{"id":"https://openalex.org/W7213287529","doi":"https://doi.org/10.64898/2026.09.09.750435","title":"nnOPN3 mediates retinal-dependent lipofuscin accumulation and its loss sensitizes keratinocytes to blue-light-induced proteomic remodeling","display_name":"nnOPN3 mediates retinal-dependent lipofuscin accumulation and its loss sensitizes keratinocytes to blue-light-induced proteomic remodeling","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213287529","doi":"https://doi.org/10.64898/2026.09.09.750435"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.09.750435","doi":"https://doi.org/10.64898/2026.09.09.750435","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750435","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750435.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750435.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019209452","display_name":"Maiza Cristina Von Dentz","orcid":"https://orcid.org/0000-0003-3332-2287","observed_orcids":["https://orcid.org/0000-0003-3332-2287"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maiza Von Dentz","raw_affiliation_strings":["Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3332-2287","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055599146","display_name":"Helena C. Junqueira","orcid":"https://orcid.org/0000-0002-0159-0191","observed_orcids":["https://orcid.org/0000-0002-0159-0191"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Helena Couto Junqueira","raw_affiliation_strings":["Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-0159-0191","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074966834","display_name":"Manuel Alejandro Herrera L\u00f3pez","orcid":"https://orcid.org/0000-0002-4518-4443","observed_orcids":["https://orcid.org/0000-0002-4518-4443"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Manuel Alejandro Herrera Lopez","raw_affiliation_strings":["Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-4518-4443","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139904075","display_name":"Gabriella Lisboa dos Santos","orcid":"https://orcid.org/0000-0001-6984-375X","observed_orcids":["https://orcid.org/0000-0001-6984-375X"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gabriella Lisboa","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-6984-375X","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036626839","display_name":"Johannes Fuchs","orcid":"https://orcid.org/0000-0001-9317-6969","observed_orcids":["https://orcid.org/0000-0001-9317-6969"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johannes Fuchs","raw_affiliation_strings":["Glycoproteomics and MS Proteomics, Science for Life Laboratory (SciLifeLab), University of Gothenburg, Sweden","Proteomics Core Facility (PCF) and BioMS, Sahlgrenska Academy, University of Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9317-6969","affiliations":[{"raw_affiliation_string":"Glycoproteomics and MS Proteomics, Science for Life Laboratory (SciLifeLab), University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I881427289"]},{"raw_affiliation_string":"Proteomics Core Facility (PCF) and BioMS, Sahlgrenska Academy, University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033705137","display_name":"Katherine Tsantarlis","orcid":"https://orcid.org/0000-0001-8497-706X","observed_orcids":["https://orcid.org/0000-0001-8497-706X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Katherine Tsantarlis","raw_affiliation_strings":["Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-8497-706X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053328406","display_name":"Carina Sihlbom","orcid":"https://orcid.org/0000-0002-1704-2333","observed_orcids":["https://orcid.org/0000-0002-1704-2333"]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carina Sihlbom Wallem","raw_affiliation_strings":["Glycoproteomics and MS Proteomics, Science for Life Laboratory (SciLifeLab), University of Gothenburg, Sweden","Proteomics Core Facility (PCF) and BioMS, Sahlgrenska Academy, University of Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-1704-2333","affiliations":[{"raw_affiliation_string":"Glycoproteomics and MS Proteomics, Science for Life Laboratory (SciLifeLab), University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495","https://openalex.org/I881427289"]},{"raw_affiliation_string":"Proteomics Core Facility (PCF) and BioMS, Sahlgrenska Academy, University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040444798","display_name":"Leonardo Vin\u00edcius Monteiro de Assis","orcid":"https://orcid.org/0000-0001-5209-0835","observed_orcids":["https://orcid.org/0000-0001-5209-0835"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I4405272501","display_name":"Wallenberg Centre for Molecular and Translational Medicine","ror":"https://ror.org/048rhnt15","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4405272501"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE","SE"],"is_corresponding":true,"raw_author_name":"Leonardo Vinicius Monteiro de Assis","raw_affiliation_strings":["Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden","Institute of Neurobiology, Center of Brain Behavior & Metabolism, University of L\u00fcbeck, Germany","University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany","Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-5209-0835","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Institute of Neurobiology, Center of Brain Behavior & Metabolism, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"University Hospital Schleswig-Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]},{"raw_affiliation_string":"Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4405272501","https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007458912","display_name":"Maur\u0131\u0301cio S. Baptista","orcid":"https://orcid.org/0000-0001-7079-7666","observed_orcids":["https://orcid.org/0000-0001-7079-7666"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maur\u00edcio da Silva Baptista","raw_affiliation_strings":["Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7079-7666","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Chemistry, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5007458912","https://openalex.org/A5040444798"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210112713","https://openalex.org/I4405272501","https://openalex.org/I881427289","https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.2451999932527542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipofuscin-accumulation","display_name":"lipofuscin accumulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/all-trans-retinal","display_name":"all-trans-retinal","score":0.8349999785423279},{"id":"https://openalex.org/keywords/opn3","display_name":"OPN3","score":0.8489999771118164},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.6480000019073486},{"id":"https://openalex.org/keywords/oxidative-stress-response","display_name":"oxidative stress response","score":0.6340000033378601},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.550000011920929},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C186198217","wikidata":"https://www.wikidata.org/wiki/Q217740","display_name":"Lipofuscin","level":2,"score":0.8335000276565552},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7044000029563904},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6947000026702881},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6333000063896179},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5782999992370605},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5612999796867371},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.44690001010894775},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.42989999055862427},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.4016999900341034},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.40139999985694885},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.39329999685287476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38589999079704285},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.3617999851703644},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.3165999948978424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3073999881744385},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C68394932","wikidata":"https://www.wikidata.org/wiki/Q12133470","display_name":"Respirometry","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.2624000012874603},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.25189998745918274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.09.750435","doi":"https://doi.org/10.64898/2026.09.09.750435","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750435","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750435.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.09.750435","doi":"https://doi.org/10.64898/2026.09.09.750435","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.09.750435","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/15/2026.09.09.750435.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5018064154","display_name":null,"funder_award_id":"541063275","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G912907925","display_name":null,"funder_award_id":"TRR 418","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"},{"id":"https://openalex.org/F4320335047","display_name":"Sahlgrenska Akademin","ror":"https://ror.org/01tm6cn81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213287529.pdf","grobid_xml":"https://content.openalex.org/works/W7213287529.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W80844995","https://openalex.org/W1482184907","https://openalex.org/W1567559703","https://openalex.org/W1751574485","https://openalex.org/W1769581193","https://openalex.org/W1980680124","https://openalex.org/W2012321776","https://openalex.org/W2025138486","https://openalex.org/W2025665129","https://openalex.org/W2038049117","https://openalex.org/W2044627868","https://openalex.org/W2044935703","https://openalex.org/W2088591017","https://openalex.org/W2100047096","https://openalex.org/W2124348590","https://openalex.org/W2146512944","https://openalex.org/W2288531112","https://openalex.org/W2336723294","https://openalex.org/W2418617288","https://openalex.org/W2513066930","https://openalex.org/W2529131874","https://openalex.org/W2597162250","https://openalex.org/W2735509655","https://openalex.org/W2748912324","https://openalex.org/W2788653860","https://openalex.org/W2800394424","https://openalex.org/W2811403767","https://openalex.org/W2888985586","https://openalex.org/W2889038927","https://openalex.org/W2889660662","https://openalex.org/W2894786641","https://openalex.org/W2896727628","https://openalex.org/W2945916168","https://openalex.org/W2948973112","https://openalex.org/W2965963448","https://openalex.org/W2979745558","https://openalex.org/W2984991656","https://openalex.org/W3000506953","https://openalex.org/W3001072279","https://openalex.org/W3003359419","https://openalex.org/W3005228847","https://openalex.org/W3032367572","https://openalex.org/W3039541678","https://openalex.org/W3049104043","https://openalex.org/W3092935658","https://openalex.org/W3120618382","https://openalex.org/W3129223107","https://openalex.org/W3129904734","https://openalex.org/W3161524177","https://openalex.org/W3178701923","https://openalex.org/W3208691473","https://openalex.org/W4280614300","https://openalex.org/W4285005648","https://openalex.org/W4286218400","https://openalex.org/W4362575039","https://openalex.org/W4376868085","https://openalex.org/W4387563973","https://openalex.org/W4390951650","https://openalex.org/W4392034145","https://openalex.org/W4393187880","https://openalex.org/W4396540347","https://openalex.org/W4402218487","https://openalex.org/W4403931031","https://openalex.org/W4407574469","https://openalex.org/W4409212495","https://openalex.org/W4410894272","https://openalex.org/W4414471953","https://openalex.org/W4416074277","https://openalex.org/W7118245515","https://openalex.org/W7159945405","https://openalex.org/W7162798807"],"related_works":["https://openalex.org/W2092872547","https://openalex.org/W2606317482","https://openalex.org/W1965590111","https://openalex.org/W2890457217","https://openalex.org/W1576741560","https://openalex.org/W1972721559","https://openalex.org/W2059407358","https://openalex.org/W7120576589","https://openalex.org/W4224539933","https://openalex.org/W1489589204"],"abstract_inverted_index":{"ABSTRACT":[0],"Lipofuscin":[1],"is":[2],"a":[3,100,150,175],"blue-light-absorbing":[4],"pigment":[5],"that":[6,73,135],"contributes":[7,15],"to":[8,16,21],"oxidative":[9],"damage.":[10],"Whether":[11],"all-trans":[12],"retinal":[13],"(atRAL)":[14],"its":[17],"formation":[18,187],"in":[19,35,141,153,174,188],"response":[20],"light":[22,137],"remains":[23],"unclear.":[24],"We":[25],"asked":[26],"whether":[27,39],"blue-light":[28,181],"photosensitization":[29],"of":[30,48,120,168],"atRAL":[31,49,112],"promotes":[32],"lipofuscin":[33,186],"accumulation":[34],"human":[36],"keratinocytes":[37],"and":[38,52,58,91,108,123,183],"this":[40,65],"depends":[41],"on":[42],"Opsin":[43],"3":[44],"(OPN3).":[45],"Blue-light":[46],"excitation":[47],"reduced":[50,64],"mitochondrial":[51,109],"lysosomal":[53],"viability,":[54],"impaired":[55],"autophagic":[56],"flux,":[57],"increased":[59],"lipofuscin.":[60],"OPN3":[61,74,82,130,154],"knockdown":[62,155],"significantly":[63],"accumulation.":[66],"Label-free":[67],"data-independent":[68],"acquisition":[69],"(DIA)":[70],"proteomics":[71],"showed":[72,134],"acts":[75],"at":[76,157],"three":[77,166],"levels.":[78],"In":[79],"the":[80,145,171,179],"dark,":[81],"loss":[83],"altered":[84],"proteome":[85,173],"networks":[86],"associated":[87],"with":[88],"autophagy,":[89],"apoptosis,":[90],"interferon-related":[92],"responses.":[93],"Under":[94],"blue":[95,136],"light,":[96],"control":[97],"cells":[98,156],"activated":[99],"stress-adaptive":[101],"program":[102],"spanning":[103],"inflammatory":[104],"regulation,":[105],"lipid":[106],"metabolism,":[107],"function,":[110],"which":[111],"strongly":[113],"amplified.":[114],"This":[115],"molecular":[116],"signature,":[117],"including":[118],"induction":[119],"cellular":[121],"respiration":[122],"ATP-production":[124],"proteins,":[125],"was":[126,131,160],"largely":[127],"absent":[128],"when":[129],"silenced.":[132],"Respirometry":[133],"suppressed":[138],"oxygen":[139],"consumption":[140],"both":[142],"lines":[143],"over":[144],"first":[146],"24":[147],"h,":[148],"but":[149],"faster":[151],"recovery":[152],"48\u201372":[158],"h":[159],"observed.":[161],"Together,":[162],"these":[163],"data":[164],"define":[165],"functions":[167],"OPN3:":[169],"maintaining":[170],"basal":[172],"blue-light-independent":[176],"manner,":[177],"enabling":[178,184],"adaptive":[180],"response,":[182],"retinal-dependent":[185],"keratinocytes.":[189]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-16T00:00:00"}