{"id":"https://openalex.org/W7212988110","doi":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","title":"The main aspects of laboratory methods for the study of dry eye syndrome","display_name":"The main aspects of laboratory methods for the study of dry eye syndrome","publication_year":2026,"publication_date":"2026-08-03","ids":{"openalex":"https://openalex.org/W7212988110","doi":"https://doi.org/10.25276/0235-4160-2026-2s-161-168"},"language":"en","primary_location":{"id":"doi:10.25276/0235-4160-2026-2s-161-168","doi":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057329591","display_name":"\u0411\u043e\u0440\u0437\u0435\u043d\u043e\u043a \u0421\u0435\u0440\u0433\u0435\u0439 \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0001-9160-6240","observed_orcids":["https://orcid.org/0000-0001-9160-6240"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.A. Borzenok","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation; Russian University of Medicine, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation; Russian University of Medicine, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013593667","display_name":"\u041c\u0443\u0448\u043a\u043e\u0432\u0430 \u0418\u0440\u0438\u043d\u0430 \u0410\u043b\u044c\u0444\u0440\u0435\u0434\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-5601-8280","observed_orcids":["https://orcid.org/0000-0002-5601-8280","https://orcid.org/0000-0003-0941-4974"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.A. Mushkova","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057091930","display_name":"\u0410. \u041d. \u041a\u0430\u0440\u0438\u043c\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6926-7780","observed_orcids":["https://orcid.org/0000-0001-6926-7780"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.N. Karimova","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047103110","display_name":"Maria R. Obraztsova","orcid":"https://orcid.org/0000-0002-9933-9754","observed_orcids":["https://orcid.org/0000-0002-9933-9754"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.R. Obraztsova","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068273110","display_name":"M. Kh. Khubetsova","orcid":"https://orcid.org/0000-0002-6378-8750","observed_orcids":["https://orcid.org/0000-0002-6378-8750"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.Kh. Khubetsova","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024795412","display_name":"Dmitriy S. Ostrovskiy","orcid":"https://orcid.org/0000-0002-2817-7102","observed_orcids":["https://orcid.org/0000-0002-2817-7102"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.S. Ostrovskiy","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015312546","display_name":"Svetlana Yu. Kalinnikova","orcid":"https://orcid.org/0000-0002-9109-2400","observed_orcids":["https://orcid.org/0000-0002-9109-2400"]},"institutions":[{"id":"https://openalex.org/I4210148519","display_name":"Intersectoral Research and Technology Complex Eye Microsurgery","ror":"https://ror.org/04w68cb80","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210148519"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S.Yu. Kalinnikova","raw_affiliation_strings":["S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210148519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210148519"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62245913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2s","first_page":"161","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":1.0},{"id":"https://openalex.org/keywords/tear-film","display_name":"tear film","score":0.8930000066757202},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/conjunctival-cytology","display_name":"conjunctival cytology","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tears","display_name":"tears","score":0.8389999866485596},{"id":"https://openalex.org/keywords/enzyme-immunoassay","display_name":"enzyme immunoassay","score":0.8730000257492065},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.8130000233650208},{"id":"https://openalex.org/keywords/keratorefractive-surgery","display_name":"keratorefractive surgery","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ocular-surface-disease","display_name":"ocular surface disease","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tear-film-break-up-time","display_name":"tear film break-up time","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2778275304","wikidata":"https://www.wikidata.org/wiki/Q76469","display_name":"Tears","level":2,"score":0.75},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.7074999809265137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6653000116348267},{"id":"https://openalex.org/C2778837293","wikidata":"https://www.wikidata.org/wiki/Q3320636","display_name":"Artificial tears","level":2,"score":0.5521000027656555},{"id":"https://openalex.org/C2776883082","wikidata":"https://www.wikidata.org/wiki/Q1162694","display_name":"Dry eyes","level":2,"score":0.5331000089645386},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.44429999589920044},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.4115999937057495},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4068000018596649},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.40299999713897705},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.40130001306533813},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33649998903274536},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2867000102996826},{"id":"https://openalex.org/C2994251472","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Eye irritation","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2780161092","wikidata":"https://www.wikidata.org/wiki/Q284411","display_name":"Refractive surgery","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C527108885","wikidata":"https://www.wikidata.org/wiki/Q835153","display_name":"Physical examination","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C2779298748","wikidata":"https://www.wikidata.org/wiki/Q913628","display_name":"Lacrimal gland","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25276/0235-4160-2026-2s-161-168","doi":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25276/0235-4160-2026-2s-161-168","doi":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","is_oa":true,"landing_page_url":"https://doi.org/10.25276/0235-4160-2026-2s-161-168","pdf_url":null,"source":{"id":"https://openalex.org/S4210176926","display_name":"Fyodorov journal of ophthalmic surgery","issn_l":"0235-4160","issn":["0235-4160","2312-4970"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312600","host_organization_name":"Publishing house\u00a0\"Ophthalmology\"","host_organization_lineage":["https://openalex.org/P4310312600"],"host_organization_lineage_names":["Publishing house\u00a0\"Ophthalmology\""],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fyodorov journal of ophthalmic surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400785387","https://openalex.org/W4390444704","https://openalex.org/W7161581480","https://openalex.org/W4361214426","https://openalex.org/W7124871919","https://openalex.org/W2557702725","https://openalex.org/W4406245784","https://openalex.org/W2898151410","https://openalex.org/W4387780909","https://openalex.org/W2050361996"],"abstract_inverted_index":{"Purpose.":[0],"To":[1,24,185],"present":[2],"modern":[3,134,162],"literature":[4,33],"data":[5],"on":[6,35,54],"the":[7,12,26,30,40,55,58,61,78,86,98,104,120,125,149,182,187,190,194,206,212,222,239,260,283],"main":[8],"laboratory":[9,135,165,225],"methods":[10,227,264],"for":[11,32,60,177],"study":[13],"of":[14,57,77,88,93,97,103,108,122,137,143,148,156,164,189,193,205,214,238,254,262,265,269,282,291],"dry":[15,109,138,215,243,275],"eye":[16,45,71,110,126,139,216,244,276],"syndrome":[17,72,111,140],"in":[18,101,181,208,231,242],"refractive":[19],"patients.":[20,271],"Material":[21],"and":[22,65,90,106,145,174,257,267],"methods.":[23],"perform":[25],"review,":[27],"we":[28],"analyzed":[29],"search":[31],"sources":[34],"PubMed":[36],"abstract":[37],"databases":[38],"by":[39],"keywords":[41],"\u00abtear":[42],"film\u00bb,":[43],"\u00abdry":[44],"syndrome\u00bb,":[46],"\u00abcytokines\u00bb,":[47],"\u00abkeratorefractive":[48],"surgery\u00bb":[49],"according":[50,220],"to":[51,64,151,200,210,221,233,259],"Russian":[52],"publications":[53],"topic":[56],"article":[59],"period":[62],"up":[63],"including":[66],"2023":[67],"year.":[68],"Results.":[69],"Dry":[70],"is":[73,160,171,198],"a":[74,94,161,172,202,235],"multifactorial":[75],"disease":[76,256],"ocular":[79,240],"surface":[80,127,241],"that":[81],"causes":[82,155,253],"visual":[83],"discomfort,":[84],"affecting":[85],"quality":[87],"life":[89],"daily":[91],"activity":[92],"person.":[95],"One":[96],"important":[99],"aspects":[100],"understanding":[102],"etiology":[105],"pathogenesis":[107],"are":[112],"mutually":[113],"compatible":[114],"or":[115,128],"independent":[116],"processes":[117],"associated":[118],"with":[119,129],"evaporation":[121],"tears":[123,144],"from":[124],"insufficient":[130],"tear":[131,195,273],"production.":[132],"The":[133],"diagnostics":[136,166],"includes":[141],"examination":[142,204,281],"goblet":[146,278],"cells":[147],"conjunctiva":[150,207],"identify":[152,250],"potential":[153,251],"root":[154,252],"this":[157,255],"condition.":[158],"There":[159],"method":[163,176],"\u2014":[167],"enzyme":[168,289],"immunoassay,":[169],"which":[170],"sensitive":[173],"specific":[175],"quantifying":[178],"inflammatory":[179,285],"mediators":[180],"lacrimal":[183,287,292],"fluid.":[184],"assess":[186],"condition":[188],"water-mucin":[191],"layer":[192],"film,":[196,274],"it":[197],"possible":[199],"conduct":[201],"cytological":[203],"order":[209],"verify":[211],"diagnosis":[213],"syndrome.":[217],"Conclusion.":[218],"Thus,":[219],"scientific":[223],"literature,":[224],"diagnostic":[226],"can":[228,248],"be":[229],"used":[230],"combination":[232],"provide":[234],"comprehensive":[236],"assessment":[237],"syndrome,":[245,277],"as":[246],"they":[247],"help":[249],"direct":[258],"development":[261],"targeted":[263],"treatment":[266],"management":[268],"such":[270],"Keywords:":[272],"cells,":[279],"histological":[280],"conjunctiva,":[284],"mediators,":[286],"fluid,":[288],"immunoassay":[290],"fluid":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-15T00:00:00"}
