{"id":"https://openalex.org/W7213360758","doi":"https://doi.org/10.64898/2026.09.14.751376","title":"A single nuclei expression resource for exploring dog brain cell transcriptomic diversity","display_name":"A single nuclei expression resource for exploring dog brain cell transcriptomic diversity","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213360758","doi":"https://doi.org/10.64898/2026.09.14.751376"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.14.751376","doi":"https://doi.org/10.64898/2026.09.14.751376","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751376","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.14.751376.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.14.751376.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050288573","display_name":"Matthew J. Christmas","orcid":"https://orcid.org/0000-0002-6355-7581","observed_orcids":["https://orcid.org/0000-0002-6355-7581"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Matthew J. Christmas","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-6355-7581","affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158503739","display_name":"Eric Pederson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eric Pederson","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067622718","display_name":"Ola Wallerman","orcid":"https://orcid.org/0000-0003-1037-7904","observed_orcids":["https://orcid.org/0000-0003-1037-7904"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ola Wallerman","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014255302","display_name":"Paul Theodor Pyl","orcid":"https://orcid.org/0000-0002-7651-883X","observed_orcids":["https://orcid.org/0000-0002-7651-883X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I4387154792","display_name":"National Bioinformatics Infrastructure Sweden","ror":"https://ror.org/00enajs79","country_code":"SE","type":"other","lineage":["https://openalex.org/I123387679","https://openalex.org/I4387153960","https://openalex.org/I4387154792"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Paul Theodor Pyl","raw_affiliation_strings":["Department of Laboratory Medicine, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund University, 221 00 Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund University, 221 00 Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2800139495","https://openalex.org/I4387154792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011664006","display_name":"Susanne E. Reinsbach","orcid":"https://orcid.org/0000-0003-0509-2488","observed_orcids":["https://orcid.org/0000-0003-0509-2488"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I4387154792","display_name":"National Bioinformatics Infrastructure Sweden","ror":"https://ror.org/00enajs79","country_code":"SE","type":"other","lineage":["https://openalex.org/I123387679","https://openalex.org/I4387153960","https://openalex.org/I4387154792"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne E. Reinsbach","raw_affiliation_strings":["Department of Laboratory Medicine, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I4387154792","https://openalex.org/I66862912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015878392","display_name":"Elisabeth Sundstr\u00f6m","orcid":"https://orcid.org/0000-0001-9526-8541","observed_orcids":["https://orcid.org/0000-0001-9526-8541"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elisabeth Sundstr\u00f6m","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151780494","display_name":"Chao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Chao Wang","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":null,"display_name":"\u00c5sa Karlsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5sa Karlsson","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042239489","display_name":"Maja L. Arendt","orcid":"https://orcid.org/0000-0003-1404-172X","observed_orcids":["https://orcid.org/0000-0003-1404-172X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Maja L. Arendt","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","Department of Veterinary Clinical Sciences, University of Copenhagen, Denmark","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Veterinary Clinical Sciences, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049172746","display_name":"Jennifer R. S. Meadows","orcid":"https://orcid.org/0000-0002-0850-230X","observed_orcids":["https://orcid.org/0000-0002-0850-230X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jennifer R. S. Meadows","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007985109","display_name":"Kerstin Lindblad\u2010Toh","orcid":"https://orcid.org/0000-0001-8338-0253","observed_orcids":["https://orcid.org/0000-0001-8338-0253"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Kerstin Lindblad-Toh","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA, USA","Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","SciLifeLab, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"SciLifeLab, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5050288573"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I2800139495"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-brain","display_name":"canine brain","score":0.921999990940094},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.7649999856948853},{"id":"https://openalex.org/keywords/brain-cell-types","display_name":"brain cell types","score":0.7889999747276306},{"id":"https://openalex.org/keywords/domestication","display_name":"domestication","score":0.6779999732971191},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.765999972820282},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cerebrum","display_name":"cerebrum","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8050000071525574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7854999899864197},{"id":"https://openalex.org/C134387633","wikidata":"https://www.wikidata.org/wiki/Q11395","display_name":"Domestication","level":2,"score":0.6463000178337097},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.515999972820282},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4611000120639801},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45899999141693115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4453999996185303},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4404999911785126},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41100001335144043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C2778144876","wikidata":"https://www.wikidata.org/wiki/Q4955745","display_name":"Brain Cell","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3481000065803528},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.29670000076293945},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2904999852180481},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2775999903678894},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26350000500679016},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.14.751376","doi":"https://doi.org/10.64898/2026.09.14.751376","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751376","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.14.751376.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.14.751376","doi":"https://doi.org/10.64898/2026.09.14.751376","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.14.751376","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/16/2026.09.14.751376.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3321450376","display_name":null,"funder_award_id":"05973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G796431723","display_name":null,"funder_award_id":"201805973","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":"https://ror.org/0554ckj21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213360758.pdf","grobid_xml":"https://content.openalex.org/works/W7213360758.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W4389132747","https://openalex.org/W4414346727"],"related_works":["https://openalex.org/W4210249175","https://openalex.org/W4286750109","https://openalex.org/W2003118493","https://openalex.org/W6892219598","https://openalex.org/W2081198093","https://openalex.org/W2062619252","https://openalex.org/W2043798190","https://openalex.org/W7223110860","https://openalex.org/W7096019258","https://openalex.org/W2971357019"],"abstract_inverted_index":{"Abstract":[0],"Domesticated":[1],"dogs":[2],"present":[3,93],"a":[4,68,134,199,224],"unique":[5],"case":[6],"in":[7,22,139,147,171,182,188],"nature":[8],"where":[9],"mutualism":[10],"with":[11,128],"and":[12,26,36,84,104,121,130,144,176,196,206],"selective":[13],"breeding":[14],"by":[15,60,229],"humans":[16,195],"has":[17],"led":[18],"to":[19,29,42,45,194],"profound":[20],"changes":[21],"their":[23,30],"environment,":[24],"physiology,":[25],"behaviour":[27],"compared":[28,193],"wolf-like":[31],"ancestors.":[32],"Dog":[33],"tameness,":[34],"sociability,":[35],"trainability":[37],"have":[38],"likely":[39],"evolved":[40],"due":[41],"significant":[43],"alterations":[44],"brain":[46,56,65],"function.":[47],"Exploring":[48],"the":[49,54,61,89,101,108,154,157,166,183,189,230],"effects":[50,212],"of":[51,63,107,137,156,185,191,209,213],"domestication":[52],"on":[53],"dog":[55,64,90,172],"will":[57],"be":[58],"facilitated":[59],"characterisation":[62],"cell":[66,86,119],"diversity,":[67],"task":[69],"which":[70],"is":[71],"not":[72],"yet":[73],"complete.":[74],"To":[75],"fill":[76],"this":[77,219],"gap,":[78],"we":[79],"use":[80,228],"single-nucleus":[81],"RNA":[82],"sequencing":[83],"survey":[85],"types":[87],"across":[88,141,165],"brain.":[91],"We":[92,152,178],"transcriptomes":[94],"from":[95,100,218],"almost":[96],"60,000":[97],"cells":[98],"sampled":[99],"cerebellum,":[102],"thalamus,":[103],"three":[105],"regions":[106],"cerebrum.":[109],"Our":[110],"analysis":[111],"identified":[112],"24":[113],"major":[114],"clusters":[115],"representing":[116],"21":[117],"broad":[118],"types,":[120],"131":[122],"subclusters":[123],"revealing":[124],"regional":[125],"variation.":[126],"Comparisons":[127],"human":[129],"mouse":[131],"datasets":[132],"revealed":[133],"high":[135],"level":[136],"conservation":[138],"neurons":[140],"mammalian":[142],"brains,":[143],"greater":[145],"divergence":[146],"glial":[148],"cells,":[149],"particularly":[150],"oligodendrocytes.":[151],"demonstrate":[153],"utility":[155],"dataset":[158],"for":[159,202,227],"interrogating":[160],"specific":[161],"gene":[162],"expression":[163,184],"patterns":[164],"brain,":[167],"including":[168],"genes":[169],"implicated":[170],"domestication,":[173],"behavioural":[174],"traits,":[175],"disease.":[177],"discover":[179],"distinct":[180],"differences":[181],"opioid":[186,214],"receptors":[187],"brains":[190],"dogs,":[192],"mice,":[197],"providing":[198],"potential":[200],"explanation":[201],"dogs\u2019":[203],"higher":[204],"tolerance":[205],"lower":[207],"risk":[208],"severe":[210],"adverse":[211],"drugs.":[215],"The":[216],"data":[217],"project":[220],"are":[221],"released":[222],"via":[223],"web":[225],"application":[226],"wider":[231],"community.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-16T00:00:00"}
