{"id":"https://openalex.org/W7213400910","doi":"https://doi.org/10.55892/jrg.v9i21.3741","title":"Uso de psicod\u00e9licos no tratamento da depress\u00e3o resistente: efic\u00e1cia cl\u00ednica e perspectivas terap\u00eauticas","display_name":"Uso de psicod\u00e9licos no tratamento da depress\u00e3o resistente: efic\u00e1cia cl\u00ednica e perspectivas terap\u00eauticas","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213400910","doi":"https://doi.org/10.55892/jrg.v9i21.3741"},"language":"pt","primary_location":{"id":"doi:10.55892/jrg.v9i21.3741","doi":"https://doi.org/10.55892/jrg.v9i21.3741","is_oa":true,"landing_page_url":"https://doi.org/10.55892/jrg.v9i21.3741","pdf_url":"https://revistajrg.com/index.php/jrg/article/download/3741/3007","source":{"id":"https://openalex.org/S4220651247","display_name":"Revista JRG de Estudos Acad\u00eamicos","issn_l":"2595-1661","issn":["2595-1661"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista JRG de Estudos Acad\u00eamicos","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revistajrg.com/index.php/jrg/article/download/3741/3007","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151907625","display_name":"Monique Vieira de Moura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10824318","display_name":"Universidade Federal de Ouro Preto","ror":"https://ror.org/056s65p46","country_code":"BR","type":"education","lineage":["https://openalex.org/I10824318"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Monique Vieira de Moura","raw_affiliation_strings":["Universidade Federal de Ouro Preto (Brasil)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de Ouro Preto (Brasil)","institution_ids":["https://openalex.org/I10824318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104334830","display_name":"Heder Albuquerque Azevedo Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Heder Albuquerque Azevedo Rocha","raw_affiliation_strings":["Hospital Israelita Albert Einstein"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151891558","display_name":"M\u00e1rcio Jos\u00e9 de Carvalho Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71437568","display_name":"Universidade de Pernambuco","ror":"https://ror.org/00gtcbp88","country_code":"BR","type":"education","lineage":["https://openalex.org/I71437568"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcio Jos\u00e9 de Carvalho Lima","raw_affiliation_strings":["UPE / Hospital Geral de Areias"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPE / Hospital Geral de Areias","institution_ids":["https://openalex.org/I71437568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151829149","display_name":"Aline Christina Mendanha Medeiros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017598443","display_name":"Universidade de Franca","ror":"https://ror.org/04zyja509","country_code":"BR","type":"education","lineage":["https://openalex.org/I3017598443"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aline Christina Mendanha Medeiros","raw_affiliation_strings":["Universidade de Franca (Unifran)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade de Franca (Unifran)","institution_ids":["https://openalex.org/I3017598443"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114496363","display_name":"Isabela Caldeira Rosolen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142340749","display_name":"Universidade de Taubat\u00e9","ror":"https://ror.org/01gt7sg63","country_code":"BR","type":"education","lineage":["https://openalex.org/I142340749"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabela Caldeira Rosolen","raw_affiliation_strings":["UNITAU Universidade de Taubat\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNITAU Universidade de Taubat\u00e9","institution_ids":["https://openalex.org/I142340749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"21","first_page":"e093741","last_page":"e093741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10214","display_name":"Psychotherapy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.9430000185966492},{"id":"https://openalex.org/keywords/psychedelics","display_name":"psychedelics","score":0.9549999833106995},{"id":"https://openalex.org/keywords/psilocybin","display_name":"psilocybin","score":0.968999981880188},{"id":"https://openalex.org/keywords/ayahuasca","display_name":"ayahuasca","score":0.9929999709129333},{"id":"https://openalex.org/keywords/n-n-dimethyltryptamine","display_name":"N,N-dimethyltryptamine","score":0.972000002861023},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5979999899864197},{"id":"https://openalex.org/keywords/remission-maintenance","display_name":"remission maintenance","score":0.5820000171661377},{"id":"https://openalex.org/keywords/functional-blindness","display_name":"functional blindness","score":0.33799999952316284},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43810001015663147},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3458000123500824},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.28029999136924744},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.24779999256134033},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.24410000443458557},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.23420000076293945},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.23180000483989716},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2312999963760376}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55892/jrg.v9i21.3741","doi":"https://doi.org/10.55892/jrg.v9i21.3741","is_oa":true,"landing_page_url":"https://doi.org/10.55892/jrg.v9i21.3741","pdf_url":"https://revistajrg.com/index.php/jrg/article/download/3741/3007","source":{"id":"https://openalex.org/S4220651247","display_name":"Revista JRG de Estudos Acad\u00eamicos","issn_l":"2595-1661","issn":["2595-1661"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista JRG de Estudos Acad\u00eamicos","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55892/jrg.v9i21.3741","doi":"https://doi.org/10.55892/jrg.v9i21.3741","is_oa":true,"landing_page_url":"https://doi.org/10.55892/jrg.v9i21.3741","pdf_url":"https://revistajrg.com/index.php/jrg/article/download/3741/3007","source":{"id":"https://openalex.org/S4220651247","display_name":"Revista JRG de Estudos Acad\u00eamicos","issn_l":"2595-1661","issn":["2595-1661"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["erih-plus","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista JRG de Estudos Acad\u00eamicos","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213400910.pdf","grobid_xml":"https://content.openalex.org/works/W7213400910.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2396675581","https://openalex.org/W2767530231","https://openalex.org/W2952169207","https://openalex.org/W3118615836","https://openalex.org/W4308146982","https://openalex.org/W4386765496","https://openalex.org/W4391810199","https://openalex.org/W4393359395","https://openalex.org/W4396699590","https://openalex.org/W4398195443","https://openalex.org/W4405376152","https://openalex.org/W4405955624","https://openalex.org/W4409638088","https://openalex.org/W4414745551","https://openalex.org/W7123039939","https://openalex.org/W7138853109","https://openalex.org/W7138880159","https://openalex.org/W7154469221","https://openalex.org/W7162570449","https://openalex.org/W7196979420"],"related_works":["https://openalex.org/W7135068628","https://openalex.org/W7014752098","https://openalex.org/W7125016393","https://openalex.org/W7133187773","https://openalex.org/W4402840510","https://openalex.org/W4405432594","https://openalex.org/W4415700928","https://openalex.org/W4393521003","https://openalex.org/W7155171938","https://openalex.org/W7024099526"],"abstract_inverted_index":{"A":[0,146],"depress\u00e3o":[1],"resistente":[2],"ao":[3],"tratamento":[4],"(DRT)":[5],"representa":[6],"uma":[7,41],"condi\u00e7\u00e3o":[8],"de":[9,36,90,94,96,119,132,134,209,214,241],"elevada":[10],"carga":[11],"cl\u00ednica":[12,232],"e":[13,62,84,181,212,238,243,248],"funcional,":[14,204],"usualmente":[15],"definida":[16],"pela":[17],"resposta":[18],"inadequada":[19],"a":[20,92,128,149,221,230],"pelo":[21],"menos":[22],"dois":[23],"tratamentos":[24],"antidepressivos":[25,38,185],"adequados.":[26],"O":[27,48],"interesse":[28],"por":[29],"psicod\u00e9licos":[30,66,115],"cl\u00e1ssicos":[31],"ressurgiu":[32],"diante":[33],"da":[34,72,167],"possibilidade":[35],"efeitos":[37],"r\u00e1pidos":[39,186],"ap\u00f3s":[40],"ou":[42,113,121],"poucas":[43],"administra\u00e7\u00f5es":[44],"em":[45,103,187,196,207,245],"contexto":[46],"supervisionado.":[47],"objetivo":[49],"desta":[50],"revis\u00e3o":[51,70],"foi":[52],"sintetizar":[53],"criticamente":[54],"as":[55],"evid\u00eancias":[56],"cl\u00ednicas":[57],"sobre":[58,202],"efic\u00e1cia,":[59],"durabilidade,":[60,142],"seguran\u00e7a":[61,206,244],"perspectivas":[63],"terap\u00eauticas":[64],"dos":[65],"na":[67,227],"DRT.":[68],"Realizou-se":[69],"integrativa":[71],"literatura,":[73],"com":[74,105,117],"busca":[75],"estruturada":[76,237],"nas":[77],"bases":[78],"PubMed/MEDLINE,":[79],"Scopus,":[80],"Web":[81],"of":[82],"Science":[83],"APA":[85],"PsycINFO,":[86],"abrangendo":[87],"estudos":[88,100,124,161,188,246],"publicados":[89],"2016":[91],"10":[93],"setembro":[95],"2026.":[97],"Foram":[98],"eleg\u00edveis":[99],"cl\u00ednicos":[101,125],"prim\u00e1rios":[102,126],"adultos":[104],"DRT":[106],"que":[107,217],"avaliaram":[108],"psilocibina,":[109,222],"ayahuasca,":[110],"N,N-dimetiltriptamina":[111],"(DMT)":[112],"outros":[114],"cl\u00e1ssicos,":[116],"desfechos":[118],"efic\u00e1cia":[120,242],"seguran\u00e7a.":[122],"Nove":[123],"compuseram":[127],"s\u00edntese":[129],"principal;":[130],"publica\u00e7\u00f5es":[131],"seguimento":[133],"coortes":[135],"j\u00e1":[136],"inclu\u00eddas":[137],"foram":[138,193],"analisadas":[139],"apenas":[140],"para":[141],"sem":[143],"dupla":[144],"contagem.":[145],"psilocibina":[147],"concentrou":[148],"evid\u00eancia":[150],"mais":[151],"robusta,":[152],"embora":[153],"os":[154,218],"ensaios":[155],"n\u00e3o":[156,174],"tenham":[157],"sido":[158],"uniformemente":[159],"positivos:":[160],"controlados":[162],"demonstraram":[163],"redu\u00e7\u00f5es":[164],"clinicamente":[165],"relevantes":[166],"gravidade":[168],"depressiva,":[169],"enquanto":[170],"o":[171],"ensaio":[172],"EPISODE":[173],"atingiu":[175],"signific\u00e2ncia":[176],"no":[177],"desfecho":[178],"prim\u00e1rio.":[179],"Ayahuasca":[180],"DMT":[182],"apresentaram":[183],"sinais":[184],"menores.":[189],"Os":[190],"eventos":[191],"adversos":[192],"predominantemente":[194],"transit\u00f3rios":[195],"ambientes":[197],"supervisionados,":[198],"mas":[199],"persistem":[200],"incertezas":[201],"cegamento":[203],"expectativa,":[205],"popula\u00e7\u00f5es":[208],"maior":[210],"risco":[211],"estrat\u00e9gias":[213],"manuten\u00e7\u00e3o.":[215],"Conclui-se":[216],"psicod\u00e9licos,":[219],"especialmente":[220],"apresentam":[223],"potencial":[224],"terap\u00eautico":[225],"relevante":[226],"DRT,":[228],"por\u00e9m":[229],"incorpora\u00e7\u00e3o":[231],"exige":[233],"sele\u00e7\u00e3o":[234],"criteriosa,":[235],"supervis\u00e3o":[236],"confirma\u00e7\u00e3o":[239],"adicional":[240],"independentes":[247],"pragmaticamente":[249],"representativos.":[250]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-17T00:00:00"}