{"id":"https://openalex.org/W7213256358","doi":"https://doi.org/10.64898/2026.09.10.749335","title":"Melatonin modulates habituation learning via the convergent action of two MT 1 -type receptors","display_name":"Melatonin modulates habituation learning via the convergent action of two MT 1 -type receptors","publication_year":2026,"publication_date":"2026-09-15","ids":{"openalex":"https://openalex.org/W7213256358","doi":"https://doi.org/10.64898/2026.09.10.749335"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.10.749335","doi":"https://doi.org/10.64898/2026.09.10.749335","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.749335","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.10.749335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048986753","display_name":"Dominique Baas","orcid":"https://orcid.org/0000-0001-7970-717X","observed_orcids":["https://orcid.org/0000-0001-7970-717X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Baas","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":"https://orcid.org/0000-0001-7970-717X","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116131997","display_name":"Isabelle Darvaux-Hubert","orcid":"https://orcid.org/0000-0001-7839-5506","observed_orcids":["https://orcid.org/0000-0001-7839-5506"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Darvaux-Hubert","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":"https://orcid.org/0000-0001-7839-5506","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092090215","display_name":"Romane Dorado-Doncel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romane Dorado-Doncel","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","Master program: Bioscience, Ecole Normale Sup\u00e9rieure de Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]},{"raw_affiliation_string":"Master program: Bioscience, Ecole Normale Sup\u00e9rieure de Lyon, France","institution_ids":["https://openalex.org/I113428412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046191637","display_name":"Andrew Hsiao","orcid":"https://orcid.org/0009-0000-1827-637X","observed_orcids":["https://orcid.org/0009-0000-1827-637X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Andrew Hsiao","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":"https://orcid.org/0009-0000-1827-637X","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120045181","display_name":"Lisa Broisin","orcid":"https://orcid.org/0009-0000-8204-9278","observed_orcids":["https://orcid.org/0009-0000-8204-9278"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lisa Broisin","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","Licence program: Science de la Vie, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France"],"raw_orcid":"https://orcid.org/0009-0000-8204-9278","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]},{"raw_affiliation_string":"Licence program: Science de la Vie, Universit\u00e9 Claude Bernard Lyon 1, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125997891","display_name":"Abdel Rahman El Hassan","orcid":"https://orcid.org/0000-0003-1782-974X","observed_orcids":["https://orcid.org/0000-0003-1782-974X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Abdel Rahman El Hassan","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":"https://orcid.org/0000-0003-1782-974X","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116132001","display_name":"Julien Perrichet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Perrichet","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023773172","display_name":"Owen Randlett","orcid":"https://orcid.org/0000-0003-0181-5239","observed_orcids":["https://orcid.org/0000-0003-0181-5239"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405258652","display_name":"M\u00e9canismes en sciences int\u00e9gratives du vivant","ror":"https://ror.org/01138xk88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4405258652"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Owen Randlett","raw_affiliation_strings":["Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France"],"raw_orcid":"https://orcid.org/0000-0003-0181-5239","affiliations":[{"raw_affiliation_string":"Laboratoire MeLiS, Universit\u00e9 Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Facult\u00e9 de M\u00e9decine et de Pharmacie, 8 avenue Rockefeller, 69008 Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023773172"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4405258652"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":1.0},{"id":"https://openalex.org/keywords/habituation","display_name":"habituation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mt1-melatonin-receptor","display_name":"MT1 receptor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8059999942779541},{"id":"https://openalex.org/keywords/crispr-mutagenesis","display_name":"CRISPR mutagenesis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/receptor-heterodimerization","display_name":"receptor heterodimerization","score":0.574999988079071},{"id":"https://openalex.org/keywords/torus-longitudinalis","display_name":"torus longitudinalis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.9940000176429749},{"id":"https://openalex.org/keywords/preoptic-area","display_name":"preoptic area","score":0.9990000128746033},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.656000018119812},{"id":"https://openalex.org/keywords/response-latency","display_name":"response latency","score":0.3240000009536743},{"id":"https://openalex.org/keywords/movement-amplitude","display_name":"movement amplitude","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.9121000170707703},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8632000088691711},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6736999750137329},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5475000143051147},{"id":"https://openalex.org/C2781269140","wikidata":"https://www.wikidata.org/wiki/Q24784310","display_name":"Melatonin receptor","level":3,"score":0.4909999966621399},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4790000021457672},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40619999170303345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3781000077724457},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.35580000281333923},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3089999854564667},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C63531555","wikidata":"https://www.wikidata.org/wiki/Q7180960","display_name":"Phase response curve","level":4,"score":0.2587999999523163},{"id":"https://openalex.org/C21786239","wikidata":"https://www.wikidata.org/wiki/Q185962","display_name":"Zeitgeber","level":4,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.10.749335","doi":"https://doi.org/10.64898/2026.09.10.749335","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.749335","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.10.749335","doi":"https://doi.org/10.64898/2026.09.10.749335","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.10.749335","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1591384720","https://openalex.org/W1968317950","https://openalex.org/W1978178232","https://openalex.org/W1981983302","https://openalex.org/W1996235270","https://openalex.org/W1998928729","https://openalex.org/W2005367665","https://openalex.org/W2007790148","https://openalex.org/W2023906702","https://openalex.org/W2050066016","https://openalex.org/W2052849392","https://openalex.org/W2055171682","https://openalex.org/W2060712753","https://openalex.org/W2078255478","https://openalex.org/W2079742787","https://openalex.org/W2084771878","https://openalex.org/W2086200773","https://openalex.org/W2089665395","https://openalex.org/W2131997132","https://openalex.org/W2151132444","https://openalex.org/W2156455154","https://openalex.org/W2158764823","https://openalex.org/W2277956273","https://openalex.org/W2341109211","https://openalex.org/W2402351661","https://openalex.org/W2570916489","https://openalex.org/W2611672506","https://openalex.org/W2621287194","https://openalex.org/W2734591620","https://openalex.org/W2792694000","https://openalex.org/W2911163976","https://openalex.org/W2930731919","https://openalex.org/W2937450972","https://openalex.org/W2949193645","https://openalex.org/W2951646122","https://openalex.org/W2969354441","https://openalex.org/W2974674466","https://openalex.org/W3000696985","https://openalex.org/W3011907952","https://openalex.org/W3032424197","https://openalex.org/W3128464824","https://openalex.org/W3207486646","https://openalex.org/W3214371609","https://openalex.org/W4207029567","https://openalex.org/W4210288281","https://openalex.org/W4281776348","https://openalex.org/W4311086329","https://openalex.org/W4313180250","https://openalex.org/W4361017293","https://openalex.org/W4361188679","https://openalex.org/W4411734573","https://openalex.org/W4412435174","https://openalex.org/W7155009341"],"related_works":["https://openalex.org/W3207486646","https://openalex.org/W1571192688","https://openalex.org/W1998928729","https://openalex.org/W4361188680","https://openalex.org/W2263609896","https://openalex.org/W2586528196","https://openalex.org/W2911163976","https://openalex.org/W7155009341","https://openalex.org/W7028189267","https://openalex.org/W2401464308"],"abstract_inverted_index":{"Abstract":[0],"Melatonin":[1,38,65,102],"is":[2],"a":[3,40,52,94,126,161],"hormone":[4],"produced":[5],"by":[6,184],"the":[7,26,46,168,176,180,188],"pineal":[8],"gland":[9],"and":[10,16,30,61,81,90,104,114,138,172,186],"retina,":[11],"with":[12,129,175],"roles":[13],"in":[14,191],"sleep":[15],"circadian":[17],"rhythms":[18],"as":[19,21,39],"well":[20],"other":[22],"neuronal":[23],"processes,":[24],"including":[25,167],"regulation":[27],"of":[28,43,49,72,78,87,98,164,214],"learning":[29],"memory.":[31],"Using":[32],"larval":[33],"zebrafish,":[34],"we":[35,56,151,196],"previously":[36],"identified":[37],"potent":[41],"modulator":[42],"habituation":[44,73,77,86],"learning:":[45,74],"progressive":[47],"suppression":[48],"responses":[50],"to":[51,136,209],"repeated":[53],"stimulus.":[54],"Here":[55],"have":[57,62],"extended":[58],"these":[59,148],"analyses":[60],"found":[63,105],"that":[64,106,198],"has":[66],"strong":[67],"effects":[68,120,189],"on":[69,121],"separate":[70],"aspects":[71],"it":[75],"potentiates":[76],"response":[79],"probability":[80],"latency,":[82],"while":[83],"simultaneously":[84],"inhibiting":[85],"movement":[88],"amplitude":[89],"duration.":[91],"We":[92],"performed":[93],"systematic":[95],"CRISPR":[96],"mutagenesis":[97],"all":[99],"six":[100],"zebrafish":[101],"receptors,":[103],"only":[107],"two":[108,199],"MT":[109,200],"1":[110,201],"-type":[111,202],"receptors":[112,124,149,203],"(Mtnr1aa":[113],"Mtnr1al)":[115],"are":[116],"required":[117],"for":[118],"Melatonin\u2019s":[119,211],"habituation.":[122],"These":[123],"showed":[125],"cooperative":[127],"interaction,":[128],"each":[130,192],"individual":[131],"mutant":[132,178],"showing":[133,142],"reduced":[134],"sensitivity":[135],"Melatonin,":[137],"mtnr1aa;mtnr1al":[139],"double":[140,177],"mutants":[141],"complete":[143],"insensitivity.":[144],"To":[145],"map":[146],"where":[147],"act,":[150],"used":[152],"whole-brain":[153],"activity":[154],"mapping.":[155],"Despite":[156],"distinct":[157],"footprints,":[158],"both":[159],"perturbed":[160],"shared":[162],"set":[163],"brain":[165],"areas,":[166],"torus":[169],"longitudinalis,":[170],"cerebellum,":[171],"preoptic":[173],"area,":[174],"producing":[179],"most":[181],"extensive":[182],"phenotype":[183],"combining":[185],"expanding":[187],"seen":[190],"single":[193],"mutant.":[194],"Thus,":[195],"propose":[197],"act":[204],"at":[205],"overlapping":[206],"circuit":[207],"nodes":[208],"reinforce":[210],"bidirectional":[212],"control":[213],"learning.":[215]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-16T00:00:00"}