{"id":"https://openalex.org/W7212969291","doi":"https://doi.org/10.3390/nu18183001","title":"Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities","display_name":"Dietary Bioactive Compounds: Cellular Sensory Pathways, Microbial Partners, and Clinical Realities","publication_year":2026,"publication_date":"2026-09-14","ids":{"openalex":"https://openalex.org/W7212969291","doi":"https://doi.org/10.3390/nu18183001","pmid":"https://pubmed.ncbi.nlm.nih.gov/42796983","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13610585"},"language":"en","primary_location":{"id":"doi:10.3390/nu18183001","doi":"https://doi.org/10.3390/nu18183001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18183001","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu18183001","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076808367","display_name":"Elandia Aparecida dos Santos","orcid":"https://orcid.org/0000-0002-5017-2500","observed_orcids":["https://orcid.org/0000-0002-5017-2500"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elandia Aparecida dos Santos","raw_affiliation_strings":["Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte 31270-901, MG, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5017-2500","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte 31270-901, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051741661","display_name":"Jacqueline Isaura Alvarez-Leite","orcid":"https://orcid.org/0000-0001-6601-9853","observed_orcids":["https://orcid.org/0000-0001-6601-9853"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Jacqueline Isaura Alvarez-Leite","raw_affiliation_strings":["Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte 31270-901, MG, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-6601-9853","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Avenida Presidente Ant\u00f4nio Carlos, 6627, Pampulha, Belo Horizonte 31270-901, MG, Brazil","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051741661"],"corresponding_institution_ids":["https://openalex.org/I110200422"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"18","first_page":"3001","last_page":"3001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-bioactive-compounds","display_name":"dietary bioactive compounds","score":1.0},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.996999979019165},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":1.0},{"id":"https://openalex.org/keywords/organosulfur-compounds","display_name":"organosulfur compounds","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7239999771118164},{"id":"https://openalex.org/keywords/food-matrix-effects","display_name":"food matrix effects","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.843999981880188},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/peroxisome-proliferator-activated-receptors","display_name":"peroxisome proliferator-activated receptors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.8820000290870667},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8730000257492065},{"id":"https://openalex.org/keywords/non-communicable-diseases","display_name":"non-communicable diseases","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5062000155448914},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.4862000048160553},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.476500004529953},{"id":"https://openalex.org/C97633540","wikidata":"https://www.wikidata.org/wiki/Q4328195","display_name":"Nutrigenomics","level":3,"score":0.4636000096797943},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4487999975681305},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.42250001430511475},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41589999198913574},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4059000015258789},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C3018263421","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Human studies","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.37209999561309814},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.37209999561309814},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.35100001096725464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34040001034736633},{"id":"https://openalex.org/C101014631","wikidata":"https://www.wikidata.org/wiki/Q4889568","display_name":"Microbial metabolism","level":3,"score":0.3303000032901764},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3237000107765198},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32269999384880066},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2863999903202057},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2838999927043915},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.27480000257492065},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.2533000111579895}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000073296","descriptor_name":"Noncommunicable Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu18183001","doi":"https://doi.org/10.3390/nu18183001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18183001","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13610585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13610585/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13610585/pdf/nutrients-18-03001.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:42796983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42796983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/nu18183001","doi":"https://doi.org/10.3390/nu18183001","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18183001","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.40450000762939453,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7212969291.pdf","grobid_xml":"https://content.openalex.org/works/W7212969291.grobid-xml"},"referenced_works_count":245,"referenced_works":["https://openalex.org/W2320568803","https://openalex.org/W2463078362","https://openalex.org/W2473615084","https://openalex.org/W2528674304","https://openalex.org/W2547130884","https://openalex.org/W2586846550","https://openalex.org/W2730479429","https://openalex.org/W2735527928","https://openalex.org/W2747688304","https://openalex.org/W2756041018","https://openalex.org/W2789509184","https://openalex.org/W2791089458","https://openalex.org/W2794417158","https://openalex.org/W2797899907","https://openalex.org/W2800386729","https://openalex.org/W2805906447","https://openalex.org/W2807428935","https://openalex.org/W2843861620","https://openalex.org/W2866753615","https://openalex.org/W2899052178","https://openalex.org/W2899176988","https://openalex.org/W2909456588","https://openalex.org/W2910016375","https://openalex.org/W2915298192","https://openalex.org/W2920630434","https://openalex.org/W2921158983","https://openalex.org/W2933365160","https://openalex.org/W2935338472","https://openalex.org/W2939645883","https://openalex.org/W2946137280","https://openalex.org/W2953603115","https://openalex.org/W2964527079","https://openalex.org/W2965079275","https://openalex.org/W2970777296","https://openalex.org/W2971556914","https://openalex.org/W2972014638","https://openalex.org/W2981983744","https://openalex.org/W2982229157","https://openalex.org/W2994682310","https://openalex.org/W2997860137","https://openalex.org/W3000538110","https://openalex.org/W3001161839","https://openalex.org/W3004261705","https://openalex.org/W3006301659","https://openalex.org/W3006796998","https://openalex.org/W3007416780","https://openalex.org/W3009952969","https://openalex.org/W3011168528","https://openalex.org/W3013754122","https://openalex.org/W3014513386","https://openalex.org/W3031966252","https://openalex.org/W3041523647","https://openalex.org/W3042137188","https://openalex.org/W3047157459","https://openalex.org/W3080263865","https://openalex.org/W3080685158","https://openalex.org/W3093082737","https://openalex.org/W3093182666","https://openalex.org/W3097882759","https://openalex.org/W3098583674","https://openalex.org/W3099682691","https://openalex.org/W3103257019","https://openalex.org/W3110884268","https://openalex.org/W3117323139","https://openalex.org/W3121734311","https://openalex.org/W3124366424","https://openalex.org/W3128219601","https://openalex.org/W3135670207","https://openalex.org/W3139599348","https://openalex.org/W3142496132","https://openalex.org/W3156918339","https://openalex.org/W3171596094","https://openalex.org/W3179255618","https://openalex.org/W3191200351","https://openalex.org/W3205202331","https://openalex.org/W3205779276","https://openalex.org/W3207242393","https://openalex.org/W3211237469","https://openalex.org/W4200024130","https://openalex.org/W4200060349","https://openalex.org/W4200189597","https://openalex.org/W4200555669","https://openalex.org/W4205694563","https://openalex.org/W4206620445","https://openalex.org/W4206638872","https://openalex.org/W4206799195","https://openalex.org/W4212904553","https://openalex.org/W4213229510","https://openalex.org/W4214597185","https://openalex.org/W4223416045","https://openalex.org/W4223585474","https://openalex.org/W4224071637","https://openalex.org/W4229442497","https://openalex.org/W4280584892","https://openalex.org/W4281291801","https://openalex.org/W4283206401","https://openalex.org/W4283218741","https://openalex.org/W4283259889","https://openalex.org/W4283653424","https://openalex.org/W4283694470","https://openalex.org/W4284975940","https://openalex.org/W4285596676","https://openalex.org/W4285795452","https://openalex.org/W4292841406","https://openalex.org/W4295125751","https://openalex.org/W4297505016","https://openalex.org/W4304811973","https://openalex.org/W4307921919","https://openalex.org/W4308555009","https://openalex.org/W4309277386","https://openalex.org/W4310553187","https://openalex.org/W4311377626","https://openalex.org/W4311522547","https://openalex.org/W4313362255","https://openalex.org/W4313893953","https://openalex.org/W4322619980","https://openalex.org/W4322720303","https://openalex.org/W4324018326","https://openalex.org/W4324029158","https://openalex.org/W4353055846","https://openalex.org/W4362700929","https://openalex.org/W4365515070","https://openalex.org/W4366987767","https://openalex.org/W4378516215","https://openalex.org/W4378639326","https://openalex.org/W4379932562","https://openalex.org/W4382679774","https://openalex.org/W4383551214","https://openalex.org/W4385617654","https://openalex.org/W4386032700","https://openalex.org/W4386223851","https://openalex.org/W4387642511","https://openalex.org/W4387661461","https://openalex.org/W4389209629","https://openalex.org/W4390175611","https://openalex.org/W4390793072","https://openalex.org/W4390820354","https://openalex.org/W4390906586","https://openalex.org/W4391542631","https://openalex.org/W4391845274","https://openalex.org/W4391849121","https://openalex.org/W4391954123","https://openalex.org/W4392163177","https://openalex.org/W4392640565","https://openalex.org/W4392859293","https://openalex.org/W4393006642","https://openalex.org/W4394760792","https://openalex.org/W4394797620","https://openalex.org/W4395114497","https://openalex.org/W4399130027","https://openalex.org/W4399363474","https://openalex.org/W4399388411","https://openalex.org/W4399568020","https://openalex.org/W4400293020","https://openalex.org/W4401356509","https://openalex.org/W4401364143","https://openalex.org/W4401833314","https://openalex.org/W4401888239","https://openalex.org/W4403013201","https://openalex.org/W4403542205","https://openalex.org/W4403545967","https://openalex.org/W4403647294","https://openalex.org/W4403651078","https://openalex.org/W4403659219","https://openalex.org/W4404067140","https://openalex.org/W4404622074","https://openalex.org/W4405079359","https://openalex.org/W4405474242","https://openalex.org/W4405560410","https://openalex.org/W4405688854","https://openalex.org/W4406107845","https://openalex.org/W4406252893","https://openalex.org/W4406354324","https://openalex.org/W4406808312","https://openalex.org/W4407038408","https://openalex.org/W4407223962","https://openalex.org/W4408055257","https://openalex.org/W4408249441","https://openalex.org/W4408679146","https://openalex.org/W4408766514","https://openalex.org/W4408808779","https://openalex.org/W4408978254","https://openalex.org/W4408996481","https://openalex.org/W4409111256","https://openalex.org/W4410049169","https://openalex.org/W4410051124","https://openalex.org/W4410813845","https://openalex.org/W4410901536","https://openalex.org/W4411192949","https://openalex.org/W4411694132","https://openalex.org/W4411823731","https://openalex.org/W4411904114","https://openalex.org/W4411973090","https://openalex.org/W4412200281","https://openalex.org/W4412437531","https://openalex.org/W4412465953","https://openalex.org/W4412930515","https://openalex.org/W4412993013","https://openalex.org/W4413302496","https://openalex.org/W4413309781","https://openalex.org/W4413487421","https://openalex.org/W4413799646","https://openalex.org/W4413862401","https://openalex.org/W4414261966","https://openalex.org/W4414347771","https://openalex.org/W4414887847","https://openalex.org/W4415213278","https://openalex.org/W4415418998","https://openalex.org/W4415854645","https://openalex.org/W4415879918","https://openalex.org/W4415954432","https://openalex.org/W4415987485","https://openalex.org/W4416287478","https://openalex.org/W4416299037","https://openalex.org/W4416361182","https://openalex.org/W4416388604","https://openalex.org/W4416943543","https://openalex.org/W4417117714","https://openalex.org/W7117153756","https://openalex.org/W7117480460","https://openalex.org/W7118565737","https://openalex.org/W7119485038","https://openalex.org/W7124318626","https://openalex.org/W7124352685","https://openalex.org/W7124830526","https://openalex.org/W7124833140","https://openalex.org/W7124879184","https://openalex.org/W7125455632","https://openalex.org/W7125477432","https://openalex.org/W7125952864","https://openalex.org/W7128695351","https://openalex.org/W7128729381","https://openalex.org/W7128805083","https://openalex.org/W7130522236","https://openalex.org/W7131782028","https://openalex.org/W7132837975","https://openalex.org/W7133217841","https://openalex.org/W7134063052","https://openalex.org/W7134125608","https://openalex.org/W7134138781","https://openalex.org/W7140033358","https://openalex.org/W7143531347","https://openalex.org/W7155697278","https://openalex.org/W7157177513","https://openalex.org/W7162449849"],"related_works":["https://openalex.org/W7167370330","https://openalex.org/W4200441251","https://openalex.org/W2921158983","https://openalex.org/W4417237797","https://openalex.org/W7167372178","https://openalex.org/W7202370022","https://openalex.org/W7221599030","https://openalex.org/W7160940824","https://openalex.org/W3123071086","https://openalex.org/W4412923446"],"abstract_inverted_index":{"Background/Objectives:":[0],"Dietary":[1,183],"bioactive":[2,143],"compounds":[3],"(BCs)":[4],"modulate":[5],"multiple":[6],"cellular":[7],"pathways":[8,194],"involved":[9],"in":[10,45,174,202],"inflammation,":[11],"oxidative":[12],"stress,":[13],"energy":[14],"metabolism,":[15,137],"and":[16,28,41,67,78,92,122,138,155,165,179,192,205],"tissue":[17],"homeostasis.":[18],"This":[19],"narrative":[20,53],"review":[21,54],"aimed":[22],"to":[23,55,196,211],"synthesize":[24],"the":[25,60,93,99,112],"mechanistic":[26],"roles":[27],"therapeutic":[29,186],"relevance":[30,69],"of":[31,70,115,190],"major":[32],"dietary":[33,71],"BC":[34],"classes,":[35],"including":[36,85],"polyphenols,":[37],"carotenoids,":[38],"organosulfur":[39],"compounds,":[40],"polyunsaturated":[42],"fatty":[43],"acids,":[44],"chronic":[46,197],"non-communicable":[47],"diseases.":[48,198],"Methods:":[49],"We":[50],"conducted":[51],"a":[52],"integrate":[56],"current":[57],"evidence":[58],"on":[59],"classification,":[61],"bioavailability,":[62,132],"molecular":[63,191],"targets,":[64],"microbiota":[65],"interactions,":[66],"clinical":[68,79],"BCs.":[72],"The":[73,103],"literature":[74,104],"considered":[75],"experimental,":[76],"observational,":[77],"studies":[80],"addressing":[81],"key":[82],"signaling":[83],"pathways,":[84],"NF-\u03baB,":[86],"Nrf2,":[87],"AMPK,":[88],"mTOR,":[89],"SIRT1,":[90],"PPARs,":[91],"NLRP3":[94],"inflammasome,":[95],"as":[96,98,188],"well":[97],"diet\u2013microbiota\u2013host":[100],"axis.":[101],"Results:":[102],"indicates":[105],"that":[106],"BCs":[107,158,184],"exert":[108],"pleiotropic":[109],"effects":[110],"through":[111],"coordinated":[113],"modulation":[114],"transcription":[116],"factors,":[117],"metabolic":[118],"sensors,":[119],"nuclear":[120],"receptors,":[121],"inflammatory":[123,152],"mediators.":[124],"Their":[125],"biological":[126],"activity":[127],"is":[128],"also":[129],"shaped":[130],"by":[131,172],"food":[133],"matrix":[134],"effects,":[135],"host":[136],"gut":[139],"microbial":[140,193],"transformation":[141],"into":[142],"metabolites.":[144],"Across":[145],"obesity,":[146],"type":[147],"2":[148],"diabetes,":[149],"cardiovascular":[150],"disease,":[151,154],"bowel":[153],"neurodegenerative":[156],"conditions,":[157],"appear":[159],"associated":[160],"with":[161],"improved":[162],"inflammatory,":[163],"metabolic,":[164],"redox":[166],"regulation.":[167],"However,":[168,199],"findings":[169],"remain":[170],"limited":[171],"heterogeneity":[173],"study":[175,203],"design,":[176],"intervention":[177],"duration,":[178],"compound":[180],"characterization.":[181],"Conclusions:":[182],"show":[185],"potential":[187],"modulators":[189],"relevant":[195],"greater":[200],"standardization":[201],"design":[204],"longer-term":[206],"human":[207],"trials":[208],"are":[209],"needed":[210],"support":[212],"robust":[213],"evidence-based":[214],"recommendations.":[215]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-15T00:00:00"}