{"id":"https://openalex.org/W7213315374","doi":"https://doi.org/10.3892/ijo.2026.5939","title":"E3 ubiquitin ligase MAGI3\u2011mediated TAZ ubiquitination suppresses the non\u2011small cell lung cancer occurrence and development by targeting the Wnt pathway","display_name":"E3 ubiquitin ligase MAGI3\u2011mediated TAZ ubiquitination suppresses the non\u2011small cell lung cancer occurrence and development by targeting the Wnt pathway","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213315374","doi":"https://doi.org/10.3892/ijo.2026.5939","pmid":"https://pubmed.ncbi.nlm.nih.gov/42757476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13729793"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2026.5939","doi":"https://doi.org/10.3892/ijo.2026.5939","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5939","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3892/ijo.2026.5939","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100384380","display_name":"Liang Ye","orcid":"https://orcid.org/0000-0002-6735-0836","observed_orcids":["https://orcid.org/0000-0002-6735-0836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ye Liang","raw_affiliation_strings":["Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy, Qingdao Integrated Chinese and Western Medicine Hospital, Qingdao, Shandong 266000, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5138431323","display_name":"Jie Zhuang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jie Zhuang","raw_affiliation_strings":["Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5138431323"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55211851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"5","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9150000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magi3","display_name":"MAGI3","score":1.0},{"id":"https://openalex.org/keywords/taz","display_name":"TAZ","score":0.6489999890327454},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.8500000238418579},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/beta-catenin-nuclear-translocation","display_name":"\u03b2-catenin nuclear translocation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/tcf-lef-transcription","display_name":"TCF/LEF transcription","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8532999753952026},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7993000149726868},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7160000205039978},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6029000282287598},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5889000296592712},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5565000176429749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5365999937057495},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49970000982284546},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.4410000145435333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42170000076293945},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41339999437332153},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.3978999853134155},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.33250001072883606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32989999651908875},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2776787872","wikidata":"https://www.wikidata.org/wiki/Q18031516","display_name":"SKP2","level":5,"score":0.26269999146461487},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25450000166893005}],"mesh":[{"descriptor_ui":"D000091364","descriptor_name":"Transcriptional Coactivator with PDZ-Binding Motif Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.2026.5939","doi":"https://doi.org/10.3892/ijo.2026.5939","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5939","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13729793","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13729793/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13729793/pdf/ijo-69-05-05939.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Oncol","raw_type":"Text"},{"id":"pmid:42757476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42757476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2026.5939","doi":"https://doi.org/10.3892/ijo.2026.5939","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2026.5939","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213315374.pdf","grobid_xml":"https://content.openalex.org/works/W7213315374.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1836452880","https://openalex.org/W1992171392","https://openalex.org/W2027150010","https://openalex.org/W2042635844","https://openalex.org/W2048182455","https://openalex.org/W2065697878","https://openalex.org/W2079512206","https://openalex.org/W2088138181","https://openalex.org/W2104091091","https://openalex.org/W2107277218","https://openalex.org/W2138064097","https://openalex.org/W2150964566","https://openalex.org/W2159310898","https://openalex.org/W2163745451","https://openalex.org/W2167898988","https://openalex.org/W2417018212","https://openalex.org/W2426003472","https://openalex.org/W2466033276","https://openalex.org/W2553689505","https://openalex.org/W2561418597","https://openalex.org/W2604165468","https://openalex.org/W2777786283","https://openalex.org/W2797729636","https://openalex.org/W2954563933","https://openalex.org/W3000466000","https://openalex.org/W3008581549","https://openalex.org/W3092112283","https://openalex.org/W3169792184","https://openalex.org/W3172344973","https://openalex.org/W3195803557","https://openalex.org/W3199064876","https://openalex.org/W4285120905","https://openalex.org/W4286433154","https://openalex.org/W4288802944","https://openalex.org/W4303981462"],"related_works":["https://openalex.org/W4200283022","https://openalex.org/W2990518753","https://openalex.org/W2978863003","https://openalex.org/W4396918956","https://openalex.org/W2506261614","https://openalex.org/W2999994809","https://openalex.org/W4223540317","https://openalex.org/W3000172807","https://openalex.org/W2897041283","https://openalex.org/W2196495372"],"abstract_inverted_index":{",":[0],"MAGI3":[1,10],"overexpression":[2],"suppressed":[3],"tumor":[4],"growth":[5],"and":[6,37,43],"lung":[7],"metastasis,":[8],"while":[9],"silencing":[11],"increased":[12],"metastatic":[13],"nodules.":[14],"The":[15],"present":[16],"study":[17],"identified":[18],"that":[19],"MAGI3,":[20],"as":[21],"a":[22],"suppressor":[23],"in":[24],"NSCLC":[25],"progression,":[26],"repressed":[27],"the":[28],"Wnt":[29],"pathway\u2011including":[30],"TAZ":[31],"degradation,":[32],"impaired":[33],"\u03b2\u2011catenin":[34],"nuclear":[35],"translocation,":[36],"diminished":[38],"TCF/LEF":[39],"transcription\u2011thereby":[40],"restraining":[41],"tumorigenesis":[42],"metastasis":[44],"of":[45],"NSCLC.":[46]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-16T00:00:00"}
