{"id":"https://openalex.org/W7213308043","doi":"https://doi.org/10.1093/ejendo/lvag096.196","title":"RC9.5 - ECE_2071 - Replacing early morning cortisol reduces fatigue: post-hoc analysis of AddiQol in CHAMPAIN, a double-blind study comparing Chronocort and Plenadren","display_name":"RC9.5 - ECE_2071 - Replacing early morning cortisol reduces fatigue: post-hoc analysis of AddiQol in CHAMPAIN, a double-blind study comparing Chronocort and Plenadren","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7213308043","doi":"https://doi.org/10.1093/ejendo/lvag096.196"},"language":"en","primary_location":{"id":"doi:10.1093/ejendo/lvag096.196","doi":"https://doi.org/10.1093/ejendo/lvag096.196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejendo/lvag096.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/ejendo/lvag096.196","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085361559","display_name":"Irina-Oana Chifu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irina Chifu","raw_affiliation_strings":["W\u00fcrzburg University Hospital Straubm\u00fchlweg Heliport , W\u00fcrzburg ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"W\u00fcrzburg University Hospital Straubm\u00fchlweg Heliport , W\u00fcrzburg ,","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151725563","display_name":"Alessandro Prete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alessandro Prete","raw_affiliation_strings":["University of Birmingham , Birmingham ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Birmingham , Birmingham ,","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008241562","display_name":"Verena Theiler\u2010Schwetz","orcid":"https://orcid.org/0000-0002-2378-689X","observed_orcids":["https://orcid.org/0000-0002-2378-689X"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Verena Theiler-Schwetz","raw_affiliation_strings":["University of Graz , Graz ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz , Graz ,","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010324154","display_name":"Wiebke Arlt","orcid":"https://orcid.org/0000-0001-5106-9719","observed_orcids":["https://orcid.org/0000-0001-5106-9719"]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wiebke Arlt","raw_affiliation_strings":["Medical Research Council Laboratory of Medical Sciences , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratory of Medical Sciences , London ,","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053319453","display_name":"Birgit Harbeck","orcid":"https://orcid.org/0000-0002-4886-0769","observed_orcids":["https://orcid.org/0000-0002-4886-0769"]},"institutions":[{"id":"https://openalex.org/I4210126759","display_name":"Amedes MVZ Hamburg","ror":"https://ror.org/02xgrds91","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210126759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Harbeck","raw_affiliation_strings":["Amedes MVZ Hamburg , Hamburg ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amedes MVZ Hamburg , Hamburg ,","institution_ids":["https://openalex.org/I4210126759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114242713","display_name":"C S Napier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Napier","raw_affiliation_strings":["Newcastle University , Newcastle upon Tyne ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle University , Newcastle upon Tyne ,","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001744820","display_name":"John D C Newell-Price","orcid":"https://orcid.org/0000-0002-0835-5493","observed_orcids":["https://orcid.org/0000-0002-0835-5493"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Newell-Price","raw_affiliation_strings":["University of Sheffield , Sheffield ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield , Sheffield ,","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088158896","display_name":"Aled Rees","orcid":"https://orcid.org/0000-0002-1165-9092","observed_orcids":["https://orcid.org/0000-0002-1165-9092"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aled Rees","raw_affiliation_strings":["University of Cardiff , Cardiff ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cardiff , Cardiff ,","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052776295","display_name":"Nicole Reisch","orcid":"https://orcid.org/0000-0002-7469-6069","observed_orcids":["https://orcid.org/0000-0002-7469-6069"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Reisch","raw_affiliation_strings":["Ludwig-Maximilians-Universitat Munchen , Munchen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig-Maximilians-Universitat Munchen , Munchen ,","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127806587","display_name":"G\u00fcnter Stalla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139985","display_name":"Medicover","ror":"https://ror.org/03zrqt452","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210139985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00fcnter Stalla","raw_affiliation_strings":["Medicover , Munchen ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicover , Munchen ,","institution_ids":["https://openalex.org/I4210139985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046137466","display_name":"Helen Coope","orcid":"https://orcid.org/0009-0008-5244-4670","observed_orcids":["https://orcid.org/0009-0008-5244-4670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Coope","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124824910","display_name":"John Porter","orcid":"https://orcid.org/0000-0002-1601-500X","observed_orcids":["https://orcid.org/0000-0002-1601-500X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Porter","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121769531","display_name":"Jo Quirke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo Quirke","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059581773","display_name":"Peter Treasure","orcid":"https://orcid.org/0000-0002-7277-0122","observed_orcids":["https://orcid.org/0000-0002-7277-0122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Treasure","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046776586","display_name":"Irmina Wlodarczyk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irmina Wlodarczyk","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037250357","display_name":"Hanna Bendfeldt","orcid":"https://orcid.org/0009-0002-2852-2209","observed_orcids":["https://orcid.org/0009-0002-2852-2209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna Bendfeldt","raw_affiliation_strings":["Immedica UK Ltd , London ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immedica UK Ltd , London ,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084322098","display_name":"Richard John M Ross","orcid":"https://orcid.org/0000-0001-9222-9678","observed_orcids":["https://orcid.org/0000-0001-9222-9678"]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Ross","raw_affiliation_strings":["University of Sheffield , Sheffield ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Sheffield , Sheffield ,","institution_ids":["https://openalex.org/I91136226"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":{"value":3798,"currency":"EUR","value_usd":4292},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"195","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/addison-s-disease","display_name":"Addison's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cortisol-replacement-therapy","display_name":"cortisol replacement therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.7519999742507935},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.9390000104904175},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sf-36","display_name":"SF-36","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cross-over-study","display_name":"cross-over study","score":0.47200000286102295},{"id":"https://openalex.org/keywords/post-hoc-analysis","display_name":"post hoc analysis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/sensitivity-analysis","display_name":"sensitivity analysis","score":0.4880000054836273},{"id":"https://openalex.org/keywords/symptoms","display_name":"clinical symptoms","score":0.7179999947547913},{"id":"https://openalex.org/keywords/physical-component-summary","display_name":"physical component summary","score":0.5590000152587891},{"id":"https://openalex.org/keywords/mental-component-score","display_name":"mental component score","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.8575999736785889},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8047999739646912},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.6747999787330627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.604200005531311},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.569100022315979},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5271999835968018},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.4726000130176544},{"id":"https://openalex.org/C62913699","wikidata":"https://www.wikidata.org/wiki/Q5173333","display_name":"Cortisol awakening response","level":3,"score":0.47130000591278076},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.4074999988079071},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40049999952316284},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.37220001220703125},{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.27070000767707825},{"id":"https://openalex.org/C2777817097","wikidata":"https://www.wikidata.org/wiki/Q8282","display_name":"Addison's disease","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C2911038130","wikidata":"https://www.wikidata.org/wiki/Q8282","display_name":"Primary Adrenal Insufficiency","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.26579999923706055},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ejendo/lvag096.196","doi":"https://doi.org/10.1093/ejendo/lvag096.196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejendo/lvag096.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ejendo/lvag096.196","doi":"https://doi.org/10.1093/ejendo/lvag096.196","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ejendo/lvag096.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7126129797","https://openalex.org/W4415452214","https://openalex.org/W7130522029","https://openalex.org/W4403151803","https://openalex.org/W4403150048","https://openalex.org/W806084087","https://openalex.org/W1965139082","https://openalex.org/W3092993296","https://openalex.org/W2794843562","https://openalex.org/W2060161855"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Cortisol":[2],"has":[3,145],"a":[4,86,327],"circadian":[5],"rhythm":[6,15],"with":[7,18,93,110],"an":[8],"early":[9,38,363],"morning":[10,39,364],"rise;":[11],"loss":[12],"of":[13,64,73,127,162,172,199,260,334,407],"this":[14],"is":[16],"associated":[17],"poor":[19],"health.":[20],"In":[21,190,236,278],"the":[22,37,62,65,108,136,173,191,237,267,279,282,362,374,391],"CHAMPAIN":[23,84],"study":[24,89],"we":[25],"demonstrated":[26],"that":[27],"twice":[28,349],"daily":[29,112],"Chronocort":[30,200,261,335,358,410],"(Efmody,":[31],"Immedica":[32],"Netherlands":[33],"B.V.),":[34],"which":[35,51,175,254,386],"replaces":[36,53],"rise":[40],"in":[41,90,107,197,258,332,370,390],"cortisol,":[42],"improved":[43,366],"QoL":[44,369],"compared":[45,79,356,411],"to":[46,80,298,357,383,412],"Plenadren":[47,113,353],"(Takeda":[48],"Ltd.":[49],"UK),":[50],"only":[52],"daytime":[54],"cortisol":[55,121,365],"levels.":[56],"This":[57,379],"post-hoc":[58],"analysis":[59,166,193,239,281],"looked":[60],"at":[61,102,185],"sub-domains":[63],"disease":[66,71,375],"specific":[67,328,376,398],"questionnaire,":[68,330],"AddiQoL":[69,144],"(Addison's":[70],"Quality":[72],"Life":[74],"questionnaire)":[75],"and":[76,104,122,129,135,151,153,179,209,230,318,396,402],"SF-36":[77,249,284,392],"V2,":[78],"other":[81],"questionnaires.":[82],"Methods":[83],"was":[85,119,138,154,167,176,182,196,242,257,271,331,345,380,387],"double-blind":[87],"cross-over":[88,174,192],"58":[91],"patients":[92],"primary":[94,117],"adrenal":[95],"insufficiency":[96],"(AI)":[97],"comparing":[98],"Chronocort,":[99],"15":[100],"mg":[101,106],"night":[103],"10":[105],"morning,":[109],"once":[111],"25":[114],"mg.":[115],"The":[116,248,324,340],"endpoint":[118],"waking":[120],"secondary":[123],"endpoints":[124],"were":[125,404],"measures":[126],"fatigue":[128,256,329,385,397,408],"QoL.":[130],"Patients":[131],"signed":[132],"informed":[133],"consent":[134],"trial":[137],"registered":[139],"(NCT":[140],"NCT05222152;":[141],"Eudract":[142],"2021-000144-21).":[143],"four":[146],"subdomains:":[147],"fatigue,":[148,346],"emotions,":[149],"symptoms,":[150],"miscellaneous":[152,231],"completed":[155],"every":[156],"4":[157],"weeks":[158],"within":[159],"2":[160],"hours":[161],"waking.":[163],"A":[164],"sensitivity":[165,238,280],"done":[168],"on":[169,373,409],"period":[170],"1":[171],"randomised":[177],"parallel-arm":[178],"blinded.":[180],"P":[181,186,206,213,222,227,233,245,263,275,292,302,308,315,321,337],"one-sided,":[183],"significance":[184],"<":[187],".025.":[188],"Results":[189],"treatment":[194,354],"effect":[195],"favour":[198,259,333],"for":[201,219],"AddiQoL:":[202],"Total":[203,240],"Score":[204,241,270],"(+3.214,":[205],"=":[207,214,223,228,234,246,264,276,293,303,309,316,322,338],".024),":[208],"subdomain":[210],"Fatigue":[211],"(+1.234,":[212],".014),":[215],"but":[216,266],"not":[217,272],"different":[218,273],"Emotions":[220],"(+0.861,":[221],".032),":[224],"Symptoms":[225],"(+0.500,":[226],".157)":[229],"(+0.676,":[232],".033).":[235],"positive":[243],"(+6.3,":[244],".0175).":[247],"V2":[250],"physical":[251,393],"component":[252,394],"score":[253,395],"includes":[255],"(+3.2,":[262],".01)":[265],"Mental":[268],"Component":[269],"(\u22120.6":[274],".7).":[277],"following":[283],"subdomains":[285],"significantly":[286],"favoured":[287],"Chronocort:":[288],"Physical":[289,299],"Functioning":[290],"(+5.42":[291],".004),":[294,317],"Role":[295],"Limitations":[296],"due":[297,382],"Health":[300,312],"(+7.59":[301],".001),":[304],"Bodily":[305],"Pain":[306],"(+4.99":[307],".022),":[310],"General":[311],"Perceptions":[313],"(+5.70":[314],"Vitality":[319],"(+7.16":[320],".002).":[323],"PROMIS":[325,400],"7b,":[326],"(\u22122.6,":[336],".024).":[339],"most":[341],"common":[342],"adverse":[343],"event":[344],"reported":[347],"by":[348],"as":[350],"many":[351],"during":[352],"(44.6%)":[355],"(20.7%).":[359],"Conclusions":[360],"Replacing":[361],"health":[367],"related":[368],"AI":[371],"based":[372],"questionnaire":[377,399],"AddiQoL.":[378],"primarily":[381],"reduced":[384],"also":[388],"seen":[389],"7b":[401],"there":[403],"fewer":[405],"reports":[406],"Plenadren.":[413]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-09-16T00:00:00"}