakuto Yamanaka","orcid":"https://orcid.org/0000-0001-7309-0762","observed_orcids":["https://orcid.org/0000-0001-7309-0762"]},"institutions":[{"id":"https://openalex.org/I168356945","display_name":"Kyoto Sangyo University","ror":"https://ror.org/05t70xh16","country_code":"JP","type":"education","lineage":["https://openalex.org/I168356945"]},{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Sakuto Yamanaka","raw_affiliation_strings":["Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan","Faculty of Life Sciences, Kyoto Sangyo University Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7309-0762","affiliations":[{"raw_affiliation_string":"Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Faculty of Life Sciences, Kyoto Sangyo University Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan","institution_ids":["https://openalex.org/I168356945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084042493","display_name":"Takahiro Yamashita","orcid":"https://orcid.org/0000-0002-7956-9288","observed_orcids":["https://orcid.org/0000-0002-7956-9288"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Yamashita","raw_affiliation_strings":["Department of Biophysics, Graduate School of Science, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7956-9288","affiliations":[{"raw_affiliation_string":"Department of Biophysics, Graduate School of Science, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056581623","display_name":"Yasuhiro Kamei","orcid":"https://orcid.org/0000-0001-6382-1365","observed_orcids":["https://orcid.org/0000-0001-6382-1365"]},"institutions":[{"id":"https://openalex.org/I138804964","display_name":"National Institute for Basic Biology","ror":"https://ror.org/05q8wtt20","country_code":"JP","type":"education","lineage":["https://openalex.org/I1319490839","https://openalex.org/I138804964","https://openalex.org/I199525922"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kamei","raw_affiliation_strings":["Trans-Scale Biology Center, National Institute for Basic Biology 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6382-1365","affiliations":[{"raw_affiliation_string":"Trans-Scale Biology Center, National Institute for Basic Biology 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan","institution_ids":["https://openalex.org/I138804964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086601107","display_name":"Hiroyuki Takeda","orcid":"https://orcid.org/0000-0002-7932-6358","observed_orcids":["https://orcid.org/0000-0002-7932-6358"]},"institutions":[{"id":"https://openalex.org/I168356945","display_name":"Kyoto Sangyo University","ror":"https://ror.org/05t70xh16","country_code":"JP","type":"education","lineage":["https://openalex.org/I168356945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Takeda","raw_affiliation_strings":["Faculty of Life Sciences, Kyoto Sangyo University Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7932-6358","affiliations":[{"raw_affiliation_string":"Faculty of Life Sciences, Kyoto Sangyo University Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan","institution_ids":["https://openalex.org/I168356945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151878030","display_name":"Takashi Yamanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Yamanaka","raw_affiliation_strings":["Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083163427","display_name":"Masato Kinoshita","orcid":"https://orcid.org/0000-0003-3936-7371","observed_orcids":["https://orcid.org/0000-0003-3936-7371"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Kinoshita","raw_affiliation_strings":["Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3936-7371","affiliations":[{"raw_affiliation_string":"Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022418578"],"corresponding_institution_ids":["https://openalex.org/I168356945","https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.45969998836517334,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.20080000162124634,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hatching","display_name":"hatching","score":0.5170000195503235},{"id":"https://openalex.org/keywords/extraocular-photoreception","display_name":"extraocular photoreception","score":0.8059999942779541},{"id":"https://openalex.org/keywords/amphiprion-ocellaris","display_name":"Amphiprion ocellaris","score":0.8999999761581421},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone","display_name":"thyrotropin-releasing hormone","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hatching-gland","display_name":"hatching gland","score":0.7540000081062317},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hatching-enzyme","display_name":"hatching enzyme","score":0.875},{"id":"https://openalex.org/keywords/opsin-expression","display_name":"opsin expression","score":0.6669999957084656},{"id":"https://openalex.org/keywords/neuroendocrine-regulation","display_name":"neuroendocrine regulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/larval-development","display_name":"larval development","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2777744765","wikidata":"https://www.wikidata.org/wiki/Q2734755","display_name":"Hatching","level":2,"score":0.9182999730110168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8756999969482422},{"id":"https://openalex.org/C30028475","wikidata":"https://www.wikidata.org/wiki/Q24785022","display_name":"Opsin","level":4,"score":0.5085999965667725},{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4821999967098236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47440001368522644},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4733000099658966},{"id":"https://openalex.org/C70055658","wikidata":"https://www.wikidata.org/wiki/Q212306","display_name":"Oviparity","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.421999990940094},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.4032999873161316},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.39010000228881836},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3894999921321869},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36629998683929443},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.33469998836517334},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C55969652","wikidata":"https://www.wikidata.org/wiki/Q259028","display_name":"photoperiodism","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C2776201343","wikidata":"https://www.wikidata.org/wiki/Q1348685","display_name":"Oreochromis mossambicus","level":4,"score":0.29490000009536743},{"id":"https://openalex.org/C2910755853","wikidata":"https://www.wikidata.org/wiki/Q17130203","display_name":"Light Cycle","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C132107708","wikidata":"https://www.wikidata.org/wiki/Q1420425","display_name":"Fish kill","level":5,"score":0.2667999863624573},{"id":"https://openalex.org/C74167732","wikidata":"https://www.wikidata.org/wiki/Q504699","display_name":"Chromatophore","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C144543706","wikidata":"https://www.wikidata.org/wiki/Q85754737","display_name":"Cryptochrome","level":4,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.14.750986","doi":"https://doi.org/10.64898/2026.09.14.750986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750986","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.14.750986","doi":"https://doi.org/10.64898/2026.09.14.750986","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.750986","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5769000053405762}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1439212495","https://openalex.org/W1895588006","https://openalex.org/W1964097117","https://openalex.org/W1968816970","https://openalex.org/W1970474210","https://openalex.org/W1987489059","https://openalex.org/W1987549356","https://openalex.org/W1988918145","https://openalex.org/W1999574084","https://openalex.org/W2020456776","https://openalex.org/W2023716724","https://openalex.org/W2045949302","https://openalex.org/W2053573702","https://openalex.org/W2059988027","https://openalex.org/W2062018285","https://openalex.org/W2071851964","https://openalex.org/W2080219886","https://openalex.org/W2090016197","https://openalex.org/W2105445881","https://openalex.org/W2110564912","https://openalex.org/W2114104545","https://openalex.org/W2115888213","https://openalex.org/W2141052558","https://openalex.org/W2142524436","https://openalex.org/W2142535486","https://openalex.org/W2149014762","https://openalex.org/W2153214460","https://openalex.org/W2153687216","https://openalex.org/W2159496605","https://openalex.org/W2160378127","https://openalex.org/W2169456326","https://openalex.org/W2171332611","https://openalex.org/W2444121280","https://openalex.org/W2777297529","https://openalex.org/W2794593985","https://openalex.org/W2896032834","https://openalex.org/W2951912016","https://openalex.org/W2956515875","https://openalex.org/W3156878319","https://openalex.org/W3159601220","https://openalex.org/W3192056904","https://openalex.org/W3214001176","https://openalex.org/W4200425121","https://openalex.org/W4220771883","https://openalex.org/W4298855151","https://openalex.org/W4402483728","https://openalex.org/W4405056737","https://openalex.org/W4406020588"],"related_works":["https://openalex.org/W4402483728","https://openalex.org/W4391932571","https://openalex.org/W4405056737","https://openalex.org/W2071851964","https://openalex.org/W4405056903","https://openalex.org/W2896453653","https://openalex.org/W1904094099","https://openalex.org/W1968816970","https://openalex.org/W61437146","https://openalex.org/W2126043193"],"abstract_inverted_index":{"Abstract":[0],"Hatching":[1],"is":[2,58],"the":[3,17,25,70,78,95,129,179,187,221],"transition":[4,204],"from":[5],"embryo":[6],"to":[7,112,167,195],"larva":[8],"in":[9,107,119,158,178,212,226],"oviparous":[10],"animals.":[11],"Birds,":[12],"reptiles,":[13],"and":[14,22,32,52,109,172],"insects":[15],"rupture":[16],"eggshell":[18],"mechanically,":[19],"whereas":[20],"fish":[21],"amphibians":[23],"digest":[24],"egg":[26],"envelope":[27],"using":[28,44],"hatching":[29,42,57,66,103,120,156],"enzymes.":[30],"When":[31],"where":[33,114],"larvae":[34,210],"emerge":[35],"influences":[36],"their":[37],"fitness.":[38],"Many":[39],"species":[40],"regulate":[41],"timing":[43],"environmental":[45],"cues,":[46],"such":[47],"as":[48,101,133],"light,":[49],"oxygen":[50],"availability,":[51],"physical":[53],"stimuli.":[54],"In":[55,141],"fish,":[56],"driven":[59],"by":[60,151],"a":[61,102,134,196,201],"neuroendocrine":[62,198],"event":[63,74],"that":[64,94,217],"triggers":[65],"enzyme":[67,131],"secretion;":[68],"however,":[69],"mechanisms":[71],"controlling":[72],"this":[73,143,224],"are":[75],"unknown.":[76],"Using":[77],"false":[79],"clownfish":[80],"Amphiprion":[81],"ocellaris":[82],",":[83,127],"which":[84],"hatches":[85],"synchronously":[86],"within":[87],"1\u20132":[88],"h":[89],"after":[90],"sunset,":[91],"we":[92],"showed":[93],"role":[96],"of":[97,138,189,223],"thyrotropin-releasing":[98],"hormone":[99],"(TRH)":[100],"hormone,":[104],"previously":[105],"established":[106],"zebrafish":[108],"medaka,":[110],"extended":[111],"clownfish,":[113,142],"TRH":[115],"activated":[116],"Ca\u00b2\u207a":[117],"signaling":[118],"gland":[121],"cells":[122],"through":[123],"its":[124],"receptor":[125],"trhra":[126],"reinforcing":[128],"TRH\u2013Ca\u00b2\u207a\u2013hatching":[130],"axis":[132],"conserved":[135,197],"core":[136],"module":[137,144,199],"teleost":[139],"hatching.":[140],"was":[145,164],"additionally":[146],"placed":[147,200],"under":[148,205],"upstream":[149],"control":[150],"extraocular":[152,193],"photoreception":[153,194],"because":[154],"dark-induced":[155],"persisted":[157],"eyeless":[159],"embryos.":[160,191],"This":[161],"photoreceptive":[162],"system":[163],"most":[165],"sensitive":[166],"green":[168],"light":[169],"(550":[170],"nm),":[171],"several":[173],"opsins":[174],"with":[175],"absorbance":[176],"maxima":[177],"corresponding":[180],"middle-to":[181],"long-wavelength":[182],"range":[183],"were":[184],"expressed":[185],"outside":[186],"eyes":[188],"pre-hatching":[190],"Coupling":[192],"critical":[202],"life-history":[203],"stringent":[206],"photic":[207],"control,":[208],"releasing":[209],"only":[211],"complete":[213],"darkness,":[214],"an":[215],"adaptation":[216],"may":[218],"have":[219],"underpinned":[220],"success":[222],"lineage":[225],"predator-rich":[227],"coral":[228],"reefs.":[229]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-17T00:00:00"}
