{"id":"https://openalex.org/W7213331338","doi":"https://doi.org/10.64898/2026.09.12.751137","title":"Phenotypic Characterization of OXA-439, an OXA-163 variant, isolated from uropathogenic Escherichia coli","display_name":"Phenotypic Characterization of OXA-439, an OXA-163 variant, isolated from uropathogenic Escherichia coli","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213331338","doi":"https://doi.org/10.64898/2026.09.12.751137"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.12.751137","doi":"https://doi.org/10.64898/2026.09.12.751137","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.12.751137","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.12.751137.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.12.751137.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115984108","display_name":"Valeria Florez\u2010Cardona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156231","display_name":"Institut Pasteur de Montevideo","ror":"https://ror.org/04dpm2z73","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210156231"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Valeria Fl\u00f3rez-Cardona","raw_affiliation_strings":["Institut Pasteur de Montevideo, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Montevideo, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210156231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151787002","display_name":"Elizabeth Ticona-Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156231","display_name":"Institut Pasteur de Montevideo","ror":"https://ror.org/04dpm2z73","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210156231"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Elizabeth Ticona-Morales","raw_affiliation_strings":["Institut Pasteur de Montevideo, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Montevideo, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210156231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151716895","display_name":"Marisabel Charlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156231","display_name":"Institut Pasteur de Montevideo","ror":"https://ror.org/04dpm2z73","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210156231"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Marisabel Charlo","raw_affiliation_strings":["Institut Pasteur de Montevideo, Montevideo, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur de Montevideo, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210156231"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005378529","display_name":"Bruno Manta","orcid":"https://orcid.org/0000-0001-8366-8935","observed_orcids":["https://orcid.org/0000-0001-8366-8935"]},"institutions":[{"id":"https://openalex.org/I4210156231","display_name":"Institut Pasteur de Montevideo","ror":"https://ror.org/04dpm2z73","country_code":"UY","type":"facility","lineage":["https://openalex.org/I4210156231"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Bruno Manta","raw_affiliation_strings":["Institut Pasteur de Montevideo, Montevideo, Uruguay"],"raw_orcid":"https://orcid.org/0000-0001-8366-8935","affiliations":[{"raw_affiliation_string":"Institut Pasteur de Montevideo, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210156231"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005378529"],"corresponding_institution_ids":["https://openalex.org/I4210156231"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/class-d-beta-lactamase","display_name":"class D beta-lactamase","score":0.8339999914169312},{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9940000176429749},{"id":"https://openalex.org/keywords/catheter-associated-urinary-tract-infection","display_name":"catheter-associated urinary tract infection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.4749999940395355},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.9006999731063843},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7202000021934509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5907999873161316},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5723000168800354},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.5527999997138977},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5425999760627747},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.529699981212616},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.5278000235557556},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.4397999942302704},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C2778193466","wikidata":"https://www.wikidata.org/wiki/Q423787","display_name":"Piperacillin","level":4,"score":0.3824999928474426},{"id":"https://openalex.org/C2781288988","wikidata":"https://www.wikidata.org/wiki/Q311379","display_name":"Beta-lactamase","level":4,"score":0.37310001254081726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34130001068115234},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.32440000772476196},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.3093999922275543},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C2776985332","wikidata":"https://www.wikidata.org/wiki/Q311055","display_name":"Escherichia","level":4,"score":0.296999990940094},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.2799000144004822},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27410000562667847},{"id":"https://openalex.org/C179470777","wikidata":"https://www.wikidata.org/wiki/Q356661","display_name":"Bacterial adhesin","level":4,"score":0.27140000462532043},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.2581000030040741}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.12.751137","doi":"https://doi.org/10.64898/2026.09.12.751137","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.12.751137","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.12.751137.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.12.751137","doi":"https://doi.org/10.64898/2026.09.12.751137","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.12.751137","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.12.751137.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4870198231","display_name":null,"funder_award_id":"COF 03/11","funder_id":"https://openalex.org/F4320310753","funder_display_name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320310753","display_name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","ror":"https://ror.org/03egaj678"},{"id":"https://openalex.org/F4320329442","display_name":"Institut Pasteur de Montevideo","ror":"https://ror.org/04dpm2z73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213331338.pdf","grobid_xml":"https://content.openalex.org/works/W7213331338.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1845997799","https://openalex.org/W1977018354","https://openalex.org/W1978817957","https://openalex.org/W1979973356","https://openalex.org/W2039994963","https://openalex.org/W2042022353","https://openalex.org/W2122705713","https://openalex.org/W2134781576","https://openalex.org/W2149187191","https://openalex.org/W2169162748","https://openalex.org/W2511867464","https://openalex.org/W2751583588","https://openalex.org/W2763677933","https://openalex.org/W2765786629","https://openalex.org/W2788228074","https://openalex.org/W2883838322","https://openalex.org/W2890151803","https://openalex.org/W2900102202","https://openalex.org/W2987720685","https://openalex.org/W2995775883","https://openalex.org/W3010894334","https://openalex.org/W3117305349","https://openalex.org/W3125219542","https://openalex.org/W3208921731","https://openalex.org/W3209528471","https://openalex.org/W4220716554","https://openalex.org/W4282976587","https://openalex.org/W4283515152","https://openalex.org/W4286001453","https://openalex.org/W4290786355","https://openalex.org/W4306871314","https://openalex.org/W4312339128","https://openalex.org/W4368358104","https://openalex.org/W4385898795","https://openalex.org/W4387164156","https://openalex.org/W4397021991","https://openalex.org/W4398182689","https://openalex.org/W4409504797","https://openalex.org/W4413026422"],"related_works":["https://openalex.org/W3089299650","https://openalex.org/W7066299568","https://openalex.org/W2134781576","https://openalex.org/W2071830328","https://openalex.org/W2581072766","https://openalex.org/W2076892753","https://openalex.org/W7096857910","https://openalex.org/W3098106087","https://openalex.org/W2141966178","https://openalex.org/W2119492721"],"abstract_inverted_index":{"Abstract":[0],"OXA-48-like":[1],"\u03b2-lactamases,":[2],"such":[3],"as":[4],"OXA-163,":[5,36],"OXA-181,":[6],"OXA-405,":[7],"OXA-505,":[8],"among":[9],"others,":[10],"are":[11],"class":[12],"D":[13],"carbapenem-hydrolyzing":[14],"enzymes":[15],"increasingly":[16],"reported":[17],"worldwide,":[18],"yet":[19],"some":[20],"variants":[21],"remain":[22],"poorly":[23],"characterized":[24],"at":[25],"the":[26,143,148,154],"phenotypic":[27],"levels.":[28],"Here,":[29],"we":[30],"report":[31],"OXA-439,":[32,62],"a":[33,38,48,92,104,130],"variant":[34],"of":[35,61,94,133],"in":[37,44,79],"producing":[39],"uropathogenic":[40],"Escherichia":[41,80],"coli":[42,81],"(UPEC)":[43],"Uruguay,":[45],"recovered":[46],"from":[47],"catheter-associated":[49],"urinary":[50],"tract":[51],"infection":[52],"with":[53,124],"discordant":[54],"routine":[55],"susceptibility":[56],"results.":[57],"The":[58],"specific":[59],"contribution":[60],"bla-":[63,66,70],"OXA-48":[64],",":[65,68],"OXA-163":[67,110],"and":[69,77,83,98,115,129,157],"OXA-439":[71,102],"were":[72],"cloned":[73],"into":[74],"pET24a":[75],"vector":[76],"expressed":[78],"BL21(DE3),":[82],"their":[84],"activity":[85,134],"was":[86],"evaluated":[87],"by":[88],"MIC":[89,127],"microdilution":[90],"against":[91],"panel":[93],"penicillins,":[95],"ESCs,":[96],"carbapenems,":[97],"\u03b2-lactam/\u03b2-lactamase":[99],"inhibitor":[100],"combinations.":[101],"exhibited":[103],"substrate":[105],"profile":[106],"highly":[107],"similar":[108],"to":[109,113,121],"conferring":[111],"resistance":[112],"piperacillin":[114],"third-generation":[116],"cephalosporins":[117],"while":[118],"remaining":[119],"susceptible":[120],"carbapenems":[122],"but":[123],"globally":[125],"reduced":[126],"values":[128],"complete":[131],"loss":[132],"toward":[135],"amoxicillin":[136],"\u00b1":[137],"clavulanate.":[138],"These":[139],"data":[140],"suggest":[141],"that":[142],"Y123H":[144],"substitution,":[145],"located":[146],"near":[147],"catalytic":[149],"Ser70/Lys73":[150],"region,":[151],"subtly":[152],"perturbs":[153],"active-site":[155],"environment":[156],"decreases":[158],"penicillinase":[159],"efficiency.":[160]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-16T00:00:00"}
