{"id":"https://openalex.org/W7213003052","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","title":"Rectal ozone insufflation modulates gut microbiota: improving lung function in mice with chronic obstructive pulmonary disease","display_name":"Rectal ozone insufflation modulates gut microbiota: improving lung function in mice with chronic obstructive pulmonary disease","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7213003052","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","pmid":"https://pubmed.ncbi.nlm.nih.gov/42734449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13667358"},"language":"en","primary_location":{"id":"doi:10.4103/mgr.medgasres-d-25-00314","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5151635683","display_name":"Qinyao Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qinyao Zhao","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100552957","display_name":"Xiaofang Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaofang Zhu","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151623393","display_name":"Pengcheng Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengcheng Wang","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115012146","display_name":"ShuangJiao Cao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuangjiao Cao","raw_affiliation_strings":["Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"John P. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John P. Williams","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056401960","display_name":"JianXiong AN","orcid":"https://orcid.org/0000-0003-4968-6392","observed_orcids":["https://orcid.org/0000-0003-4968-6392"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jianxiong An","raw_affiliation_strings":["Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","Department of Anesthesiology for the Integrated Traditional Chinese and Western Medicine Hospital, Southern Medical University, Guangzhou, Guangdong Province, China","Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","Laboratory of Ozone Medicine and Institute for Innovation Diagnosis & Treatment in Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China"],"raw_orcid":"https://orcid.org/0000-0003-4968-6392","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Anesthesiology for the Integrated Traditional Chinese and Western Medicine Hospital, Southern Medical University, Guangzhou, Guangdong Province, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Ozone Medicine and Institute for Innovation Diagnosis & Treatment in Anesthesiology, Shandong Second Medical University, Weifang, Shandong Province, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056401960"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6194774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"70","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13365","display_name":"Medical and Biological Ozone Research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13365","display_name":"Medical and Biological Ozone Research","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.1023000031709671,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7369999885559082},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7279999852180481},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9300000071525574},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8409000039100647},{"id":"https://openalex.org/C2776892627","wikidata":"https://www.wikidata.org/wiki/Q6042053","display_name":"Insufflation","level":2,"score":0.6234999895095825},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5169000029563904},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.5031999945640564},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.484499990940094},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.45509999990463257},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.424699991941452},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4124000072479248},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41200000047683716},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3982999920845032},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.385699987411499},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37439998984336853},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C2777104659","wikidata":"https://www.wikidata.org/wiki/Q3508797","display_name":"Obstructive lung disease","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C2779283356","wikidata":"https://www.wikidata.org/wiki/Q1426433","display_name":"Ozone therapy","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C2781074409","wikidata":"https://www.wikidata.org/wiki/Q158716","display_name":"Rectum","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.26499998569488525},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.25380000472068787}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000069467","descriptor_name":"Fecal Microbiota Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007327","descriptor_name":"Insufflation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010126","descriptor_name":"Ozone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4103/mgr.medgasres-d-25-00314","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},{"id":"pmid:42734449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42734449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical gas research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13667358","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13667358/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Gas Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4103/mgr.medgasres-d-25-00314","doi":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","is_oa":true,"landing_page_url":"https://doi.org/10.4103/mgr.medgasres-d-25-00314","pdf_url":null,"source":{"id":"https://openalex.org/S2764726520","display_name":"Medical Gas Research","issn_l":"2045-9912","issn":["2045-9912"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Gas Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415339544","https://openalex.org/W7172543966","https://openalex.org/W3180923817","https://openalex.org/W4281691459","https://openalex.org/W2995610953","https://openalex.org/W2970913452","https://openalex.org/W7160570056","https://openalex.org/W7212245532","https://openalex.org/W2793464221","https://openalex.org/W4387819536"],"abstract_inverted_index":{"Ozone":[0],"rectal":[1,27,65,74,102,140,159],"insufflation":[2,28,66,75,103,160],"possesses":[3],"anti-inflammatory":[4],"and":[5,8,14,34,60,81,84,164,178],"antioxidant":[6],"effects":[7,24],"is":[9],"used":[10],"for":[11],"the":[12,23,36,41,90,105,135,175],"treatment":[13,117],"prevention":[15],"of":[16,25,43,58,94,123,138],"diseases.":[17],"This":[18],"study":[19],"aimed":[20],"to":[21,120,145],"investigate":[22],"ozone":[26,64,73,101,139,158],"on":[29],"chronic":[30,48,95,111,147,168],"obstructive":[31,49,96,112,148,169],"pulmonary":[32,50,77,82,97,113,149,170],"disease":[33,51,98,114,150,171],"explore":[35],"potential":[37],"underlying":[38],"mechanisms":[39],"from":[40],"perspective":[42],"gut":[44,107,136,176],"microbiology.":[45],"A":[46],"mouse":[47],"model":[52],"was":[53,143],"established":[54],"by":[55,173],"intratracheal":[56],"spraying":[57],"lipopolysaccharide":[59],"elastase.":[61],"Mice":[62],"received":[63],"intervention":[67],"following":[68],"modeling.":[69],"We":[70],"found":[71],"that":[72,134,157],"improved":[76],"function,":[78],"alleviated":[79],"emphysema":[80],"fibrosis,":[83],"reduced":[85],"inflammatory":[86],"cytokine":[87],"levels":[88],"in":[89,110,167],"bronchoalveolar":[91],"lavage":[92],"fluid":[93],"mice.":[99,115],"Additionally,":[100],"modulated":[104],"pathogenic-to-beneficial":[106],"bacteria":[108],"ratio":[109],"The":[116,127],"also":[118],"led":[119],"an":[121],"upregulation":[122],"short-chain":[124],"fatty":[125],"acids.":[126],"fecal":[128],"microbiota":[129,137,177],"transplantation":[130],"results":[131],"further":[132],"confirmed":[133],"insufflation-treated":[141],"mice":[142,172],"sufficient":[144],"attenuate":[146],"symptoms.":[151],"In":[152],"summary,":[153],"our":[154],"findings":[155],"indicate":[156],"enhances":[161],"lung":[162],"function":[163],"reduces":[165],"inflammation":[166],"modulating":[174],"its":[179],"associated":[180],"metabolites.":[181]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-15T00:00:00"}
