{"id":"https://openalex.org/W7213270771","doi":"https://doi.org/10.26434/chemrxiv.15008903/v1","title":"Electrosynthesis of Bis-spirocycles via a Radical Strain-Release Dearomatization Cascade","display_name":"Electrosynthesis of Bis-spirocycles via a Radical Strain-Release Dearomatization Cascade","publication_year":2026,"publication_date":"2026-09-16","ids":{"openalex":"https://openalex.org/W7213270771","doi":"https://doi.org/10.26434/chemrxiv.15008903/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15008903/v1","doi":"https://doi.org/10.26434/chemrxiv.15008903/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008903/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008903/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008903/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151830274","display_name":"Pooja Bhardwaj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pooja Bhardwaj","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110415627","display_name":"B K Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Braja Kishor Paul","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151829256","display_name":"Padmanabha Samanta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Padmanabha Samanta","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094218575","display_name":"Pintu Kumbhakar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pintu Kumbhakar","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115426464","display_name":"Aritri Saha","orcid":"https://orcid.org/0009-0007-3265-370X","observed_orcids":["https://orcid.org/0009-0007-3265-370X"]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aritri Saha","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030434402","display_name":"Suman De Sarkar","orcid":"https://orcid.org/0000-0002-6342-4711","observed_orcids":["https://orcid.org/0000-0002-6342-4711"]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suman De Sarkar","raw_affiliation_strings":["Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India"],"raw_orcid":"https://orcid.org/0000-0002-6342-4711","affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences , Indian Institute of Science Education and Research Kolkata , Mohanpur-741246 , West Bengal , India","institution_ids":["https://openalex.org/I127439422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I127439422"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrochemical-synthesis","display_name":"electrochemical synthesis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/electrochemical-oxidation","display_name":"electrochemical oxidation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bicyclo-1-1-0-butanes","display_name":"bicyclo[1.1.0]butanes","score":0.906000018119812},{"id":"https://openalex.org/keywords/radical-cascade","display_name":"radical cascade","score":0.9330000281333923},{"id":"https://openalex.org/keywords/anodization","display_name":"anodic oxidation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/functional-group-tolerance","display_name":"functional group tolerance","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.821399986743927},{"id":"https://openalex.org/C193115255","wikidata":"https://www.wikidata.org/wiki/Q377408","display_name":"Electrosynthesis","level":4,"score":0.7703999876976013},{"id":"https://openalex.org/C20327893","wikidata":"https://www.wikidata.org/wiki/Q7280479","display_name":"Radical cyclization","level":2,"score":0.7103000283241272},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.5358999967575073},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.4828000068664551},{"id":"https://openalex.org/C96444392","wikidata":"https://www.wikidata.org/wiki/Q1993452","display_name":"Radical ion","level":3,"score":0.46480000019073486},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.41499999165534973},{"id":"https://openalex.org/C58548122","wikidata":"https://www.wikidata.org/wiki/Q838390","display_name":"Cascade reaction","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31349998712539673},{"id":"https://openalex.org/C169749651","wikidata":"https://www.wikidata.org/wiki/Q902198","display_name":"Radical substitution","level":3,"score":0.30970001220703125},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3010999858379364},{"id":"https://openalex.org/C2777155434","wikidata":"https://www.wikidata.org/wiki/Q3743176","display_name":"Free-radical reaction","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C172713056","wikidata":"https://www.wikidata.org/wiki/Q2295560","display_name":"Radical-nucleophilic aromatic substitution","level":4,"score":0.2874999940395355},{"id":"https://openalex.org/C2777389692","wikidata":"https://www.wikidata.org/wiki/Q4802699","display_name":"Aryl radical","level":4,"score":0.28279998898506165},{"id":"https://openalex.org/C2780995637","wikidata":"https://www.wikidata.org/wiki/Q466403","display_name":"Radical initiator","level":4,"score":0.27639999985694885},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15008903/v1","doi":"https://doi.org/10.26434/chemrxiv.15008903/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008903/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008903/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15008903/v1","doi":"https://doi.org/10.26434/chemrxiv.15008903/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15008903/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15008903/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327182","display_name":"Indian Institute of Science Education and Research Mohali","ror":"https://ror.org/01vztzd79"},{"id":"https://openalex.org/F4320327976","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213270771.pdf","grobid_xml":"https://content.openalex.org/works/W7213270771.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171987700","https://openalex.org/W7000115968","https://openalex.org/W4403700897","https://openalex.org/W4401929982","https://openalex.org/W4412467914","https://openalex.org/W3195657077","https://openalex.org/W4289262026","https://openalex.org/W4389816936","https://openalex.org/W3175926240","https://openalex.org/W4414393507"],"abstract_inverted_index":{"This":[0],"report":[1],"presents":[2],"an":[3,53],"electro-oxidative":[4],"approach":[5],"to":[6,61],"synthesize":[7],"functionalized":[8],"bis-spirocycles":[9],"by":[10],"combining":[11],"the":[12,62],"strain-release":[13,64],"reactivity":[14],"of":[15,41],"bicyclo[1.1.0]butanes":[16],"(BCBs)":[17],"with":[18,46],"arene":[19],"dearomatization":[20],"in":[21],"a":[22],"radical":[23,26,56,59],"cascade.":[24],"Various":[25],"precursors":[27],"can":[28],"undergo":[29],"this":[30],"transformation":[31],"under":[32],"mild,":[33],"oxidant-":[34],"and":[35,67],"mediator-free":[36],"conditions,":[37],"allowing":[38],"efficient":[39],"production":[40],"complex,":[42],"three-dimensional":[43],"bis-spirocyclic":[44],"structures":[45],"high":[47],"functional-group":[48],"tolerance.":[49],"Mechanistic":[50],"investigations":[51],"indicate":[52],"anodically":[54],"driven":[55],"cascade,":[57],"involving":[58],"addition":[60],"BCB,":[63],"ring":[65],"opening,":[66],"subsequent":[68],"ipso-dearomatization.":[69]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-16T00:00:00"}
