{"id":"https://openalex.org/W7213115144","doi":"https://doi.org/10.64898/2026.09.07.749713","title":"Microenvironmental and transcriptional determinants of the robustness of spinal cord regeneration in zebrafish","display_name":"Microenvironmental and transcriptional determinants of the robustness of spinal cord regeneration in zebrafish","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7213115144","doi":"https://doi.org/10.64898/2026.09.07.749713","pmid":"https://pubmed.ncbi.nlm.nih.gov/42779586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13596170"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.07.749713","doi":"https://doi.org/10.64898/2026.09.07.749713","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749713","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749713.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749713.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058396375","display_name":"Pierre Gillotay","orcid":"https://orcid.org/0009-0001-0034-5426","observed_orcids":["https://orcid.org/0009-0001-0034-5426"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Gillotay","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":"https://orcid.org/0009-0001-0034-5426","affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069512298","display_name":"Sushant Bangru","orcid":"https://orcid.org/0000-0001-9602-0783","observed_orcids":["https://orcid.org/0000-0001-9602-0783"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushant Bangru","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":"https://orcid.org/0000-0001-9602-0783","affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076945321","display_name":"Jingwen Shen","orcid":"https://orcid.org/0000-0003-4653-916X","observed_orcids":["https://orcid.org/0000-0003-4653-916X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingwen Shen","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":"https://orcid.org/0000-0003-4653-916X","affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123680215","display_name":"Bethany Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany Moore","raw_affiliation_strings":["Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089267930","display_name":"Jianhong Ou","orcid":"https://orcid.org/0000-0002-8652-2488","observed_orcids":["https://orcid.org/0000-0002-8652-2488"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhong Ou","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083447121","display_name":"Ron M. Stewart","orcid":"https://orcid.org/0000-0002-9041-1828","observed_orcids":["https://orcid.org/0000-0002-9041-1828"]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Stewart","raw_affiliation_strings":["Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082015658","display_name":"Kenneth D. Poss","orcid":"https://orcid.org/0000-0002-6743-5709","observed_orcids":["https://orcid.org/0000-0002-6743-5709"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth D. Poss","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","Morgridge Institute for Research, Madison, WI, United States"],"raw_orcid":"https://orcid.org/0000-0002-6743-5709","affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, United States","institution_ids":["https://openalex.org/I29680605"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082015658"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I29680605"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.19189999997615814,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.07000000029802322,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-regeneration","display_name":"spinal cord regeneration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.8560000061988831},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7910000085830688},{"id":"https://openalex.org/keywords/locomotor-recovery","display_name":"locomotor recovery","score":0.7710000276565552},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.656000018119812},{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.7519999742507935},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.7490000128746033},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9480000138282776},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.6290000081062317},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8127999901771545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.79830002784729},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6121000051498413},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6119999885559082},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6079000234603882},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5564000010490417},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.5453000068664551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5117999911308289},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.4472000002861023},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.4034999907016754},{"id":"https://openalex.org/C2780205056","wikidata":"https://www.wikidata.org/wiki/Q7308048","display_name":"Regenerative process","level":3,"score":0.3732999861240387},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.34940001368522644},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3434999883174896},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C78577261","wikidata":"https://www.wikidata.org/wiki/Q3391691","display_name":"Floor plate","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26339998841285706}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.07.749713","doi":"https://doi.org/10.64898/2026.09.07.749713","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749713","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749713.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42779586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13596170","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42779586/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.07.749713","doi":"https://doi.org/10.64898/2026.09.07.749713","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.07.749713","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/14/2026.09.07.749713.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306621","display_name":"Belgian American Educational Foundation","ror":"https://ror.org/014rsed66"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7213115144.pdf","grobid_xml":"https://content.openalex.org/works/W7213115144.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1529957136","https://openalex.org/W1834172848","https://openalex.org/W1974765744","https://openalex.org/W2022689175","https://openalex.org/W2037806376","https://openalex.org/W2047585900","https://openalex.org/W2050662417","https://openalex.org/W2100412095","https://openalex.org/W2989611105","https://openalex.org/W3033392434","https://openalex.org/W3164097469","https://openalex.org/W4282821576","https://openalex.org/W4313569219","https://openalex.org/W4381988718","https://openalex.org/W7162418523"],"related_works":["https://openalex.org/W7095176767","https://openalex.org/W3030576664","https://openalex.org/W3171156526","https://openalex.org/W2170459165","https://openalex.org/W2792597096","https://openalex.org/W2965609852","https://openalex.org/W2974035452","https://openalex.org/W1498402239","https://openalex.org/W2992933863","https://openalex.org/W4292543165"],"abstract_inverted_index":{"Abstract":[0],"Unlike":[1],"mammals,":[2],"adult":[3],"zebrafish":[4,21],"can":[5],"regenerate":[6],"spinal":[7,191],"cord":[8,192],"tissue":[9,65,219],"after":[10,190],"complete":[11],"transection.":[12],"We":[13,57],"report":[14],"here":[15],"that":[16,59,90,115,147],"a":[17,64,100,170,205,215],"substantial":[18],"proportion":[19],"of":[20,39,99,162,164,173,207],"receiving":[22],"this":[23,33],"injury":[24],"fail":[25],"to":[26,43,77,221],"regain":[27],"locomotor":[28],"function,":[29],"and":[30,50,75,85,131,139,186,202,224],"we":[31,46,113],"analyzed":[32],"critically.":[34],"After":[35],"stratifying":[36],"large":[37],"cohorts":[38],"injured":[40],"animals":[41,62],"according":[42],"functional":[44,225],"recovery,":[45,182],"directly":[47],"compared":[48],"recovered":[49],"non-recovered":[51],"individuals":[52],"at":[53],"matched":[54],"post-injury":[55],"stages.":[56],"find":[58,114],"permanently":[60],"paralyzed":[61],"form":[63],"bridge":[66,184],"across":[67],"the":[68,96],"lesion":[69],"yet":[70],"exhibit":[71],"impaired":[72,127,180],"axonal":[73,222],"invasion":[74],"regrowth":[76],"downstream":[78],"targets.":[79],"Integrative":[80],"single-nucleus":[81],"profiling,":[82],"spatial":[83],"transcriptomics,":[84],"regulatory":[86,121,137],"network":[87,138],"analyses":[88,142],"revealed":[89],"regenerative":[91,103,116,174,209],"success":[92,201],"is":[93],"characterized":[94],"by":[95],"coordinated":[97],"establishment":[98],"permissive":[101],"multicellular":[102,218],"state":[104],"rather":[105],"than":[106],"major":[107],"differences":[108,199],"in":[109,204],"cellular":[110,140],"composition.":[111],"Furthermore,":[112],"failure":[117,203],"involves":[118],"persistent":[119],"non-permissive":[120],"programs,":[122],"including":[123],"extracellular":[124],"matrix":[125],"remodeling,":[126],"adaptive":[128],"T-cell":[129],"activation,":[130],"reduced":[132],"axon":[133,188],"growth-associated":[134],"signaling.":[135],"Gene":[136],"trajectory":[141],"identified":[143,167],"candidate":[144],"transcriptional":[145],"regulators":[146],"could":[148],"not":[149],"be":[150],"resolved":[151],"through":[152],"differential":[153],"expression":[154],"analysis":[155],"alone.":[156],"Functional":[157],"CRISPR":[158],"F":[159],"0":[160],"screening":[161],"several":[163],"these":[165],"candidates":[166],"hoxb5a":[168,177,212],"as":[169,214],"critical":[171],"determinant":[172],"outcome.":[175],"Stable":[176],"mutants":[178],"exhibited":[179],"swimming":[181],"disrupted":[183],"formation,":[185],"limited":[187],"bridging":[189],"injury.":[193],"Together,":[194],"our":[195],"findings":[196],"reveal":[197],"key":[198],"between":[200],"model":[206],"elevated":[208],"capacity,":[210],"with":[211],"acting":[213],"regulator":[216],"linking":[217],"remodeling":[220],"regeneration":[223],"recovery.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-15T00:00:00"}