{"id":"https://openalex.org/W7213258591","doi":"https://doi.org/10.48550/arxiv.2609.14709","title":"An immune world model for multiscale forecasting and therapeutic hypothesis generation","display_name":"An immune world model for multiscale forecasting and therapeutic hypothesis generation","publication_year":2026,"publication_date":"2026-09-13","ids":{"openalex":"https://openalex.org/W7213258591","doi":"https://doi.org/10.48550/arxiv.2609.14709"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2609.14709","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.14709","pdf_url":"https://arxiv.org/pdf/2609.14709","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2609.14709","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041810936","display_name":"Taoyong Cui","orcid":"https://orcid.org/0000-0002-5532-6636","observed_orcids":["https://orcid.org/0000-0002-5532-6636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cui, Taoyong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151726630","display_name":"Xi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wang, Xi","raw_affiliation_strings":["Department of Chemistry , New York University , New York , NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry , New York University , New York , NY , USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022284072","display_name":"Zonghang Li","orcid":"https://orcid.org/0000-0002-2796-039X","observed_orcids":["https://orcid.org/0000-0002-2796-039X","https://orcid.org/0009-0004-9999-6449"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Li, Zonghang","raw_affiliation_strings":["Department of Computer Science and Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151820097","display_name":"Jinchao Ding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ding, Jinchao","raw_affiliation_strings":["PhAI Labs, Inc. , Palo Alto , CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhAI Labs, Inc. , Palo Alto , CA , USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151725774","display_name":"Lingsen You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"You, Lingsen","raw_affiliation_strings":["Department of Pathology , Stanford University School of Medicine , Stanford , CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Stanford University School of Medicine , Stanford , CA , USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151877426","display_name":"Yuzhi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu, Yuzhi","raw_affiliation_strings":["Department of Chemistry , New York University , New York , NY , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry , New York University , New York , NY , USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151700896","display_name":"Wanghan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu, Wanghan","raw_affiliation_strings":["Shanghai Jiao Tong University , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University , Shanghai , China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125554383","display_name":"Fang Wu","orcid":"https://orcid.org/0000-0001-7240-3915","observed_orcids":["https://orcid.org/0000-0001-7240-3915"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wu, Fang","raw_affiliation_strings":["Department of Computer Science , Stanford University , Stanford , CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science , Stanford University , Stanford , CA , USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081938206","display_name":"Kejun Ying","orcid":"https://orcid.org/0000-0002-1791-6176","observed_orcids":["https://orcid.org/0000-0002-1791-6176"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying, Kejun","raw_affiliation_strings":["Harvard University , Cambridge , MA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard University , Cambridge , MA , USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137037507","display_name":"Wanli Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ouyang, Wanli","raw_affiliation_strings":["Multimedia Laboratory , Department of Information Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multimedia Laboratory , Department of Information Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134939296","display_name":"Pheng Ann Heng","orcid":"https://orcid.org/0000-0003-3055-5034","observed_orcids":["https://orcid.org/0000-0003-3055-5034"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Heng, Pheng Ann","raw_affiliation_strings":["Department of Computer Science and Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , The Chinese University of Hong Kong , Hong Kong SAR , China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151821018","display_name":"Ling Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang, Ling","raw_affiliation_strings":["PhAI Labs, Inc. , Palo Alto , CA , USA","Princeton University , Princeton , NJ , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhAI Labs, Inc. , Palo Alto , CA , USA","institution_ids":[]},{"raw_affiliation_string":"Princeton University , Princeton , NJ , USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151708794","display_name":"Zhenfei Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yin, Zhenfei","raw_affiliation_strings":["PhAI Labs, Inc. , Palo Alto , CA , USA","University of Oxford , Oxford , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhAI Labs, Inc. , Palo Alto , CA , USA","institution_ids":[]},{"raw_affiliation_string":"University of Oxford , Oxford , UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100864921","display_name":"Yingcheng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wu, Yingcheng","raw_affiliation_strings":["Department of Pathology , Stanford University School of Medicine , Stanford , CA , USA","PhAI Labs, Inc. , Palo Alto , CA , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology , Stanford University School of Medicine , Stanford , CA , USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"PhAI Labs, Inc. , Palo Alto , CA , USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12391","display_name":"Artificial Immune Systems Applications","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.14110000431537628,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.10610000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.4560000002384186},{"id":"https://openalex.org/keywords/ai-scientists","display_name":"AI scientists","score":0.6060000061988831},{"id":"https://openalex.org/keywords/il-36gamma","display_name":"IL-36\u03b3","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cytokine-combinations","display_name":"cytokine combinations","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7354000210762024},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5174999833106995},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5012000203132629},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.44369998574256897},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.3612000048160553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3538999855518341},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34869998693466187},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33169999718666077},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C38042653","wikidata":"https://www.wikidata.org/wiki/Q1500332","display_name":"Psychoneuroimmunology","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C93768804","wikidata":"https://www.wikidata.org/wiki/Q2518735","display_name":"Artificial immune system","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27239999175071716},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2574000060558319},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2609.14709","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.14709","pdf_url":"https://arxiv.org/pdf/2609.14709","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2609.14709","doi":"https://doi.org/10.48550/arxiv.2609.14709","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2609.14709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2609.14709","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2609.14709","pdf_url":"https://arxiv.org/pdf/2609.14709","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213258591.pdf","grobid_xml":"https://content.openalex.org/works/W7213258591.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966217032","https://openalex.org/W2039123767","https://openalex.org/W2097733789","https://openalex.org/W2108825235","https://openalex.org/W2205886515","https://openalex.org/W2561754210","https://openalex.org/W2562947047","https://openalex.org/W2578528809","https://openalex.org/W2587048937","https://openalex.org/W2791483720","https://openalex.org/W2796207838","https://openalex.org/W2801309958","https://openalex.org/W2897815318","https://openalex.org/W2899145148","https://openalex.org/W2901677030","https://openalex.org/W2949177718","https://openalex.org/W2965552103","https://openalex.org/W2966465234","https://openalex.org/W2969093152","https://openalex.org/W2984472267","https://openalex.org/W2993905360","https://openalex.org/W3027051073","https://openalex.org/W3037257919","https://openalex.org/W3129866267","https://openalex.org/W3164692211","https://openalex.org/W4225598893","https://openalex.org/W4281716291","https://openalex.org/W4375955255","https://openalex.org/W4378838672","https://openalex.org/W4389991792","https://openalex.org/W4392168151","https://openalex.org/W4399387478","https://openalex.org/W4403925918","https://openalex.org/W4406170795","https://openalex.org/W4412709685","https://openalex.org/W4416043407","https://openalex.org/W4416702492","https://openalex.org/W4417414129","https://openalex.org/W7119591224","https://openalex.org/W7164497504","https://openalex.org/W7167668826"],"related_works":["https://openalex.org/W4409413294","https://openalex.org/W2240271288","https://openalex.org/W7104263705","https://openalex.org/W2067844471","https://openalex.org/W7163675356","https://openalex.org/W7213452588","https://openalex.org/W7095847733","https://openalex.org/W3009604588","https://openalex.org/W4416975498","https://openalex.org/W4396814098"],"abstract_inverted_index":{"Immune":[0,29,49,98,131],"therapies":[1],"act":[2],"across":[3,42],"cell-intrinsic":[4],"programs,":[5,81],"tissue":[6,85],"ecosystems,":[7],"and":[8,45,56,58,75,84,90,93,149],"patient-specific":[9],"immune":[10,40,139],"states,":[11],"yet":[12],"most":[13],"predictors":[14],"address":[15],"these":[16],"scales":[17],"separately.":[18],"We":[19],"used":[20],"a":[21,116,121,135],"governed":[22,122],"evolutionary":[23],"AI":[24,143],"Scientist":[25,52],"to":[26,72,87,109],"construct":[27],"the":[28,59,150],"World":[30,50,99,132],"Model,":[31],"an":[32],"action-conditioned":[33],"model":[34,62,70,145],"that":[35,141],"learns":[36],"how":[37],"interventions":[38,74],"move":[39],"states":[41],"cellular,":[43],"tissue,":[44],"individual":[46],"levels.":[47],"The":[48,68,130],"Model--building":[51],"searched":[53],"candidate":[54],"architectures":[55],"workflows,":[57],"resulting":[60],"world":[61],"was":[63],"frozen":[64,69],"before":[65],"independent":[66],"confirmation.":[67],"generalized":[71],"unseen":[73,95],"biological":[76],"contexts,":[77],"recovered":[78],"intervention-specific":[79],"cellular":[80],"integrated":[82],"cell":[83],"information":[86],"improve":[88],"ecosystem":[89],"patient-response":[91],"prediction,":[92],"forecast":[94],"perturbation":[96],"combinations.":[97],"Model--guided":[100],"analysis":[101],"then":[102],"combined":[103],"measured":[104],"perturbations":[105],"with":[106],"cross-axis":[107],"inference":[108],"nominate":[110],"IL-36$\u03b3$":[111],"plus":[112],"SIRP$\u03b1$":[113],"inhibition":[114],"as":[115],"complementary-axis":[117],"therapeutic":[118,155],"hypothesis,":[119],"whereas":[120],"self-correction":[123],"audit":[124],"rejected":[125],"every":[126],"screened":[127],"cytokine":[128],"pair.":[129],"Model":[133],"provides":[134],"framework":[136],"for":[137],"multiscale":[138],"simulation":[140],"connects":[142],"Scientist-driven":[144],"construction,":[146],"intervention":[147],"forecasting,":[148],"generation":[151],"of":[152],"prospectively":[153],"testable":[154],"hypotheses.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-16T00:00:00"}
