{"id":"https://openalex.org/W7213315849","doi":"https://doi.org/10.64898/2026.09.10.750095","title":"DiffGSP: reversing mRNA diffusion to unlock high-fidelity spatial transcriptomics","display_name":"DiffGSP: reversing mRNA diffusion to unlock high-fidelity spatial transcriptomics","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213315849","doi":"https://doi.org/10.64898/2026.09.10.750095"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.10.750095","doi":"https://doi.org/10.64898/2026.09.10.750095","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750095","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.10.750095.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.10.750095.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101957664","display_name":"Jixin Liu","orcid":"https://orcid.org/0000-0003-1304-6465","observed_orcids":["https://orcid.org/0000-0003-1304-6465"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jixin Liu","raw_affiliation_strings":["Mathematical Research Center, Shandong University, Jinan, Shandong 250100, China","School of Mathematics, Shandong University, Jinan, Shandong 250100, China"],"raw_orcid":"https://orcid.org/0000-0003-1304-6465","affiliations":[{"raw_affiliation_string":"Mathematical Research Center, Shandong University, Jinan, Shandong 250100, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, Shandong 250100, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159832255","display_name":"Shuli Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuli Sun","raw_affiliation_strings":["Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations), Shandong University, Qingdao 266237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations), Shandong University, Qingdao 266237, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399042","display_name":"Yang Xu","orcid":"https://orcid.org/0000-0002-2091-9175","observed_orcids":["https://orcid.org/0000-0002-2091-9175"]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]},{"id":"https://openalex.org/I4387153646","display_name":"BGI Research","ror":"https://ror.org/05gsxrt27","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xu","raw_affiliation_strings":["BGI Research, Chongqing 401329, China","BGI Research, Shenzhen 518083, China","State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Research, Chongqing 401329, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139952068","display_name":"Shuai Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Jiang","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, Shandong 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, Shandong 250100, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018648659","display_name":"Shuhuan Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]},{"id":"https://openalex.org/I4387153646","display_name":"BGI Research","ror":"https://ror.org/05gsxrt27","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhuan Cao","raw_affiliation_strings":["BGI Research, Chongqing 401329, China","BGI Research, Shenzhen 518083, China","State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Research, Chongqing 401329, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696676","display_name":"Guojun Li","orcid":"https://orcid.org/0000-0001-9505-1502","observed_orcids":["https://orcid.org/0000-0001-9505-1502"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojun Li","raw_affiliation_strings":["Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations), Shandong University, Qingdao 266237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Mathematics and Interdisciplinary Sciences (Frontiers Science Center for Nonlinear Expectations), Shandong University, Qingdao 266237, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151752304","display_name":"Xin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]},{"id":"https://openalex.org/I4387153646","display_name":"BGI Research","ror":"https://ror.org/05gsxrt27","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhao","raw_affiliation_strings":["BGI Research, Chongqing 401329, China","BGI Research, Shenzhen 518083, China","Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen 518083, China","State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Research, Chongqing 401329, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Human Disease Genomics, BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I4387153646"]},{"raw_affiliation_string":"State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China","institution_ids":["https://openalex.org/I100135526","https://openalex.org/I4387153646"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017344694","display_name":"Bingqiang Liu","orcid":"https://orcid.org/0000-0002-5734-1135","observed_orcids":["https://orcid.org/0000-0002-5734-1135"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bingqiang Liu","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, Shandong 250100, China","Shandong National Center for Applied Mathematics, Jinan, Shandong 250100, China","State Key Laboratory of Cryptography and Digital Economy Security, Shandong University, Jinan, Shandong 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, Shandong 250100, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Shandong National Center for Applied Mathematics, Jinan, Shandong 250100, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Cryptography and Digital Economy Security, Shandong University, Jinan, Shandong 250100, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017344694"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11911","display_name":"Spatial and Panel Data Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/diffusion-correction","display_name":"diffusion correction","score":0.550000011920929},{"id":"https://openalex.org/keywords/graph-signal-processing","display_name":"graph signal processing","score":0.8790000081062317},{"id":"https://openalex.org/keywords/fick-s-law","display_name":"Fick's law","score":0.9919999837875366},{"id":"https://openalex.org/keywords/spatial-misalignment","display_name":"spatial misalignment","score":0.7720000147819519},{"id":"https://openalex.org/keywords/physics-informed-modeling","display_name":"physics-informed modeling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tissue-processing-artifacts","display_name":"tissue processing artifacts","score":0.6690000295639038},{"id":"https://openalex.org/keywords/mouse-brain","display_name":"mouse brain","score":0.5720000267028809},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.7749999761581421},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tertiary-lymphoid-structures","display_name":"tertiary lymphoid structures","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6444000005722046},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6229000091552734},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6136000156402588},{"id":"https://openalex.org/C2781085045","wikidata":"https://www.wikidata.org/wiki/Q7318308","display_name":"Reversing","level":2,"score":0.6107000112533569},{"id":"https://openalex.org/C175779824","wikidata":"https://www.wikidata.org/wiki/Q7574078","display_name":"Spatial organization","level":2,"score":0.5823000073432922},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5285999774932861},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.5281999707221985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4950000047683716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44830000400543213},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.41510000824928284},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.414900004863739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3995000123977661},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C64754055","wikidata":"https://www.wikidata.org/wiki/Q7574053","display_name":"Spatial contextual awareness","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C29648211","wikidata":"https://www.wikidata.org/wiki/Q1995607","display_name":"Directionality","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.32820001244544983},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2646999955177307},{"id":"https://openalex.org/C121475858","wikidata":"https://www.wikidata.org/wiki/Q2735911","display_name":"Spatial filter","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.10.750095","doi":"https://doi.org/10.64898/2026.09.10.750095","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750095","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.10.750095.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.10.750095","doi":"https://doi.org/10.64898/2026.09.10.750095","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.750095","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.10.750095.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6206124459","display_name":null,"funder_award_id":"62272270","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320311026","display_name":"Shandong University","ror":"https://ror.org/0207yh398"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320335581","display_name":"Young Scientists Fund","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213315849.pdf","grobid_xml":"https://content.openalex.org/works/W7213315849.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2945848398"],"related_works":["https://openalex.org/W7169510202","https://openalex.org/W4414930887","https://openalex.org/W7203703310","https://openalex.org/W3134766331","https://openalex.org/W4399983952","https://openalex.org/W7213751111","https://openalex.org/W7134855891","https://openalex.org/W4394870153","https://openalex.org/W4404122385","https://openalex.org/W7155464221"],"abstract_inverted_index":{"Abstract":[0],"Spatial":[1],"transcriptomics":[2,51,167],"enables":[3,125,179],"gene":[4,54,96,116,138,175],"expression":[5,55,97,117,176],"profiling":[6],"within":[7],"intact":[8],"tissues":[9],"while":[10],"preserving":[11],"spatial":[12,43,50,60,64,95,115,166,174],"context,":[13],"providing":[14],"unprecedented":[15],"insights":[16],"into":[17],"cellular":[18],"organization":[19],"and":[20,66,91,104,148,161,178],"function.":[21],"However,":[22],"mRNA":[23],"diffusion":[24],"during":[25],"tissue":[26],"processing":[27,85],"can":[28],"cause":[29],"transcripts":[30],"originating":[31],"from":[32],"adjacent":[33],"cells":[34],"to":[35,58,86,113,164],"be":[36],"captured":[37],"at":[38],"a":[39,46,75,157],"given":[40],"spot.":[41],"This":[42],"misalignment":[44],"challenges":[45],"fundamental":[47],"premise":[48],"of":[49,111,128,173],"that":[52,78],"measured":[53],"faithfully":[56],"corresponds":[57],"its":[59],"origin,":[61],"thereby":[62],"compromising":[63],"fidelity":[65,172],"potentially":[67],"biasing":[68],"biological":[69,182],"interpretation.":[70,183],"Here,":[71],"we":[72],"present":[73],"DiffGSP,":[74],"physics-informed":[76],"framework":[77,160],"integrates":[79],"Fick\u2019s":[80],"law":[81],"with":[82],"graph":[83],"signal":[84],"explicitly":[87],"model":[88],"diffusion-induced":[89,122],"distortions":[90],"recover":[92],"the":[93,108,126,133,141,171],"underlying":[94],"landscape.":[98],"Comprehensive":[99],"benchmarking":[100],"across":[101],"diverse":[102],"datasets":[103],"evaluation":[105],"metrics":[106],"demonstrates":[107],"consistent":[109],"ability":[110],"DiffGSP":[112,124,169],"restore":[114],"patterns.":[118],"By":[119],"computationally":[120],"reversing":[121],"distortions,":[123],"discovery":[127],"fine":[129],"anatomical":[130],"structures":[131,151],"in":[132,140,145,152],"mouse":[134],"brain,":[135],"spatially":[136],"organized":[137],"modules":[139],"kidney,":[142],"intratumoral":[143],"heterogeneity":[144],"colorectal":[146],"cancer,":[147],"tertiary":[149],"lymphoid":[150],"lung":[153],"adenocarcinoma.":[154],"Built":[155],"on":[156],"physically":[158],"interpretable":[159],"broadly":[162],"applicable":[163],"sequencing-based":[165],"technologies,":[168],"improves":[170],"reconstruction":[177],"more":[180],"reliable":[181]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-16T00:00:00"}