{"id":"https://openalex.org/W7213324313","doi":"https://doi.org/10.1038/s41598-026-68178-2","title":"Hemocompatibility of the Realheart TAH against SynCardia TAH in full-body circulation with human blood","display_name":"Hemocompatibility of the Realheart TAH against SynCardia TAH in full-body circulation with human blood","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213324313","doi":"https://doi.org/10.1038/s41598-026-68178-2"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-68178-2","doi":"https://doi.org/10.1038/s41598-026-68178-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68178-2","pdf_url":"https://www.nature.com/articles/s41598-026-68178-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-68178-2.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029797740","display_name":"Shaikh Faisal Zaman","orcid":"https://orcid.org/0000-0002-3144-3176","observed_orcids":["https://orcid.org/0000-0002-3144-3176"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4405269709","display_name":"Scandinavian Real Heart AB (Sweden)","ror":"https://ror.org/04zp4gs45","country_code":"SE","type":"company","lineage":["https://openalex.org/I4405269709"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Shaikh Faisal Zaman","raw_affiliation_strings":["Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-3144-3176","affiliations":[{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden","institution_ids":["https://openalex.org/I4405269709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024807833","display_name":"Kerstin J\u00f6nsson\u2010Vides\u00e4ter","orcid":"https://orcid.org/0009-0007-9775-1757","observed_orcids":["https://orcid.org/0009-0007-9775-1757"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kerstin J\u00f6nsson Vides\u00e4ter","raw_affiliation_strings":["Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Huddinge, Sweden"],"raw_orcid":"https://orcid.org/0009-0007-9775-1757","affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Huddinge, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024667144","display_name":"Thomas Finocchiaro","orcid":"https://orcid.org/0000-0002-2722-0260","observed_orcids":["https://orcid.org/0000-0002-2722-0260"]},"institutions":[{"id":"https://openalex.org/I4405269709","display_name":"Scandinavian Real Heart AB (Sweden)","ror":"https://ror.org/04zp4gs45","country_code":"SE","type":"company","lineage":["https://openalex.org/I4405269709"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Thomas Finocchiaro","raw_affiliation_strings":["Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-2722-0260","affiliations":[{"raw_affiliation_string":"Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden","institution_ids":["https://openalex.org/I4405269709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030357239","display_name":"Oliver Voigt","orcid":"https://orcid.org/0009-0003-0529-0836","observed_orcids":["https://orcid.org/0009-0003-0529-0836"]},"institutions":[{"id":"https://openalex.org/I4405269709","display_name":"Scandinavian Real Heart AB (Sweden)","ror":"https://ror.org/04zp4gs45","country_code":"SE","type":"company","lineage":["https://openalex.org/I4405269709"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Oliver Voigt","raw_affiliation_strings":["Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden"],"raw_orcid":"https://orcid.org/0009-0003-0529-0836","affiliations":[{"raw_affiliation_string":"Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden","institution_ids":["https://openalex.org/I4405269709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075686650","display_name":"Ina Laura Perkins","orcid":"https://orcid.org/0000-0003-2521-4171","observed_orcids":["https://orcid.org/0000-0003-2521-4171"]},"institutions":[{"id":"https://openalex.org/I4405269709","display_name":"Scandinavian Real Heart AB (Sweden)","ror":"https://ror.org/04zp4gs45","country_code":"SE","type":"company","lineage":["https://openalex.org/I4405269709"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ina Laura Perkins","raw_affiliation_strings":["Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-2521-4171","affiliations":[{"raw_affiliation_string":"Scandinavian Real Heart AB, Hydrov\u00e4gen 4, V\u00e4ster\u00e5s, 721 36, Sweden","institution_ids":["https://openalex.org/I4405269709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029797740"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4405269709"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-artificial-heart","display_name":"total artificial heart","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bridge-to-transplantation","display_name":"bridge to transplant","score":0.597000002861023},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.5019999742507935},{"id":"https://openalex.org/keywords/mock-circulation-loop","display_name":"mock circulation loop","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.7850000262260437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6872000098228455},{"id":"https://openalex.org/C2776342676","wikidata":"https://www.wikidata.org/wiki/Q126888","display_name":"Artificial heart","level":2,"score":0.6414999961853027},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5636000037193298},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5450999736785889},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.5113999843597412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47749999165534973},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4505000114440918},{"id":"https://openalex.org/C2985453986","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Blood circulation","level":2,"score":0.4140999913215637},{"id":"https://openalex.org/C3020437955","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Human blood","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4004000127315521},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C3020745077","wikidata":"https://www.wikidata.org/wiki/Q48996800","display_name":"Bridge to transplantation","level":4,"score":0.3772999942302704},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.37389999628067017},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C2778715992","wikidata":"https://www.wikidata.org/wiki/Q372409","display_name":"Venae cavae","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41598-026-68178-2","doi":"https://doi.org/10.1038/s41598-026-68178-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68178-2","pdf_url":"https://www.nature.com/articles/s41598-026-68178-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:4b5ae31f791147439ecac7faeb853eec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4b5ae31f791147439ecac7faeb853eec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-68178-2","doi":"https://doi.org/10.1038/s41598-026-68178-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68178-2","pdf_url":"https://www.nature.com/articles/s41598-026-68178-2.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213324313.pdf","grobid_xml":"https://content.openalex.org/works/W7213324313.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1849825171","https://openalex.org/W1971098886","https://openalex.org/W1978239102","https://openalex.org/W2034058223","https://openalex.org/W2035936381","https://openalex.org/W2036927323","https://openalex.org/W2040982820","https://openalex.org/W2041754893","https://openalex.org/W2050370340","https://openalex.org/W2066711941","https://openalex.org/W2070530429","https://openalex.org/W2071969279","https://openalex.org/W2075169049","https://openalex.org/W2081892141","https://openalex.org/W2085749584","https://openalex.org/W2141902027","https://openalex.org/W2408897458","https://openalex.org/W2758930747","https://openalex.org/W2978457333","https://openalex.org/W3009977875","https://openalex.org/W3013511872","https://openalex.org/W3033046011","https://openalex.org/W3198792590","https://openalex.org/W4200110896","https://openalex.org/W4362735731","https://openalex.org/W4387624616","https://openalex.org/W4402755025","https://openalex.org/W4411375100","https://openalex.org/W4412107700","https://openalex.org/W4413154020","https://openalex.org/W4414208078","https://openalex.org/W7122699872","https://openalex.org/W7155056199"],"related_works":["https://openalex.org/W7155056199","https://openalex.org/W7221948627","https://openalex.org/W4414290666","https://openalex.org/W4211090960","https://openalex.org/W4413561520","https://openalex.org/W2118384134","https://openalex.org/W4225858203","https://openalex.org/W2888029573","https://openalex.org/W4380319650","https://openalex.org/W3013959999"],"abstract_inverted_index":{"Abstract":[0],"The":[1,52],"SynCardia":[2,84,147,180],"Total":[3],"Artificial":[4],"Heart":[5],"(TAH)":[6],"is":[7,55],"FDA-approved":[8],"for":[9,45,70,127,146,154],"bridge":[10],"to":[11,102,186],"transplantation":[12],"and":[13,47,74,85,111,130,148,171],"has":[14],"been":[15],"implanted":[16],"in":[17,34,87,105,163],">":[18],"2,100":[19],"patients.":[20],"Clinical":[21],"data":[22,42],"demonstrate":[23],"hemolysis":[24],"whilst":[25,188],"preserving":[26],"von":[27],"Willebrand":[28],"factor":[29],"(VWF),":[30],"but":[31],"no":[32],"published":[33],"vitro":[35],"blood":[36,76,98,115],"damage":[37],"profile":[38],"exists.":[39],"Such":[40],"baseline":[41],"are":[43],"important":[44],"developing":[46],"evaluating":[48],"next-generation":[49],"TAH":[50,54,61],"systems.":[51],"Realheart":[53,86,155,193],"a":[56,88,106,160],"four-chamber":[57],"pulsatile":[58],"positive":[59],"displacement":[60],"which":[62],"mimics":[63],"the":[64,81],"natural":[65],"heart\u2019s":[66],"atrioventricular":[67],"plane":[68],"movement":[69],"physiological":[71],"flow":[72],"patterns":[73],"gentle":[75],"handling.":[77],"This":[78],"study":[79],"compares":[80],"hemocompatibility":[82,197],"of":[83,95],"full-body":[89,200],"circulation":[90,201],"test":[91],"setup.":[92],"Hemolysis":[93],"testing":[94],"pooled":[96],"human":[97],"was":[99,140],"performed":[100],"according":[101],"ASTM":[103],"standards":[104],"mock":[107],"loop":[108],"simulating":[109],"systemic":[110],"pulmonary":[112],"circulation.":[113],"Complete":[114],"counts":[116],"were":[117,125,167],"obtained":[118],"using":[119],"automated":[120],"hematology":[121],"analysis.":[122],"Plasma":[123],"samples":[124],"assessed":[126],"VWF":[128],"activity":[129],"antigen":[131],"by":[132],"ELISA.":[133],"Mean":[134],"mgNIH":[135],"(":[136,156,176],"n":[137],"=":[138,158,178],"6)":[139],"226.0":[141],"\u00b1":[142,150,169,173],"30.6":[143],"mg/100":[144,152],"L":[145,153],"35.5":[149],"4.3":[151],"p":[157,177],"0.002),":[159],"6.36-fold":[161],"increase":[162],"SynCardia.":[164],"MIH":[165],"values":[166],"20.80":[168],"2.65":[170],"3.27":[172],"0.37,":[174],"respectively":[175],"0.002).":[179],"significantly":[181],"increased":[182],"cell-derived":[183],"fragments":[184],"compared":[185],"Realheart,":[187],"both":[189],"devices":[190],"preserved":[191],"VWF.":[192],"demonstrated":[194],"substantially":[195],"improved":[196],"under":[198],"matched":[199],"conditions.":[202]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-16T00:00:00"}