{"id":"https://openalex.org/W7213335256","doi":"https://doi.org/10.64898/2026.09.15.26362919","title":"Longitudinal interferon signatures are associated with disease flare in dermatomyositis","display_name":"Longitudinal interferon signatures are associated with disease flare in dermatomyositis","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213335256","doi":"https://doi.org/10.64898/2026.09.15.26362919"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.15.26362919","doi":"https://doi.org/10.64898/2026.09.15.26362919","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26362919","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/15/2026.09.15.26362919.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/15/2026.09.15.26362919.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151742769","display_name":"Peixi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peixi Liu","raw_affiliation_strings":["Interdisciplinary Cancer Sciences Program, McGill University, Montreal, QC, Canada","Lady Davis Institute for Medical Research, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Cancer Sciences Program, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Montreal, Canada","institution_ids":["https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013073698","display_name":"Hsiang Chou","orcid":"https://orcid.org/0000-0002-9849-0559","observed_orcids":["https://orcid.org/0000-0002-9849-0559","https://orcid.org/0009-0009-0718-1653"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiang Chou","raw_affiliation_strings":["Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049570437","display_name":"Martin Jarry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Jarry","raw_affiliation_strings":["Patient representative"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient representative","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105250440","display_name":"Marie Hudson","orcid":"https://orcid.org/0000-0001-6718-2468","observed_orcids":["https://orcid.org/0000-0001-6718-2468","https://orcid.org/0000-0002-7121-0959"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie Hudson","raw_affiliation_strings":["Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","Division of Rheumatology, Jewish General Hospital, Montreal, Canada","Lady Davis Institute for Medical Research, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7121-0959","affiliations":[{"raw_affiliation_string":"Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Division of Rheumatology, Jewish General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2801824472"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Montreal, Canada","institution_ids":["https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089111286","display_name":"Sonia Victoria Del Rincon","orcid":"https://orcid.org/0000-0002-6350-0227","observed_orcids":["https://orcid.org/0000-0002-6350-0227"]},"institutions":[{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sonia Del Rincon","raw_affiliation_strings":["Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","Lady Davis Institute for Medical Research, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6350-0227","affiliations":[{"raw_affiliation_string":"Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Montreal, Canada","institution_ids":["https://openalex.org/I4405267356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005520548","display_name":"Philippe Lefran\u00e7ois","orcid":"https://orcid.org/0000-0003-2939-7956","observed_orcids":["https://orcid.org/0000-0003-2939-7956"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Philippe Lefran\u00e7ois","raw_affiliation_strings":["Division of Dermatology, Jewish General Hospital, Montreal, Canada","Interdisciplinary Cancer Sciences Program, McGill University, Montreal, QC, Canada","Lady Davis Institute for Medical Research, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2939-7956","affiliations":[{"raw_affiliation_string":"Division of Dermatology, Jewish General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2801824472"]},{"raw_affiliation_string":"Interdisciplinary Cancer Sciences Program, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Montreal, Canada","institution_ids":["https://openalex.org/I4405267356"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008365737","display_name":"Val\u00e9rie Leclair","orcid":"https://orcid.org/0000-0001-8643-6697","observed_orcids":["https://orcid.org/0000-0001-8643-6697"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Val\u00e9rie Leclair","raw_affiliation_strings":["Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","Division of Rheumatology, Jewish General Hospital, Montreal, Canada","Lady Davis Institute for Medical Research, Montreal, Canada"],"raw_orcid":"https://orcid.org/0000-0001-8643-6697","affiliations":[{"raw_affiliation_string":"Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"Division of Rheumatology, Jewish General Hospital, Montreal, Canada","institution_ids":["https://openalex.org/I2801824472"]},{"raw_affiliation_string":"Lady Davis Institute for Medical Research, Montreal, Canada","institution_ids":["https://openalex.org/I4405267356"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008365737"],"corresponding_institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dermatomyositis","display_name":"dermatomyositis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/disease-flares","display_name":"disease flares","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interferon-gene-signature","display_name":"interferon gene signature","score":0.8790000081062317},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6039999723434448},{"id":"https://openalex.org/keywords/anti-mda5-antibody","display_name":"anti-MDA5 antibodies","score":0.625},{"id":"https://openalex.org/keywords/ifn-gamma-response","display_name":"IFN-gamma response","score":0.9890000224113464},{"id":"https://openalex.org/keywords/disease-activity-monitoring","display_name":"disease activity monitoring","score":0.6439999938011169},{"id":"https://openalex.org/keywords/self-collected-blood-samples","display_name":"self-collected blood samples","score":0.656000018119812},{"id":"https://openalex.org/keywords/rna-integrity","display_name":"RNA integrity","score":0.4560000002384186},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.815500020980835},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.7473999857902527},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5267000198364258},{"id":"https://openalex.org/C2779387793","wikidata":"https://www.wikidata.org/wiki/Q980926","display_name":"Polymyositis","level":2,"score":0.4794999957084656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47920000553131104},{"id":"https://openalex.org/C2778552304","wikidata":"https://www.wikidata.org/wiki/Q6318950","display_name":"Juvenile dermatomyositis","level":3,"score":0.4587000012397766},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4562999904155731},{"id":"https://openalex.org/C2781232998","wikidata":"https://www.wikidata.org/wiki/Q1433212","display_name":"Myositis","level":2,"score":0.428600013256073},{"id":"https://openalex.org/C2779588948","wikidata":"https://www.wikidata.org/wiki/Q628261","display_name":"Flare","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3856000006198883},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3474000096321106},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.34119999408721924},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.3269999921321869},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.3206000030040741},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C2992264114","wikidata":"https://www.wikidata.org/wiki/Q1394551","display_name":"Clinical disease","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.2533999979496002},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.15.26362919","doi":"https://doi.org/10.64898/2026.09.15.26362919","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26362919","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/15/2026.09.15.26362919.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.15.26362919","doi":"https://doi.org/10.64898/2026.09.15.26362919","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.15.26362919","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/15/2026.09.15.26362919.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320319925","display_name":"Arthritis Society","ror":"https://ror.org/00bpw5437"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213335256.pdf","grobid_xml":"https://content.openalex.org/works/W7213335256.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1951724000","https://openalex.org/W1976373964","https://openalex.org/W1998217022","https://openalex.org/W2016103707","https://openalex.org/W2081458590","https://openalex.org/W2108234281","https://openalex.org/W2124807661","https://openalex.org/W2130410032","https://openalex.org/W2179438025","https://openalex.org/W2400700193","https://openalex.org/W2432815617","https://openalex.org/W2774486220","https://openalex.org/W2796867710","https://openalex.org/W2951912016","https://openalex.org/W2964849163","https://openalex.org/W3040539644","https://openalex.org/W3043627823","https://openalex.org/W3094309738","https://openalex.org/W3138383770","https://openalex.org/W3165822352","https://openalex.org/W3215682729","https://openalex.org/W4214760420","https://openalex.org/W4221046228","https://openalex.org/W4242289937","https://openalex.org/W4302023865","https://openalex.org/W4322757880","https://openalex.org/W4323356830","https://openalex.org/W4366988880","https://openalex.org/W4387403670","https://openalex.org/W4416093407"],"related_works":["https://openalex.org/W2400700193","https://openalex.org/W2016103707","https://openalex.org/W3136878212","https://openalex.org/W1976373964","https://openalex.org/W2042615668","https://openalex.org/W2514488813","https://openalex.org/W4366988880","https://openalex.org/W2971977977","https://openalex.org/W4386216419","https://openalex.org/W2033903988"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Disease":[2,127],"flares":[3],"in":[4,24,89,215,275,279,312,348,355,358],"dermatomyositis":[5],"(DM)":[6],"are":[7,22],"unpredictable":[8],"and":[9,52,73,113,194,202,314,321],"often":[10],"detected":[11],"weeks":[12],"to":[13,164,197],"months":[14,107],"after":[15],"their":[16,27,101,252],"onset.":[17],"Interferon":[18],"(IFN)-related":[19],"gene":[20,49,200,304,310,351],"signatures":[21,50,366],"implicated":[23],"DM,":[25],"but":[26],"value":[28],"for":[29,105,135,143,261,370],"longitudinal":[30,38,342,371],"flare":[31,88,250,281,315],"prediction":[32],"remains":[33],"unclear.":[34],"We":[35],"hypothesized":[36],"that":[37,159],"transcriptomic":[39,346],"profiling":[40,347],"using":[41,108,184],"minimally":[42,70],"invasive":[43],"blood":[44,156,171,264,343],"microsampling":[45,344],"would":[46],"detect":[47],"IFN":[48,270,318,322,350],"preceding":[51],"during":[53,206,251],"DM":[54,207,211],"disease":[55,72,102,372],"flares.":[56,208],"Methods":[57],"In":[58],"this":[59,216],"feasibility":[60,338],"study,":[61],"patients":[62,152,212,229,247],"were":[63,160,213,230,272,353],"included":[64,190,214],"if":[65],"they":[66],"had":[67],"inactive":[68],"or":[69,93],"active":[71],"at":[74,237],"least":[75],"one":[76],"of":[77,96,240,244,302,308,339,364],"the":[78,90,109,149,165,245,262,326,336],"following":[79],"criteria:":[80],"recent":[81],"diagnosis":[82],"within":[83],"2":[84,136,220],"years,":[85],"a":[86,131,146,233,249,290],"documented":[87],"prior":[91],"year,":[92],"ongoing":[94],"tapering":[95],"immunosuppressive":[97],"therapy.":[98],"Patients":[99],"self-assessed":[100],"activity":[103],"weekly":[104,155,170,263],"6":[106],"International":[110],"Myositis":[111],"Assessment":[112],"Clinical":[114],"Study":[115],"group":[116],"(IMACS)":[117],"patient":[118,288],"global":[119],"assessment":[120],"(PtGA;":[121],"numerical":[122],"rating":[123],"scale,":[124],"range":[125],"0-10).":[126],"flares,":[128],"defined":[129],"as":[130,289,367],"PtGA":[132],"increase":[133],">2":[134],"consecutive":[137],"weeks,":[138],"triggered":[139],"an":[140,185],"in-person":[141],"visit":[142],"confirmation":[144],"by":[145,162],"physician.":[147],"During":[148],"follow-up":[150],"period,":[151],"also":[153],"self-collected":[154],"microsamples":[157,265],"(125uL)":[158],"shipped":[161],"courier":[163],"study":[166,217,238,334],"center.":[167],"From":[168],"those":[169],"microsamples,":[172],"RNA":[173,203,258],"sequencing":[174],"was":[175,267],"performed":[176],"on":[177],"54":[178],"samples":[179,277,282,316],"collected":[180,266],"across":[181],"9":[182],"timepoints":[183],"Illumina":[186],"platform.":[187],"Bioinformatic":[188],"analyses":[189],"alignment,":[191],"quality":[192],"assessment,":[193],"gene-level":[195],"quantification":[196],"evaluate":[198],"differential":[199],"expression":[201],"processing":[204],"changes":[205],"Results":[209],"Six":[210],"(2":[218],"anti-MDA5,":[219],"anti-Mi2,":[221],"1":[222,224],"anti-NXP2,":[223],"no":[225,280],"myositis-specific":[226],"antibodies).":[227],"All":[228],"women":[231],"with":[232,286,317,345],"mean":[234,256],"age":[235],"(SD)":[236,257],"entry":[239],"54(8)":[241],"years.":[242],"Three":[243],"six":[246],"experienced":[248],"6-month":[253],"follow-up.":[254],"The":[255],"integrity":[259],"score":[260,352],"7,61":[268],"(0,64).":[269],"scores":[271],"significantly":[273],"higher":[274,354],"flare-associated":[276,356],"than":[278,357],"(linear":[283],"mixed-effects":[284],"model":[285],"individual":[287],"random":[291],"intercept,":[292],"P":[293],"=":[294],"5.13":[295],"\u00d7":[296],"10\u207b\u2074).":[297],"Gene":[298],"set":[299],"enrichment":[300,307,330],"analysis":[301],"hallmark":[303],"sets":[305,311],"identified":[306],"IFN-related":[309,365],"pre-flare":[313],"Alpha":[319],"Response":[320,324],"Gamma":[323],"showing":[325],"highest":[327],"positive":[328],"normalized":[329],"scores.":[331],"Conclusion":[332],"This":[333],"demonstrates":[335],"technical":[337],"combining":[340],"home-based":[341],"dermatomyositis.":[349],"no-flare":[359],"samples,":[360],"supporting":[361],"further":[362],"investigation":[363],"candidate":[368],"biomarkers":[369],"monitoring.":[373]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-16T00:00:00"}