{"id":"https://openalex.org/W7213288961","doi":"https://doi.org/10.64898/2026.09.09.750457","title":"Sarcomere length, fascicle length, and serial sarcomere number are preserved in paretic hindlimb muscles following chronic stroke in rats despite persistent motor impairment","display_name":"Sarcomere length, fascicle length, and serial sarcomere number are preserved in paretic hindlimb muscles following chronic stroke in rats despite persistent motor impairment","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213288961","doi":"https://doi.org/10.64898/2026.09.09.750457"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.09.750457","doi":"https://doi.org/10.64898/2026.09.09.750457","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750457","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750457.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750457.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066605195","display_name":"Stephanie A. Ross","orcid":"https://orcid.org/0000-0003-3512-9579","observed_orcids":["https://orcid.org/0000-0003-3512-9579"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Stephanie A. Ross","raw_affiliation_strings":["Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada"],"raw_orcid":"https://orcid.org/0000-0003-3512-9579","affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151839438","display_name":"Sydney N. Dorscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sydney N. Dorscher","raw_affiliation_strings":["Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125406868","display_name":"Timothy R. Leonard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Timothy R. Leonard","raw_affiliation_strings":["Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109237419","display_name":"Ruth A. Seerattan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ruth A. Seerattan","raw_affiliation_strings":["Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047765476","display_name":"Dale Corbett","orcid":"https://orcid.org/0000-0003-0217-4576","observed_orcids":["https://orcid.org/0000-0003-0217-4576"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dale Corbett","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa ON, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069322953","display_name":"Walter Herzog","orcid":"https://orcid.org/0000-0002-5341-0033","observed_orcids":["https://orcid.org/0000-0002-5341-0033","https://orcid.org/0009-0009-2898-1991"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Walter Herzog","raw_affiliation_strings":["Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066605195"],"corresponding_institution_ids":["https://openalex.org/I168635309"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.302700012922287,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-stroke","display_name":"chronic stroke","score":0.968999981880188},{"id":"https://openalex.org/keywords/sarcomere-length","display_name":"sarcomere length","score":0.9049999713897705},{"id":"https://openalex.org/keywords/fascicle-length","display_name":"fascicle length","score":0.8920000195503235},{"id":"https://openalex.org/keywords/muscle-architecture","display_name":"muscle architecture","score":0.6579999923706055},{"id":"https://openalex.org/keywords/paretic-limb","display_name":"paretic limb","score":0.8659999966621399},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.6869999766349792},{"id":"https://openalex.org/keywords/photothrombotic-stroke","display_name":"photothrombotic stroke","score":0.8489999771118164},{"id":"https://openalex.org/keywords/lateral-gastrocnemius","display_name":"lateral gastrocnemius","score":0.9120000004768372},{"id":"https://openalex.org/keywords/extensor-digitorum-longus","display_name":"extensor digitorum longus","score":1.0},{"id":"https://openalex.org/keywords/muscle-use","display_name":"muscle use","score":0.4189999997615814},{"id":"https://openalex.org/keywords/joint-angles","display_name":"joint angles","score":0.4300000071525574},{"id":"https://openalex.org/keywords/skeletal-muscle-structure","display_name":"skeletal muscle structure","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.9613999724388123},{"id":"https://openalex.org/C110537703","wikidata":"https://www.wikidata.org/wiki/Q5436639","display_name":"Fascicle","level":2,"score":0.8314999938011169},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6430000066757202},{"id":"https://openalex.org/C2777001087","wikidata":"https://www.wikidata.org/wiki/Q6940306","display_name":"Muscle architecture","level":2,"score":0.6313999891281128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5817999839782715},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.42309999465942383},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.3898000121116638},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.3774999976158142},{"id":"https://openalex.org/C3018579778","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Chronic stroke","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2687999904155731},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2687999904155731}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.09.750457","doi":"https://doi.org/10.64898/2026.09.09.750457","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750457","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750457.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.09.750457","doi":"https://doi.org/10.64898/2026.09.09.750457","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750457","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750457.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213288961.pdf","grobid_xml":"https://content.openalex.org/works/W7213288961.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1482601876","https://openalex.org/W1555351365","https://openalex.org/W1972714808","https://openalex.org/W1980573962","https://openalex.org/W2011858010","https://openalex.org/W2016242699","https://openalex.org/W2023729390","https://openalex.org/W2038188196","https://openalex.org/W2046765245","https://openalex.org/W2046950038","https://openalex.org/W2047917359","https://openalex.org/W2064052038","https://openalex.org/W2067905539","https://openalex.org/W2105845652","https://openalex.org/W2123564531","https://openalex.org/W2130801249","https://openalex.org/W2132091723","https://openalex.org/W2144181217","https://openalex.org/W2150650847","https://openalex.org/W2156833447","https://openalex.org/W2161214961","https://openalex.org/W2164898586","https://openalex.org/W2168759496","https://openalex.org/W2170130305","https://openalex.org/W2228483624","https://openalex.org/W2399286426","https://openalex.org/W2891688353","https://openalex.org/W2894664655","https://openalex.org/W2916358247","https://openalex.org/W2922783632","https://openalex.org/W2971287565","https://openalex.org/W3001309827","https://openalex.org/W3006045596","https://openalex.org/W3014762249","https://openalex.org/W3035008804","https://openalex.org/W3039057887","https://openalex.org/W3149185598","https://openalex.org/W3160758999","https://openalex.org/W3165580165","https://openalex.org/W3175948556","https://openalex.org/W3184633142","https://openalex.org/W4221136077","https://openalex.org/W4384935484","https://openalex.org/W4398241721","https://openalex.org/W4411541236","https://openalex.org/W4412049108","https://openalex.org/W7126046312"],"related_works":["https://openalex.org/W3012084956","https://openalex.org/W2888438942","https://openalex.org/W2003168657","https://openalex.org/W3016939464","https://openalex.org/W4411875497","https://openalex.org/W3112676353","https://openalex.org/W4280537746","https://openalex.org/W2016242699","https://openalex.org/W2159553510","https://openalex.org/W2246921484"],"abstract_inverted_index":{"Abstract":[0],"Stroke":[1,107],"causes":[2],"motor":[3,60,126],"impairments":[4],"that":[5,205],"are":[6],"commonly":[7],"attributed":[8],"to":[9,166,241],"altered":[10],"neural":[11,17,207,238],"control,":[12],"but":[13,156],"chronic":[14,32],"changes":[15,218,228],"in":[16,45,151,192,216,219,224],"activation":[18],"and":[19,37,77,86,98,102,130,137,145,162,174,176,185,243],"muscle":[20,26],"use":[21],"may":[22,229],"also":[23],"influence":[24],"skeletal":[25,47],"structure.":[27],"This":[28],"study":[29],"examined":[30],"whether":[31],"stroke":[33,55,136,152,211],"alters":[34],"sarcomere":[35,43,100,128,147,172,178,220,227],"length":[36,92,101,129,144,173,196,221],"dispersion,":[38,175],"fascicle":[39,91,96],"length,":[40,171],"or":[41,56,140,194,222],"serial":[42,146,177],"number":[44,148,179],"adult":[46],"muscle.":[48,250],"Twenty-four":[49],"female":[50],"Sprague-Dawley":[51],"rats":[52],"underwent":[53],"photothrombotic":[54],"sham":[57,138,154],"surgery.":[58],"Limb-specific":[59],"impairment":[61,111,208],"was":[62],"assessed":[63],"longitudinally":[64],"using":[65,104],"a":[66],"beam":[67,117],"traversal":[68,118],"task.":[69],"At":[70],"4.5":[71],"months":[72],"post-surgery,":[73],"the":[74,113,182,198,235,244,249],"lateral":[75,183],"gastrocnemius":[76,184],"extensor":[78,186],"digitorum":[79,187],"longus":[80],"muscles":[81],"were":[82,149,159,163],"harvested":[83],"from":[84,94],"paretic":[85,114],"non-paretic":[87],"limbs.":[88,142],"We":[89],"measured":[90],"directly":[93],"isolated":[95],"bundles":[97],"quantified":[99],"dispersion":[103,131],"laser":[105],"diffraction.":[106],"animals":[108,139],"exhibited":[109],"persistent":[110,125,206],"of":[112,237],"limb":[115],"during":[116],"with":[119,190],"elevated":[120],"misstep":[121],"rates.":[122],"Despite":[123],"this":[124],"impairment,":[127],"did":[132],"not":[133,160,213],"differ":[134],"between":[135,141,181],"Fascicle":[143,170],"greater":[150],"than":[153],"animals,":[155],"these":[157],"differences":[158,191],"limb-specific":[161],"therefore":[164],"unlikely":[165],"reflect":[167],"stroke-related":[168],"changes.":[169],"differed":[180],"longus,":[188],"consistent":[189],"architecture":[193],"relative":[195,240],"at":[197],"selected":[199],"joint":[200],"angles.":[201],"These":[202],"findings":[203],"indicate":[204],"following":[209],"adult-onset":[210],"does":[212],"necessarily":[214],"result":[215],"substantial":[217],"sarcomeres":[223],"series.":[225],"Instead,":[226],"depend":[230],"on":[231],"additional":[232],"factors,":[233],"including":[234],"timing":[236],"injury":[239],"growth":[242],"mechanical":[245],"environment":[246],"experienced":[247],"by":[248]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-16T00:00:00"}
