{"id":"https://openalex.org/W7213262002","doi":"https://doi.org/10.1042/cs20261592","title":"Gut microbiota modulates Hyodeoxycholic Acid to Inhibit Leukemia Development","display_name":"Gut microbiota modulates Hyodeoxycholic Acid to Inhibit Leukemia Development","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213262002","doi":"https://doi.org/10.1042/cs20261592","pmid":"https://pubmed.ncbi.nlm.nih.gov/42742127"},"language":"en","primary_location":{"id":"doi:10.1042/cs20261592","doi":"https://doi.org/10.1042/cs20261592","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20261592","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1042/cs20261592","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051707054","display_name":"\u80e1\u5efa\u8fbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianda Hu","raw_affiliation_strings":["Fujian Medical University, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University, Quanzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101646899","display_name":"Wanying Liu","orcid":"https://orcid.org/0000-0003-0937-9865","observed_orcids":["https://orcid.org/0000-0003-0937-9865"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanying Liu","raw_affiliation_strings":["Second Affiliated Hospital of Fujian Medical University, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Fujian Medical University, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115593901","display_name":"Jiajie Yang","orcid":"https://orcid.org/0009-0006-9432-4963","observed_orcids":["https://orcid.org/0009-0006-9432-4963"]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajie Yang","raw_affiliation_strings":["Second Affiliated Hospital of Fujian Medical University, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Fujian Medical University, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480546","display_name":"Yanxin Chen","orcid":"https://orcid.org/0000-0001-5230-571X","observed_orcids":["https://orcid.org/0000-0001-5230-571X","https://orcid.org/0000-0003-0156-3502"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanxin Chen","raw_affiliation_strings":["Fujian Medical University Union Hospital\u798f\u5efa\u533b\u79d1\u5927\u5b66\u534f\u548c\u533b\u9662, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital\u798f\u5efa\u533b\u79d1\u5927\u5b66\u534f\u548c\u533b\u9662, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083823437","display_name":"Shaozhen Chen","orcid":"https://orcid.org/0000-0001-8420-2707","observed_orcids":["https://orcid.org/0000-0001-8420-2707"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaozhen Chen","raw_affiliation_strings":["The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University,, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Department of Hematology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University,, Fuzhou, China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151704375","display_name":"Jiazheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134617","display_name":"Second Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/03wnxd135","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiazheng Li","raw_affiliation_strings":["Second Affiliated Hospital of Fujian Medical University, Quanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Fujian Medical University, Quanzhou, China","institution_ids":["https://openalex.org/I4210134617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151829663","display_name":"Ting Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Yang","raw_affiliation_strings":["First Affiliated Hospital of Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Affiliated Hospital of Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I4210121761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059951295","display_name":"Guanbin Zhang","orcid":"https://orcid.org/0000-0003-2037-343X","observed_orcids":["https://orcid.org/0000-0003-2037-343X"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanbin Zhang","raw_affiliation_strings":["Chengdu University of Traditional Chinese Medicine, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu University of Traditional Chinese Medicine, Chengdu, China","institution_ids":["https://openalex.org/I53411278"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051707054"],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67999932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hyodeoxycholic-acid","display_name":"hyodeoxycholic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8263999819755554},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.7372000217437744},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6258000135421753},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.6223000288009644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5810999870300293},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5343999862670898},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.5321999788284302},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4900999963283539},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4189999997615814},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4108000099658966},{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.4052000045776367},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.3621000051498413},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3450999855995178},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.3240000009536743},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31040000915527344},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3077000081539154},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3019999861717224},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.271699994802475},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26570001244544983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1042/cs20261592","doi":"https://doi.org/10.1042/cs20261592","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20261592","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:42742127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42742127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/cs20261592","doi":"https://doi.org/10.1042/cs20261592","is_oa":true,"landing_page_url":"https://doi.org/10.1042/cs20261592","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6958059072494507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5253598553","display_name":null,"funder_award_id":"82,470,173","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"To":[0],"explore":[1],"the":[2,55,184],"role":[3],"of":[4,57,85,106],"gut":[5,45,138],"microbiota":[6,46,71,139],"and":[7,26,28,35,82,101,110,127,142,152,187],"bile":[8,86],"acid":[9,37],"metabolism":[10],"in":[11,44,78,118,169],"Acute":[12],"myeloid":[13],"leukemia":[14,80,125],"(AML),":[15],"we":[16],"analyzed":[17],"samples":[18],"from":[19],"29":[20],"patients":[21],"via":[22],"16S":[23],"rDNA":[24],"sequencing":[25],"LC-QTOF-MS,":[27],"performed":[29],"functional":[30],"studies":[31],"on":[32],"Enterococcus":[33,58,150],"faecalis":[34,76,162],"hyodeoxycholic":[36],"(HDCA).":[38],"Results":[39],"revealed":[40],"a":[41,119],"dynamic":[42],"shift":[43],"diversity":[47,141],"during":[48],"treatment,":[49],"which":[50],"recovered":[51],"after":[52,67],"therapy.":[53],"Notably,":[54],"abundance":[56],"at":[59],"baseline":[60,132,153],"was":[61,143],"significantly":[62],"correlated":[63,135],"with":[64,136,145,166],"clinical":[65],"response":[66],"treatment.":[68],"Furthermore,":[69],"fecal":[70,170],"transplantation":[72],"(FMT)":[73],"using":[74],"E.":[75,161],"reduced":[77],"vivo":[79],"burden":[81],"increased":[83],"levels":[84,151],"acids":[87],"such":[88],"as":[89],"HDCA.":[90],"In":[91,148],"vitro":[92],"analyses":[93],"demonstrated":[94],"that":[95],"HDCA":[96,123,134,154,173],"suppresses":[97],"AML":[98,158,165],"cell":[99,111,185],"growth":[100],"promotes":[102],"apoptosis":[103],"through":[104],"inhibition":[105],"NF-\u03baB,":[107,179],"mitochondrial":[108,181],"dysfunction,":[109],"cycle":[112],"arrest.":[113],"These":[114],"findings":[115],"were":[116],"corroborated":[117],"mouse":[120],"model,":[121],"where":[122],"delayed":[124],"progression":[126],"improved":[128],"survival.":[129],"Clinically,":[130],"higher":[131],"serum":[133],"greater":[137],"\u03b1":[140],"associated":[144],"complete":[146],"remission.":[147],"summary,":[149],"are":[155],"linked":[156],"to":[157],"treatment":[159],"outcomes.":[160],"FMT":[163],"ameliorates":[164],"concurrent":[167],"rises":[168],"HDCA,":[171],"while":[172],"exerts":[174],"anti-leukemic":[175],"effects":[176],"by":[177],"targeting":[178],"disrupting":[180],"integrity,":[182],"arresting":[183],"cycle,":[186],"triggering":[188],"apoptosis.":[189]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-09-16T00:00:00"}