{"id":"https://openalex.org/W7213338336","doi":"https://doi.org/10.3390/jcm15208146","title":"External Validation of MRI-Based Prostate Cancer Risk Calculators in a Contemporary Pre-Biopsy mpMRI Cohort","display_name":"External Validation of MRI-Based Prostate Cancer Risk Calculators in a Contemporary Pre-Biopsy mpMRI Cohort","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7213338336","doi":"https://doi.org/10.3390/jcm15208146","pmid":"https://pubmed.ncbi.nlm.nih.gov/42941658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13706581"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15208146","doi":"https://doi.org/10.3390/jcm15208146","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208146","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jcm15208146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086667530","display_name":"Hubert Griessner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hubert Grie\u00dfner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041797666","display_name":"Sarah L\u00fcck","orcid":"https://orcid.org/0009-0007-2975-1923","observed_orcids":["https://orcid.org/0009-0007-2975-1923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Luck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151756148","display_name":"Julia K. Peters","orcid":"https://orcid.org/0009-0005-2286-1631","observed_orcids":["https://orcid.org/0009-0005-2286-1631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia K. Peters","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-2286-1631","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024700425","display_name":"Kathrin Olesch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathrin Olesch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151800899","display_name":"Manuel Schlachter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Schlachter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027424943","display_name":"Lukas Oberhammer","orcid":"https://orcid.org/0000-0002-9147-2032","observed_orcids":["https://orcid.org/0000-0002-9147-2032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Oberhammer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9147-2032","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085178415","display_name":"Maximilian Pallauf","orcid":"https://orcid.org/0000-0002-8496-4506","observed_orcids":["https://orcid.org/0000-0002-8496-4506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian Pallauf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083267243","display_name":"Lukas Lusuardi","orcid":"https://orcid.org/0000-0002-5284-7276","observed_orcids":["https://orcid.org/0000-0002-5284-7276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lukas Lusuardi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5284-7276","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5138819889","display_name":"Philipp N. Haid","orcid":"https://orcid.org/0009-0003-7909-4862","observed_orcids":["https://orcid.org/0009-0003-7909-4862"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Philipp N. Haid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7909-4862","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5138819889"],"corresponding_institution_ids":[],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68646832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"20","first_page":"8146","last_page":"8146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinically-significant-prostate-cancer","display_name":"clinically significant prostate cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.7919999957084656},{"id":"https://openalex.org/keywords/prostate-cancer-risk-calculator","display_name":"prostate cancer risk calculator","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mri-targeted-biopsy","display_name":"MRI-guided biopsy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/unnecessary-prostate-biopsy","display_name":"unnecessary prostate biopsy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/clinical-utility","display_name":"clinical utility","score":0.4790000021457672},{"id":"https://openalex.org/keywords/head-to-head-comparison","display_name":"head-to-head comparison","score":0.6259999871253967},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.6259999871253967},{"id":"https://openalex.org/keywords/isup-grade-group","display_name":"ISUP grade group","score":0.5720000267028809},{"id":"https://openalex.org/keywords/decision-curve-analysis","display_name":"decision curve analysis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/net-benefit","display_name":"net benefit","score":0.75},{"id":"https://openalex.org/keywords/prostate-cancer-screening","display_name":"prostate cancer screening","score":0.3619999885559082},{"id":"https://openalex.org/keywords/prostate-cancer-risk-stratification","display_name":"prostate cancer risk stratification","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8792999982833862},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.746999979019165},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5426999926567078},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5145000219345093},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.4812000095844269},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4602000117301941},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.43860000371932983},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.4020000100135803},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3903999924659729},{"id":"https://openalex.org/C3020452639","wikidata":"https://www.wikidata.org/wiki/Q454812","display_name":"Clinical judgment","level":2,"score":0.33559998869895935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31690001487731934},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2858999967575073},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2696000039577484}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm15208146","doi":"https://doi.org/10.3390/jcm15208146","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208146","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202609.1224.v1","doi":"https://doi.org/10.20944/preprints202609.1224.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202609.1224.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13706581","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13706581/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13706581/pdf/jcm-15-08146.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:42941658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42941658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm15208146","doi":"https://doi.org/10.3390/jcm15208146","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208146","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327318","display_name":"Paracelsus Medizinische Privatuniversit\u00e4t","ror":"https://ror.org/03z3mg085"},{"id":"https://openalex.org/F4320329768","display_name":"Salzburger Landesregierung","ror":"https://ror.org/0500kmp11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213338336.pdf","grobid_xml":"https://content.openalex.org/works/W7213338336.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1861816385","https://openalex.org/W1989403098","https://openalex.org/W2016639151","https://openalex.org/W2027576789","https://openalex.org/W2128409425","https://openalex.org/W2165416035","https://openalex.org/W2328176404","https://openalex.org/W2604294081","https://openalex.org/W2887766402","https://openalex.org/W2922071185","https://openalex.org/W2970477064","https://openalex.org/W2977262858","https://openalex.org/W2982018822","https://openalex.org/W2995133231","https://openalex.org/W3135056272","https://openalex.org/W3152287098","https://openalex.org/W3164926988","https://openalex.org/W3192144639","https://openalex.org/W4214806444","https://openalex.org/W4290723258","https://openalex.org/W4392548366","https://openalex.org/W4399567860","https://openalex.org/W4409195820","https://openalex.org/W4411734316","https://openalex.org/W4413642945","https://openalex.org/W7165546753","https://openalex.org/W7165564752"],"related_works":["https://openalex.org/W4290723258","https://openalex.org/W4411734316","https://openalex.org/W4393199804","https://openalex.org/W2995133231","https://openalex.org/W4392548366","https://openalex.org/W3188128342","https://openalex.org/W3135056272","https://openalex.org/W4283319724","https://openalex.org/W2921530182","https://openalex.org/W7213668254"],"abstract_inverted_index":{"Background:":[0],"MpMRI-integrated":[1],"risk":[2,52,118,332,382],"calculators":[3,53,189,210,333,383],"have":[4,22],"been":[5],"developed":[6,54],"to":[7,239,251,287,290,297,317,366,417],"improve":[8],"individualized":[9,392],"prediction":[10],"of":[11,99,144,149,158,177,195,292,319,380],"clinically":[12,100,419],"significant":[13,101],"prostate":[14,50,95,102],"cancer":[15,51,103],"(csPCa)":[16],"before":[17],"biopsy.":[18,96,301],"Although":[19],"these":[20],"models":[21,75],"demonstrated":[23,224,334],"good":[24],"predictive":[25],"performance":[26,32],"in":[27,65,164,192,384,390],"previous":[28],"validation":[29,176,414],"studies,":[30],"their":[31],"and":[33,41,60,71,93,115,128,152,161,264,273,280,295,309,322,329,336,407],"clinical":[34,226,401],"utility":[35,134,350],"may":[36],"vary":[37],"across":[38,141],"patient":[39,79],"populations":[40],"diagnostic":[42],"pathways.":[43],"This":[44],"study":[45],"externally":[46],"validated":[47],"the":[48,77,113,178,202,242,262,267,271,304,327,377,400],"mpMRI-based":[49],"by":[55,90,278],"Radtke":[56,114,328],"et":[57,62],"al.":[58,63],"(Radtke-RC)":[59],"Alberts":[61,116,330],"(Alberts-RC)":[64],"a":[66,142,345],"contemporary":[67],"pre-biopsy":[68,87],"mpMRI":[69,88],"population":[70,388],"directly":[72],"compared":[73,129],"both":[74,188,209],"within":[76],"same":[78],"population.":[80],"Methods:":[81],"We":[82],"retrospectively":[83],"included":[84],"patients":[85],"undergoing":[86],"followed":[89],"combined":[91],"MRI-targeted":[92],"systematic":[94],"Predicted":[97],"probabilities":[98],"(csPCa;":[104],"ISUP":[105],"Grade":[106],"Group":[107],"\u2265":[108],"2)":[109],"were":[110,173,190,307],"calculated":[111],"using":[112,123,130,137],"MRI-integrated":[117,331,381],"calculators.":[119],"Discrimination":[120],"was":[121,135,206,259,351],"assessed":[122],"receiver":[124],"operating":[125],"characteristic":[126],"analysis":[127,140,223],"DeLong\u2019s":[131],"test.":[132],"Clinical":[133,349],"evaluated":[136],"decision":[138],"curve":[139,222],"range":[143],"threshold":[145],"probabilities,":[146],"with":[147,183,314,341,354],"thresholds":[148,362],"12%,":[150,254],"20%,":[151,270],"30%":[153],"used":[154],"for":[155,175,187,208,213,217,261,266,339],"descriptive":[156],"interpretation":[157],"net":[159,232,246],"benefit":[160,233,247,256,357],"potential":[162,365],"reductions":[163,306],"unnecessary":[165,276,300,368,405],"biopsies.":[166],"Results:":[167],"Of":[168],"171":[169],"screened":[170],"patients,":[171,194,284,313],"164":[172],"eligible":[174],"Radtke-RC,":[179],"including":[180],"62":[181],"(37.8%)":[182],"csPCa.":[184,200,410],"Complete":[185],"data":[186],"available":[191],"114":[193],"whom":[196],"41":[197],"(36.0%)":[198],"had":[199],"In":[201],"head-to-head":[203],"cohort,":[204],"discrimination":[205,338],"acceptable":[207,335],"(AUC":[211],"0.785":[212],"Radtke-RC":[214,229,263,272],"vs.":[215],"0.767":[216],"Alberts-RC;":[218],"DeLong":[219],"p=0.318).":[220],"Decision":[221],"threshold-dependent":[225],"utility.":[227],"The":[228],"provided":[230,244],"greater":[231,245],"than":[234],"biopsy-all":[235,258,359],"from":[236,248],"approximately":[237,249,293,320],"9%":[238],"69%,":[240],"whereas":[241],"Alberts-RC":[243,274],"18%":[250],"56%.":[252],"At":[253,269,302],"incremental":[255,356],"over":[257,358],"marginal":[260],"absent":[265],"Alberts-RC.":[268],"reduced":[275],"biopsies":[277,369],"7.9":[279],"4.4":[281],"per":[282,311],"100":[283,312],"respectively,":[285],"corresponding":[286,305],"numbers":[288,315],"needed":[289,316],"assess":[291,318],"13":[294],"23":[296],"avoid":[298],"one":[299],"30%,":[303],"12.9":[308],"10.8":[310],"8":[321],"9,":[323],"respectively.":[324],"Conclusions:":[325],"Both":[326],"comparable":[337],"csPCa,":[340],"neither":[342],"model":[343],"showing":[344],"clear":[346],"overall":[347],"advantage.":[348],"strongly":[352],"threshold-dependent,":[353],"limited":[355],"at":[360,370],"low":[361],"but":[363],"increasing":[364],"reduce":[367],"higher":[371],"thresholds.":[372,421],"These":[373],"findings":[374],"suggest":[375],"that":[376],"principal":[378],"value":[379],"an":[385],"already":[386],"MRI-selected":[387],"lies":[389],"supporting":[391],"biopsy":[393,406],"decisions.":[394],"Threshold":[395],"selection":[396],"should":[397],"therefore":[398],"reflect":[399],"trade-off":[402],"between":[403],"avoiding":[404],"minimizing":[408],"missed":[409],"Further":[411],"prospective":[412],"multicentre":[413],"is":[415],"warranted":[416],"define":[418],"appropriate":[420]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-16T00:00:00"}
