{"id":"https://openalex.org/W7213402182","doi":"https://doi.org/10.1093/ajrcmb/aanag179","title":"Interrogation of functional variants in COPD GWAS loci by massively parallel reporter assays","display_name":"Interrogation of functional variants in COPD GWAS loci by massively parallel reporter assays","publication_year":2026,"publication_date":"2026-09-10","ids":{"openalex":"https://openalex.org/W7213402182","doi":"https://doi.org/10.1093/ajrcmb/aanag179","pmid":"https://pubmed.ncbi.nlm.nih.gov/42745457"},"language":"en","primary_location":{"id":"doi:10.1093/ajrcmb/aanag179","doi":"https://doi.org/10.1093/ajrcmb/aanag179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajrcmb/aanag179","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151890180","display_name":"Lu Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Gong","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038148195","display_name":"Feng Guo","orcid":"https://orcid.org/0000-0002-4506-7618","observed_orcids":["https://orcid.org/0000-0002-4506-7618"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Guo","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005872181","display_name":"Divyaa Srinivasan","orcid":"https://orcid.org/0000-0003-0080-7317","observed_orcids":["https://orcid.org/0000-0003-0080-7317"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divyaa Srinivasan","raw_affiliation_strings":["Division of Pulmonary and Critical Care , Department of Medicine","University of Virginia Department of Genome Science, , Charlottesville, VA 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care , Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Virginia Department of Genome Science, , Charlottesville, VA 22903","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029228127","display_name":"Dandi Qiao","orcid":"https://orcid.org/0000-0001-9450-205X","observed_orcids":["https://orcid.org/0000-0001-9450-205X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dandi Qiao","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vidhi Malik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidhi Malik","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151921242","display_name":"Nicholaus DeCuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholaus DeCuzzi","raw_affiliation_strings":["Division of Pulmonary and Critical Care , Department of Medicine","University of Virginia Department of Genome Science, , Charlottesville, VA 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care , Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Virginia Department of Genome Science, , Charlottesville, VA 22903","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151891194","display_name":"Matthew Hegedus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Hegedus","raw_affiliation_strings":["Division of Pulmonary and Critical Care , Department of Medicine","University of Virginia Department of Genome Science, , Charlottesville, VA 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care , Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Virginia Department of Genome Science, , Charlottesville, VA 22903","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuzhen Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuzhen Yu","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015782324","display_name":"Wardatul Jannat Anamika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wardatul Jannat Anamika","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127711686","display_name":"Shreya Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shreya Mishra","raw_affiliation_strings":["Cleveland Clinic Foundation Department of Quantitative Health Sciences, Lerner Research Institute, , Cleveland, OH 44195,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation Department of Quantitative Health Sciences, Lerner Research Institute, , Cleveland, OH 44195,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151880420","display_name":"Christopher Benway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Benway","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102766810","display_name":"Jiangyuan Liu","orcid":"https://orcid.org/0000-0001-8467-857X","observed_orcids":["https://orcid.org/0000-0001-8467-857X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiangyuan Liu","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123091607","display_name":"JunYi Duan","orcid":"https://orcid.org/0009-0007-7873-1822","observed_orcids":["https://orcid.org/0009-0007-7873-1822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyi Duan","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060010965","display_name":"Yihan Zhou","orcid":"https://orcid.org/0000-0002-6970-065X","observed_orcids":["https://orcid.org/0000-0002-6970-065X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yihan Zhou","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151916280","display_name":"Ming Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Hu","raw_affiliation_strings":["Cleveland Clinic Foundation Department of Quantitative Health Sciences, Lerner Research Institute, , Cleveland, OH 44195,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation Department of Quantitative Health Sciences, Lerner Research Institute, , Cleveland, OH 44195,","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018495347","display_name":"Michael H. Cho","orcid":"https://orcid.org/0000-0002-4907-1657","observed_orcids":["https://orcid.org/0000-0002-4907-1657"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H Cho","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K Silverman","raw_affiliation_strings":["Channing Division of Network Medicine , Brigham and Women's Hospital","Harvard Medical School , Boston, MA 02115,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Division of Network Medicine , Brigham and Women's Hospital","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School , Boston, MA 02115,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110919558","display_name":"Anny Xiaobo Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anny Xiaobo Zhou","raw_affiliation_strings":["Division of Pulmonary and Critical Care , Department of Medicine","University of Virginia Department of Genome Science, , Charlottesville, VA 22903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care , Department of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Virginia Department of Genome Science, , Charlottesville, VA 22903","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7795523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09920000284910202,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gwas-loci","display_name":"GWAS loci","score":0.8379999995231628},{"id":"https://openalex.org/keywords/functional-variants","display_name":"functional variants","score":0.7329999804496765},{"id":"https://openalex.org/keywords/regulatory-variants","display_name":"regulatory variants","score":0.7049999833106995},{"id":"https://openalex.org/keywords/massively-parallel-reporter-assay","display_name":"massively parallel reporter assay","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ruvbl1","display_name":"RUVBL1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/rab7","display_name":"Rab7","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fam13a","display_name":"FAM13A","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allele-specific-effects","display_name":"allele-specific effects","score":0.5929999947547913},{"id":"https://openalex.org/keywords/h3k27ac","display_name":"H3K27ac","score":0.7319999933242798},{"id":"https://openalex.org/keywords/open-chromatin","display_name":"open chromatin","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7960000038146973},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/crispr-interference","display_name":"CRISPR interference","score":0.7910000085830688},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.597000002861023},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7703999876976013},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6827999949455261},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6380000114440918},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6098999977111816},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5990999937057495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5681999921798706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5443999767303467},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5414000153541565},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4066999852657318},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.39480000734329224},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3837999999523163},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.3700999915599823},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.3675999939441681},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.34779998660087585},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.33799999952316284},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.31929999589920044},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3001999855041504},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.2946000099182129},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2888000011444092},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.26980000734329224},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.2619999945163727},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2563000023365021},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ajrcmb/aanag179","doi":"https://doi.org/10.1093/ajrcmb/aanag179","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajrcmb/aanag179","pdf_url":null,"source":{"id":"https://openalex.org/S171155024","display_name":"American Journal of Respiratory Cell and Molecular Biology","issn_l":"1044-1549","issn":["1044-1549","1535-4989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Respiratory Cell and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:42745457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42745457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5507485866546631}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"RATIONALE:":[0],"Genome-wide":[1],"association":[2],"study":[3],"(GWAS)":[4],"loci":[5,70,216],"often":[6],"contain":[7],"many":[8],"linked":[9,226],"variants,":[10],"making":[11],"it":[12],"difficult":[13],"to":[14,32,62,105,143,228],"determine":[15],"which":[16],"variant":[17],"is":[18],"functionally":[19],"relevant.":[20],"Massively":[21],"parallel":[22],"reporter":[23,94],"assays":[24],"(MPRA)":[25],"allow":[26],"experimental":[27],"testing":[28],"of":[29,164,168],"candidate":[30,110,148,229],"variants":[31,65,80,159,224],"identify":[33,63],"those":[34],"with":[35,160],"regulatory":[36,223],"activity.":[37],"Prior":[38],"chronic":[39],"obstructive":[40],"pulmonary":[41],"disease":[42],"(COPD)":[43],"MPRA":[44,82],"studies":[45],"have":[46],"largely":[47],"focused":[48],"on":[49],"individual":[50],"loci,":[51],"whereas":[52],"broader":[53],"multi-locus,":[54],"multi-cell-type":[55],"interrogation":[56],"remains":[57],"limited.":[58],"OBJECTIVES:":[59],"We":[60,77,112,201],"aim":[61],"functional":[64,222],"in":[66,83,127,177,191],"five":[67],"COPD":[68,209,215],"GWAS":[69],"across":[71,217],"three":[72,218],"lung-relevant":[73],"cell":[74,195,219],"types.":[75],"METHODS:":[76],"screened":[78],"1120":[79],"using":[81,135],"epithelial":[84,132],"(16HBE),":[85],"fibroblast":[86],"(MRC5),":[87],"and":[88,100,121,170,186,197,206,225],"endothelial":[89],"(HUVEC)":[90],"cells":[91,134],"followed":[92],"by":[93,125,189],"assay":[95],"validation.":[96],"Public":[97],"Hi-C,":[98],"ChIP-seq":[99],"ATAC-seq":[101],"datasets":[102],"were":[103],"analyzed":[104],"evaluate":[106],"chromatin":[107,172],"context":[108],"near":[109,173],"variants.":[111],"further":[113],"performed":[114,142],"CRISPR":[115],"interference":[116],"(CRISPRi)":[117],"targeting":[118],"variant-containing":[119],"regions":[120],"measured":[122],"gene":[123,210],"expression":[124],"RT-qPCR":[126],"primary":[128,198],"normal":[129],"human":[130],"bronchial":[131],"(NHBE)":[133],"two":[136,182],"gRNAs":[137],"per":[138],"variant.":[139],"Co-immunoprecipitation":[140],"was":[141,175],"test":[144],"interaction":[145,203],"between":[146,204],"selected":[147],"genes.":[149],"MEASUREMENTS":[150],"AND":[151],"MAIN":[152],"RESULTS:":[153],"In":[154],"MPRA,":[155],"we":[156],"identified":[157,181,221],"25":[158],"allele-specific":[161],"effects":[162],"(\u223c2%":[163],"tested":[165],"variants).":[166],"Enrichment":[167],"H3K27Ac":[169],"open":[171],"rs35421223":[174,190],"detected":[176,202],"16HBE":[178,194],"cells.":[179,200],"CRISPRi":[180],"SNP-gene":[183],"pairs,":[184],"RUVBL1":[185,205],"RAB7A":[187],"regulated":[188],"both":[192],"the":[193,207],"line":[196],"NHBE":[199],"known":[208],"product":[211],"FAM13A.":[212],"CONCLUSIONS:":[213],"Screening":[214],"types":[220],"them":[227],"target":[230],"genes":[231],"for":[232],"future":[233],"mechanistic":[234],"studies.":[235]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-09-17T00:00:00"}