{"id":"https://openalex.org/W7213181983","doi":"https://doi.org/10.64898/2026.09.11.747888","title":"A panel of Diversity Outbred mouse embryonic stem cells: enabling the functional characterization of natural genetic variation in vitro","display_name":"A panel of Diversity Outbred mouse embryonic stem cells: enabling the functional characterization of natural genetic variation in vitro","publication_year":2026,"publication_date":"2026-09-13","ids":{"openalex":"https://openalex.org/W7213181983","doi":"https://doi.org/10.64898/2026.09.11.747888","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622625"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.11.747888","doi":"https://doi.org/10.64898/2026.09.11.747888","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.747888","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.11.747888.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.11.747888.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059506070","display_name":"Megan Brady","orcid":"https://orcid.org/0000-0002-1650-6167","observed_orcids":["https://orcid.org/0000-0002-1650-6167"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan M. Brady","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-1650-6167","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089743440","display_name":"Emily Swanzey","orcid":"https://orcid.org/0000-0003-2581-6498","observed_orcids":["https://orcid.org/0000-0003-2581-6498"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Swanzey","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0003-2581-6498","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151634492","display_name":"Kathryn Janeczko","orcid":"https://orcid.org/0009-0007-6133-8426","observed_orcids":["https://orcid.org/0009-0007-6133-8426"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Janeczko","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0009-0007-6133-8426","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012522236","display_name":"Samuel J. Widmayer","orcid":"https://orcid.org/0000-0002-1200-4768","observed_orcids":["https://orcid.org/0000-0002-1200-4768"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel J. Widmayer","raw_affiliation_strings":["Genomic Medicine, The Jackson Laboratory, Farmington, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-1200-4768","affiliations":[{"raw_affiliation_string":"Genomic Medicine, The Jackson Laboratory, Farmington, CT, USA","institution_ids":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031845290","display_name":"Hannah B. Dewey","orcid":"https://orcid.org/0000-0002-3009-0452","observed_orcids":["https://orcid.org/0000-0002-3009-0452"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah B. Dewey","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-3009-0452","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017451446","display_name":"Selcan Aydin","orcid":"https://orcid.org/0000-0002-0457-9641","observed_orcids":["https://orcid.org/0000-0002-0457-9641"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selcan Aydin","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-0457-9641","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029183644","display_name":"Whitney Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Whitney Martin","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044147989","display_name":"Catherine Brunton","orcid":"https://orcid.org/0000-0002-8502-6693","observed_orcids":["https://orcid.org/0000-0002-8502-6693"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Brunton","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-8502-6693","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052835554","display_name":"Anuj Srivastava","orcid":"https://orcid.org/0000-0002-8455-3993","observed_orcids":["https://orcid.org/0000-0002-8455-3993"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anuj Srivastava","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-8455-3993","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030457099","display_name":"Daniel M. Gatti","orcid":"https://orcid.org/0000-0003-0667-9926","observed_orcids":["https://orcid.org/0000-0003-0667-9926"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel M. Gatti","raw_affiliation_strings":["Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0003-0667-9926","affiliations":[{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018279869","display_name":"Laura G. Reinholdt","orcid":"https://orcid.org/0000-0003-4054-4048","observed_orcids":["https://orcid.org/0000-0003-4054-4048"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura G. Reinholdt","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0003-4054-4048","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067281001","display_name":"Steven C. Munger","orcid":"https://orcid.org/0000-0002-8458-1871","observed_orcids":["https://orcid.org/0000-0002-8458-1871"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Munger","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0002-8458-1871","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052070663","display_name":"Christopher L. Baker","orcid":"https://orcid.org/0000-0001-6677-0356","observed_orcids":["https://orcid.org/0000-0001-6677-0356"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher L. Baker","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":"https://orcid.org/0000-0001-6677-0356","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Tufts University, Boston, MA, USA","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Mammalian Genetics, The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052070663"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210115256"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diversity-outbred-mice","display_name":"Diversity Outbred mice","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9580000042915344},{"id":"https://openalex.org/keywords/natural-genetic-variation","display_name":"natural genetic variation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cadmium-exposure","display_name":"cadmium exposure","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ribosome-biogenesis","display_name":"ribosome biogenesis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/allelic-variation","display_name":"allelic variation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8600999712944031},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.6901000142097473},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6890000104904175},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6765000224113464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6448000073432922},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4584999978542328},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4099999964237213},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37049999833106995},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3652999997138977},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.36090001463890076},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3142000138759613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.3012000024318695},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2896000146865845},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.26910001039505005},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C167683757","wikidata":"https://www.wikidata.org/wiki/Q5937774","display_name":"Human evolutionary genetics","level":4,"score":0.25189998745918274}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.11.747888","doi":"https://doi.org/10.64898/2026.09.11.747888","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.747888","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.11.747888.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622625","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818346/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622625/pdf/nihpp-2026.09.11.747888v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42818346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.09.11.747888","doi":"https://doi.org/10.64898/2026.09.11.747888","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.11.747888","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/13/2026.09.11.747888.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5864329260","display_name":"Genetically Diverse Mouse Embryonic Stem Cells: A Platform for Cellular Systems Genetics","funder_award_id":"R24OD030037","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000878127","display_name":"Cellular Systems Genetic Approaches to Understanding Regulatory Variation","funder_award_id":"R35GM133724","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213181983.pdf","grobid_xml":"https://content.openalex.org/works/W7213181983.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1521876081","https://openalex.org/W1539026881","https://openalex.org/W1581281722","https://openalex.org/W1950808594","https://openalex.org/W1951724000","https://openalex.org/W1977481448","https://openalex.org/W1999962568","https://openalex.org/W2005501593","https://openalex.org/W2024074032","https://openalex.org/W2034772886","https://openalex.org/W2058521801","https://openalex.org/W2059073891","https://openalex.org/W2062220093","https://openalex.org/W2068780842","https://openalex.org/W2078663366","https://openalex.org/W2094991879","https://openalex.org/W2099095082","https://openalex.org/W2099540110","https://openalex.org/W2119156348","https://openalex.org/W2124985265","https://openalex.org/W2135203759","https://openalex.org/W2140056768","https://openalex.org/W2142482111","https://openalex.org/W2147993424","https://openalex.org/W2157579468","https://openalex.org/W2162683818","https://openalex.org/W2171314628","https://openalex.org/W2179438025","https://openalex.org/W2212640525","https://openalex.org/W2221387489","https://openalex.org/W2314463797","https://openalex.org/W2434017435","https://openalex.org/W2474470222","https://openalex.org/W2517125215","https://openalex.org/W2530086808","https://openalex.org/W2547171535","https://openalex.org/W2559582740","https://openalex.org/W2560195193","https://openalex.org/W2565616863","https://openalex.org/W2604155358","https://openalex.org/W2737735855","https://openalex.org/W2738015524","https://openalex.org/W2791355502","https://openalex.org/W2810174949","https://openalex.org/W2884236732","https://openalex.org/W2919941598","https://openalex.org/W2925811989","https://openalex.org/W2950395494","https://openalex.org/W2951027090","https://openalex.org/W2953351374","https://openalex.org/W2963589105","https://openalex.org/W3017335882","https://openalex.org/W3042896257","https://openalex.org/W3048813231","https://openalex.org/W3048837873","https://openalex.org/W3091103931","https://openalex.org/W3092395341","https://openalex.org/W3092395528","https://openalex.org/W3133859624","https://openalex.org/W3134023604","https://openalex.org/W3152850638","https://openalex.org/W3184263265","https://openalex.org/W4200138877","https://openalex.org/W4200619080","https://openalex.org/W4220719675","https://openalex.org/W4223900539","https://openalex.org/W4285590906","https://openalex.org/W4293107728","https://openalex.org/W4297348437","https://openalex.org/W4308141402","https://openalex.org/W4319812277","https://openalex.org/W4387931150","https://openalex.org/W4388828078","https://openalex.org/W4391824133","https://openalex.org/W4392111117","https://openalex.org/W4393057611","https://openalex.org/W4393863188","https://openalex.org/W4395478393","https://openalex.org/W4399441079","https://openalex.org/W4400263806","https://openalex.org/W4400344904","https://openalex.org/W4400735087","https://openalex.org/W4401621419","https://openalex.org/W4403288729","https://openalex.org/W4405281217","https://openalex.org/W4410115121","https://openalex.org/W4410123422","https://openalex.org/W4411153696","https://openalex.org/W4411863428","https://openalex.org/W4412552474","https://openalex.org/W4414011347","https://openalex.org/W7130422717","https://openalex.org/W7138038555","https://openalex.org/W7160061498","https://openalex.org/W7161697267"],"related_works":["https://openalex.org/W4399441079","https://openalex.org/W7160061498","https://openalex.org/W3091103931","https://openalex.org/W4410115121","https://openalex.org/W4406824876","https://openalex.org/W2086253822","https://openalex.org/W3048837873","https://openalex.org/W4200619080","https://openalex.org/W2109196885","https://openalex.org/W2495888621"],"abstract_inverted_index":{"Summary":[0],"Phenotypic":[1],"variation":[2,89,178],"in":[3,55,59,96,101,112,117,144,158,162,179,236,248],"pluripotent":[4,17,145],"stem":[5,69],"cells":[6,146],"arises":[7],"largely":[8],"from":[9,29,73],"genetic":[10,30,34,106,228],"variants":[11],"that":[12,140,225],"impact":[13],"stability":[14],"of":[15,108,135,187,221,230,239],"the":[16,38,49,81,91,105,124,227,231],"state,":[18],"response":[19,113],"to":[20,36,114,198,205],"differentiation":[21,99,181],"cues,":[22],"and":[23,43,87,93,98,137,147,189,201,213,217,244],"cell":[24,70,150],"fate":[25],"diversification.":[26],"Panels":[27],"derived":[28,72,149],"reference":[31],"populations":[32],"leverage":[33],"diversity":[35],"map":[37],"loci":[39,136,188,240],"influencing":[40],"these":[41],"molecular":[42,142],"cellular":[44],"traits.":[45],"Here":[46],"we":[47],"describe":[48,94],"first":[50],"publicly":[51,154],"available":[52,155],"resource":[53,156],"for":[54,157,234,242],"vitro":[56,159],"systems":[57],"genetics":[58,161,194],"Mus":[60,163],"musculus":[61,164],":":[62],"299":[63,165],"genetically":[64,209],"diverse,":[65],"highly":[66],"heterozygous":[67],"embryonic":[68],"lines":[71],"Diversity":[74,166,222],"Outbred":[75],"mice,":[76],"with":[77],"minimal":[78],"kinship":[79,173],"across":[80,90,208],"panel.":[82],"We":[83],"characterize":[84],"genomic":[85],"integrity":[86],"allelic":[88,170],"panel":[92,132,220],"differences":[95,111],"pluripotency":[97],"networks":[100,182,203],"embryoid":[102,118],"bodies.":[103],"Mapping":[104],"determinants":[107],"gene":[109],"expression":[110,175],"cadmium":[115],"exposure":[116],"bodies":[119],"identified":[120],"13":[121],"regulatory":[122,202],"hotspots,":[123],"largest":[125],"acting":[126],"on":[127],"ribosome":[128],"biogenesis":[129],"genes.":[130],"This":[131],"enables":[133,184],"mapping":[134,186,238],"gene-by-environment":[138],"interactions":[139,191],"influence":[141],"identity":[143],"their":[148],"types.":[151],"Highlights":[152],"First":[153],"system":[160],"Outbred-derived":[167,223],"mESCs":[168,224],"recapitulate":[169],"diversity,":[171],"low":[172],"Gene":[174],"analysis":[176],"shows":[177],"pluripotency,":[180],"Panel":[183],"high-resolution":[185,237],"G\u00d7E":[190,245],"eTOC":[192],"Systems":[193],"resources":[195],"are":[196],"needed":[197],"identify":[199],"genes":[200],"contributing":[204],"complex":[206],"traits":[207],"diverse":[210],"populations.":[211],"Baker":[212],"colleagues":[214],"generated,":[215],"genotyped,":[216],"characterized":[218],"a":[219],"maintains":[226],"heterozygosity":[229],"source":[232],"population":[233],"use":[235],"responsible":[241],"developmental":[243],"phenotypes,":[246],"enabling":[247],"vivo":[249],"functional":[250],"validation.":[251]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-09-15T00:00:00"}
